1b8i - Revision history

OCA at 23:20, 27 December 2023

2023-12-27T23:20:46Z

←Older revision		Revision as of 23:20, 27 December 2023
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	<StructureSection load='1b8i' size='340' side='right'caption='[[1b8i]], [[Resolution\|resolution]] 2.40Å' scene=''>		<StructureSection load='1b8i' size='340' side='right'caption='[[1b8i]], [[Resolution\|resolution]] 2.40Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1b8i]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Drome Drome~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1B8I OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1B8I FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1b8i]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Drosophila_melanogaster Drosophila melanogaster]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1B8I OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1B8I FirstGlance]. <br>
-	</td></tr><tr id='~~gene~~'><td class="sblockLbl"><b>[[~~Gene~~\|~~Gene~~:]]</b></td><td class="sblockDat">~~UBX (~~[~~https://www~~.~~ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info~~&~~srchmode=5&id=7227 DROME])~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.4Å</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1b8i FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1b8i OCA], [https://pdbe.org/1b8i PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1b8i RCSB], [https://www.ebi.ac.uk/pdbsum/1b8i PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1b8i ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1b8i FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1b8i OCA], [https://pdbe.org/1b8i PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1b8i RCSB], [https://www.ebi.ac.uk/pdbsum/1b8i PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1b8i ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/EXD_DROME EXD_DROME]] Transcription factor which acts with the selector homeodomain proteins altering the regulation of downstream target genes such as wingless (wg), teashirt (tsh) and decapentaplegic (dpp), thus affecting segmental identity. Delimits the eye field and prevent inappropriate eye development. Required for proper localization of chordotonal organs within the peripheral nervous system.<ref>PMID:8104703</ref> <ref>PMID:8100142</ref> <ref>PMID:7914871</ref> <ref>PMID:9346235</ref> <ref>PMID:9463350</ref> <ref>PMID:9450936</ref> [[https://www.uniprot.org/uniprot/UBX_DROME UBX_DROME]] Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Binds the consensus region 5'-TTAAT[GT][GA]-3'. This homeotic protein controls development of the cells in the posterior thoracic and first abdominal segments. It activates the synthesis of the decapentaplegic (DPP) growth factor.	+	[https://www.uniprot.org/uniprot/UBX_DROME UBX_DROME] Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Binds the consensus region 5'-TTAAT[GT][GA]-3'. This homeotic protein controls development of the cells in the posterior thoracic and first abdominal segments. It activates the synthesis of the decapentaplegic (DPP) growth factor.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 32:		Line 32:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Drome~~]]	+	[[Category: Drosophila melanogaster]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Aggarwal~~, A K~~]]	+	[[Category: Aggarwal AK]]
-	[[Category: Mann~~, R S~~]]	+	[[Category: Mann RS]]
-	[[Category: Passner~~, J M~~]]	+	[[Category: Passner JM]]
-	[[Category: Ryoo, H D]]	+	[[Category: Ryoo H-D]]
-	[[Category: Shen, L]]	+	[[Category: Shen L]]
-	~~[[Category: Development]]~~	+
-	~~[[Category: Dna binding]]~~	+
-	~~[[Category: Homeodomain]]~~	+
-	~~[[Category: Homeotic protein]]~~	+
-	~~[[Category: Specificity]]~~	+
-	~~[[Category: Transcription-dna complex~~]]	+

OCA at 14:44, 3 November 2021

2021-11-03T14:44:59Z

←Older revision		Revision as of 14:44, 3 November 2021
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	<StructureSection load='1b8i' size='340' side='right'caption='[[1b8i]], [[Resolution\|resolution]] 2.40Å' scene=''>		<StructureSection load='1b8i' size='340' side='right'caption='[[1b8i]], [[Resolution\|resolution]] 2.40Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1b8i]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1B8I OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1B8I FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1b8i]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Drome Drome]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1B8I OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1B8I FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1b8i FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1b8i OCA], [https://pdbe.org/1b8i PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1b8i RCSB], [https://www.ebi.ac.uk/pdbsum/1b8i PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1b8i ProSAT]</span></td></tr>	+	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">UBX ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=7227 DROME])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1b8i FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1b8i OCA], [https://pdbe.org/1b8i PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1b8i RCSB], [https://www.ebi.ac.uk/pdbsum/1b8i PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1b8i ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 31:		Line 32:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Drome]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Aggarwal, A K]]		[[Category: Aggarwal, A K]]

