1bmb - Revision history

OCA at 05:38, 9 August 2023

2023-08-09T05:38:55Z

←Older revision		Revision as of 05:38, 9 August 2023
Line 3:		Line 3:
	<StructureSection load='1bmb' size='340' side='right'caption='[[1bmb]], [[Resolution\|resolution]] 1.80Å' scene=''>		<StructureSection load='1bmb' size='340' side='right'caption='[[1bmb]], [[Resolution\|resolution]] 1.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1bmb]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1BMB OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=1BMB FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1bmb]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1BMB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1BMB FirstGlance]. <br>
-	</td></tr><tr id='~~NonStdRes~~'><td class="sblockLbl"><b>[[~~Non-Standard_Residue~~\|~~NonStd Res~~:]]</b></td><td class="sblockDat">~~<scene name='pdbligand=PTR:O~~-~~PHOSPHOTYROSINE'>PTR</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.8Å</td></tr>
-	<tr id='~~gene~~'><td class="sblockLbl"><b>[[~~Gene~~\|~~Gene~~:]]</b></td><td class="sblockDat">~~GRB2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode~~=~~Info&srchmode~~=~~5&id=9606 HUMAN])~~</td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PTR:O-PHOSPHOTYROSINE'>PTR</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=1bmb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1bmb OCA], [~~http~~://pdbe.org/1bmb PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=1bmb RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/1bmb PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=1bmb ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1bmb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1bmb OCA], [https://pdbe.org/1bmb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1bmb RCSB], [https://www.ebi.ac.uk/pdbsum/1bmb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1bmb ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/GRB2_HUMAN GRB2_HUMAN]] Adapter protein that provides a critical link between cell surface growth factor receptors and the Ras signaling pathway.<ref>PMID:1322798</ref> <ref>PMID:8178156</ref> <ref>PMID:19815557</ref> Isoform 2 does not bind to phosphorylated epidermal growth factor receptor (EGFR) but inhibits EGF-induced transactivation of a RAS-responsive element. Isoform 2 acts as a dominant negative protein over GRB2 and by suppressing proliferative signals, may trigger active programmed cell death.<ref>PMID:1322798</ref> <ref>PMID:8178156</ref> <ref>PMID:19815557</ref>	+	[https://www.uniprot.org/uniprot/GRB2_HUMAN GRB2_HUMAN] Adapter protein that provides a critical link between cell surface growth factor receptors and the Ras signaling pathway.<ref>PMID:1322798</ref> <ref>PMID:8178156</ref> <ref>PMID:19815557</ref> Isoform 2 does not bind to phosphorylated epidermal growth factor receptor (EGFR) but inhibits EGF-induced transactivation of a RAS-responsive element. Isoform 2 acts as a dominant negative protein over GRB2 and by suppressing proliferative signals, may trigger active programmed cell death.<ref>PMID:1322798</ref> <ref>PMID:8178156</ref> <ref>PMID:19815557</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 37:		Line 37:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Rondeau~~, J M~~]]	+	[[Category: Rondeau JM]]
-	[[Category: Zurini, M]]	+	[[Category: Zurini M]]
-	~~[[Category: Adaptor protein]]~~	+
-	~~[[Category: Hormone-growth factor complex]]~~	+
-	~~[[Category: Ras pathway]]~~	+
-	~~[[Category: Sh2 domain]]~~	+
-	~~[[Category: Signal transduction~~]]	+

OCA at 10:14, 18 November 2020

2020-11-18T10:14:55Z

←Older revision		Revision as of 10:14, 18 November 2020
Line 1:		Line 1:

	==GRB2-SH2 DOMAIN IN COMPLEX WITH KPFY*VNVEF (PKF270-974)==		==GRB2-SH2 DOMAIN IN COMPLEX WITH KPFY*VNVEF (PKF270-974)==
-	<StructureSection load='1bmb' size='340' side='right' caption='[[1bmb]], [[Resolution\|resolution]] 1.80Å' scene=''>	+	<StructureSection load='1bmb' size='340' side='right'caption='[[1bmb]], [[Resolution\|resolution]] 1.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1bmb]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1BMB OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1BMB FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1bmb]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1BMB OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=1BMB FirstGlance]. <br>
	</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=PTR:O-PHOSPHOTYROSINE'>PTR</scene></td></tr>		</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=PTR:O-PHOSPHOTYROSINE'>PTR</scene></td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">GRB2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">GRB2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1bmb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1bmb OCA], [http://pdbe.org/1bmb PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1bmb RCSB], [http://www.ebi.ac.uk/pdbsum/1bmb PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1bmb ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=1bmb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1bmb OCA], [http://pdbe.org/1bmb PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1bmb RCSB], [http://www.ebi.ac.uk/pdbsum/1bmb PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1bmb ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 14:		Line 14:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/bm/1bmb_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/bm/1bmb_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
Line 29:		Line 29:
	</div>		</div>
	<div class="pdbe-citations 1bmb" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 1bmb" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Growth factor receptor-bound protein\|Growth factor receptor-bound protein]]
		+	*[[Growth factor receptor-bound proteins 3D structures\|Growth factor receptor-bound proteins 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
Line 34:		Line 38:
	</StructureSection>		</StructureSection>
	[[Category: Human]]		[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Rondeau, J M]]		[[Category: Rondeau, J M]]
	[[Category: Zurini, M]]		[[Category: Zurini, M]]

