1aji - Revision history

OCA at 09:46, 26 May 2021

2021-05-26T09:46:05Z

←Older revision		Revision as of 09:46, 26 May 2021
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	<StructureSection load='1aji' size='340' side='right'caption='[[1aji]]' scene=''>		<StructureSection load='1aji' size='340' side='right'caption='[[1aji]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1AJI FirstGlance]. <br>	+	<table><tr><td colspan='2'>For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1AJI FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1aji FirstGlance], [~~http~~://www.ebi.ac.uk/pdbsum/1aji PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=1aji ProSAT]</span></td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1aji FirstGlance], [https://www.ebi.ac.uk/pdbsum/1aji PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1aji ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 07:47, 21 August 2019

2019-08-21T07:47:53Z

←Older revision		Revision as of 07:47, 21 August 2019
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	==APO-CALMODULIN IN COMPLEX WITH BRUSH BORDER MYOSIN I IQ MOTIF, THEORETICAL MODEL==		==APO-CALMODULIN IN COMPLEX WITH BRUSH BORDER MYOSIN I IQ MOTIF, THEORETICAL MODEL==
-	<StructureSection load='1aji' size='340' side='right' caption='[[1aji]]' scene=''>	+	<StructureSection load='1aji' size='340' side='right'caption='[[1aji]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1AJI FirstGlance]. <br>		<table><tr><td colspan='2'>For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1AJI FirstGlance]. <br>
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	</StructureSection>		</StructureSection>
	[[Category: Theoretical Model]]		[[Category: Theoretical Model]]
		+	[[Category: Large Structures]]
	[[Category: Cohen, C]]		[[Category: Cohen, C]]
	[[Category: Houdusse, A]]		[[Category: Houdusse, A]]

OCA at 10:46, 15 November 2017

2017-11-15T10:46:28Z

←Older revision		Revision as of 10:46, 15 November 2017
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	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1AJI FirstGlance]. <br>		<table><tr><td colspan='2'>For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1AJI FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1aji FirstGlance], [http://www.ebi.ac.uk/pdbsum/1aji PDBsum]</span></td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1aji FirstGlance], [http://www.ebi.ac.uk/pdbsum/1aji PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1aji ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 08:41, 11 February 2016

2016-02-11T08:41:13Z

←Older revision		Revision as of 08:41, 11 February 2016
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		+	{{Theoretical_model}}
		+
	==APO-CALMODULIN IN COMPLEX WITH BRUSH BORDER MYOSIN I IQ MOTIF, THEORETICAL MODEL==		==APO-CALMODULIN IN COMPLEX WITH BRUSH BORDER MYOSIN I IQ MOTIF, THEORETICAL MODEL==
	<StructureSection load='1aji' size='340' side='right' caption='[[1aji]]' scene=''>		<StructureSection load='1aji' size='340' side='right' caption='[[1aji]]' scene=''>
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Theoretical Model]]
	[[Category: Cohen, C]]		[[Category: Cohen, C]]
	[[Category: Houdusse, A]]		[[Category: Houdusse, A]]

OCA at 08:50, 11 September 2015

2015-09-11T08:50:49Z

←Older revision		Revision as of 08:50, 11 September 2015
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	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 1aji" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>

OCA at 10:19, 22 December 2014

2014-12-22T10:19:13Z

←Older revision		Revision as of 10:19, 22 December 2014
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	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1AJI FirstGlance]. <br>		<table><tr><td colspan='2'>For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1AJI FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1aji FirstGlance], [http://www.ebi.ac.uk/pdbsum/1aji PDBsum]</span></td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1aji FirstGlance], [http://www.ebi.ac.uk/pdbsum/1aji PDBsum]</span></td></tr>
-	<table>	+	</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==

OCA at 08:14, 30 July 2014

2014-07-30T08:14:43Z

←Older revision		Revision as of 08:14, 30 July 2014
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-	~~{{Theoretical_model}}~~	+	==APO-CALMODULIN IN COMPLEX WITH BRUSH BORDER MYOSIN I IQ MOTIF, THEORETICAL MODEL==
		+	<StructureSection load='1aji' size='340' side='right' caption='[[1aji]]' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1AJI FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1aji FirstGlance], [http://www.ebi.ac.uk/pdbsum/1aji PDBsum]</span></td></tr>
		+	<table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	BACKGROUND: In contrast to conventional muscle myosins, where two different light chains (LCs) stabilize the elongated regulatory domain (RD) region of the head portion of the molecule, unconventional myosins are a diverse group of motors in which from one to six calmodulin (CaM) subunits are bound tandemly to the RD. In both cases, the heavy chains of the RDs have special sequences called "IQ motifs' to which the LCs or CaM bind. A previously puzzling aspect of certain unconventional myosins is their unusual mode of regulation, where activation of motility occurs at low levels of Ca2+. Although the atomic structure of the conventional muscle myosin RD has been determined, no crystallographic structure of the RD of an unconventional myosin is yet available. RESULTS: We have constructed a model of vertebrate CaM bound to the first IQ motif present in the neck region of an unconventional myosin (chicken brush border myosin I), using strict binding rules derived from the crystal structure of the scallop RD. The model accounts for aspects of the regulation of many unconventional myosins where CaM is bound at low levels of Ca2+ and released or changed in conformation at high levels of Ca2+. The conformational changes as a function of Ca2+ depend not only on the precise sequence of the IQ motifs but also on the interactions between CaM molecules bound to adjacent sites on the myosin heavy chain. CONCLUSIONS: According to our model, the full versatility of CaM binding to target peptides is displayed in the regulation of unconventional myosins. At low concentrations of Ca2+, CaM binds in a manner similar to the LCs of conventional myosins. At higher Ca2+ concentrations, CaM changes conformation and acts as a switch to regulate the activity of the unconventional myosin molecules.

