1b0m - Revision history

OCA at 05:34, 9 August 2023

2023-08-09T05:34:38Z

←Older revision		Revision as of 05:34, 9 August 2023
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	<StructureSection load='1b0m' size='340' side='right'caption='[[1b0m]], [[Resolution\|resolution]] 2.50Å' scene=''>		<StructureSection load='1b0m' size='340' side='right'caption='[[1b0m]], [[Resolution\|resolution]] 2.50Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1b0m]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Pig Pig~~]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=1atq 1atq]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1B0M OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1B0M FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1b0m]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Sus_scrofa Sus scrofa]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=1atq 1atq]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1B0M OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1B0M FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=FLC:CITRATE+ANION'>FLC</scene>~~, ~~<scene name='pdbligand=SF4:IRON/SULFUR+CLUSTER'>SF4</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.5Å</td></tr>
-	<tr id='~~activity~~'><td class="sblockLbl"><b>~~Activity~~:</b></td><td class="sblockDat"><~~span class~~='~~plainlinks~~'>~~[https:~~/~~/en.wikipedia.org/wiki/Aconitate_hydratase Aconitate hydratase]~~, ~~with EC number [https~~:/~~/www.brenda-enzymes.info/php/result_flat.php4?ecno=4.2.1.3 4.2.1.3]~~ </~~span~~></td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FLC:CITRATE+ANION'>FLC</scene>, <scene name='pdbligand=SF4:IRON/SULFUR+CLUSTER'>SF4</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1b0m FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1b0m OCA], [https://pdbe.org/1b0m PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1b0m RCSB], [https://www.ebi.ac.uk/pdbsum/1b0m PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1b0m ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1b0m FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1b0m OCA], [https://pdbe.org/1b0m PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1b0m RCSB], [https://www.ebi.ac.uk/pdbsum/1b0m PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1b0m ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/ACON_PIG ACON_PIG]] Catalyzes the isomerization of citrate to isocitrate via cis-aconitate.	+	[https://www.uniprot.org/uniprot/ACON_PIG ACON_PIG] Catalyzes the isomerization of citrate to isocitrate via cis-aconitate.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 36:		Line 36:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Aconitate hydratase]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Pig~~]]	+	[[Category: Sus scrofa]]
-	[[Category: Lauble, H]]	+	[[Category: Lauble H]]
-	[[Category: Lloyd~~, S J~~]]	+	[[Category: Lloyd SJ]]
-	[[Category: Prasad~~, G S~~]]	+	[[Category: Prasad GS]]
-	[[Category: Stout~~, C D]]~~	+	[[Category: Stout CD]]
-	~~[[Category: Aconitase r644q]]~~	+
-	~~[[Category: Fluorocitrate complex]]~~	+
-	~~[[Category: Hydrolase~~]]	+

OCA at 14:42, 3 November 2021

2021-11-03T14:42:47Z

←Older revision		Revision as of 14:42, 3 November 2021
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	<StructureSection load='1b0m' size='340' side='right'caption='[[1b0m]], [[Resolution\|resolution]] 2.50Å' scene=''>		<StructureSection load='1b0m' size='340' side='right'caption='[[1b0m]], [[Resolution\|resolution]] 2.50Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1b0m]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Pig Pig]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=1atq 1atq]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1B0M OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1B0M FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1b0m]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Pig Pig]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=1atq 1atq]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1B0M OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1B0M FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FLC:CITRATE+ANION'>FLC</scene>, <scene name='pdbligand=SF4:IRON/SULFUR+CLUSTER'>SF4</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FLC:CITRATE+ANION'>FLC</scene>, <scene name='pdbligand=SF4:IRON/SULFUR+CLUSTER'>SF4</scene></td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://en.wikipedia.org/wiki/Aconitate_hydratase Aconitate hydratase], with EC number [~~http~~://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.2.1.3 4.2.1.3] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Aconitate_hydratase Aconitate hydratase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.2.1.3 4.2.1.3] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1b0m FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1b0m OCA], [~~http~~://pdbe.org/1b0m PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=1b0m RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/1b0m PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=1b0m ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1b0m FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1b0m OCA], [https://pdbe.org/1b0m PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1b0m RCSB], [https://www.ebi.ac.uk/pdbsum/1b0m PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1b0m ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/ACON_PIG ACON_PIG]] Catalyzes the isomerization of citrate to isocitrate via cis-aconitate.	+	[[https://www.uniprot.org/uniprot/ACON_PIG ACON_PIG]] Catalyzes the isomerization of citrate to isocitrate via cis-aconitate.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]