OCA at 06:57, 24 February 2021

2021-02-24T06:57:52Z

←Older revision		Revision as of 06:57, 24 February 2021
Line 3:		Line 3:
	<StructureSection load='1b8i' size='340' side='right'caption='[[1b8i]], [[Resolution\|resolution]] 2.40Å' scene=''>		<StructureSection load='1b8i' size='340' side='right'caption='[[1b8i]], [[Resolution\|resolution]] 2.40Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1b8i]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1B8I OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1B8I FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1b8i]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1B8I OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1B8I FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1b8i FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1b8i OCA], [~~http~~://pdbe.org/1b8i PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=1b8i RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/1b8i PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=1b8i ProSAT]</span></td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1b8i FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1b8i OCA], [https://pdbe.org/1b8i PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1b8i RCSB], [https://www.ebi.ac.uk/pdbsum/1b8i PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1b8i ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/EXD_DROME EXD_DROME]] Transcription factor which acts with the selector homeodomain proteins altering the regulation of downstream target genes such as wingless (wg), teashirt (tsh) and decapentaplegic (dpp), thus affecting segmental identity. Delimits the eye field and prevent inappropriate eye development. Required for proper localization of chordotonal organs within the peripheral nervous system.<ref>PMID:8104703</ref> <ref>PMID:8100142</ref> <ref>PMID:7914871</ref> <ref>PMID:9346235</ref> <ref>PMID:9463350</ref> <ref>PMID:9450936</ref> [[~~http~~://www.uniprot.org/uniprot/UBX_DROME UBX_DROME]] Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Binds the consensus region 5'-TTAAT[GT][GA]-3'. This homeotic protein controls development of the cells in the posterior thoracic and first abdominal segments. It activates the synthesis of the decapentaplegic (DPP) growth factor.	+	[[https://www.uniprot.org/uniprot/EXD_DROME EXD_DROME]] Transcription factor which acts with the selector homeodomain proteins altering the regulation of downstream target genes such as wingless (wg), teashirt (tsh) and decapentaplegic (dpp), thus affecting segmental identity. Delimits the eye field and prevent inappropriate eye development. Required for proper localization of chordotonal organs within the peripheral nervous system.<ref>PMID:8104703</ref> <ref>PMID:8100142</ref> <ref>PMID:7914871</ref> <ref>PMID:9346235</ref> <ref>PMID:9463350</ref> <ref>PMID:9450936</ref> [[https://www.uniprot.org/uniprot/UBX_DROME UBX_DROME]] Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Binds the consensus region 5'-TTAAT[GT][GA]-3'. This homeotic protein controls development of the cells in the posterior thoracic and first abdominal segments. It activates the synthesis of the decapentaplegic (DPP) growth factor.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]

OCA at 09:21, 21 May 2019

2019-05-21T09:21:41Z

←Older revision		Revision as of 09:21, 21 May 2019
Line 1:		Line 1:

	==STRUCTURE OF THE HOMEOTIC UBX/EXD/DNA TERNARY COMPLEX==		==STRUCTURE OF THE HOMEOTIC UBX/EXD/DNA TERNARY COMPLEX==
-	<StructureSection load='1b8i' size='340' side='right' caption='[[1b8i]], [[Resolution\|resolution]] 2.40Å' scene=''>	+	<StructureSection load='1b8i' size='340' side='right'caption='[[1b8i]], [[Resolution\|resolution]] 2.40Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1b8i]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1B8I OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1B8I FirstGlance]. <br>		<table><tr><td colspan='2'>[[1b8i]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1B8I OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1B8I FirstGlance]. <br>
Line 12:		Line 12:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/b8/1b8i_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/b8/1b8i_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
Line 31:		Line 31:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Aggarwal, A K]]		[[Category: Aggarwal, A K]]
	[[Category: Mann, R S]]		[[Category: Mann, R S]]

