1bpi - Revision history

OCA at 15:35, 13 March 2024

2024-03-13T15:35:06Z

←Older revision		Revision as of 15:35, 13 March 2024
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	<StructureSection load='1bpi' size='340' side='right'caption='[[1bpi]], [[Resolution\|resolution]] 1.09Å' scene=''>		<StructureSection load='1bpi' size='340' side='right'caption='[[1bpi]], [[Resolution\|resolution]] 1.09Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1bpi]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1BPI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1BPI FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1bpi]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1BPI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1BPI FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.09Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1bpi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1bpi OCA], [https://pdbe.org/1bpi PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1bpi RCSB], [https://www.ebi.ac.uk/pdbsum/1bpi PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1bpi ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1bpi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1bpi OCA], [https://pdbe.org/1bpi PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1bpi RCSB], [https://www.ebi.ac.uk/pdbsum/1bpi PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1bpi ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/BPT1_BOVIN BPT1_BOVIN]] Inhibits trypsin, kallikrein, chymotrypsin, and plasmin.	+	[https://www.uniprot.org/uniprot/BPT1_BOVIN BPT1_BOVIN] Inhibits trypsin, kallikrein, chymotrypsin, and plasmin.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1bpi ConSurf].		</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1bpi ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
-	<div style="background-color:#fffaf0;">
-	== Publication Abstract from PubMed ==
-	The structure of bovine pancreatic trypsin inhibitor has been refined to a resolution of 1.1 A against data collected at 125 K. The space group of the form II crystal is P2(1)2(1)2(1) with a = 75.39(3), b = 22.581(7), c = 28.606 (9) A (cf. a = 74.1, b = 23.4, c = 28.9 A at room temperature). The structure was refined by restrained least-squares minimization of summation operator w(F (o)(2)- F (c)(2))(2) with the SHELXL93 program. As the model improved, water molecules were included and exceptionally clear electron density was found for two residues, Gly57 and Ala58, that had been largely obscured at room temperature. The side chains of residues Glu7 and Arg53 were modelled over two positions with refined occupancy factors. The final model contains 145.6 water molecules distributed over 167 sites, and a single phosphate group disordered over two sites. The root-mean-square discrepancy between Calpha atoms in residues Arg1-Gly56 at room and low temperatures is 0.4 A. A comparison of models refined with anisotropic and isotropic thermal parameters revealed that there were no significant differences in atomic positions. The final weighted R-factor on F(2) (wR(2)) for data in the range 10-1.1 A was 35.9% for the anisotropic model and 40.9% for the isotropic model. Conventional R-factors based on F for F > 4sigma(F) were 12.2 and 14.6%, respectively, corresponding to 16.1 and 18.7% on all data. These large R-factor differences were not reflected in values of R(free), which were not significantly different at 21.5(5) and 21.8(4)%, respectively. These results, along with the relatively straightforward nature of the refinement, clearly highlight the benefits of low-temperature data collection.

-	Structure of bovine pancreatic trypsin inhibitor at 125 K definition of carboxyl-terminal residues Gly57 and Ala58.,Parkin S, Rupp B, Hope H Acta Crystallogr D Biol Crystallogr. 1996 Jan 1;52(Pt 1):18-29. PMID:15299722<ref>PMID:15299722</ref>	+	==See Also==
-		+	*[[BPTI 3D structures\|BPTI 3D structures]]
-	~~From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>~~	+
-	~~</div>~~	+
-	~~<div class="pdbe-citations 1bpi" style="background-color:#fffaf0;"></div>~~	+
-	== ~~References~~ ==	+
-	~~<references/>~~	+
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Bos taurus]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Hope, H]]	+	[[Category: Hope H]]
-	[[Category: Parkin, S]]	+	[[Category: Parkin S]]
-	[[Category: Rupp, B]]	+	[[Category: Rupp B]]

