1apt - Revision history

OCA at 15:27, 13 March 2024

2024-03-13T15:27:11Z

←Older revision		Revision as of 15:27, 13 March 2024
Line 3:		Line 3:
	<StructureSection load='1apt' size='340' side='right'caption='[[1apt]], [[Resolution\|resolution]] 1.80Å' scene=''>		<StructureSection load='1apt' size='340' side='right'caption='[[1apt]], [[Resolution\|resolution]] 1.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1apt]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Cbs_340.48 Cbs 340.48~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1APT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1APT FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1apt]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Penicillium_janthinellum Penicillium janthinellum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1APT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1APT FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=MAN:ALPHA~~-~~D-MANNOSE'>MAN</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.8Å</td></tr>
-	<tr id='~~NonStdRes~~'><td class="sblockLbl"><b>[[~~Non-Standard_Residue~~\|~~NonStd Res~~:]]</b></td><td class="sblockDat"><scene name='pdbligand=IVA:ISOVALERIC+ACID'>IVA</scene>, <scene name='pdbligand=LTA:4,8-DIAMINO-3-HYDROXY-OCTANOIC+ACID+ETHYL+ESTER'>LTA</scene><~~/td></tr>~~	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=IVA:ISOVALERIC+ACID'>IVA</scene>, <scene name='pdbligand=LTA:4,8-DIAMINO-3-HYDROXY-OCTANOIC+ACID+ETHYL+ESTER'>LTA</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene></td></tr>
-	~~<tr id~~='~~related'><td class~~=~~"sblockLbl"><b>[[Related_structure\|Related~~:~~]]</b></td><td class="sblockDat"><div style='overflow: auto; max~~-~~height: 3em;~~'>~~[[1apu\|1apu]], [[1apv\|1apv]], [[1apw\|1apw]]~~</~~div></td></tr>~~	+
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Penicillopepsin Penicillopepsin], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.23.20 3.4.23.20] </span></td></tr>	+
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1apt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1apt OCA], [https://pdbe.org/1apt PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1apt RCSB], [https://www.ebi.ac.uk/pdbsum/1apt PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1apt ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1apt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1apt OCA], [https://pdbe.org/1apt PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1apt RCSB], [https://www.ebi.ac.uk/pdbsum/1apt PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1apt ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/PEPA1_PENJA PEPA1_PENJA] Secreted aspartic endopeptidase that allows assimilation of proteinaceous substrates. The scissile peptide bond is attacked by a nucleophilic water molecule activated by two aspartic residues in the active site. Shows a broad primary substrate specificity. Favors hydrophobic residues at the P1 and P1' positions, but can also activate trypsinogen and hydrolyze the B chain of insulin between positions 'Gly-20' and 'Glu-21'.<ref>PMID:4946839</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 24:		Line 24:
	*[[Penicillopepsin\|Penicillopepsin]]		*[[Penicillopepsin\|Penicillopepsin]]
	*[[Pepsin\|Pepsin]]		*[[Pepsin\|Pepsin]]
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Cbs 340 48]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Penicillopepsin~~]]	+	[[Category: Penicillium janthinellum]]
-	[[Category: James~~, M N.G~~]]	+	[[Category: James MNG]]
-	[[Category: Sielecki~~, A R]]~~	+	[[Category: Sielecki AR]]
-	~~[[Category: Acid proteinase]]~~	+
-	~~[[Category: Hydrolase-hydrolase inhibitor complex~~]]	+

OCA at 09:47, 26 May 2021

2021-05-26T09:47:47Z

←Older revision		Revision as of 09:47, 26 May 2021
Line 3:		Line 3:
	<StructureSection load='1apt' size='340' side='right'caption='[[1apt]], [[Resolution\|resolution]] 1.80Å' scene=''>		<StructureSection load='1apt' size='340' side='right'caption='[[1apt]], [[Resolution\|resolution]] 1.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1apt]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Cbs_340.48 Cbs 340.48]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1APT OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1APT FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1apt]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Cbs_340.48 Cbs 340.48]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1APT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1APT FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene></td></tr>
	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=IVA:ISOVALERIC+ACID'>IVA</scene>, <scene name='pdbligand=LTA:4,8-DIAMINO-3-HYDROXY-OCTANOIC+ACID+ETHYL+ESTER'>LTA</scene></td></tr>		<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=IVA:ISOVALERIC+ACID'>IVA</scene>, <scene name='pdbligand=LTA:4,8-DIAMINO-3-HYDROXY-OCTANOIC+ACID+ETHYL+ESTER'>LTA</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1apu\|1apu]], [[1apv\|1apv]], [[1apw\|1apw]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1apu\|1apu]], [[1apv\|1apv]], [[1apw\|1apw]]</div></td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://en.wikipedia.org/wiki/Penicillopepsin Penicillopepsin], with EC number [~~http~~://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.23.20 3.4.23.20] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Penicillopepsin Penicillopepsin], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.23.20 3.4.23.20] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1apt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1apt OCA], [~~http~~://pdbe.org/1apt PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=1apt RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/1apt PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=1apt ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1apt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1apt OCA], [https://pdbe.org/1apt PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1apt RCSB], [https://www.ebi.ac.uk/pdbsum/1apt PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1apt ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==