OCA at 10:50, 8 November 2017

2017-11-08T10:50:44Z

←Older revision		Revision as of 10:50, 8 November 2017
Line 1:		Line 1:
		+
	==GRB2-SH2 DOMAIN IN COMPLEX WITH KPFY*VNVEF (PKF270-974)==		==GRB2-SH2 DOMAIN IN COMPLEX WITH KPFY*VNVEF (PKF270-974)==
	<StructureSection load='1bmb' size='340' side='right' caption='[[1bmb]], [[Resolution\|resolution]] 1.80Å' scene=''>		<StructureSection load='1bmb' size='340' side='right' caption='[[1bmb]], [[Resolution\|resolution]] 1.80Å' scene=''>
Line 5:		Line 6:
	</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=PTR:O-PHOSPHOTYROSINE'>PTR</scene></td></tr>		</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=PTR:O-PHOSPHOTYROSINE'>PTR</scene></td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">GRB2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">GRB2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1bmb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1bmb OCA], [http://pdbe.org/1bmb PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1bmb RCSB], [http://www.ebi.ac.uk/pdbsum/1bmb PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1bmb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1bmb OCA], [http://pdbe.org/1bmb PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1bmb RCSB], [http://www.ebi.ac.uk/pdbsum/1bmb PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1bmb ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 28:		Line 29:
	</div>		</div>
	<div class="pdbe-citations 1bmb" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 1bmb" style="background-color:#fffaf0;"></div>
-
-	==See Also==
-	*[[Growth factor receptor-bound protein\|Growth factor receptor-bound protein]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 23:33, 7 February 2016

2016-02-07T23:33:07Z

←Older revision		Revision as of 23:33, 7 February 2016
Line 17:		Line 17:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1bmb ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 05:52, 10 September 2015

2015-09-10T05:52:14Z

←Older revision		Revision as of 05:52, 10 September 2015
Line 2:		Line 2:
	<StructureSection load='1bmb' size='340' side='right' caption='[[1bmb]], [[Resolution\|resolution]] 1.80Å' scene=''>		<StructureSection load='1bmb' size='340' side='right' caption='[[1bmb]], [[Resolution\|resolution]] 1.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1bmb]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1BMB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1BMB FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1bmb]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1BMB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1BMB FirstGlance]. <br>
	</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=PTR:O-PHOSPHOTYROSINE'>PTR</scene></td></tr>		</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=PTR:O-PHOSPHOTYROSINE'>PTR</scene></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">GRB2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 ~~Homo sapiens~~])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">GRB2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1bmb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1bmb OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1bmb RCSB], [http://www.ebi.ac.uk/pdbsum/1bmb PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1bmb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1bmb OCA], [http://pdbe.org/1bmb PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1bmb RCSB], [http://www.ebi.ac.uk/pdbsum/1bmb PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 27:		Line 27:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 1bmb" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 34:		Line 35:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Homo sapiens~~]]	+	[[Category: Human]]
	[[Category: Rondeau, J M]]		[[Category: Rondeau, J M]]
	[[Category: Zurini, M]]		[[Category: Zurini, M]]

OCA at 18:58, 24 December 2014

2014-12-24T18:58:44Z

←Older revision		Revision as of 18:58, 24 December 2014
Line 7:		Line 7:
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1bmb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1bmb OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1bmb RCSB], [http://www.ebi.ac.uk/pdbsum/1bmb PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1bmb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1bmb OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1bmb RCSB], [http://www.ebi.ac.uk/pdbsum/1bmb PDBsum]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/GRB2_HUMAN GRB2_HUMAN]] Adapter protein that provides a critical link between cell surface growth factor receptors and the Ras signaling pathway.<ref>PMID:1322798</ref> <ref>PMID:8178156</ref> <ref>PMID:19815557</ref> Isoform 2 does not bind to phosphorylated epidermal growth factor receptor (EGFR) but inhibits EGF-induced transactivation of a RAS-responsive element. Isoform 2 acts as a dominant negative protein over GRB2 and by suppressing proliferative signals, may trigger active programmed cell death.<ref>PMID:1322798</ref> <ref>PMID:8178156</ref> <ref>PMID:19815557</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]

OCA at 11:10, 22 December 2014

2014-12-22T11:10:15Z

←Older revision		Revision as of 11:10, 22 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1bmb]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1BMB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1BMB FirstGlance]. <br>		<table><tr><td colspan='2'>[[1bmb]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1BMB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1BMB FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=PTR:O-PHOSPHOTYROSINE'>PTR</scene></td></tr>	+	</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=PTR:O-PHOSPHOTYROSINE'>PTR</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">GRB2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">GRB2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1bmb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1bmb OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1bmb RCSB], [http://www.ebi.ac.uk/pdbsum/1bmb PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1bmb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1bmb OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1bmb RCSB], [http://www.ebi.ac.uk/pdbsum/1bmb PDBsum]</span></td></tr>
-	<table>	+	</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 33:		Line 33:
	</StructureSection>		</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
-	[[Category: Rondeau, J M.]]	+	[[Category: Rondeau, J M]]
-	[[Category: Zurini, M.]]	+	[[Category: Zurini, M]]
	[[Category: Adaptor protein]]		[[Category: Adaptor protein]]
	[[Category: Hormone-growth factor complex]]		[[Category: Hormone-growth factor complex]]

