1c08 - Revision history

OCA at 05:47, 31 May 2023

2023-05-31T05:47:38Z

←Older revision		Revision as of 05:47, 31 May 2023
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	<StructureSection load='1c08' size='340' side='right'caption='[[1c08]], [[Resolution\|resolution]] 2.30Å' scene=''>		<StructureSection load='1c08' size='340' side='right'caption='[[1c08]], [[Resolution\|resolution]] 2.30Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1c08]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Gallus_gallus Gallus gallus] and [https://en.wikipedia.org/wiki/~~Lk3_transgenic_mice Lk3 transgenic mice~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1C08 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1C08 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1c08]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Gallus_gallus Gallus gallus] and [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1C08 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1C08 FirstGlance]. <br>
	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1c08 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1c08 OCA], [https://pdbe.org/1c08 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1c08 RCSB], [https://www.ebi.ac.uk/pdbsum/1c08 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1c08 ProSAT]</span></td></tr>		</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1c08 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1c08 OCA], [https://pdbe.org/1c08 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1c08 RCSB], [https://www.ebi.ac.uk/pdbsum/1c08 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1c08 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/~~LYSC_CHICK LYSC_CHICK~~]] Lysozymes have primarily a bacteriolytic function; those in tissues and body fluids are associated with the monocyte-macrophage system and enhance the activity of immunoagents. Has bacteriolytic activity against M.luteus.<ref>PMID:22044478</ref>	+	[https://www.uniprot.org/uniprot/KV5A9_MOUSE KV5A9_MOUSE]
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 37:		Line 37:
	[[Category: Gallus gallus]]		[[Category: Gallus gallus]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Lk3 transgenic mice~~]]	+	[[Category: Mus musculus]]
-	[[Category: Kondo, H]]	+	[[Category: Kondo H]]
-	[[Category: Kumagai, I]]	+	[[Category: Kumagai I]]
-	[[Category: Matsushima, M]]	+	[[Category: Matsushima M]]
-	[[Category: Shiroishi, M]]	+	[[Category: Shiroishi M]]
-	[[Category: Tsumoto, K]]	+	[[Category: Tsumoto K]]
-	~~[[Category: Antigen-antibody complex]]~~	+
-	~~[[Category: Immune system-hydrolase complex~~]]	+

OCA at 10:32, 14 July 2021

2021-07-14T10:32:02Z

←Older revision		Revision as of 10:32, 14 July 2021
Line 3:		Line 3:
	<StructureSection load='1c08' size='340' side='right'caption='[[1c08]], [[Resolution\|resolution]] 2.30Å' scene=''>		<StructureSection load='1c08' size='340' side='right'caption='[[1c08]], [[Resolution\|resolution]] 2.30Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1c08]] is a 3 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Gallus_gallus Gallus gallus] and [~~http~~://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1C08 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1C08 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1c08]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Gallus_gallus Gallus gallus] and [https://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1C08 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1C08 FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1c08 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1c08 OCA], [~~http~~://pdbe.org/1c08 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=1c08 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/1c08 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=1c08 ProSAT]</span></td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1c08 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1c08 OCA], [https://pdbe.org/1c08 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1c08 RCSB], [https://www.ebi.ac.uk/pdbsum/1c08 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1c08 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/LYSC_CHICK LYSC_CHICK]] Lysozymes have primarily a bacteriolytic function; those in tissues and body fluids are associated with the monocyte-macrophage system and enhance the activity of immunoagents. Has bacteriolytic activity against M.luteus.<ref>PMID:22044478</ref>	+	[[https://www.uniprot.org/uniprot/LYSC_CHICK LYSC_CHICK]] Lysozymes have primarily a bacteriolytic function; those in tissues and body fluids are associated with the monocyte-macrophage system and enhance the activity of immunoagents. Has bacteriolytic activity against M.luteus.<ref>PMID:22044478</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]