OCA at 07:23, 21 August 2019

2019-08-21T07:23:39Z

←Older revision		Revision as of 07:23, 21 August 2019
Line 1:		Line 1:

	==CRYSTALLOGRAPHIC ANALYSIS OF A PEPSTATIN ANALOGUE BINDING TO THE ASPARTYL PROTEINASE PENICILLOPEPSIN AT 1.8 ANGSTROMS RESOLUTION==		==CRYSTALLOGRAPHIC ANALYSIS OF A PEPSTATIN ANALOGUE BINDING TO THE ASPARTYL PROTEINASE PENICILLOPEPSIN AT 1.8 ANGSTROMS RESOLUTION==
-	<StructureSection load='1apt' size='340' side='right' caption='[[1apt]], [[Resolution\|resolution]] 1.80Å' scene=''>	+	<StructureSection load='1apt' size='340' side='right'caption='[[1apt]], [[Resolution\|resolution]] 1.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1apt]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Cbs_340.48 Cbs 340.48]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1APT OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1APT FirstGlance]. <br>		<table><tr><td colspan='2'>[[1apt]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Cbs_340.48 Cbs 340.48]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1APT OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1APT FirstGlance]. <br>
Line 14:		Line 14:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ap/1apt_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ap/1apt_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
Line 20:		Line 20:
	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1apt ConSurf].		</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1apt ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
		+
		+	==See Also==
		+	*[[Penicillopepsin\|Penicillopepsin]]
		+	*[[Pepsin\|Pepsin]]
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: Cbs 340 48]]		[[Category: Cbs 340 48]]
		+	[[Category: Large Structures]]
	[[Category: Penicillopepsin]]		[[Category: Penicillopepsin]]
	[[Category: James, M N.G]]		[[Category: James, M N.G]]

OCA at 10:47, 15 November 2017

2017-11-15T10:47:23Z

←Older revision		Revision as of 10:47, 15 November 2017
Line 1:		Line 1:
		+
	==CRYSTALLOGRAPHIC ANALYSIS OF A PEPSTATIN ANALOGUE BINDING TO THE ASPARTYL PROTEINASE PENICILLOPEPSIN AT 1.8 ANGSTROMS RESOLUTION==		==CRYSTALLOGRAPHIC ANALYSIS OF A PEPSTATIN ANALOGUE BINDING TO THE ASPARTYL PROTEINASE PENICILLOPEPSIN AT 1.8 ANGSTROMS RESOLUTION==
	<StructureSection load='1apt' size='340' side='right' caption='[[1apt]], [[Resolution\|resolution]] 1.80Å' scene=''>		<StructureSection load='1apt' size='340' side='right' caption='[[1apt]], [[Resolution\|resolution]] 1.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1apt]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Penja Penja~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1APT OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1APT FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1apt]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Cbs_340.48 Cbs 340.48]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1APT OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1APT FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene></td></tr>
	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=IVA:ISOVALERIC+ACID'>IVA</scene>, <scene name='pdbligand=LTA:4,8-DIAMINO-3-HYDROXY-OCTANOIC+ACID+ETHYL+ESTER'>LTA</scene></td></tr>		<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=IVA:ISOVALERIC+ACID'>IVA</scene>, <scene name='pdbligand=LTA:4,8-DIAMINO-3-HYDROXY-OCTANOIC+ACID+ETHYL+ESTER'>LTA</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1apu\|1apu]], [[1apv\|1apv]], [[1apw\|1apw]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1apu\|1apu]], [[1apv\|1apv]], [[1apw\|1apw]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Penicillopepsin Penicillopepsin], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.23.20 3.4.23.20] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Penicillopepsin Penicillopepsin], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.23.20 3.4.23.20] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1apt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1apt OCA], [http://pdbe.org/1apt PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1apt RCSB], [http://www.ebi.ac.uk/pdbsum/1apt PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1apt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1apt OCA], [http://pdbe.org/1apt PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1apt RCSB], [http://www.ebi.ac.uk/pdbsum/1apt PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1apt ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 19:		Line 20:
	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1apt ConSurf].		</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1apt ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
-
-	==See Also==
-	*[[Penicillopepsin\|Penicillopepsin]]
-	*[[Pepsin\|Pepsin]]
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Cbs 340 48]]
	[[Category: Penicillopepsin]]		[[Category: Penicillopepsin]]
-	[[Category: Penja]]
	[[Category: James, M N.G]]		[[Category: James, M N.G]]
	[[Category: Sielecki, A R]]		[[Category: Sielecki, A R]]
	[[Category: Acid proteinase]]		[[Category: Acid proteinase]]
	[[Category: Hydrolase-hydrolase inhibitor complex]]		[[Category: Hydrolase-hydrolase inhibitor complex]]

