1awn - Revision history

OCA at 15:02, 2 June 2021

2021-06-02T15:02:12Z

←Older revision		Revision as of 15:02, 2 June 2021
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	<StructureSection load='1awn' size='340' side='right'caption='[[1awn]]' scene=''>		<StructureSection load='1awn' size='340' side='right'caption='[[1awn]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1AWN FirstGlance]. <br>	+	<table><tr><td colspan='2'>For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1AWN FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1awn FirstGlance], [~~http~~://www.ebi.ac.uk/pdbsum/1awn PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=1awn ProSAT]</span></td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1awn FirstGlance], [https://www.ebi.ac.uk/pdbsum/1awn PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1awn ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 16:39, 28 August 2019

2019-08-28T16:39:03Z

←Older revision		Revision as of 16:39, 28 August 2019
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	==HOMOLOGY MODEL OF BOVINE SOLUBLE GUANYLYL CYCLASE==		==HOMOLOGY MODEL OF BOVINE SOLUBLE GUANYLYL CYCLASE==
-	<StructureSection load='1awn' size='340' side='right' caption='[[1awn]]' scene=''>	+	<StructureSection load='1awn' size='340' side='right'caption='[[1awn]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1AWN FirstGlance]. <br>		<table><tr><td colspan='2'>For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1AWN FirstGlance]. <br>
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	</StructureSection>		</StructureSection>
	[[Category: Theoretical Model]]		[[Category: Theoretical Model]]
		+	[[Category: Large Structures]]
	[[Category: Hurley, J H]]		[[Category: Hurley, J H]]
	[[Category: Rao, V D]]		[[Category: Rao, V D]]

OCA at 11:04, 22 November 2017

2017-11-22T11:04:57Z

←Older revision		Revision as of 11:04, 22 November 2017
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	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1AWN FirstGlance]. <br>		<table><tr><td colspan='2'>For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1AWN FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1awn FirstGlance], [http://www.ebi.ac.uk/pdbsum/1awn PDBsum]</span></td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1awn FirstGlance], [http://www.ebi.ac.uk/pdbsum/1awn PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1awn ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 08:43, 11 February 2016

2016-02-11T08:43:15Z

←Older revision		Revision as of 08:43, 11 February 2016
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		+	{{Theoretical_model}}
		+
	==HOMOLOGY MODEL OF BOVINE SOLUBLE GUANYLYL CYCLASE==		==HOMOLOGY MODEL OF BOVINE SOLUBLE GUANYLYL CYCLASE==
	<StructureSection load='1awn' size='340' side='right' caption='[[1awn]]' scene=''>		<StructureSection load='1awn' size='340' side='right' caption='[[1awn]]' scene=''>
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Theoretical Model]]
	[[Category: Hurley, J H]]		[[Category: Hurley, J H]]
	[[Category: Rao, V D]]		[[Category: Rao, V D]]

OCA at 09:28, 10 September 2015

2015-09-10T09:28:29Z

←Older revision		Revision as of 09:28, 10 September 2015
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	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 1awn" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>

OCA at 11:49, 22 December 2014

2014-12-22T11:49:56Z

←Older revision		Revision as of 11:49, 22 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1AWN FirstGlance]. <br>		<table><tr><td colspan='2'>For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1AWN FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1awn FirstGlance], [http://www.ebi.ac.uk/pdbsum/1awn PDBsum]</span></td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1awn FirstGlance], [http://www.ebi.ac.uk/pdbsum/1awn PDBsum]</span></td></tr>
-	<table>	+	</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==

OCA at 08:06, 30 July 2014

2014-07-30T08:06:07Z

←Older revision		Revision as of 08:06, 30 July 2014
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-	~~{{Theoretical_model}}~~	+	==HOMOLOGY MODEL OF BOVINE SOLUBLE GUANYLYL CYCLASE==
		+	<StructureSection load='1awn' size='340' side='right' caption='[[1awn]]' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1AWN FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1awn FirstGlance], [http://www.ebi.ac.uk/pdbsum/1awn PDBsum]</span></td></tr>
		+	<table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The adenylyl and guanylyl cyclases catalyze the formation of 3', 5'-cyclic adenosine or guanosine monophosphate from the corresponding nucleoside 5'-triphosphate. The guanylyl cyclases, the mammalian adenylyl cyclases, and their microbial homologues function as pairs of homologous catalytic domains. The crystal structure of the rat type II adenylyl cyclase C2 catalytic domain was used to model by homology a mammalian adenylyl cyclase C1-C2 domain pair, a homodimeric adenylyl cyclase of Dictyostelium discoideum, a heterodimeric soluble guanylyl cyclase, and a homodimeric membrane guanylyl cyclase. Mg2+ATP or Mg2+GTP were docked into the active sites based on known stereochemical constraints on their conformation. The models are consistent with the activities of seven active-site mutants. Asp-310 and Glu-432 of type I adenylyl cyclase coordinate a Mg2+ ion. The D310S and D310A mutants have 10-fold reduced Vmax and altered [Mg2+] dependence. The NTP purine moieties bind in mostly hydrophobic pockets. Specificity is conferred by a Lys and an Asp in adenylyl cyclase, and a Glu, an Arg, and a Cys in guanylyl cyclase. The models predict that an Asp from one domain is a general base in the reaction, and that the transition state is stabilized by a conserved Asn-Arg pair on the other domain.