OCA at 06:14, 17 August 2017

2017-08-17T06:14:14Z

←Older revision		Revision as of 06:14, 17 August 2017
Line 1:		Line 1:
		+
	==STRUCTURE OF THE HOMEOTIC UBX/EXD/DNA TERNARY COMPLEX==		==STRUCTURE OF THE HOMEOTIC UBX/EXD/DNA TERNARY COMPLEX==
	<StructureSection load='1b8i' size='340' side='right' caption='[[1b8i]], [[Resolution\|resolution]] 2.40Å' scene=''>		<StructureSection load='1b8i' size='340' side='right' caption='[[1b8i]], [[Resolution\|resolution]] 2.40Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1b8i]] is a 4 chain structure ~~with sequence from [http://en.wikipedia.org/wiki/Drome Drome]~~. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1B8I OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1B8I FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1b8i]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1B8I OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1B8I FirstGlance]. <br>
-	</td></tr>~~<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">UBX ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=7227 DROME])</td></tr>~~	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1b8i FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1b8i OCA], [http://pdbe.org/1b8i PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1b8i RCSB], [http://www.ebi.ac.uk/pdbsum/1b8i PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1b8i ProSAT]</span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1b8i FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1b8i OCA], [http://pdbe.org/1b8i PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1b8i RCSB], [http://www.ebi.ac.uk/pdbsum/1b8i PDBsum]</span></td></tr>	+
	</table>		</table>
	== Function ==		== Function ==
Line 16:		Line 16:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1b8i ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 31:		Line 31:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Drome]]
	[[Category: Aggarwal, A K]]		[[Category: Aggarwal, A K]]
	[[Category: Mann, R S]]		[[Category: Mann, R S]]

OCA at 00:14, 12 September 2015

2015-09-12T00:14:33Z

←Older revision		Revision as of 00:14, 12 September 2015
Line 2:		Line 2:
	<StructureSection load='1b8i' size='340' side='right' caption='[[1b8i]], [[Resolution\|resolution]] 2.40Å' scene=''>		<StructureSection load='1b8i' size='340' side='right' caption='[[1b8i]], [[Resolution\|resolution]] 2.40Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1b8i]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Drosophila_melanogaster Drosophila melanogaster~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1B8I OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1B8I FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1b8i]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Drome Drome]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1B8I OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1B8I FirstGlance]. <br>
-	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">UBX ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=7227 ~~Drosophila melanogaster~~])</td></tr>	+	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">UBX ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=7227 DROME])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1b8i FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1b8i OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1b8i RCSB], [http://www.ebi.ac.uk/pdbsum/1b8i PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1b8i FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1b8i OCA], [http://pdbe.org/1b8i PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1b8i RCSB], [http://www.ebi.ac.uk/pdbsum/1b8i PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 26:		Line 26:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 1b8i" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Drosophila melanogaster~~]]	+	[[Category: Drome]]
	[[Category: Aggarwal, A K]]		[[Category: Aggarwal, A K]]
	[[Category: Mann, R S]]		[[Category: Mann, R S]]

OCA at 21:16, 25 December 2014

2014-12-25T21:16:11Z

←Older revision		Revision as of 21:16, 25 December 2014
Line 6:		Line 6:
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1b8i FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1b8i OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1b8i RCSB], [http://www.ebi.ac.uk/pdbsum/1b8i PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1b8i FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1b8i OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1b8i RCSB], [http://www.ebi.ac.uk/pdbsum/1b8i PDBsum]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/EXD_DROME EXD_DROME]] Transcription factor which acts with the selector homeodomain proteins altering the regulation of downstream target genes such as wingless (wg), teashirt (tsh) and decapentaplegic (dpp), thus affecting segmental identity. Delimits the eye field and prevent inappropriate eye development. Required for proper localization of chordotonal organs within the peripheral nervous system.<ref>PMID:8104703</ref> <ref>PMID:8100142</ref> <ref>PMID:7914871</ref> <ref>PMID:9346235</ref> <ref>PMID:9463350</ref> <ref>PMID:9450936</ref> [[http://www.uniprot.org/uniprot/UBX_DROME UBX_DROME]] Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Binds the consensus region 5'-TTAAT[GT][GA]-3'. This homeotic protein controls development of the cells in the posterior thoracic and first abdominal segments. It activates the synthesis of the decapentaplegic (DPP) growth factor.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]