OCA at 09:56, 1 April 2020

2020-04-01T09:56:41Z

←Older revision		Revision as of 09:56, 1 April 2020
Line 1:		Line 1:

	==ACONITASE R644Q:FLUOROCITRATE COMPLEX==		==ACONITASE R644Q:FLUOROCITRATE COMPLEX==
-	<StructureSection load='1b0m' size='340' side='right' caption='[[1b0m]], [[Resolution\|resolution]] 2.50Å' scene=''>	+	<StructureSection load='1b0m' size='340' side='right'caption='[[1b0m]], [[Resolution\|resolution]] 2.50Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1b0m]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Pig Pig]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=1atq 1atq]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1B0M OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1B0M FirstGlance]. <br>		<table><tr><td colspan='2'>[[1b0m]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Pig Pig]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=1atq 1atq]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1B0M OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1B0M FirstGlance]. <br>
Line 31:		Line 31:

	==See Also==		==See Also==
-	*[[Aconitase\|Aconitase]]	+	*[[Aconitase 3D structures\|Aconitase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
Line 37:		Line 37:
	</StructureSection>		</StructureSection>
	[[Category: Aconitate hydratase]]		[[Category: Aconitate hydratase]]
		+	[[Category: Large Structures]]
	[[Category: Pig]]		[[Category: Pig]]
	[[Category: Lauble, H]]		[[Category: Lauble, H]]

OCA at 05:42, 27 June 2018

2018-06-27T05:42:30Z

←Older revision		Revision as of 05:42, 27 June 2018
Line 14:		Line 14:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/b0/1b0m_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/b0/1b0m_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
Line 29:		Line 29:
	</div>		</div>
	<div class="pdbe-citations 1b0m" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 1b0m" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Aconitase\|Aconitase]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 11:05, 22 November 2017

2017-11-22T11:05:05Z

←Older revision		Revision as of 11:05, 22 November 2017
Line 1:		Line 1:
		+
	==ACONITASE R644Q:FLUOROCITRATE COMPLEX==		==ACONITASE R644Q:FLUOROCITRATE COMPLEX==
	<StructureSection load='1b0m' size='340' side='right' caption='[[1b0m]], [[Resolution\|resolution]] 2.50Å' scene=''>		<StructureSection load='1b0m' size='340' side='right' caption='[[1b0m]], [[Resolution\|resolution]] 2.50Å' scene=''>
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	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FLC:CITRATE+ANION'>FLC</scene>, <scene name='pdbligand=SF4:IRON/SULFUR+CLUSTER'>SF4</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FLC:CITRATE+ANION'>FLC</scene>, <scene name='pdbligand=SF4:IRON/SULFUR+CLUSTER'>SF4</scene></td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Aconitate_hydratase Aconitate hydratase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.2.1.3 4.2.1.3] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Aconitate_hydratase Aconitate hydratase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.2.1.3 4.2.1.3] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1b0m FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1b0m OCA], [http://pdbe.org/1b0m PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1b0m RCSB], [http://www.ebi.ac.uk/pdbsum/1b0m PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1b0m FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1b0m OCA], [http://pdbe.org/1b0m PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1b0m RCSB], [http://www.ebi.ac.uk/pdbsum/1b0m PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1b0m ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
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	</div>		</div>
	<div class="pdbe-citations 1b0m" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 1b0m" style="background-color:#fffaf0;"></div>
-
-	==See Also==
-	*[[Aconitase\|Aconitase]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 03:49, 9 February 2016