OCA at 07:06, 10 October 2019

2019-10-10T07:06:26Z

←Older revision		Revision as of 07:06, 10 October 2019
Line 1:		Line 1:

	==CRYSTAL STRUCTURE OF HYHEL-10 FV-HEN LYSOZYME COMPLEX==		==CRYSTAL STRUCTURE OF HYHEL-10 FV-HEN LYSOZYME COMPLEX==
-	<StructureSection load='1c08' size='340' side='right' caption='[[1c08]], [[Resolution\|resolution]] 2.30Å' scene=''>	+	<StructureSection load='1c08' size='340' side='right'caption='[[1c08]], [[Resolution\|resolution]] 2.30Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1c08]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Gallus_gallus Gallus gallus] and [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1C08 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1C08 FirstGlance]. <br>		<table><tr><td colspan='2'>[[1c08]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Gallus_gallus Gallus gallus] and [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1C08 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1C08 FirstGlance]. <br>
Line 12:		Line 12:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/c0/1c08_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/c0/1c08_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
Line 30:		Line 30:
	==See Also==		==See Also==
	*[[Lysozyme 3D structures\|Lysozyme 3D structures]]		*[[Lysozyme 3D structures\|Lysozyme 3D structures]]
-	*[[3D structures ~~of monoclonal antibody~~\|3D structures ~~of monoclonal antibody~~]]	+	*[[Monoclonal Antibodies 3D structures\|Monoclonal Antibodies 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
Line 36:		Line 36:
	</StructureSection>		</StructureSection>
	[[Category: Gallus gallus]]		[[Category: Gallus gallus]]
		+	[[Category: Large Structures]]
	[[Category: Lk3 transgenic mice]]		[[Category: Lk3 transgenic mice]]
	[[Category: Kondo, H]]		[[Category: Kondo, H]]

OCA at 08:04, 29 November 2017

2017-11-29T08:04:56Z

←Older revision		Revision as of 08:04, 29 November 2017
Line 1:		Line 1:
		+
	==CRYSTAL STRUCTURE OF HYHEL-10 FV-HEN LYSOZYME COMPLEX==		==CRYSTAL STRUCTURE OF HYHEL-10 FV-HEN LYSOZYME COMPLEX==
	<StructureSection load='1c08' size='340' side='right' caption='[[1c08]], [[Resolution\|resolution]] 2.30Å' scene=''>		<StructureSection load='1c08' size='340' side='right' caption='[[1c08]], [[Resolution\|resolution]] 2.30Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1c08]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Chick Chick~~] and [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1C08 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1C08 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1c08]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Gallus_gallus Gallus gallus] and [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1C08 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1C08 FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1c08 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1c08 OCA], [http://pdbe.org/1c08 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1c08 RCSB], [http://www.ebi.ac.uk/pdbsum/1c08 PDBsum]</span></td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1c08 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1c08 OCA], [http://pdbe.org/1c08 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1c08 RCSB], [http://www.ebi.ac.uk/pdbsum/1c08 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1c08 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 29:		Line 30:
	==See Also==		==See Also==
	*[[Lysozyme 3D structures\|Lysozyme 3D structures]]		*[[Lysozyme 3D structures\|Lysozyme 3D structures]]
-	*[[~~Monoclonal Antibody~~\|~~Monoclonal Antibody~~]]	+	*[[3D structures of monoclonal antibody\|3D structures of monoclonal antibody]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Chick~~]]	+	[[Category: Gallus gallus]]
	[[Category: Lk3 transgenic mice]]		[[Category: Lk3 transgenic mice]]
	[[Category: Kondo, H]]		[[Category: Kondo, H]]

OCA at 13:21, 8 February 2016

2016-02-08T13:21:20Z

←Older revision		Revision as of 13:21, 8 February 2016
Line 15:		Line 15:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1c08 ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 11:58, 10 September 2015