OCA at 15:14, 29 September 2014

2014-09-29T15:14:27Z

←Older revision		Revision as of 15:14, 29 September 2014
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-	~~{{STRUCTURE_1bmb\| PDB=1bmb \| SCENE= }}~~	+	==GRB2-SH2 DOMAIN IN COMPLEX WITH KPFY*VNVEF (PKF270-974)==
-	===GRB2-SH2 DOMAIN IN COMPLEX WITH KPFY*VNVEF (PKF270-974)===	+	<StructureSection load='1bmb' size='340' side='right' caption='[[1bmb]], [[Resolution\|resolution]] 1.80Å' scene=''>
-	~~{{ABSTRACT_PUBMED_10090780}}~~	+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[1bmb]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1BMB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1BMB FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=PTR:O-PHOSPHOTYROSINE'>PTR</scene></td></tr>
		+	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">GRB2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1bmb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1bmb OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1bmb RCSB], [http://www.ebi.ac.uk/pdbsum/1bmb PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/bm/1bmb_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Following earlier work on cystine-bridged peptides, cyclic phosphopeptides containing nonreducible mimics of cystine were synthesized that show high affinity and specificity toward the Src homology (SH2) domain of the growth factor receptor-binding protein (Grb2). Replacement of the cystine in the cyclic heptapeptide cyclo(CYVNVPC) by D-alpha-acetylthialysine or D-alpha-lysine gave cyclo(YVNVP(D-alpha-acetyl-thiaK)) (22) and cyclo(YVNVP(D-alpha-acetyl-K)) (30), which showed improved binding 10-fold relative to that of the control peptide KPFYVNVEF (1). NMR spectroscopy and molecular modeling experiments indicate that a beta-turn conformation centered around YVNV is essential for high-affinity binding. X-ray structure analyses show that the linear peptide 1 and the cyclic compound 21 adopt a similar binding mode with a beta-turn conformation. Our data confirm the unique structural requirements of the ligand binding site of the SH2 domain of Grb2. Moreover, the potency of our cyclic lactams can be explained by the stabilization of the beta-turn conformation by three intramolecular hydrogen bonds (one mediated by an H2O molecule). These stable and easily accessible cyclic peptides can serve as templates for the evaluation of phosphotyrosine surrogates and further chemical elaboration.

-	~~==About this Structure==~~	+	Structural and conformational requirements for high-affinity binding to the SH2 domain of Grb2(1).,Ettmayer P, France D, Gounarides J, Jarosinski M, Martin MS, Rondeau JM, Sabio M, Topiol S, Weidmann B, Zurini M, Bair KW J Med Chem. 1999 Mar 25;42(6):971-80. PMID:10090780<ref>PMID:10090780</ref>
-	~~[[1bmb]] is a 2 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Homo_sapiens Homo sapiens]~~. ~~Full crystallographic information is available from [http~~://~~oca~~.~~weizmann~~.ac.il/~~oca-bin/ocashort?id=1BMB OCA].~~	+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>

	==See Also==		==See Also==
	*[[Growth factor receptor-bound protein\|Growth factor receptor-bound protein]]		*[[Growth factor receptor-bound protein\|Growth factor receptor-bound protein]]
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	<~~ref group="xtra">PMID:010090780<~~/~~ref~~><~~references group="xtra"~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Rondeau, J M.]]		[[Category: Rondeau, J M.]]

OCA at 12:10, 18 March 2013

2013-03-18T12:10:32Z

←Older revision		Revision as of 12:10, 18 March 2013
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-	[[Image:1bmb.png\|left\|200px]]
-
	{{STRUCTURE_1bmb\| PDB=1bmb \| SCENE= }}		{{STRUCTURE_1bmb\| PDB=1bmb \| SCENE= }}
-
	===GRB2-SH2 DOMAIN IN COMPLEX WITH KPFY*VNVEF (PKF270-974)===		===GRB2-SH2 DOMAIN IN COMPLEX WITH KPFY*VNVEF (PKF270-974)===
-
	{{ABSTRACT_PUBMED_10090780}}		{{ABSTRACT_PUBMED_10090780}}

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	==See Also==		==See Also==
-	*[[Growth factor receptor-bound protein 2\|Growth factor receptor-bound protein 2]]	+	*[[Growth factor receptor-bound protein\|Growth factor receptor-bound protein]]

	==Reference==		==Reference==

OCA: Protected "1bmb" [edit=sysop:move=sysop]

2012-10-20T08:10:20Z

Protected "1bmb" [edit=sysop:move=sysop]

←Older revision

Revision as of 08:10, 20 October 2012