1bff - Revision history

OCA at 11:00, 2 August 2023

2023-08-02T11:00:52Z

←Older revision		Revision as of 11:00, 2 August 2023
Line 3:		Line 3:
	<StructureSection load='1bff' size='340' side='right'caption='[[1bff]], [[Resolution\|resolution]] 2.00Å' scene=''>		<StructureSection load='1bff' size='340' side='right'caption='[[1bff]], [[Resolution\|resolution]] 2.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1bff]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1BFF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1BFF FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1bff]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1BFF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1BFF FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BME:BETA-MERCAPTOETHANOL'>BME</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BME:BETA-MERCAPTOETHANOL'>BME</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1bff FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1bff OCA], [https://pdbe.org/1bff PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1bff RCSB], [https://www.ebi.ac.uk/pdbsum/1bff PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1bff ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1bff FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1bff OCA], [https://pdbe.org/1bff PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1bff RCSB], [https://www.ebi.ac.uk/pdbsum/1bff PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1bff ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/FGF2_HUMAN FGF2_HUMAN]] Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro.<ref>PMID:1721615</ref> <ref>PMID:8663044</ref>	+	[https://www.uniprot.org/uniprot/FGF2_HUMAN FGF2_HUMAN] Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro.<ref>PMID:1721615</ref> <ref>PMID:8663044</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 35:		Line 36:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Eriksson~~, E S~~]]	+	[[Category: Eriksson ES]]
-	[[Category: Kastrup~~, J S]]~~	+	[[Category: Kastrup JS]]
-	~~[[Category: Growth factor~~]]	+

OCA at 06:59, 24 February 2021

2021-02-24T06:59:02Z

←Older revision		Revision as of 06:59, 24 February 2021
Line 3:		Line 3:
	<StructureSection load='1bff' size='340' side='right'caption='[[1bff]], [[Resolution\|resolution]] 2.00Å' scene=''>		<StructureSection load='1bff' size='340' side='right'caption='[[1bff]], [[Resolution\|resolution]] 2.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1bff]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1BFF OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1BFF FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1bff]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1BFF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1BFF FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BME:BETA-MERCAPTOETHANOL'>BME</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BME:BETA-MERCAPTOETHANOL'>BME</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1bff FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1bff OCA], [~~http~~://pdbe.org/1bff PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=1bff RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/1bff PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=1bff ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1bff FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1bff OCA], [https://pdbe.org/1bff PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1bff RCSB], [https://www.ebi.ac.uk/pdbsum/1bff PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1bff ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/FGF2_HUMAN FGF2_HUMAN]] Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro.<ref>PMID:1721615</ref> <ref>PMID:8663044</ref>	+	[[https://www.uniprot.org/uniprot/FGF2_HUMAN FGF2_HUMAN]] Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro.<ref>PMID:1721615</ref> <ref>PMID:8663044</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 30:		Line 30:

	==See Also==		==See Also==
-	*[[Fibroblast growth factor\|Fibroblast growth factor]]	+	*[[Fibroblast growth factor 3D structures\|Fibroblast growth factor 3D structures]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 08:38, 21 May 2019

2019-05-21T08:38:01Z

←Older revision		Revision as of 08:38, 21 May 2019
Line 1:		Line 1:

	==THE 154 AMINO ACID FORM OF HUMAN BASIC FIBROBLAST GROWTH FACTOR==		==THE 154 AMINO ACID FORM OF HUMAN BASIC FIBROBLAST GROWTH FACTOR==
-	<StructureSection load='1bff' size='340' side='right' caption='[[1bff]], [[Resolution\|resolution]] 2.00Å' scene=''>	+	<StructureSection load='1bff' size='340' side='right'caption='[[1bff]], [[Resolution\|resolution]] 2.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1bff]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1BFF OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1BFF FirstGlance]. <br>		<table><tr><td colspan='2'>[[1bff]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1BFF OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1BFF FirstGlance]. <br>
Line 13:		Line 13:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/bf/1bff_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/bf/1bff_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
Line 35:		Line 35:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Eriksson, E S]]		[[Category: Eriksson, E S]]
	[[Category: Kastrup, J S]]		[[Category: Kastrup, J S]]
	[[Category: Growth factor]]		[[Category: Growth factor]]