2016-02-09T03:49:10Z

←Older revision		Revision as of 03:49, 9 February 2016
Line 17:		Line 17:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1b0m ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 18:20, 10 September 2015

2015-09-10T18:20:18Z

←Older revision		Revision as of 18:20, 10 September 2015
Line 2:		Line 2:
	<StructureSection load='1b0m' size='340' side='right' caption='[[1b0m]], [[Resolution\|resolution]] 2.50Å' scene=''>		<StructureSection load='1b0m' size='340' side='right' caption='[[1b0m]], [[Resolution\|resolution]] 2.50Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1b0m]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Sus_scrofa Sus scrofa~~]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=1atq 1atq]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1B0M OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1B0M FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1b0m]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Pig Pig]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=1atq 1atq]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1B0M OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1B0M FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FLC:CITRATE+ANION'>FLC</scene>, <scene name='pdbligand=SF4:IRON/SULFUR+CLUSTER'>SF4</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FLC:CITRATE+ANION'>FLC</scene>, <scene name='pdbligand=SF4:IRON/SULFUR+CLUSTER'>SF4</scene></td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Aconitate_hydratase Aconitate hydratase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.2.1.3 4.2.1.3] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Aconitate_hydratase Aconitate hydratase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.2.1.3 4.2.1.3] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1b0m FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1b0m OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1b0m RCSB], [http://www.ebi.ac.uk/pdbsum/1b0m PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1b0m FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1b0m OCA], [http://pdbe.org/1b0m PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1b0m RCSB], [http://www.ebi.ac.uk/pdbsum/1b0m PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 27:		Line 27:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 1b0m" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 35:		Line 36:
	</StructureSection>		</StructureSection>
	[[Category: Aconitate hydratase]]		[[Category: Aconitate hydratase]]
-	[[Category: ~~Sus scrofa~~]]	+	[[Category: Pig]]
	[[Category: Lauble, H]]		[[Category: Lauble, H]]
	[[Category: Lloyd, S J]]		[[Category: Lloyd, S J]]

OCA at 04:12, 25 December 2014

2014-12-25T04:12:38Z

←Older revision		Revision as of 04:12, 25 December 2014
Line 7:		Line 7:
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1b0m FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1b0m OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1b0m RCSB], [http://www.ebi.ac.uk/pdbsum/1b0m PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1b0m FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1b0m OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1b0m RCSB], [http://www.ebi.ac.uk/pdbsum/1b0m PDBsum]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/ACON_PIG ACON_PIG]] Catalyzes the isomerization of citrate to isocitrate via cis-aconitate.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]

OCA at 11:25, 22 December 2014

2014-12-22T11:25:04Z

←Older revision		Revision as of 11:25, 22 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1b0m]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Sus_scrofa Sus scrofa]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=1atq 1atq]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1B0M OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1B0M FirstGlance]. <br>		<table><tr><td colspan='2'>[[1b0m]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Sus_scrofa Sus scrofa]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=1atq 1atq]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1B0M OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1B0M FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FLC:CITRATE+ANION'>FLC</scene>, <scene name='pdbligand=SF4:IRON/SULFUR+CLUSTER'>SF4</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FLC:CITRATE+ANION'>FLC</scene>, <scene name='pdbligand=SF4:IRON/SULFUR+CLUSTER'>SF4</scene></td></tr>
-	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Aconitate_hydratase Aconitate hydratase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.2.1.3 4.2.1.3] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Aconitate_hydratase Aconitate hydratase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.2.1.3 4.2.1.3] </span></td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1b0m FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1b0m OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1b0m RCSB], [http://www.ebi.ac.uk/pdbsum/1b0m PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1b0m FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1b0m OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1b0m RCSB], [http://www.ebi.ac.uk/pdbsum/1b0m PDBsum]</span></td></tr>
-	<table>	+	</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 34:		Line 34:
	[[Category: Aconitate hydratase]]		[[Category: Aconitate hydratase]]
	[[Category: Sus scrofa]]		[[Category: Sus scrofa]]
-	[[Category: Lauble, H.]]	+	[[Category: Lauble, H]]
-	[[Category: Lloyd, S J.]]	+	[[Category: Lloyd, S J]]
-	[[Category: Prasad, G S.]]	+	[[Category: Prasad, G S]]
-	[[Category: Stout, C D.]]	+	[[Category: Stout, C D]]
	[[Category: Aconitase r644q]]		[[Category: Aconitase r644q]]
	[[Category: Fluorocitrate complex]]		[[Category: Fluorocitrate complex]]
	[[Category: Hydrolase]]		[[Category: Hydrolase]]

