1ct1 - Revision history

OCA at 05:54, 9 August 2023

2023-08-09T05:54:40Z

←Older revision		Revision as of 05:54, 9 August 2023
Line 3:		Line 3:
	<StructureSection load='1ct1' size='340' side='right'caption='[[1ct1]], [[Resolution\|resolution]] 2.30Å' scene=''>		<StructureSection load='1ct1' size='340' side='right'caption='[[1ct1]], [[Resolution\|resolution]] 2.30Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1ct1]] is a 5 chain structure with sequence from [https://en.wikipedia.org/wiki/~~"bacillo_virgola_del_koch"_trevisan_1884 "bacillo virgola del koch" trevisan 1884~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1CT1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1CT1 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1ct1]] is a 5 chain structure with sequence from [https://en.wikipedia.org/wiki/Vibrio_cholerae Vibrio cholerae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1CT1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1CT1 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BGC:BETA-D-GLUCOSE'>BGC</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GAL:BETA-D-GALACTOSE'>GAL</scene>, <scene name='pdbligand=NGA:N-ACETYL-D-GALACTOSAMINE'>NGA</scene>~~</td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.3Å</td></tr>
-	~~<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat">~~<scene name='pdbligand=SIA:O-SIALIC+ACID'>SIA</scene></td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BGC:BETA-D-GLUCOSE'>BGC</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GAL:BETA-D-GALACTOSE'>GAL</scene>, <scene name='pdbligand=NGA:N-ACETYL-D-GALACTOSAMINE'>NGA</scene>, <scene name='pdbligand=SIA:O-SIALIC+ACID'>SIA</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1ct1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ct1 OCA], [https://pdbe.org/1ct1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1ct1 RCSB], [https://www.ebi.ac.uk/pdbsum/1ct1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1ct1 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1ct1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ct1 OCA], [https://pdbe.org/1ct1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1ct1 RCSB], [https://www.ebi.ac.uk/pdbsum/1ct1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1ct1 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/CHTB_VIBCH CHTB_VIBCH]] The B subunit pentameric ring directs the A subunit to its target by binding to the GM1 gangliosides present on the surface of the intestinal epithelial cells. It can bind five GM1 gangliosides. It has no toxic activity by itself.	+	[https://www.uniprot.org/uniprot/CHTB_VIBCH CHTB_VIBCH] The B subunit pentameric ring directs the A subunit to its target by binding to the GM1 gangliosides present on the surface of the intestinal epithelial cells. It can bind five GM1 gangliosides. It has no toxic activity by itself.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 27:		Line 27:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Bacillo virgola del koch trevisan 1884]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Hol, W G.J~~]]	+	[[Category: Vibrio cholerae]]
-	[[Category: ~~Merritt, E A~~]]	+	[[Category: Hol WGJ]]
-	[[Category: ~~Enterotoxin]]~~	+	[[Category: Merritt EA]]
-	~~[[Category: Oligosaccharide]]~~	+
-	~~[[Category: Toxin-receptor complex~~]]	+