OCA at 06:04, 17 August 2017

2017-08-17T06:04:48Z

←Older revision		Revision as of 06:04, 17 August 2017
Line 1:		Line 1:
		+
	==THE 154 AMINO ACID FORM OF HUMAN BASIC FIBROBLAST GROWTH FACTOR==		==THE 154 AMINO ACID FORM OF HUMAN BASIC FIBROBLAST GROWTH FACTOR==
	<StructureSection load='1bff' size='340' side='right' caption='[[1bff]], [[Resolution\|resolution]] 2.00Å' scene=''>		<StructureSection load='1bff' size='340' side='right' caption='[[1bff]], [[Resolution\|resolution]] 2.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1bff]] is a 1 chain structure ~~with sequence from [http://en.wikipedia.org/wiki/Human Human]~~. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1BFF OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1BFF FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1bff]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1BFF OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1BFF FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BME:BETA-MERCAPTOETHANOL'>BME</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BME:BETA-MERCAPTOETHANOL'>BME</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1bff FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1bff OCA], [http://pdbe.org/1bff PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1bff RCSB], [http://www.ebi.ac.uk/pdbsum/1bff PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1bff FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1bff OCA], [http://pdbe.org/1bff PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1bff RCSB], [http://www.ebi.ac.uk/pdbsum/1bff PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1bff ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 16:		Line 17:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1bff ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 34:		Line 35:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Human]]
	[[Category: Eriksson, E S]]		[[Category: Eriksson, E S]]
	[[Category: Kastrup, J S]]		[[Category: Kastrup, J S]]
	[[Category: Growth factor]]		[[Category: Growth factor]]

OCA at 10:28, 11 September 2015

2015-09-11T10:28:28Z

←Older revision		Revision as of 10:28, 11 September 2015
Line 2:		Line 2:
	<StructureSection load='1bff' size='340' side='right' caption='[[1bff]], [[Resolution\|resolution]] 2.00Å' scene=''>		<StructureSection load='1bff' size='340' side='right' caption='[[1bff]], [[Resolution\|resolution]] 2.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1bff]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1BFF OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1BFF FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1bff]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1BFF OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1BFF FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BME:BETA-MERCAPTOETHANOL'>BME</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BME:BETA-MERCAPTOETHANOL'>BME</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1bff FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1bff OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1bff RCSB], [http://www.ebi.ac.uk/pdbsum/1bff PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1bff FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1bff OCA], [http://pdbe.org/1bff PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1bff RCSB], [http://www.ebi.ac.uk/pdbsum/1bff PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 26:		Line 26:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 1bff" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 33:		Line 34:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Homo sapiens~~]]	+	[[Category: Human]]
	[[Category: Eriksson, E S]]		[[Category: Eriksson, E S]]
	[[Category: Kastrup, J S]]		[[Category: Kastrup, J S]]
	[[Category: Growth factor]]		[[Category: Growth factor]]

OCA at 15:12, 25 December 2014

2014-12-25T15:12:12Z

←Older revision		Revision as of 15:12, 25 December 2014
Line 6:		Line 6:
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1bff FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1bff OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1bff RCSB], [http://www.ebi.ac.uk/pdbsum/1bff PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1bff FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1bff OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1bff RCSB], [http://www.ebi.ac.uk/pdbsum/1bff PDBsum]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/FGF2_HUMAN FGF2_HUMAN]] Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro.<ref>PMID:1721615</ref> <ref>PMID:8663044</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]

OCA at 08:32, 22 December 2014

2014-12-22T08:32:28Z

←Older revision		Revision as of 08:32, 22 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1bff]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1BFF OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1BFF FirstGlance]. <br>		<table><tr><td colspan='2'>[[1bff]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1BFF OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1BFF FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BME:BETA-MERCAPTOETHANOL'>BME</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BME:BETA-MERCAPTOETHANOL'>BME</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1bff FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1bff OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1bff RCSB], [http://www.ebi.ac.uk/pdbsum/1bff PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1bff FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1bff OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1bff RCSB], [http://www.ebi.ac.uk/pdbsum/1bff PDBsum]</span></td></tr>
-	<table>	+	</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 32:		Line 32:
	</StructureSection>		</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
-	[[Category: Eriksson, E S.]]	+	[[Category: Eriksson, E S]]
-	[[Category: Kastrup, J S.]]	+	[[Category: Kastrup, J S]]
	[[Category: Growth factor]]		[[Category: Growth factor]]