-	~~[[Image~~:~~1aji~~.~~png\|left\|200px]]~~	+	A model of Ca(2+)-free calmodulin binding to unconventional myosins reveals how calmodulin acts as a regulatory switch.,Houdusse A, Silver M, Cohen C Structure. 1996 Dec 15;4(12):1475-90. PMID:8994973<ref>PMID:8994973</ref>

-	~~{{STRUCTURE_1aji\| PDB=1aji \| SCENE= }}~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~===APO-CALMODULIN IN COMPLEX WITH BRUSH BORDER MYOSIN I IQ MOTIF~~, ~~THEORETICAL MODEL===~~	+	== References ==
-		+	<references/>
-	~~{{ABSTRACT_PUBMED_8994973}}~~	+	__TOC__
-		+	</StructureSection>
-	==~~Reference~~==	+
-	<~~ref group="xtra">PMID:008994973<~~/~~ref~~><~~references group="xtra"~~/>	+
	[[Category: Cohen, C]]		[[Category: Cohen, C]]
	[[Category: Houdusse, A]]		[[Category: Houdusse, A]]

OCA: Protected "1aji" [edit=sysop:move=sysop]

2012-10-21T10:02:42Z

Protected "1aji" [edit=sysop:move=sysop]

←Older revision

Revision as of 10:02, 21 October 2012

OCA at 10:02, 21 October 2012

2012-10-21T10:02:38Z

←Older revision		Revision as of 10:02, 21 October 2012
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	{{Theoretical_model}}		{{Theoretical_model}}
-	~~{{Seed}}~~	+
	[[Image:1aji.png\|left\|200px]]		[[Image:1aji.png\|left\|200px]]

-	<!--
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-	or leave the SCENE parameter empty for the default display.
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	{{STRUCTURE_1aji\| PDB=1aji \| SCENE= }}		{{STRUCTURE_1aji\| PDB=1aji \| SCENE= }}

	===APO-CALMODULIN IN COMPLEX WITH BRUSH BORDER MYOSIN I IQ MOTIF, THEORETICAL MODEL===		===APO-CALMODULIN IN COMPLEX WITH BRUSH BORDER MYOSIN I IQ MOTIF, THEORETICAL MODEL===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_8994973}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 8994973 is the PubMed ID number.
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	{{ABSTRACT_PUBMED_8994973}}		{{ABSTRACT_PUBMED_8994973}}
-
-	==About this Structure==
-	Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1AJI OCA].

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~8994973~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:008994973</ref><references group="xtra"/>
	[[Category: Cohen, C]]		[[Category: Cohen, C]]
	[[Category: Houdusse, A]]		[[Category: Houdusse, A]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Apr 8 09:27:07 2010''

OCA at 06:27, 8 April 2010

2010-04-08T06:27:08Z

←Older revision		Revision as of 06:27, 8 April 2010
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-	~~'''Theoretical Model'''~~	+	{{Theoretical_model}}
		+	{{Seed}}
		+	[[Image:1aji.png\|left\|200px]]

-	The ~~entry 1AJI~~ is ~~a Theoretical Model titled 'APO-CALMODULIN IN COMPLEX WITH BRUSH BORDER MYOSIN I IQ MOTIF~~, ~~THEORETICAL MODEL'~~.	+	<!--
		+	The line below this paragraph, containing "STRUCTURE_1aji", creates the "Structure Box" on the page.
		+	You may change the PDB parameter (which sets the PDB file loaded into the applet)
		+	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
		+	or leave the SCENE parameter empty for the default display.
		+	-->
		+	{{STRUCTURE_1aji\| PDB=1aji \| SCENE= }}

-	~~[[Category:Theoretical Model]]~~	+	===APO-CALMODULIN IN COMPLEX WITH BRUSH BORDER MYOSIN I IQ MOTIF, THEORETICAL MODEL===


-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Wed Jul 30~~ 09:48:~~46 2008~~''	+	<!--
		+	The line below this paragraph, {{ABSTRACT_PUBMED_8994973}}, adds the Publication Abstract to the page
		+	(as it appears on PubMed at http://www.pubmed.gov), where 8994973 is the PubMed ID number.
		+	-->
		+	{{ABSTRACT_PUBMED_8994973}}
		+
		+	==About this Structure==
		+	Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1AJI OCA].
		+
		+	==Reference==
		+	<ref group="xtra">PMID:8994973</ref><references group="xtra"/>
		+	[[Category: Cohen, C]]
		+	[[Category: Houdusse, A]]
		+
		+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Apr 8 09:27:07 2010''