OCA at 15:18, 3 March 2021

2021-03-03T15:18:46Z

←Older revision		Revision as of 15:18, 3 March 2021
Line 3:		Line 3:
	<StructureSection load='1ct1' size='340' side='right'caption='[[1ct1]], [[Resolution\|resolution]] 2.30Å' scene=''>		<StructureSection load='1ct1' size='340' side='right'caption='[[1ct1]], [[Resolution\|resolution]] 2.30Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1ct1]] is a 5 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1CT1 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1CT1 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1ct1]] is a 5 chain structure with sequence from [https://en.wikipedia.org/wiki/"bacillo_virgola_del_koch"_trevisan_1884 "bacillo virgola del koch" trevisan 1884]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1CT1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1CT1 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BGC:BETA-D-GLUCOSE'>BGC</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GAL:BETA-D-GALACTOSE'>GAL</scene>, <scene name='pdbligand=NGA:N-ACETYL-D-GALACTOSAMINE'>NGA</scene>, <scene name='pdbligand=SIA:O-SIALIC+ACID'>SIA</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BGC:BETA-D-GLUCOSE'>BGC</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GAL:BETA-D-GALACTOSE'>GAL</scene>, <scene name='pdbligand=NGA:N-ACETYL-D-GALACTOSAMINE'>NGA</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca.weizmann~~.~~ac.il/oca-docs~~/fgij/fg.htm?mol=1ct1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ct1 OCA], [~~http~~://pdbe.org/1ct1 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=1ct1 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/1ct1 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=1ct1 ProSAT]</span></td></tr>	+	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=SIA:O-SIALIC+ACID'>SIA</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1ct1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ct1 OCA], [https://pdbe.org/1ct1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1ct1 RCSB], [https://www.ebi.ac.uk/pdbsum/1ct1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1ct1 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/CHTB_VIBCH CHTB_VIBCH]] The B subunit pentameric ring directs the A subunit to its target by binding to the GM1 gangliosides present on the surface of the intestinal epithelial cells. It can bind five GM1 gangliosides. It has no toxic activity by itself.	+	[[https://www.uniprot.org/uniprot/CHTB_VIBCH CHTB_VIBCH]] The B subunit pentameric ring directs the A subunit to its target by binding to the GM1 gangliosides present on the surface of the intestinal epithelial cells. It can bind five GM1 gangliosides. It has no toxic activity by itself.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 26:		Line 27:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Bacillo virgola del koch trevisan 1884]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Hol, W G.J]]		[[Category: Hol, W G.J]]

OCA at 07:24, 29 May 2019

2019-05-29T07:24:43Z

←Older revision		Revision as of 07:24, 29 May 2019
Line 1:		Line 1:

	==CHOLERA TOXIN B-PENTAMER MUTANT G33R BOUND TO RECEPTOR PENTASACCHARIDE==		==CHOLERA TOXIN B-PENTAMER MUTANT G33R BOUND TO RECEPTOR PENTASACCHARIDE==
-	<StructureSection load='1ct1' size='340' side='right' caption='[[1ct1]], [[Resolution\|resolution]] 2.30Å' scene=''>	+	<StructureSection load='1ct1' size='340' side='right'caption='[[1ct1]], [[Resolution\|resolution]] 2.30Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1ct1]] is a 5 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1CT1 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1CT1 FirstGlance]. <br>		<table><tr><td colspan='2'>[[1ct1]] is a 5 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1CT1 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1CT1 FirstGlance]. <br>
Line 20:		Line 20:

	==See Also==		==See Also==
-	*[[Cholera toxin\|Cholera toxin]]	+	*[[Cholera toxin 3D structures\|Cholera toxin 3D structures]]
	*[[User:David Solfiell/sandbox 1\|User:David Solfiell/sandbox 1]]		*[[User:David Solfiell/sandbox 1\|User:David Solfiell/sandbox 1]]
	== References ==		== References ==
Line 26:		Line 26:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Hol, W G.J]]		[[Category: Hol, W G.J]]
	[[Category: Merritt, E A]]		[[Category: Merritt, E A]]

OCA at 11:10, 24 August 2017

2017-08-24T11:10:39Z

←Older revision		Revision as of 11:10, 24 August 2017
Line 1:		Line 1:
		+
	==CHOLERA TOXIN B-PENTAMER MUTANT G33R BOUND TO RECEPTOR PENTASACCHARIDE==		==CHOLERA TOXIN B-PENTAMER MUTANT G33R BOUND TO RECEPTOR PENTASACCHARIDE==
	<StructureSection load='1ct1' size='340' side='right' caption='[[1ct1]], [[Resolution\|resolution]] 2.30Å' scene=''>		<StructureSection load='1ct1' size='340' side='right' caption='[[1ct1]], [[Resolution\|resolution]] 2.30Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1ct1]] is a 5 chain structure ~~with sequence from [http://en.wikipedia.org/wiki/"bacillo_virgola_del_koch"_trevisan_1884 "bacillo virgola del koch" trevisan 1884]~~. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1CT1 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1CT1 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1ct1]] is a 5 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1CT1 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1CT1 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BGC:BETA-D-GLUCOSE'>BGC</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GAL:BETA-D-GALACTOSE'>GAL</scene>, <scene name='pdbligand=NGA:N-ACETYL-D-GALACTOSAMINE'>NGA</scene>~~</td></tr>~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BGC:BETA-D-GLUCOSE'>BGC</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GAL:BETA-D-GALACTOSE'>GAL</scene>, <scene name='pdbligand=NGA:N-ACETYL-D-GALACTOSAMINE'>NGA</scene>, <scene name='pdbligand=SIA:O-SIALIC+ACID'>SIA</scene></td></tr>
-	~~<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat">~~<scene name='pdbligand=SIA:O-SIALIC+ACID'>SIA</scene></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ct1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ct1 OCA], [http://pdbe.org/1ct1 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1ct1 RCSB], [http://www.ebi.ac.uk/pdbsum/1ct1 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1ct1 ProSAT]</span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ct1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ct1 OCA], [http://pdbe.org/1ct1 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1ct1 RCSB], [http://www.ebi.ac.uk/pdbsum/1ct1 PDBsum]</span></td></tr>	+
	</table>		</table>
	== Function ==		== Function ==
Line 26:		Line 26:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Bacillo virgola del koch trevisan 1884]]
	[[Category: Hol, W G.J]]		[[Category: Hol, W G.J]]
	[[Category: Merritt, E A]]		[[Category: Merritt, E A]]

