1c44 - Revision history

OCA at 23:23, 27 December 2023

2023-12-27T23:23:26Z

←Older revision		Revision as of 23:23, 27 December 2023
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	<StructureSection load='1c44' size='340' side='right'caption='[[1c44]], [[Resolution\|resolution]] 1.80Å' scene=''>		<StructureSection load='1c44' size='340' side='right'caption='[[1c44]], [[Resolution\|resolution]] 1.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1c44]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/~~European_rabbit European rabbit~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1C44 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1C44 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1c44]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Oryctolagus_cuniculus Oryctolagus cuniculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1C44 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1C44 FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1c44 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1c44 OCA], [https://pdbe.org/1c44 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1c44 RCSB], [https://www.ebi.ac.uk/pdbsum/1c44 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1c44 ProSAT]</span></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.8Å</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1c44 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1c44 OCA], [https://pdbe.org/1c44 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1c44 RCSB], [https://www.ebi.ac.uk/pdbsum/1c44 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1c44 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/~~NLTP_RABIT NLTP_RABIT~~]~~] Mediates~~ in vitro the transfer of all common phospholipids, cholesterol and gangliosides ~~between membranes~~. May play a role in regulating steroidogenesis (By similarity).	+	[https://www.uniprot.org/uniprot/SCP2_RABIT SCP2_RABIT] Plays a crucial role in the peroxisomal oxidation of branched-chain fatty acids. Catalyzes the last step of the peroxisomal beta-oxidation of branched chain fatty acids and the side chain of the bile acid intermediates di- and trihydroxycoprostanic acids (DHCA and THCA) (By similarity). Also active with medium and long straight chain 3-oxoacyl-CoAs. Stimulates the microsomal conversion of 7-dehydrocholesterol to cholesterol and transfers phosphatidylcholine and 7-dehydrocholesterol between membrances, in vitro (By similarity). Isoforms SCP2 and SCPx cooperate in peroxisomal oxidation of certain naturally occurring tetramethyl-branched fatty acyl-CoAs (By similarity).[UniProtKB:P11915][UniProtKB:P22307][UniProtKB:P32020] Mediates the transfer of all common phospholipids, cholesterol and gangliosides from the endoplasmic reticulum to the plasma membrane (PubMed:9711242). May play a role in regulating steroidogenesis (By similarity). Stimulates the microsomal conversion of 7-dehydrocholesterol to cholesterol (By similarity). Also binds fatty acids and fatty acyl Coenzyme A (CoA) such as phytanoyl-CoA. Involved in the regulation phospholipid synthesis in endoplasmic reticulum enhancing the incorporation of exogenous fatty acid into glycerides. Seems to stimulate the rate-limiting step in phosphatidic acid formation mediated by GPAT3. Isoforms SCP2 and SCPx cooperate in peroxisomal oxidation of certain naturally occurring tetramethyl-branched fatty acyl-CoAs (By similarity).[UniProtKB:P11915][UniProtKB:P22307][UniProtKB:P32020]<ref>PMID:9711242</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: European rabbit]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Choinowski, T~~]]	+	[[Category: Oryctolagus cuniculus]]
-	[[Category: ~~Hauser, H~~]]	+	[[Category: Choinowski T]]
-	[[Category: ~~Piontek, K~~]]	+	[[Category: Hauser H]]
-	[[Category: ~~Fatty acid binding]]~~	+	[[Category: Piontek K]]
-	~~[[Category: Fatty acyl coa binding]]~~	+
-	~~[[Category: Lipid binding protein]]~~	+
-	~~[[Category: Non specific lipid transfer protein]]~~	+
-	~~[[Category: Sterol carrier protein~~]]	+

OCA at 10:32, 14 July 2021

2021-07-14T10:32:56Z

←Older revision		Revision as of 10:32, 14 July 2021
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	<StructureSection load='1c44' size='340' side='right'caption='[[1c44]], [[Resolution\|resolution]] 1.80Å' scene=''>		<StructureSection load='1c44' size='340' side='right'caption='[[1c44]], [[Resolution\|resolution]] 1.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1c44]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/European_rabbit European rabbit]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1C44 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1C44 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1c44]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/European_rabbit European rabbit]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1C44 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1C44 FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1c44 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1c44 OCA], [~~http~~://pdbe.org/1c44 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=1c44 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/1c44 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=1c44 ProSAT]</span></td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1c44 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1c44 OCA], [https://pdbe.org/1c44 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1c44 RCSB], [https://www.ebi.ac.uk/pdbsum/1c44 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1c44 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/NLTP_RABIT NLTP_RABIT]] Mediates in vitro the transfer of all common phospholipids, cholesterol and gangliosides between membranes. May play a role in regulating steroidogenesis (By similarity).	+	[[https://www.uniprot.org/uniprot/NLTP_RABIT NLTP_RABIT]] Mediates in vitro the transfer of all common phospholipids, cholesterol and gangliosides between membranes. May play a role in regulating steroidogenesis (By similarity).
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]