OCA at 08:00, 10 February 2016

2016-02-10T08:00:04Z

←Older revision		Revision as of 08:00, 10 February 2016
Line 17:		Line 17:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1apt ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>

OCA at 06:55, 11 September 2015

2015-09-11T06:55:23Z

←Older revision		Revision as of 06:55, 11 September 2015
Line 2:		Line 2:
	<StructureSection load='1apt' size='340' side='right' caption='[[1apt]], [[Resolution\|resolution]] 1.80Å' scene=''>		<StructureSection load='1apt' size='340' side='right' caption='[[1apt]], [[Resolution\|resolution]] 1.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1apt]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Penicillium_janthinellum Penicillium janthinellum~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1APT OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1APT FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1apt]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Penja Penja]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1APT OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1APT FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene></td></tr>
	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=IVA:ISOVALERIC+ACID'>IVA</scene>, <scene name='pdbligand=LTA:4,8-DIAMINO-3-HYDROXY-OCTANOIC+ACID+ETHYL+ESTER'>LTA</scene></td></tr>		<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=IVA:ISOVALERIC+ACID'>IVA</scene>, <scene name='pdbligand=LTA:4,8-DIAMINO-3-HYDROXY-OCTANOIC+ACID+ETHYL+ESTER'>LTA</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1apu\|1apu]], [[1apv\|1apv]], [[1apw\|1apw]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1apu\|1apu]], [[1apv\|1apv]], [[1apw\|1apw]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Penicillopepsin Penicillopepsin], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.23.20 3.4.23.20] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Penicillopepsin Penicillopepsin], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.23.20 3.4.23.20] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1apt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1apt OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1apt RCSB], [http://www.ebi.ac.uk/pdbsum/1apt PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1apt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1apt OCA], [http://pdbe.org/1apt PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1apt RCSB], [http://www.ebi.ac.uk/pdbsum/1apt PDBsum]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 25:		Line 25:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Penicillium janthinellum]]
	[[Category: Penicillopepsin]]		[[Category: Penicillopepsin]]
		+	[[Category: Penja]]
	[[Category: James, M N.G]]		[[Category: James, M N.G]]
	[[Category: Sielecki, A R]]		[[Category: Sielecki, A R]]
	[[Category: Acid proteinase]]		[[Category: Acid proteinase]]
	[[Category: Hydrolase-hydrolase inhibitor complex]]		[[Category: Hydrolase-hydrolase inhibitor complex]]

