1cv4 - Revision history

OCA at 06:46, 7 February 2024

2024-02-07T06:46:02Z

←Older revision		Revision as of 06:46, 7 February 2024
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	<StructureSection load='1cv4' size='340' side='right'caption='[[1cv4]], [[Resolution\|resolution]] 1.90Å' scene=''>		<StructureSection load='1cv4' size='340' side='right'caption='[[1cv4]], [[Resolution\|resolution]] 1.90Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1cv4]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Bpt4 Bpt4~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1CV4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1CV4 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1cv4]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_virus_T4 Escherichia virus T4]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1CV4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1CV4 FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>~~, ~~<scene name='pdbligand=HED:2-HYDROXYETHYL+DISULFIDE'>HED</scene></td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.9Å</td></tr>
-	~~<tr id='related'><td class="sblockLbl"><b>~~[[~~Related_structure~~\|~~Related:~~]]~~</b></td><td class="sblockDat"><div style='overflow: auto~~; max-height: 3em;'>[[1ctw\|1ctw]], [[1cu0\|1cu0]], [[1cu2\|1cu2]], [[1cu3\|1cu3]], [[1cu6\|1cu6]], [[1cu5\|1cu5]], [[1cup\|1cup]], [[1cuq\|1cuq]], [[1cv0\|1cv0]], [[1cv1\|1cv1]], [[1qsq\|1qsq]], [[1cv3\|1cv3]], [[1cv5\|1cv5]], [[1cv6\|1cv6]], [[1cvk\|1cvk]], [[1d2w\|1d2w]], [[1d2y\|1d2y]], [[1d3f\|1d3f]], [[1d3j\|1d3j]]</div></td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=HED:2-HYDROXYETHYL+DISULFIDE'>HED</scene></td></tr>
-	<tr id='~~gene~~'><td class="sblockLbl"><b>[[~~Gene~~\|~~Gene~~:]]</b></td><td class="sblockDat"~~>GENE E ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&~~id=~~10665 BPT4])</td~~><~~/tr>~~	+
-	~~<tr id~~='~~activity'><td class~~=~~"sblockLbl"><b>Activity~~:~~</b~~></td><~~td class~~=~~"sblockDat"><span class~~=~~'plainlinks~~'>~~[https://en.wikipedia.org/wiki/Lysozyme Lysozyme], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.17 3.2.1.17]~~ </~~span~~></td></tr>	+
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1cv4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1cv4 OCA], [https://pdbe.org/1cv4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1cv4 RCSB], [https://www.ebi.ac.uk/pdbsum/1cv4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1cv4 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1cv4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1cv4 OCA], [https://pdbe.org/1cv4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1cv4 RCSB], [https://www.ebi.ac.uk/pdbsum/1cv4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1cv4 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/~~LYS_BPT4 LYS_BPT4~~]~~] Helps~~ to ~~release~~ the mature ~~phage~~ particles ~~from~~ the cell ~~wall by breaking~~ down the peptidoglycan.	+	[https://www.uniprot.org/uniprot/ENLYS_BPT4 ENLYS_BPT4] Endolysin with lysozyme activity that degrades host peptidoglycans and participates with the holin and spanin proteins in the sequential events which lead to the programmed host cell lysis releasing the mature viral particles. Once the holin has permeabilized the host cell membrane, the endolysin can reach the periplasm and break down the peptidoglycan layer.<ref>PMID:22389108</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1cv4 ConSurf].		</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1cv4 ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
-	<div style="background-color:#fffaf0;">
-	== Publication Abstract from PubMed ==
-	In an attempt to identify a systematic relation between the structure of a protein and its folding kinetics, the rate of folding was determined for 20 mutants of T4 lysozyme in which a bulky, buried, nonpolar wild-type residue (Leu, Ile, Phe, Val, or Met) was substituted with alanine. Methionine, which approximated the size of the original side chain but which is of different shape and flexibility, was also substituted at most of the same sites. Mutations that substantially destabilize the protein and are located in the carboxy-terminal domain generally slow the rate of folding. Destabilizing mutations in the amino-terminal domain, however, have little effect on the rate of folding. Mutations that have little effect on stability tend to have little effect on the rate, no matter where they are located. These results suggest that, at the rate-limiting step, elements of structure in the C-terminal domain are formed and have a structure similar to that of the fully folded protein. Consistent with this, two variants that somewhat increase the rate of folding (Phe104 --> Met and Val149 --> Met) are located within the carboxy-terminal domain and maintain or improve packing with very little perturbation of the wild-type structure.
-
-	Methionine and alanine substitutions show that the formation of wild-type-like structure in the carboxy-terminal domain of T4 lysozyme is a rate-limiting step in folding.,Gassner NC, Baase WA, Lindstrom JD, Lu J, Dahlquist FW, Matthews BW Biochemistry. 1999 Nov 2;38(44):14451-60. PMID:10545167<ref>PMID:10545167</ref>
-
-	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	</div>
-	<div class="pdbe-citations 1cv4" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Bpt4~~]]	+	[[Category: Escherichia virus T4]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	~~[[Category: Lysozyme]]~~	+	[[Category: Baase WA]]
-	[[Category: Baase~~, W A~~]]	+	[[Category: Gassner NC]]
-	[[Category: Gassner~~, N C~~]]	+	[[Category: Lindstrom J]]
-	[[Category: Lindstrom, J]]	+	[[Category: Lu J]]
-	[[Category: Lu, J]]	+	[[Category: Matthews BW]]
-	[[Category: Matthews~~, B W]]~~	+
-	~~[[Category: Hydrolase]]~~	+
-	~~[[Category: Methionine core mutant]]~~	+
-	~~[[Category: Protein engineering]]~~	+
-	~~[[Category: Protein folding]]~~	+
-	~~[[Category: T4 lysozyme~~]]	+