2015-09-10T11:58:03Z

←Older revision		Revision as of 11:58, 10 September 2015
Line 2:		Line 2:
	<StructureSection load='1c08' size='340' side='right' caption='[[1c08]], [[Resolution\|resolution]] 2.30Å' scene=''>		<StructureSection load='1c08' size='340' side='right' caption='[[1c08]], [[Resolution\|resolution]] 2.30Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1c08]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Gallus_gallus Gallus gallus~~] and [http://en.wikipedia.org/wiki/~~Mus_musculus Mus musculus~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1C08 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1C08 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1c08]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Chick Chick] and [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1C08 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1C08 FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1c08 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1c08 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1c08 RCSB], [http://www.ebi.ac.uk/pdbsum/1c08 PDBsum]</span></td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1c08 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1c08 OCA], [http://pdbe.org/1c08 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1c08 RCSB], [http://www.ebi.ac.uk/pdbsum/1c08 PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 25:		Line 25:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 1c08" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 33:		Line 34:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Gallus gallus~~]]	+	[[Category: Chick]]
-	[[Category: ~~Mus musculus~~]]	+	[[Category: Lk3 transgenic mice]]
	[[Category: Kondo, H]]		[[Category: Kondo, H]]
	[[Category: Kumagai, I]]		[[Category: Kumagai, I]]

OCA at 23:37, 24 December 2014

2014-12-24T23:37:27Z

←Older revision		Revision as of 23:37, 24 December 2014
Line 5:		Line 5:
	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1c08 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1c08 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1c08 RCSB], [http://www.ebi.ac.uk/pdbsum/1c08 PDBsum]</span></td></tr>		</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1c08 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1c08 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1c08 RCSB], [http://www.ebi.ac.uk/pdbsum/1c08 PDBsum]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/LYSC_CHICK LYSC_CHICK]] Lysozymes have primarily a bacteriolytic function; those in tissues and body fluids are associated with the monocyte-macrophage system and enhance the activity of immunoagents. Has bacteriolytic activity against M.luteus.<ref>PMID:22044478</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]

OCA at 10:59, 22 December 2014

2014-12-22T10:59:41Z

←Older revision		Revision as of 10:59, 22 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1c08]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Gallus_gallus Gallus gallus] and [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1C08 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1C08 FirstGlance]. <br>		<table><tr><td colspan='2'>[[1c08]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Gallus_gallus Gallus gallus] and [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1C08 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1C08 FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1c08 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1c08 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1c08 RCSB], [http://www.ebi.ac.uk/pdbsum/1c08 PDBsum]</span></td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1c08 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1c08 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1c08 RCSB], [http://www.ebi.ac.uk/pdbsum/1c08 PDBsum]</span></td></tr>
-	<table>	+	</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 33:		Line 33:
	[[Category: Gallus gallus]]		[[Category: Gallus gallus]]
	[[Category: Mus musculus]]		[[Category: Mus musculus]]
-	[[Category: Kondo, H.]]	+	[[Category: Kondo, H]]
-	[[Category: Kumagai, I.]]	+	[[Category: Kumagai, I]]
-	[[Category: Matsushima, M.]]	+	[[Category: Matsushima, M]]
-	[[Category: Shiroishi, M.]]	+	[[Category: Shiroishi, M]]
-	[[Category: Tsumoto, K.]]	+	[[Category: Tsumoto, K]]
	[[Category: Antigen-antibody complex]]		[[Category: Antigen-antibody complex]]
	[[Category: Immune system-hydrolase complex]]		[[Category: Immune system-hydrolase complex]]