OCA at 11:43, 22 December 2014

2014-12-22T11:43:39Z

←Older revision		Revision as of 11:43, 22 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1apt]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Penicillium_janthinellum Penicillium janthinellum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1APT OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1APT FirstGlance]. <br>		<table><tr><td colspan='2'>[[1apt]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Penicillium_janthinellum Penicillium janthinellum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1APT OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1APT FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=IVA:ISOVALERIC+ACID'>IVA</scene>, <scene name='pdbligand=LTA:4,8-DIAMINO-3-HYDROXY-OCTANOIC+ACID+ETHYL+ESTER'>LTA</scene></td></tr>	+	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=IVA:ISOVALERIC+ACID'>IVA</scene>, <scene name='pdbligand=LTA:4,8-DIAMINO-3-HYDROXY-OCTANOIC+ACID+ETHYL+ESTER'>LTA</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1apu\|1apu]], [[1apv\|1apv]], [[1apw\|1apw]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1apu\|1apu]], [[1apv\|1apv]], [[1apw\|1apw]]</td></tr>
-	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Penicillopepsin Penicillopepsin], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.23.20 3.4.23.20] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Penicillopepsin Penicillopepsin], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.23.20 3.4.23.20] </span></td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1apt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1apt OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1apt RCSB], [http://www.ebi.ac.uk/pdbsum/1apt PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1apt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1apt OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1apt RCSB], [http://www.ebi.ac.uk/pdbsum/1apt PDBsum]</span></td></tr>
-	<table>	+	</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 27:		Line 27:
	[[Category: Penicillium janthinellum]]		[[Category: Penicillium janthinellum]]
	[[Category: Penicillopepsin]]		[[Category: Penicillopepsin]]
-	[[Category: James, M N.G.]]	+	[[Category: James, M N.G]]
-	[[Category: Sielecki, A R.]]	+	[[Category: Sielecki, A R]]
	[[Category: Acid proteinase]]		[[Category: Acid proteinase]]
	[[Category: Hydrolase-hydrolase inhibitor complex]]		[[Category: Hydrolase-hydrolase inhibitor complex]]

OCA at 08:15, 30 July 2014

2014-07-30T08:15:21Z

←Older revision		Revision as of 08:15, 30 July 2014
Line 1:		Line 1:
-	~~[[Image:1apt.png\|left\|200px]]~~	+	==CRYSTALLOGRAPHIC ANALYSIS OF A PEPSTATIN ANALOGUE BINDING TO THE ASPARTYL PROTEINASE PENICILLOPEPSIN AT 1.8 ANGSTROMS RESOLUTION==
-		+	<StructureSection load='1apt' size='340' side='right' caption='[[1apt]], [[Resolution\|resolution]] 1.80Å' scene=''>
-	~~{{STRUCTURE_1apt\| PDB=1apt \| SCENE= }}~~	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[1apt]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Penicillium_janthinellum Penicillium janthinellum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1APT OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1APT FirstGlance]. <br>
-	===CRYSTALLOGRAPHIC ANALYSIS OF A PEPSTATIN ANALOGUE BINDING TO THE ASPARTYL PROTEINASE PENICILLOPEPSIN AT 1.8 ANGSTROMS RESOLUTION===	+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene><br>
-		+	<tr><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=IVA:ISOVALERIC+ACID'>IVA</scene>, <scene name='pdbligand=LTA:4,8-DIAMINO-3-HYDROXY-OCTANOIC+ACID+ETHYL+ESTER'>LTA</scene></td></tr>
-		+	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1apu\|1apu]], [[1apv\|1apv]], [[1apw\|1apw]]</td></tr>
-	==~~About this Structure~~==	+	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Penicillopepsin Penicillopepsin], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.23.20 3.4.23.20] </span></td></tr>
-	[[1apt]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Penicillium_janthinellum Penicillium janthinellum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1APT OCA].	+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1apt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1apt OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1apt RCSB], [http://www.ebi.ac.uk/pdbsum/1apt PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ap/1apt_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>

	==See Also==		==See Also==
	*[[Penicillopepsin\|Penicillopepsin]]		*[[Penicillopepsin\|Penicillopepsin]]
	*[[Pepsin\|Pepsin]]		*[[Pepsin\|Pepsin]]
		+	__TOC__
		+	</StructureSection>
	[[Category: Penicillium janthinellum]]		[[Category: Penicillium janthinellum]]
	[[Category: Penicillopepsin]]		[[Category: Penicillopepsin]]

OCA at 16:53, 20 October 2012

2012-10-20T16:53:45Z

←Older revision		Revision as of 16:53, 20 October 2012
Line 7:		Line 7:

	==About this Structure==		==About this Structure==
-	[[1apt]] is a 2 chain structure ~~of [[Penicillopepsin]] and [[Pepsin]]~~ with sequence from [http://en.wikipedia.org/wiki/Penicillium_janthinellum Penicillium janthinellum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1APT OCA].	+	[[1apt]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Penicillium_janthinellum Penicillium janthinellum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1APT OCA].

	==See Also==		==See Also==

OCA: Protected "1apt" [edit=sysop:move=sysop]

2012-07-26T23:09:53Z

Protected "1apt" [edit=sysop:move=sysop]

←Older revision

Revision as of 23:09, 26 July 2012