OCA at 14:56, 3 November 2021

2021-11-03T14:56:53Z

OCA at 10:18, 18 November 2020

2020-11-18T10:18:54Z

←Older revision		Revision as of 10:18, 18 November 2020
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	==T4 LYSOZYME MUTANT L118M==		==T4 LYSOZYME MUTANT L118M==
-	<StructureSection load='1cv4' size='340' side='right' caption='[[1cv4]], [[Resolution\|resolution]] 1.90Å' scene=''>	+	<StructureSection load='1cv4' size='340' side='right'caption='[[1cv4]], [[Resolution\|resolution]] 1.90Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1cv4]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Bpt4 Bpt4]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1CV4 OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1CV4 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1cv4]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Bpt4 Bpt4]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1CV4 OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=1CV4 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=HED:2-HYDROXYETHYL+DISULFIDE'>HED</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=HED:2-HYDROXYETHYL+DISULFIDE'>HED</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1ctw\|1ctw]], [[1cu0\|1cu0]], [[1cu2\|1cu2]], [[1cu3\|1cu3]], [[1cu6\|1cu6]], [[1cu5\|1cu5]], [[1cup\|1cup]], [[1cuq\|1cuq]], [[1cv0\|1cv0]], [[1cv1\|1cv1]], [[1qsq\|1qsq]], [[1cv3\|1cv3]], [[1cv5\|1cv5]], [[1cv6\|1cv6]], [[1cvk\|1cvk]], [[1d2w\|1d2w]], [[1d2y\|1d2y]], [[1d3f\|1d3f]], [[1d3j\|1d3j]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1ctw\|1ctw]], [[1cu0\|1cu0]], [[1cu2\|1cu2]], [[1cu3\|1cu3]], [[1cu6\|1cu6]], [[1cu5\|1cu5]], [[1cup\|1cup]], [[1cuq\|1cuq]], [[1cv0\|1cv0]], [[1cv1\|1cv1]], [[1qsq\|1qsq]], [[1cv3\|1cv3]], [[1cv5\|1cv5]], [[1cv6\|1cv6]], [[1cvk\|1cvk]], [[1d2w\|1d2w]], [[1d2y\|1d2y]], [[1d3f\|1d3f]], [[1d3j\|1d3j]]</td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">GENE E ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10665 BPT4])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">GENE E ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10665 BPT4])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Lysozyme Lysozyme], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.17 3.2.1.17] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Lysozyme Lysozyme], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.17 3.2.1.17] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1cv4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1cv4 OCA], [http://pdbe.org/1cv4 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1cv4 RCSB], [http://www.ebi.ac.uk/pdbsum/1cv4 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1cv4 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=1cv4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1cv4 OCA], [http://pdbe.org/1cv4 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1cv4 RCSB], [http://www.ebi.ac.uk/pdbsum/1cv4 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1cv4 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 31:		Line 31:
	</div>		</div>
	<div class="pdbe-citations 1cv4" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 1cv4" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Lysozyme 3D structures\|Lysozyme 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
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	</StructureSection>		</StructureSection>
	[[Category: Bpt4]]		[[Category: Bpt4]]
		+	[[Category: Large Structures]]
	[[Category: Lysozyme]]		[[Category: Lysozyme]]
	[[Category: Baase, W A]]		[[Category: Baase, W A]]