OCA at 05:12, 3 October 2014

2014-10-03T05:12:59Z

←Older revision		Revision as of 05:12, 3 October 2014
Line 1:		Line 1:
-	[[~~Image~~:1b0m.~~png\|left~~\|200px]]	+	==ACONITASE R644Q:FLUOROCITRATE COMPLEX==
		+	<StructureSection load='1b0m' size='340' side='right' caption='[[1b0m]], [[Resolution\|resolution]] 2.50Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[1b0m]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Sus_scrofa Sus scrofa]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=1atq 1atq]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1B0M OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1B0M FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FLC:CITRATE+ANION'>FLC</scene>, <scene name='pdbligand=SF4:IRON/SULFUR+CLUSTER'>SF4</scene><br>
		+	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Aconitate_hydratase Aconitate hydratase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.2.1.3 4.2.1.3] </span></td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1b0m FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1b0m OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1b0m RCSB], [http://www.ebi.ac.uk/pdbsum/1b0m PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/b0/1b0m_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The crystal structure of the S642A mutant of mitochondrial aconitase (mAc) with citrate bound has been determined at 1.8 A resolution and 100 K to capture this binding mode of substrates to the native enzyme. The 2.0 A resolution, 100 K crystal structure of the S642A mutant with isocitrate binding provides a control, showing that the Ser --> Ala replacement does not alter the binding of substrates in the active site. The aconitase mechanism requires that the intermediate product, cis-aconitate, flip over by 180 degrees about the C alpha-C beta double bond. Only one of these two alternative modes of binding, that of the isocitrate mode, has been previously visualized. Now, however, the structure revealing the citrate mode of binding provides direct support for the proposed enzyme mechanism.

-	~~{{STRUCTURE_1b0m\| PDB=1b0m \| SCENE= }}~~	+	The mechanism of aconitase: 1.8 A resolution crystal structure of the S642a:citrate complex.,Lloyd SJ, Lauble H, Prasad GS, Stout CD Protein Sci. 1999 Dec;8(12):2655-62. PMID:10631981<ref>PMID:10631981</ref>

-	~~===ACONITASE R644Q:FLUOROCITRATE COMPLEX===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_10631981}}~~	+
-		+
-	~~==About this Structure==~~	+
-	~~[[1b0m]] is~~ a ~~1 chain structure with sequence from [http://en.wikipedia.org/wiki/Sus_scrofa Sus scrofa]. This structure supersedes~~ the ~~now removed PDB entry [http://oca~~.~~weizmann~~.ac.il/~~oca-bin/send-pdb?obs=1&id=1atq 1atq]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1B0M OCA].~~	+

	==See Also==		==See Also==
	*[[Aconitase\|Aconitase]]		*[[Aconitase\|Aconitase]]
-	*[[Samer Kawak Sandbox 4\|Samer Kawak Sandbox 4]]	+	== References ==
-		+	<references/>
-	==~~Reference~~==	+	__TOC__
-	<~~ref group="xtra">PMID:010631981<~~/~~ref~~><~~references group="xtra"~~/>	+	</StructureSection>
	[[Category: Aconitate hydratase]]		[[Category: Aconitate hydratase]]
	[[Category: Sus scrofa]]		[[Category: Sus scrofa]]