OCA at 03:10, 7 August 2014

2014-08-07T03:10:37Z

←Older revision		Revision as of 03:10, 7 August 2014
Line 1:		Line 1:
-	[[~~Image~~:1bff.~~png\|left~~\|200px]]	+	==THE 154 AMINO ACID FORM OF HUMAN BASIC FIBROBLAST GROWTH FACTOR==
		+	<StructureSection load='1bff' size='340' side='right' caption='[[1bff]], [[Resolution\|resolution]] 2.00Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[1bff]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1BFF OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1BFF FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BME:BETA-MERCAPTOETHANOL'>BME</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene><br>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1bff FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1bff OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1bff RCSB], [http://www.ebi.ac.uk/pdbsum/1bff PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/bf/1bff_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The crystal structure of the 154-amino-acid form of human basic fibroblast growth factor (hbFGF154), probably representing the intact form of hbFGF as deduced from the open reading frame of hbFGF cDNA, was determined by X-ray crystallography and refined to a crystallographic residual of 19.0% for all data between 20.0 and 2.0 A resolution. Crystals were obtained from recombinant hbFGF154 expressed in E. coli. hbFGF154 has the same overall structure as the N-terminus truncated 146-amino-acid form. The structure has a Kunitz-type fold and is built of 12 beta-strands of which six antiparallel strands form a beta-sheet barrel. In the structure it was possible to locate two additional residues at the N terminus and the last three C-terminal amino-acid residues, which seem to be disordered in all but one of the reported structures of the truncated form of hbFGF. The C-terminal amino-acid residues are part of the last beta-strand through the formation of a hydrogen bond between the main-chain amide group of Ala152 and the carbonyl O atom of Pro28. An apparent phosphate ion is bound within the basic region on the surface of the molecule and has as ligands the side chains of Asn35, Arg128 and Lys133 and two water molecules. A slightly different hydrogen-bonding pattern to the phosphate ion is observed as compared with the sulfate ions in the truncated forms [Eriksson, Cousens & Matthews (1993). Protein Sci. 2, 1274-1284; Zhang, Cousens, Barr & Sprang (1991). Proc. Natl Acad. Sci. USA, 88, 3446-3450]. One molecule of beta-mercaptoethanol forms a disulfide bridge to Cys77.

-	~~{{STRUCTURE_1bff\| PDB=1bff \| SCENE= }}~~	+	X-ray structure of the 154-amino-acid form of recombinant human basic fibroblast growth factor. comparison with the truncated 146-amino-acid form.,Kastrup JS, Eriksson ES, Dalboge H, Flodgaard H Acta Crystallogr D Biol Crystallogr. 1997 Mar 1;53(Pt 2):160-8. PMID:15299950<ref>PMID:15299950</ref>

-	~~===THE 154 AMINO ACID FORM OF HUMAN BASIC FIBROBLAST GROWTH FACTOR===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>

-	~~{{ABSTRACT_PUBMED_15299950}}~~	+	==See Also==
-		+	*[[Fibroblast growth factor\|Fibroblast growth factor]]
-	==~~About this Structure~~==	+	== References ==
-	[[~~1bff~~]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1BFF OCA].	+	<references/>
-		+	__TOC__
-	==~~Reference~~==	+	</StructureSection>
-	<~~ref group="xtra">PMID:015299950<~~/~~ref~~><~~references group="xtra"~~/>	+
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Eriksson, E S.]]		[[Category: Eriksson, E S.]]
	[[Category: Kastrup, J S.]]		[[Category: Kastrup, J S.]]
	[[Category: Growth factor]]		[[Category: Growth factor]]

OCA: Protected "1bff" [edit=sysop:move=sysop]

2012-10-21T20:03:39Z

Protected "1bff" [edit=sysop:move=sysop]

←Older revision

Revision as of 20:03, 21 October 2012

OCA at 20:03, 21 October 2012

2012-10-21T20:03:37Z

←Older revision		Revision as of 20:03, 21 October 2012
Line 1:		Line 1:
-	{{Seed}}
	[[Image:1bff.png\|left\|200px]]		[[Image:1bff.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_1bff", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_1bff\| PDB=1bff \| SCENE= }}		{{STRUCTURE_1bff\| PDB=1bff \| SCENE= }}

	===THE 154 AMINO ACID FORM OF HUMAN BASIC FIBROBLAST GROWTH FACTOR===		===THE 154 AMINO ACID FORM OF HUMAN BASIC FIBROBLAST GROWTH FACTOR===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_15299950}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 15299950 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_15299950}}		{{ABSTRACT_PUBMED_15299950}}

	==About this Structure==		==About this Structure==
-	~~1BFF~~ is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1BFF OCA].	+	[[1bff]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1BFF OCA].

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~15299950~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:015299950</ref><references group="xtra"/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Eriksson, E S.]]		[[Category: Eriksson, E S.]]
	[[Category: Kastrup, J S.]]		[[Category: Kastrup, J S.]]
	[[Category: Growth factor]]		[[Category: Growth factor]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 19:54:00 2009''