OCA at 06:08, 31 January 2018

2018-01-31T06:08:54Z

←Older revision		Revision as of 06:08, 31 January 2018
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	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/cv/1cv4_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/cv/1cv4_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
Line 31:		Line 31:
	</div>		</div>
	<div class="pdbe-citations 1cv4" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 1cv4" style="background-color:#fffaf0;"></div>
-
-	==See Also==
-	*[[Lysozyme 3D structures\|Lysozyme 3D structures]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 10:59, 8 November 2017

2017-11-08T10:59:56Z

←Older revision		Revision as of 10:59, 8 November 2017
Line 1:		Line 1:
		+
	==T4 LYSOZYME MUTANT L118M==		==T4 LYSOZYME MUTANT L118M==
	<StructureSection load='1cv4' size='340' side='right' caption='[[1cv4]], [[Resolution\|resolution]] 1.90Å' scene=''>		<StructureSection load='1cv4' size='340' side='right' caption='[[1cv4]], [[Resolution\|resolution]] 1.90Å' scene=''>
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	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">GENE E ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10665 BPT4])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">GENE E ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10665 BPT4])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Lysozyme Lysozyme], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.17 3.2.1.17] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Lysozyme Lysozyme], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.17 3.2.1.17] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1cv4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1cv4 OCA], [http://pdbe.org/1cv4 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1cv4 RCSB], [http://www.ebi.ac.uk/pdbsum/1cv4 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1cv4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1cv4 OCA], [http://pdbe.org/1cv4 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1cv4 RCSB], [http://www.ebi.ac.uk/pdbsum/1cv4 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1cv4 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==

OCA at 23:56, 7 February 2016

2016-02-07T23:56:40Z

←Older revision		Revision as of 23:56, 7 February 2016
Line 19:		Line 19:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1cv4 ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 06:01, 10 September 2015

2015-09-10T06:01:41Z

←Older revision		Revision as of 06:01, 10 September 2015
Line 2:		Line 2:
	<StructureSection load='1cv4' size='340' side='right' caption='[[1cv4]], [[Resolution\|resolution]] 1.90Å' scene=''>		<StructureSection load='1cv4' size='340' side='right' caption='[[1cv4]], [[Resolution\|resolution]] 1.90Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1cv4]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Enterobacteria_phage_t4 Enterobacteria phage t4~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1CV4 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1CV4 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1cv4]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Bpt4 Bpt4]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1CV4 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1CV4 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=HED:2-HYDROXYETHYL+DISULFIDE'>HED</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=HED:2-HYDROXYETHYL+DISULFIDE'>HED</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1ctw\|1ctw]], [[1cu0\|1cu0]], [[1cu2\|1cu2]], [[1cu3\|1cu3]], [[1cu6\|1cu6]], [[1cu5\|1cu5]], [[1cup\|1cup]], [[1cuq\|1cuq]], [[1cv0\|1cv0]], [[1cv1\|1cv1]], [[1qsq\|1qsq]], [[1cv3\|1cv3]], [[1cv5\|1cv5]], [[1cv6\|1cv6]], [[1cvk\|1cvk]], [[1d2w\|1d2w]], [[1d2y\|1d2y]], [[1d3f\|1d3f]], [[1d3j\|1d3j]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1ctw\|1ctw]], [[1cu0\|1cu0]], [[1cu2\|1cu2]], [[1cu3\|1cu3]], [[1cu6\|1cu6]], [[1cu5\|1cu5]], [[1cup\|1cup]], [[1cuq\|1cuq]], [[1cv0\|1cv0]], [[1cv1\|1cv1]], [[1qsq\|1qsq]], [[1cv3\|1cv3]], [[1cv5\|1cv5]], [[1cv6\|1cv6]], [[1cvk\|1cvk]], [[1d2w\|1d2w]], [[1d2y\|1d2y]], [[1d3f\|1d3f]], [[1d3j\|1d3j]]</td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">GENE E ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10665 ~~Enterobacteria phage T4~~])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">GENE E ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10665 BPT4])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Lysozyme Lysozyme], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.17 3.2.1.17] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Lysozyme Lysozyme], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.17 3.2.1.17] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1cv4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1cv4 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1cv4 RCSB], [http://www.ebi.ac.uk/pdbsum/1cv4 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1cv4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1cv4 OCA], [http://pdbe.org/1cv4 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1cv4 RCSB], [http://www.ebi.ac.uk/pdbsum/1cv4 PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 29:		Line 29:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 1cv4" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 36:		Line 37:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Enterobacteria phage t4~~]]	+	[[Category: Bpt4]]
	[[Category: Lysozyme]]		[[Category: Lysozyme]]
	[[Category: Baase, W A]]		[[Category: Baase, W A]]