OCA at 09:17, 22 December 2014

2014-12-22T09:17:31Z

←Older revision		Revision as of 09:17, 22 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1b8i]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Drosophila_melanogaster Drosophila melanogaster]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1B8I OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1B8I FirstGlance]. <br>		<table><tr><td colspan='2'>[[1b8i]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Drosophila_melanogaster Drosophila melanogaster]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1B8I OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1B8I FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">UBX ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=7227 Drosophila melanogaster])</td></tr>	+	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">UBX ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=7227 Drosophila melanogaster])</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1b8i FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1b8i OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1b8i RCSB], [http://www.ebi.ac.uk/pdbsum/1b8i PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1b8i FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1b8i OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1b8i RCSB], [http://www.ebi.ac.uk/pdbsum/1b8i PDBsum]</span></td></tr>
-	<table>	+	</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 29:		Line 29:
	</StructureSection>		</StructureSection>
	[[Category: Drosophila melanogaster]]		[[Category: Drosophila melanogaster]]
-	[[Category: Aggarwal, A K.]]	+	[[Category: Aggarwal, A K]]
-	[[Category: Mann, R S.]]	+	[[Category: Mann, R S]]
-	[[Category: Passner, J M.]]	+	[[Category: Passner, J M]]
-	[[Category: Ryoo, H D.]]	+	[[Category: Ryoo, H D]]
-	[[Category: Shen, L.]]	+	[[Category: Shen, L]]
	[[Category: Development]]		[[Category: Development]]
	[[Category: Dna binding]]		[[Category: Dna binding]]

OCA at 03:21, 7 August 2014

2014-08-07T03:21:42Z

←Older revision		Revision as of 03:21, 7 August 2014
Line 1:		Line 1:
-	[[~~Image~~:1b8i.~~png\|left~~\|200px]]	+	==STRUCTURE OF THE HOMEOTIC UBX/EXD/DNA TERNARY COMPLEX==
		+	<StructureSection load='1b8i' size='340' side='right' caption='[[1b8i]], [[Resolution\|resolution]] 2.40Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[1b8i]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Drosophila_melanogaster Drosophila melanogaster]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1B8I OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1B8I FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">UBX ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=7227 Drosophila melanogaster])</td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1b8i FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1b8i OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1b8i RCSB], [http://www.ebi.ac.uk/pdbsum/1b8i PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/b8/1b8i_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	During the development of multicellular organisms, gene expression must be tightly regulated, both spatially and temporally. One set of transcription factors that are important in animal development is encoded by the homeotic (Hox) genes, which govern the choice between alternative developmental pathways along the anterior-posterior axis. Hox proteins, such as Drosophila Ultrabithorax, have low DNA-binding specificity by themselves but gain affinity and specificity when they bind together with the homeoprotein Extradenticle (or Pbxl in mammals). To understand the structural basis of Hox-Extradenticle pairing, we determine here the crystal structure of an Ultrabithorax-Extradenticle-DNA complex at 2.4 A resolution, using the minimal polypeptides that form a cooperative heterodimer. The Ultrabithorax and Extradenticle homeodomains bind opposite faces of the DNA, with their DNA-recognition helices almost touching each other. However, most of the cooperative interactions arise from the YPWM amino-acid motif of Ultrabithorax-located amino-terminally to its homeodomain-which forms a reverse turn and inserts into a hydrophobic pocket on the Extradenticle homeodomain surface. Together, these protein-DNA and protein-protein interactions define the general principles by which homeotic proteins interact with Extradenticle (or Pbx1) to affect development along the anterior-posterior axis of animals.

-	~~{{STRUCTURE_1b8i\| PDB=1b8i \| SCENE= }}~~	+	Structure of a DNA-bound Ultrabithorax-Extradenticle homeodomain complex.,Passner JM, Ryoo HD, Shen L, Mann RS, Aggarwal AK Nature. 1999 Feb 25;397(6721):714-9. PMID:10067897<ref>PMID:10067897</ref>

-	~~===STRUCTURE OF THE HOMEOTIC UBX~~/~~EXD/DNA TERNARY COMPLEX===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_10067897}}~~	+	== References ==
-		+	<references/>
-	~~==About this Structure==~~	+	__TOC__
-	~~[[1b8i]] is~~ a ~~4 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Drosophila_melanogaster Drosophila melanogaster]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=1B8I OCA].~~	+	</StructureSection>
-		+
-	==~~Reference~~==	+
-	<~~ref group="xtra">PMID:010067897<~~/~~ref~~><~~ref group="xtra">PMID:011258480</ref><ref group="xtra">PMID:015048824</ref><references group="xtra"~~/>	+
	[[Category: Drosophila melanogaster]]		[[Category: Drosophila melanogaster]]
	[[Category: Aggarwal, A K.]]		[[Category: Aggarwal, A K.]]

OCA: Protected "1b8i" [edit=sysop:move=sysop]

2012-10-21T14:27:44Z

Protected "1b8i" [edit=sysop:move=sysop]

←Older revision

Revision as of 14:27, 21 October 2012