OCA at 18:46, 10 September 2015

2015-09-10T18:46:46Z

←Older revision		Revision as of 18:46, 10 September 2015
Line 2:		Line 2:
	<StructureSection load='1ct1' size='340' side='right' caption='[[1ct1]], [[Resolution\|resolution]] 2.30Å' scene=''>		<StructureSection load='1ct1' size='340' side='right' caption='[[1ct1]], [[Resolution\|resolution]] 2.30Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1ct1]] is a 5 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Vibrio_cholerae Vibrio cholerae~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1CT1 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1CT1 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1ct1]] is a 5 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillo_virgola_del_koch"_trevisan_1884 "bacillo virgola del koch" trevisan 1884]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1CT1 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1CT1 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BGC:BETA-D-GLUCOSE'>BGC</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GAL:BETA-D-GALACTOSE'>GAL</scene>, <scene name='pdbligand=NGA:N-ACETYL-D-GALACTOSAMINE'>NGA</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BGC:BETA-D-GLUCOSE'>BGC</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GAL:BETA-D-GALACTOSE'>GAL</scene>, <scene name='pdbligand=NGA:N-ACETYL-D-GALACTOSAMINE'>NGA</scene></td></tr>
	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=SIA:O-SIALIC+ACID'>SIA</scene></td></tr>		<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=SIA:O-SIALIC+ACID'>SIA</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ct1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ct1 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1ct1 RCSB], [http://www.ebi.ac.uk/pdbsum/1ct1 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ct1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ct1 OCA], [http://pdbe.org/1ct1 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1ct1 RCSB], [http://www.ebi.ac.uk/pdbsum/1ct1 PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 17:		Line 17:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 1ct1" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 25:		Line 26:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Vibrio cholerae~~]]	+	[[Category: Bacillo virgola del koch trevisan 1884]]
	[[Category: Hol, W G.J]]		[[Category: Hol, W G.J]]
	[[Category: Merritt, E A]]		[[Category: Merritt, E A]]

OCA at 04:32, 25 December 2014

2014-12-25T04:32:21Z

←Older revision		Revision as of 04:32, 25 December 2014
Line 7:		Line 7:
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ct1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ct1 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1ct1 RCSB], [http://www.ebi.ac.uk/pdbsum/1ct1 PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ct1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ct1 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1ct1 RCSB], [http://www.ebi.ac.uk/pdbsum/1ct1 PDBsum]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/CHTB_VIBCH CHTB_VIBCH]] The B subunit pentameric ring directs the A subunit to its target by binding to the GM1 gangliosides present on the surface of the intestinal epithelial cells. It can bind five GM1 gangliosides. It has no toxic activity by itself.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==