OCA at 06:48, 10 October 2019

2019-10-10T06:48:18Z

←Older revision		Revision as of 06:48, 10 October 2019
Line 1:		Line 1:

	==STEROL CARRIER PROTEIN 2 (SCP2) FROM RABBIT==		==STEROL CARRIER PROTEIN 2 (SCP2) FROM RABBIT==
-	<StructureSection load='1c44' size='340' side='right' caption='[[1c44]], [[Resolution\|resolution]] 1.80Å' scene=''>	+	<StructureSection load='1c44' size='340' side='right'caption='[[1c44]], [[Resolution\|resolution]] 1.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1c44]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/European_rabbit European rabbit]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1C44 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1C44 FirstGlance]. <br>		<table><tr><td colspan='2'>[[1c44]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/European_rabbit European rabbit]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1C44 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1C44 FirstGlance]. <br>
Line 12:		Line 12:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/c4/1c44_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/c4/1c44_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
Line 32:		Line 32:
	</StructureSection>		</StructureSection>
	[[Category: European rabbit]]		[[Category: European rabbit]]
		+	[[Category: Large Structures]]
	[[Category: Choinowski, T]]		[[Category: Choinowski, T]]
	[[Category: Hauser, H]]		[[Category: Hauser, H]]

OCA at 08:10, 29 November 2017

2017-11-29T08:10:43Z

←Older revision		Revision as of 08:10, 29 November 2017
Line 1:		Line 1:
		+
	==STEROL CARRIER PROTEIN 2 (SCP2) FROM RABBIT==		==STEROL CARRIER PROTEIN 2 (SCP2) FROM RABBIT==
	<StructureSection load='1c44' size='340' side='right' caption='[[1c44]], [[Resolution\|resolution]] 1.80Å' scene=''>		<StructureSection load='1c44' size='340' side='right' caption='[[1c44]], [[Resolution\|resolution]] 1.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1c44]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/European_rabbit European rabbit]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1C44 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1C44 FirstGlance]. <br>		<table><tr><td colspan='2'>[[1c44]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/European_rabbit European rabbit]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1C44 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1C44 FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1c44 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1c44 OCA], [http://pdbe.org/1c44 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1c44 RCSB], [http://www.ebi.ac.uk/pdbsum/1c44 PDBsum]</span></td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1c44 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1c44 OCA], [http://pdbe.org/1c44 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1c44 RCSB], [http://www.ebi.ac.uk/pdbsum/1c44 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1c44 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==

OCA at 11:02, 8 February 2016

2016-02-08T11:02:48Z

←Older revision		Revision as of 11:02, 8 February 2016
Line 15:		Line 15:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1c44 ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 10:53, 10 September 2015

2015-09-10T10:53:01Z

←Older revision		Revision as of 10:53, 10 September 2015
Line 2:		Line 2:
	<StructureSection load='1c44' size='340' side='right' caption='[[1c44]], [[Resolution\|resolution]] 1.80Å' scene=''>		<StructureSection load='1c44' size='340' side='right' caption='[[1c44]], [[Resolution\|resolution]] 1.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1c44]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Oryctolagus_cuniculus Oryctolagus cuniculus~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1C44 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1C44 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1c44]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/European_rabbit European rabbit]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1C44 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1C44 FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1c44 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1c44 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1c44 RCSB], [http://www.ebi.ac.uk/pdbsum/1c44 PDBsum]</span></td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1c44 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1c44 OCA], [http://pdbe.org/1c44 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1c44 RCSB], [http://www.ebi.ac.uk/pdbsum/1c44 PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 25:		Line 25:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 1c44" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Oryctolagus cuniculus~~]]	+	[[Category: European rabbit]]
	[[Category: Choinowski, T]]		[[Category: Choinowski, T]]
	[[Category: Hauser, H]]		[[Category: Hauser, H]]

OCA at 22:51, 24 December 2014

2014-12-24T22:51:15Z

←Older revision		Revision as of 22:51, 24 December 2014
Line 5:		Line 5:
	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1c44 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1c44 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1c44 RCSB], [http://www.ebi.ac.uk/pdbsum/1c44 PDBsum]</span></td></tr>		</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1c44 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1c44 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1c44 RCSB], [http://www.ebi.ac.uk/pdbsum/1c44 PDBsum]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/NLTP_RABIT NLTP_RABIT]] Mediates in vitro the transfer of all common phospholipids, cholesterol and gangliosides between membranes. May play a role in regulating steroidogenesis (By similarity).
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]