OCA at 07:01, 24 February 2021

2021-02-24T07:01:36Z

←Older revision		Revision as of 07:01, 24 February 2021
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	<StructureSection load='1bpi' size='340' side='right'caption='[[1bpi]], [[Resolution\|resolution]] 1.09Å' scene=''>		<StructureSection load='1bpi' size='340' side='right'caption='[[1bpi]], [[Resolution\|resolution]] 1.09Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1bpi]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1BPI OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1BPI FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1bpi]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1BPI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1BPI FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1bpi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1bpi OCA], [~~http~~://pdbe.org/1bpi PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=1bpi RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/1bpi PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=1bpi ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1bpi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1bpi OCA], [https://pdbe.org/1bpi PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1bpi RCSB], [https://www.ebi.ac.uk/pdbsum/1bpi PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1bpi ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/BPT1_BOVIN BPT1_BOVIN]] Inhibits trypsin, kallikrein, chymotrypsin, and plasmin.	+	[[https://www.uniprot.org/uniprot/BPT1_BOVIN BPT1_BOVIN]] Inhibits trypsin, kallikrein, chymotrypsin, and plasmin.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 28:		Line 28:
	</div>		</div>
	<div class="pdbe-citations 1bpi" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 1bpi" style="background-color:#fffaf0;"></div>
-
-	==See Also==
-	*[[BPTI 3D structures\|BPTI 3D structures]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 08:51, 21 May 2019

2019-05-21T08:51:52Z

←Older revision		Revision as of 08:51, 21 May 2019
Line 1:		Line 1:

	==THE STRUCTURE OF BOVINE PANCREATIC TRYPSIN INHIBITOR AT 125K: DEFINITION OF CARBOXYL-TERMINAL RESIDUES GLYCINE-57 AND ALANINE-58==		==THE STRUCTURE OF BOVINE PANCREATIC TRYPSIN INHIBITOR AT 125K: DEFINITION OF CARBOXYL-TERMINAL RESIDUES GLYCINE-57 AND ALANINE-58==
-	<StructureSection load='1bpi' size='340' side='right' caption='[[1bpi]], [[Resolution\|resolution]] 1.09Å' scene=''>	+	<StructureSection load='1bpi' size='340' side='right'caption='[[1bpi]], [[Resolution\|resolution]] 1.09Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1bpi]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1BPI OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1BPI FirstGlance]. <br>		<table><tr><td colspan='2'>[[1bpi]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1BPI OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1BPI FirstGlance]. <br>
Line 13:		Line 13:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/bp/1bpi_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/bp/1bpi_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
Line 30:		Line 30:

	==See Also==		==See Also==
-	*[[~~Basic Pancreatic Trypsin Inhibitor~~\|~~Basic Pancreatic Trypsin Inhibitor~~]]	+	*[[BPTI 3D structures\|BPTI 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Hope, H]]		[[Category: Hope, H]]
	[[Category: Parkin, S]]		[[Category: Parkin, S]]
	[[Category: Rupp, B]]		[[Category: Rupp, B]]

OCA at 06:13, 17 August 2017

2017-08-17T06:13:56Z

←Older revision		Revision as of 06:13, 17 August 2017
Line 1:		Line 1:
		+
	==THE STRUCTURE OF BOVINE PANCREATIC TRYPSIN INHIBITOR AT 125K: DEFINITION OF CARBOXYL-TERMINAL RESIDUES GLYCINE-57 AND ALANINE-58==		==THE STRUCTURE OF BOVINE PANCREATIC TRYPSIN INHIBITOR AT 125K: DEFINITION OF CARBOXYL-TERMINAL RESIDUES GLYCINE-57 AND ALANINE-58==
	<StructureSection load='1bpi' size='340' side='right' caption='[[1bpi]], [[Resolution\|resolution]] 1.09Å' scene=''>		<StructureSection load='1bpi' size='340' side='right' caption='[[1bpi]], [[Resolution\|resolution]] 1.09Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1bpi]] is a 1 chain structure ~~with sequence from [http://en.wikipedia.org/wiki/Bovin Bovin]~~. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1BPI OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1BPI FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1bpi]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1BPI OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1BPI FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1bpi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1bpi OCA], [http://pdbe.org/1bpi PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1bpi RCSB], [http://www.ebi.ac.uk/pdbsum/1bpi PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1bpi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1bpi OCA], [http://pdbe.org/1bpi PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1bpi RCSB], [http://www.ebi.ac.uk/pdbsum/1bpi PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1bpi ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 16:		Line 17:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1bpi ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Bovin]]
	[[Category: Hope, H]]		[[Category: Hope, H]]
	[[Category: Parkin, S]]		[[Category: Parkin, S]]
	[[Category: Rupp, B]]		[[Category: Rupp, B]]