OCA at 21:27, 22 December 2014

2014-12-22T21:27:05Z

←Older revision		Revision as of 21:27, 22 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1ct1]] is a 5 chain structure with sequence from [http://en.wikipedia.org/wiki/Vibrio_cholerae Vibrio cholerae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1CT1 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1CT1 FirstGlance]. <br>		<table><tr><td colspan='2'>[[1ct1]] is a 5 chain structure with sequence from [http://en.wikipedia.org/wiki/Vibrio_cholerae Vibrio cholerae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1CT1 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1CT1 FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BGC:BETA-D-GLUCOSE'>BGC</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GAL:BETA-D-GALACTOSE'>GAL</scene>, <scene name='pdbligand=NGA:N-ACETYL-D-GALACTOSAMINE'>NGA</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BGC:BETA-D-GLUCOSE'>BGC</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GAL:BETA-D-GALACTOSE'>GAL</scene>, <scene name='pdbligand=NGA:N-ACETYL-D-GALACTOSAMINE'>NGA</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=SIA:O-SIALIC+ACID'>SIA</scene></td></tr>	+	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=SIA:O-SIALIC+ACID'>SIA</scene></td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ct1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ct1 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1ct1 RCSB], [http://www.ebi.ac.uk/pdbsum/1ct1 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ct1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ct1 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1ct1 RCSB], [http://www.ebi.ac.uk/pdbsum/1ct1 PDBsum]</span></td></tr>
-	<table>	+	</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 24:		Line 24:
	</StructureSection>		</StructureSection>
	[[Category: Vibrio cholerae]]		[[Category: Vibrio cholerae]]
-	[[Category: Hol, W G.J.]]	+	[[Category: Hol, W G.J]]
-	[[Category: Merritt, E A.]]	+	[[Category: Merritt, E A]]
	[[Category: Enterotoxin]]		[[Category: Enterotoxin]]
	[[Category: Oligosaccharide]]		[[Category: Oligosaccharide]]
	[[Category: Toxin-receptor complex]]		[[Category: Toxin-receptor complex]]

OCA at 09:13, 27 August 2014

2014-08-27T09:13:59Z

←Older revision		Revision as of 09:13, 27 August 2014
Line 1:		Line 1:
-	[[~~Image:~~1ct1.~~png~~\|~~left~~\|~~200px~~]]	+	==CHOLERA TOXIN B-PENTAMER MUTANT G33R BOUND TO RECEPTOR PENTASACCHARIDE==
		+	<StructureSection load='1ct1' size='340' side='right' caption='[[1ct1]], [[Resolution\|resolution]] 2.30Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[1ct1]] is a 5 chain structure with sequence from [http://en.wikipedia.org/wiki/Vibrio_cholerae Vibrio cholerae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1CT1 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1CT1 FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BGC:BETA-D-GLUCOSE'>BGC</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GAL:BETA-D-GALACTOSE'>GAL</scene>, <scene name='pdbligand=NGA:N-ACETYL-D-GALACTOSAMINE'>NGA</scene><br>
		+	<tr><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=SIA:O-SIALIC+ACID'>SIA</scene></td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ct1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ct1 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1ct1 RCSB], [http://www.ebi.ac.uk/pdbsum/1ct1 PDBsum]</span></td></tr>
		+	<table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The wide range of receptor binding affinities reported to result from mutations at residue Gly 33 of the cholera toxin B-pentamer (CTB) has been most puzzling. For instance, introduction of an aspartate at this position abolishes receptor binding, whereas substitution by arginine retains receptor affinity despite the larger side chain. We now report the structure determination and 2.3-A refinement of the CTB mutant Gly 33-->Arg complexed with the GM1 oligosaccharide, as well as the 2.2-A refinement of a Gly 33-->Asp mutant of the closely related Escherichia coli heat-labile enterotoxin B-pentamer (LTB). Two of the five receptor binding sites in the Gly 33-->Arg CTB mutant are occupied by bound GM1 oligosaccharide; two other sites are involved in a reciprocal toxin:toxin interaction; one site is unoccupied. We further report a higher resolution (2.0 A) determination and refinement of the wild-type CTB:GM1 oligosaccharide complex in which all five oligosaccharides are seen to be bound in essentially identical conformations. Saccharide conformation and binding interactions are very similar in both the CTB wild-type and Gly 33-->Arg mutant complexes. The protein conformation observed for the binding-deficient Gly 33-->Asp mutant of LTB does not differ substantially from that seen in the toxin:saccharide complexes. The critical nature of the side chain of residue 33 is apparently due to a limited range of subtle rearrangements available to both the toxin and the saccharide to accommodate receptor binding. The intermolecular interactions seen in the CTB (Gly 33-->Arg) complex with oligosaccharide suggest that the affinity of this mutant for the receptor is close to the self-affinity corresponding to the toxin:toxin binding interaction that has now been observed in crystal structures of three CTB mutants.