OCA at 09:42, 22 December 2014

2014-12-22T09:42:55Z

←Older revision		Revision as of 09:42, 22 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1c44]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Oryctolagus_cuniculus Oryctolagus cuniculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1C44 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1C44 FirstGlance]. <br>		<table><tr><td colspan='2'>[[1c44]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Oryctolagus_cuniculus Oryctolagus cuniculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1C44 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1C44 FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1c44 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1c44 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1c44 RCSB], [http://www.ebi.ac.uk/pdbsum/1c44 PDBsum]</span></td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1c44 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1c44 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1c44 RCSB], [http://www.ebi.ac.uk/pdbsum/1c44 PDBsum]</span></td></tr>
-	<table>	+	</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 28:		Line 28:
	</StructureSection>		</StructureSection>
	[[Category: Oryctolagus cuniculus]]		[[Category: Oryctolagus cuniculus]]
-	[[Category: Choinowski, T.]]	+	[[Category: Choinowski, T]]
-	[[Category: Hauser, H.]]	+	[[Category: Hauser, H]]
-	[[Category: Piontek, K.]]	+	[[Category: Piontek, K]]
	[[Category: Fatty acid binding]]		[[Category: Fatty acid binding]]
	[[Category: Fatty acyl coa binding]]		[[Category: Fatty acyl coa binding]]

OCA at 17:04, 20 August 2014

2014-08-20T17:04:56Z

←Older revision		Revision as of 17:04, 20 August 2014
Line 1:		Line 1:
-	[[~~Image~~:1c44.~~png\|left~~\|200px]]	+	==STEROL CARRIER PROTEIN 2 (SCP2) FROM RABBIT==
		+	<StructureSection load='1c44' size='340' side='right' caption='[[1c44]], [[Resolution\|resolution]] 1.80Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[1c44]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Oryctolagus_cuniculus Oryctolagus cuniculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1C44 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1C44 FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1c44 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1c44 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1c44 RCSB], [http://www.ebi.ac.uk/pdbsum/1c44 PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/c4/1c44_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Sterol carrier protein 2, also known as nonspecific lipid transfer protein is a ubiquitous, small, basic protein of 13 kDa found in animals. Its primary structure is highly conserved between different species, and it has been implicated in the intracellular transport of lipids and in a wide range of other in vitro functions related to sterol and fatty acid metabolism. Sterol carrier protein 2 deficiency in mice leads to elevated concentrations of phytanic acid in the serum and causes hepatocarcinogenesis. However, its actual physiological role is still unknown. Although sterol carrier protein 2 has been studied extensively in the past 20 years, very little is known concerning its three-dimensional structure. The crystal structure of rabbit sterol carrier protein 2, determined at 1.8 A resolution with the MIRAS method, shows a unique alpha/beta-fold. The core of this protein forms a five-stranded antiparallel beta-sheet flanked by five helices. A C-terminal segment (residues 114-123), together with part of the beta-sheet and four alpha-helices, form a hydrophobic tunnel providing the environment for apolar ligands such as fatty acids and fatty acyl-coenzyme As. Structurally well-characterized nonspecific lipid transfer proteins from plants have hydrophobic tunnel-like cavities, which were identified as the binding site for fatty acids and related apolar ligands. Despite the fact that plant nonspecific lipid transfer proteins are smaller proteins than sterol carrier protein 2, show no sequence homology to sterol carrier protein 2, and are structurally unrelated, the cavities of these two classes of proteins are very similar with respect to size, shape, and hydrophobicity, suggesting a common functional role.

-	~~{{STRUCTURE_1c44\| PDB=1c44 \| SCENE= }}~~	+	Structure of sterol carrier protein 2 at 1.8 A resolution reveals a hydrophobic tunnel suitable for lipid binding.,Choinowski T, Hauser H, Piontek K Biochemistry. 2000 Feb 29;39(8):1897-902. PMID:10684638<ref>PMID:10684638</ref>

-	~~===STEROL CARRIER PROTEIN 2 (SCP2) FROM RABBIT===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_10684638}}~~	+	== References ==
-		+	<references/>
-	~~==About this Structure==~~	+	__TOC__
-	~~[[1c44]] is~~ a ~~1 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Oryctolagus_cuniculus Oryctolagus cuniculus]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=1C44 OCA].~~	+	</StructureSection>
-		+
-	==~~Reference~~==	+
-	<~~ref group="xtra">PMID:010684638<~~/~~ref~~><~~ref group="xtra">PMID:014695246</ref><references group="xtra"~~/>	+
	[[Category: Oryctolagus cuniculus]]		[[Category: Oryctolagus cuniculus]]
	[[Category: Choinowski, T.]]		[[Category: Choinowski, T.]]

OCA: Protected "1c44" [edit=sysop:move=sysop]

2012-10-21T20:11:23Z

Protected "1c44" [edit=sysop:move=sysop]

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Revision as of 20:11, 21 October 2012