OCA at 15:13, 11 September 2015

2015-09-11T15:13:14Z

←Older revision		Revision as of 15:13, 11 September 2015
Line 2:		Line 2:
	<StructureSection load='1bpi' size='340' side='right' caption='[[1bpi]], [[Resolution\|resolution]] 1.09Å' scene=''>		<StructureSection load='1bpi' size='340' side='right' caption='[[1bpi]], [[Resolution\|resolution]] 1.09Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1bpi]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Bos_taurus Bos taurus~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1BPI OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1BPI FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1bpi]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Bovin Bovin]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1BPI OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1BPI FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1bpi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1bpi OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1bpi RCSB], [http://www.ebi.ac.uk/pdbsum/1bpi PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1bpi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1bpi OCA], [http://pdbe.org/1bpi PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1bpi RCSB], [http://www.ebi.ac.uk/pdbsum/1bpi PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 26:		Line 26:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 1bpi" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 33:		Line 34:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Bos taurus~~]]	+	[[Category: Bovin]]
	[[Category: Hope, H]]		[[Category: Hope, H]]
	[[Category: Parkin, S]]		[[Category: Parkin, S]]
	[[Category: Rupp, B]]		[[Category: Rupp, B]]

OCA at 18:13, 25 December 2014

2014-12-25T18:13:54Z

←Older revision		Revision as of 18:13, 25 December 2014
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	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1bpi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1bpi OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1bpi RCSB], [http://www.ebi.ac.uk/pdbsum/1bpi PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1bpi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1bpi OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1bpi RCSB], [http://www.ebi.ac.uk/pdbsum/1bpi PDBsum]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/BPT1_BOVIN BPT1_BOVIN]] Inhibits trypsin, kallikrein, chymotrypsin, and plasmin.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]

OCA at 10:47, 22 December 2014

2014-12-22T10:47:13Z

←Older revision		Revision as of 10:47, 22 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1bpi]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1BPI OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1BPI FirstGlance]. <br>		<table><tr><td colspan='2'>[[1bpi]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1BPI OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1BPI FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1bpi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1bpi OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1bpi RCSB], [http://www.ebi.ac.uk/pdbsum/1bpi PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1bpi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1bpi OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1bpi RCSB], [http://www.ebi.ac.uk/pdbsum/1bpi PDBsum]</span></td></tr>
-	<table>	+	</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 32:		Line 32:
	</StructureSection>		</StructureSection>
	[[Category: Bos taurus]]		[[Category: Bos taurus]]
-	[[Category: Hope, H.]]	+	[[Category: Hope, H]]
-	[[Category: Parkin, S.]]	+	[[Category: Parkin, S]]
-	[[Category: Rupp, B.]]	+	[[Category: Rupp, B]]

OCA at 09:45, 13 August 2014

2014-08-13T09:45:05Z

←Older revision		Revision as of 09:45, 13 August 2014
Line 1:		Line 1:
-	[[~~Image~~:1bpi.~~png\|left~~\|200px]]	+	==THE STRUCTURE OF BOVINE PANCREATIC TRYPSIN INHIBITOR AT 125K: DEFINITION OF CARBOXYL-TERMINAL RESIDUES GLYCINE-57 AND ALANINE-58==
		+	<StructureSection load='1bpi' size='340' side='right' caption='[[1bpi]], [[Resolution\|resolution]] 1.09Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[1bpi]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1BPI OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1BPI FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene><br>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1bpi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1bpi OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1bpi RCSB], [http://www.ebi.ac.uk/pdbsum/1bpi PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/bp/1bpi_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The structure of bovine pancreatic trypsin inhibitor has been refined to a resolution of 1.1 A against data collected at 125 K. The space group of the form II crystal is P2(1)2(1)2(1) with a = 75.39(3), b = 22.581(7), c = 28.606 (9) A (cf. a = 74.1, b = 23.4, c = 28.9 A at room temperature). The structure was refined by restrained least-squares minimization of summation operator w(F (o)(2)- F (c)(2))(2) with the SHELXL93 program. As the model improved, water molecules were included and exceptionally clear electron density was found for two residues, Gly57 and Ala58, that had been largely obscured at room temperature. The side chains of residues Glu7 and Arg53 were modelled over two positions with refined occupancy factors. The final model contains 145.6 water molecules distributed over 167 sites, and a single phosphate group disordered over two sites. The root-mean-square discrepancy between Calpha atoms in residues Arg1-Gly56 at room and low temperatures is 0.4 A. A comparison of models refined with anisotropic and isotropic thermal parameters revealed that there were no significant differences in atomic positions. The final weighted R-factor on F(2) (wR(2)) for data in the range 10-1.1 A was 35.9% for the anisotropic model and 40.9% for the isotropic model. Conventional R-factors based on F for F > 4sigma(F) were 12.2 and 14.6%, respectively, corresponding to 16.1 and 18.7% on all data. These large R-factor differences were not reflected in values of R(free), which were not significantly different at 21.5(5) and 21.8(4)%, respectively. These results, along with the relatively straightforward nature of the refinement, clearly highlight the benefits of low-temperature data collection.