-	~~{{STRUCTURE_1ct1\| PDB=1ct1 \| SCENE= }}~~	+	Structural studies of receptor binding by cholera toxin mutants.,Merritt EA, Sarfaty S, Jobling MG, Chang T, Holmes RK, Hirst TR, Hol WG Protein Sci. 1997 Jul;6(7):1516-28. PMID:9232653<ref>PMID:9232653</ref>

-	~~===CHOLERA TOXIN B-PENTAMER MUTANT G33R BOUND TO RECEPTOR PENTASACCHARIDE===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_9232653}}~~	+
-		+
-	~~==About this Structure==~~	+
-	~~[[1ct1]] is~~ a ~~5 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Vibrio_cholerae Vibrio cholerae]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=1CT1 OCA].~~	+

	==See Also==		==See Also==
	*[[Cholera toxin\|Cholera toxin]]		*[[Cholera toxin\|Cholera toxin]]
	*[[User:David Solfiell/sandbox 1\|User:David Solfiell/sandbox 1]]		*[[User:David Solfiell/sandbox 1\|User:David Solfiell/sandbox 1]]
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	<~~ref group="xtra">PMID:009232653<~~/~~ref~~><~~references group="xtra"~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Vibrio cholerae]]		[[Category: Vibrio cholerae]]
	[[Category: Hol, W G.J.]]		[[Category: Hol, W G.J.]]

OCA at 12:41, 20 October 2012

2012-10-20T12:41:37Z

←Older revision		Revision as of 12:41, 20 October 2012
Line 8:		Line 8:

	==About this Structure==		==About this Structure==
-	[[1ct1]] is a 5 chain structure ~~of [[Cholera toxin]] and [[User:David Solfiell/sandbox 1]]~~ with sequence from [http://en.wikipedia.org/wiki/Vibrio_cholerae Vibrio cholerae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1CT1 OCA].	+	[[1ct1]] is a 5 chain structure with sequence from [http://en.wikipedia.org/wiki/Vibrio_cholerae Vibrio cholerae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1CT1 OCA].

	==See Also==		==See Also==

OCA at 09:34, 26 July 2012

2012-07-26T09:34:12Z

←Older revision		Revision as of 09:34, 26 July 2012
Line 1:		Line 1:
	[[Image:1ct1.png\|left\|200px]]		[[Image:1ct1.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_1ct1", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_1ct1\| PDB=1ct1 \| SCENE= }}		{{STRUCTURE_1ct1\| PDB=1ct1 \| SCENE= }}

	===CHOLERA TOXIN B-PENTAMER MUTANT G33R BOUND TO RECEPTOR PENTASACCHARIDE===		===CHOLERA TOXIN B-PENTAMER MUTANT G33R BOUND TO RECEPTOR PENTASACCHARIDE===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_9232653}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 9232653 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_9232653}}		{{ABSTRACT_PUBMED_9232653}}

	==About this Structure==		==About this Structure==
-	[[1ct1]] is a 5 chain structure of [[Cholera toxin]] with sequence from [http://en.wikipedia.org/wiki/Vibrio_cholerae Vibrio cholerae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1CT1 OCA].	+	[[1ct1]] is a 5 chain structure of [[Cholera toxin]] and [[User:David Solfiell/sandbox 1]] with sequence from [http://en.wikipedia.org/wiki/Vibrio_cholerae Vibrio cholerae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1CT1 OCA].

	==See Also==		==See Also==
-	*[[Cholera toxin]]	+	*[[Cholera toxin\|Cholera toxin]]
		+	*[[User:David Solfiell/sandbox 1\|User:David Solfiell/sandbox 1]]

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~9232653~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:009232653</ref><references group="xtra"/>
	[[Category: Vibrio cholerae]]		[[Category: Vibrio cholerae]]
	[[Category: Hol, W G.J.]]		[[Category: Hol, W G.J.]]
Line 31:		Line 21:
	[[Category: Enterotoxin]]		[[Category: Enterotoxin]]
	[[Category: Oligosaccharide]]		[[Category: Oligosaccharide]]
-	[[Category: Toxin/receptor complex]]	+	[[Category: Toxin-receptor complex]]