OCA at 16:56, 20 August 2014

2014-08-20T16:56:28Z

←Older revision		Revision as of 16:56, 20 August 2014
Line 1:		Line 1:
-	[[~~Image~~:1c08.~~png\|left~~\|200px]]	+	==CRYSTAL STRUCTURE OF HYHEL-10 FV-HEN LYSOZYME COMPLEX==
		+	<StructureSection load='1c08' size='340' side='right' caption='[[1c08]], [[Resolution\|resolution]] 2.30Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[1c08]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Gallus_gallus Gallus gallus] and [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1C08 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1C08 FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1c08 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1c08 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1c08 RCSB], [http://www.ebi.ac.uk/pdbsum/1c08 PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/c0/1c08_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	In order to address the recognition mechanism of the fragments of antibody variable regions, termed Fv, toward their target antigen, an x-ray crystal structure of an anti-hen egg white lysozyme antibody (HyHEL-10) Fv fragment complexed with its cognate antigen, hen egg white lysozyme (HEL), was solved at 2.3 A. The overall structure of the complex is similar to that reported in a previous article dealing with the Fab fragment-HEL complex (PDB ID code,). However, the areas of Fv covered by HEL upon complex formation increased by about 100 A(2) in comparison with the Fab-HEL complex, and two local structural differences were observed in the heavy chain of the variable region (VH). In addition, small but significant local structural changes were observed in the antigen, HEL. The x-ray data permitted the identification of two water molecules between the VH and HEL and six water molecules retained in the interface between the antigen and the light chain complementarity determining regions (CDRs) 2 and 3 (CDR-L2 and CDR-L3). These water molecules bridge the antigen-antibody interface through hydrogen bond formation in the VL-HEL interface. Eleven water molecules were found to complete the imperfect VH-VL interface, suggesting that solvent molecules mediate the stabilization of interaction between variable regions. These results suggest that the unfavorable effect of deletion of constant regions on the antigen-antibody interaction is compensated by an increase in favorable interactions, including structural changes in the antigen-antibody interface and solvent-mediated hydrogen bond formation upon complex formation, which may lead to a minimum decreased affinity of the antibody Fv fragment toward its antigen.

-	~~{{STRUCTURE_1c08\| PDB=1c08 \| SCENE= }}~~	+	Crystal structure of anti-Hen egg white lysozyme antibody (HyHEL-10) Fv-antigen complex. Local structural changes in the protein antigen and water-mediated interactions of Fv-antigen and light chain-heavy chain interfaces.,Kondo H, Shiroishi M, Matsushima M, Tsumoto K, Kumagai I J Biol Chem. 1999 Sep 24;274(39):27623-31. PMID:10488102<ref>PMID:10488102</ref>

-	~~===CRYSTAL STRUCTURE OF HYHEL-10 FV-HEN LYSOZYME COMPLEX===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_10488102}}~~	+
-		+
-	~~==About this Structure==~~	+
-	~~[[1c08]] is~~ a ~~3 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Gallus_gallus Gallus gallus] and [http://en~~.~~wikipedia.org~~/~~wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1C08 OCA].~~	+

	==See Also==		==See Also==
-	*[[~~Hen Egg-White (HEW)~~ Lysozyme\|~~Hen Egg-White (HEW)~~ Lysozyme]]	+	*[[Lysozyme 3D structures\|Lysozyme 3D structures]]
-		+	*[[Monoclonal Antibody\|Monoclonal Antibody]]
-	==~~Reference~~==	+	== References ==
-	<~~ref group="xtra">PMID:010488102<~~/~~ref~~><~~references group="xtra"~~/>	+	<references/>
		+	__TOC__
		+	</StructureSection>
	[[Category: Gallus gallus]]		[[Category: Gallus gallus]]
	[[Category: Mus musculus]]		[[Category: Mus musculus]]

OCA at 10:16, 20 October 2012

2012-10-20T10:16:41Z

←Older revision		Revision as of 10:16, 20 October 2012
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	==About this Structure==		==About this Structure==
-	[[1c08]] is a 3 chain structure ~~of [[Hen Egg-White (HEW) Lysozyme]]~~ with sequence from [http://en.wikipedia.org/wiki/Gallus_gallus Gallus gallus] and [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1C08 OCA].	+	[[1c08]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Gallus_gallus Gallus gallus] and [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1C08 OCA].

	==See Also==		==See Also==