-	~~{{STRUCTURE_1bpi\| PDB=1bpi \| SCENE= }}~~	+	Structure of bovine pancreatic trypsin inhibitor at 125 K definition of carboxyl-terminal residues Gly57 and Ala58.,Parkin S, Rupp B, Hope H Acta Crystallogr D Biol Crystallogr. 1996 Jan 1;52(Pt 1):18-29. PMID:15299722<ref>PMID:15299722</ref>

-	~~===THE STRUCTURE OF BOVINE PANCREATIC TRYPSIN INHIBITOR AT 125K: DEFINITION OF CARBOXYL-TERMINAL RESIDUES GLYCINE-57 AND ALANINE-58===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_15299722}}~~	+
-		+
-	~~==About this Structure==~~	+
-	~~[[1bpi]] is~~ a ~~1 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Bos_taurus Bos taurus]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=1BPI OCA].~~	+

	==See Also==		==See Also==
	*[[Basic Pancreatic Trypsin Inhibitor\|Basic Pancreatic Trypsin Inhibitor]]		*[[Basic Pancreatic Trypsin Inhibitor\|Basic Pancreatic Trypsin Inhibitor]]
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	<~~ref group="xtra">PMID:015299722<~~/~~ref~~><~~ref group="xtra">PMID:011734033</ref><ref group="xtra">PMID:015267926</ref><ref group="xtra">PMID:019113835</ref><references group="xtra"~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Bos taurus]]		[[Category: Bos taurus]]
	[[Category: Hope, H.]]		[[Category: Hope, H.]]
	[[Category: Parkin, S.]]		[[Category: Parkin, S.]]
	[[Category: Rupp, B.]]		[[Category: Rupp, B.]]

OCA at 19:51, 20 October 2012

2012-10-20T19:51:06Z

←Older revision		Revision as of 19:51, 20 October 2012
Line 8:		Line 8:

	==About this Structure==		==About this Structure==
-	[[1bpi]] is a 1 chain structure ~~of [[Basic Pancreatic Trypsin Inhibitor]]~~ with sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1BPI OCA].	+	[[1bpi]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1BPI OCA].

	==See Also==		==See Also==

OCA at 08:40, 27 July 2012

2012-07-27T08:40:49Z

←Older revision		Revision as of 08:40, 27 July 2012
Line 1:		Line 1:
	[[Image:1bpi.png\|left\|200px]]		[[Image:1bpi.png\|left\|200px]]

-	<!--
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-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
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-	or leave the SCENE parameter empty for the default display.
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	{{STRUCTURE_1bpi\| PDB=1bpi \| SCENE= }}		{{STRUCTURE_1bpi\| PDB=1bpi \| SCENE= }}

	===THE STRUCTURE OF BOVINE PANCREATIC TRYPSIN INHIBITOR AT 125K: DEFINITION OF CARBOXYL-TERMINAL RESIDUES GLYCINE-57 AND ALANINE-58===		===THE STRUCTURE OF BOVINE PANCREATIC TRYPSIN INHIBITOR AT 125K: DEFINITION OF CARBOXYL-TERMINAL RESIDUES GLYCINE-57 AND ALANINE-58===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_15299722}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 15299722 is the PubMed ID number.
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	{{ABSTRACT_PUBMED_15299722}}		{{ABSTRACT_PUBMED_15299722}}

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	==See Also==		==See Also==
-	*[[Basic Pancreatic Trypsin Inhibitor]]	+	*[[Basic Pancreatic Trypsin Inhibitor\|Basic Pancreatic Trypsin Inhibitor]]

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~15299722~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:015299722</ref><ref group="xtra">PMID:011734033</ref><ref group="xtra">PMID:015267926</ref><ref group="xtra">PMID:019113835</ref><references group="xtra"/>
	[[Category: Bos taurus]]		[[Category: Bos taurus]]
	[[Category: Hope, H.]]		[[Category: Hope, H.]]
	[[Category: Parkin, S.]]		[[Category: Parkin, S.]]
	[[Category: Rupp, B.]]		[[Category: Rupp, B.]]