D. William O'Neal II/Sandbox1
From Proteopedia
Contents
|
Under Construction
Xenotransplantation, Xenografts
What is Xenotransplantation?
According to the United States Food & Drug Administration, "Xenotransplantation is any procedure that involves the transplantation, implantation or infusion into a human recipient of either (a) live cells, tissues, or organs from a nonhuman animal source, or (b) human body fluids, cells, tissues or organs that have had ex vivo contact with live nonhuman animal cells, tissues or organs."[1] In other words, xenotransplantation is the process of transferring body fluids, cells, organs, or tissues from a non-human animal into a human. Currently, genetically modified porcine (pig) donors are thought to be the most promising.
Why Xenotransplantation?
Patient mortality due to lack of availability of donor organs remains a growing concern.
Rejection of Xenografts [2]
Hyperacute Rejection
Associated Genes
hCD46
hCD55
hCD59
GGTA1 (Sus scrofa)
Acute Humoral Rejection
Associated Genes
Innate Cellular Rejection
Associated Genes
Adaptive Cellular Rejection
Associated Genes
Coagulation Disorder
Systemic Inflammation
Cross Species Infection
</StructureSection>
References
- ↑ Xenotransplantation. https://www.fda.gov/vaccines-blood-biologics/xenotransplantation. Accessed 9 September 2024.
- ↑ (1) Lei, T.; Chen, L.; Wang, K.; Du, S.; Gonelle-Gispert, C.; Wang, Y.; Buhler, L. H. Genetic Engineering of Pigs for Xenotransplantation to Overcome Immune Rejection and Physiological Incompatibilities: The First Clinical Steps. Front Immunol 2022, 13, 1031185. https://doi.org/10.3389/fimmu.2022.1031185.