-	~~[[Image~~:~~1awn~~.~~png\|left\|200px]]~~	+	Catalytic mechanism of the adenylyl and guanylyl cyclases: modeling and mutational analysis.,Liu Y, Ruoho AE, Rao VD, Hurley JH Proc Natl Acad Sci U S A. 1997 Dec 9;94(25):13414-9. PMID:9391039<ref>PMID:9391039</ref>

-	~~{{STRUCTURE_1awn\| PDB=1awn \| SCENE= }}~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	==~~=HOMOLOGY MODEL OF BOVINE SOLUBLE GUANYLYL CYCLASE===~~	+	== References ==
-		+	<references/>
-	~~{{ABSTRACT_PUBMED_9391039}}~~	+	__TOC__
-		+	</StructureSection>
-	~~==Reference~~==	+
-	<~~ref group="xtra">PMID:009391039<~~/~~ref~~><~~references group="xtra"~~/>	+
	[[Category: Hurley, J H]]		[[Category: Hurley, J H]]
	[[Category: Rao, V D]]		[[Category: Rao, V D]]

OCA: Protected "1awn" [edit=sysop:move=sysop]

2012-10-21T09:47:13Z

Protected "1awn" [edit=sysop:move=sysop]

←Older revision

Revision as of 09:47, 21 October 2012

OCA at 09:47, 21 October 2012

2012-10-21T09:47:10Z

←Older revision		Revision as of 09:47, 21 October 2012
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	{{Theoretical_model}}		{{Theoretical_model}}
-	~~{{Seed}}~~	+
	[[Image:1awn.png\|left\|200px]]		[[Image:1awn.png\|left\|200px]]

-	<!--
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	{{STRUCTURE_1awn\| PDB=1awn \| SCENE= }}		{{STRUCTURE_1awn\| PDB=1awn \| SCENE= }}

	===HOMOLOGY MODEL OF BOVINE SOLUBLE GUANYLYL CYCLASE===		===HOMOLOGY MODEL OF BOVINE SOLUBLE GUANYLYL CYCLASE===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_9391039}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 9391039 is the PubMed ID number.
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	{{ABSTRACT_PUBMED_9391039}}		{{ABSTRACT_PUBMED_9391039}}
-
-	==About this Structure==
-	Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1AWN OCA].

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~9391039~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:009391039</ref><references group="xtra"/>
	[[Category: Hurley, J H]]		[[Category: Hurley, J H]]
	[[Category: Rao, V D]]		[[Category: Rao, V D]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Apr 8 08:58:00 2010''

OCA at 05:58, 8 April 2010

2010-04-08T05:58:01Z

←Older revision		Revision as of 05:58, 8 April 2010
Line 1:		Line 1:
-	~~'''Theoretical Model'''~~	+	{{Theoretical_model}}
		+	{{Seed}}
		+	[[Image:1awn.png\|left\|200px]]

-	The ~~entry 1AWN~~ is ~~a Theoretical Model titled 'HOMOLOGY MODEL OF BOVINE SOLUBLE GUANYLYL CYCLASE'~~.	+	<!--
		+	The line below this paragraph, containing "STRUCTURE_1awn", creates the "Structure Box" on the page.
		+	You may change the PDB parameter (which sets the PDB file loaded into the applet)
		+	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
		+	or leave the SCENE parameter empty for the default display.
		+	-->
		+	{{STRUCTURE_1awn\| PDB=1awn \| SCENE= }}

-	~~[[Category:Theoretical Model]]~~	+	===HOMOLOGY MODEL OF BOVINE SOLUBLE GUANYLYL CYCLASE===


-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Wed Jul 30 09~~:48:~~54 2008~~''	+	<!--
		+	The line below this paragraph, {{ABSTRACT_PUBMED_9391039}}, adds the Publication Abstract to the page
		+	(as it appears on PubMed at http://www.pubmed.gov), where 9391039 is the PubMed ID number.
		+	-->
		+	{{ABSTRACT_PUBMED_9391039}}
		+
		+	==About this Structure==
		+	Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1AWN OCA].
		+
		+	==Reference==
		+	<ref group="xtra">PMID:9391039</ref><references group="xtra"/>
		+	[[Category: Hurley, J H]]
		+	[[Category: Rao, V D]]
		+
		+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Apr 8 08:58:00 2010''