OCA at 19:06, 24 December 2014

2014-12-24T19:06:24Z

←Older revision		Revision as of 19:06, 24 December 2014
Line 9:		Line 9:
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1cv4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1cv4 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1cv4 RCSB], [http://www.ebi.ac.uk/pdbsum/1cv4 PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1cv4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1cv4 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1cv4 RCSB], [http://www.ebi.ac.uk/pdbsum/1cv4 PDBsum]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/LYS_BPT4 LYS_BPT4]] Helps to release the mature phage particles from the cell wall by breaking down the peptidoglycan.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]

OCA at 20:53, 22 December 2014

2014-12-22T20:53:43Z

←Older revision		Revision as of 20:53, 22 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1cv4]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Enterobacteria_phage_t4 Enterobacteria phage t4]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1CV4 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1CV4 FirstGlance]. <br>		<table><tr><td colspan='2'>[[1cv4]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Enterobacteria_phage_t4 Enterobacteria phage t4]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1CV4 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1CV4 FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=HED:2-HYDROXYETHYL+DISULFIDE'>HED</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=HED:2-HYDROXYETHYL+DISULFIDE'>HED</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1ctw\|1ctw]], [[1cu0\|1cu0]], [[1cu2\|1cu2]], [[1cu3\|1cu3]], [[1cu6\|1cu6]], [[1cu5\|1cu5]], [[1cup\|1cup]], [[1cuq\|1cuq]], [[1cv0\|1cv0]], [[1cv1\|1cv1]], [[1qsq\|1qsq]], [[1cv3\|1cv3]], [[1cv5\|1cv5]], [[1cv6\|1cv6]], [[1cvk\|1cvk]], [[1d2w\|1d2w]], [[1d2y\|1d2y]], [[1d3f\|1d3f]], [[1d3j\|1d3j]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1ctw\|1ctw]], [[1cu0\|1cu0]], [[1cu2\|1cu2]], [[1cu3\|1cu3]], [[1cu6\|1cu6]], [[1cu5\|1cu5]], [[1cup\|1cup]], [[1cuq\|1cuq]], [[1cv0\|1cv0]], [[1cv1\|1cv1]], [[1qsq\|1qsq]], [[1cv3\|1cv3]], [[1cv5\|1cv5]], [[1cv6\|1cv6]], [[1cvk\|1cvk]], [[1d2w\|1d2w]], [[1d2y\|1d2y]], [[1d3f\|1d3f]], [[1d3j\|1d3j]]</td></tr>
-	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">GENE E ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10665 Enterobacteria phage T4])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">GENE E ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10665 Enterobacteria phage T4])</td></tr>
-	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Lysozyme Lysozyme], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.17 3.2.1.17] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Lysozyme Lysozyme], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.17 3.2.1.17] </span></td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1cv4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1cv4 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1cv4 RCSB], [http://www.ebi.ac.uk/pdbsum/1cv4 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1cv4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1cv4 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1cv4 RCSB], [http://www.ebi.ac.uk/pdbsum/1cv4 PDBsum]</span></td></tr>
-	<table>	+	</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 36:		Line 36:
	[[Category: Enterobacteria phage t4]]		[[Category: Enterobacteria phage t4]]
	[[Category: Lysozyme]]		[[Category: Lysozyme]]
-	[[Category: Baase, W A.]]	+	[[Category: Baase, W A]]
-	[[Category: Gassner, N C.]]	+	[[Category: Gassner, N C]]
-	[[Category: Lindstrom, J.]]	+	[[Category: Lindstrom, J]]
-	[[Category: Lu, J.]]	+	[[Category: Lu, J]]
-	[[Category: Matthews, B W.]]	+	[[Category: Matthews, B W]]
	[[Category: Hydrolase]]		[[Category: Hydrolase]]
	[[Category: Methionine core mutant]]		[[Category: Methionine core mutant]]

OCA at 09:28, 27 August 2014

2014-08-27T09:28:45Z

←Older revision		Revision as of 09:28, 27 August 2014
Line 1:		Line 1:
-	[[~~Image:~~1cv4.~~png~~\|~~left~~\|200px]]	+	==T4 LYSOZYME MUTANT L118M==
		+	<StructureSection load='1cv4' size='340' side='right' caption='[[1cv4]], [[Resolution\|resolution]] 1.90Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[1cv4]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Enterobacteria_phage_t4 Enterobacteria phage t4]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1CV4 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1CV4 FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=HED:2-HYDROXYETHYL+DISULFIDE'>HED</scene><br>
		+	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1ctw\|1ctw]], [[1cu0\|1cu0]], [[1cu2\|1cu2]], [[1cu3\|1cu3]], [[1cu6\|1cu6]], [[1cu5\|1cu5]], [[1cup\|1cup]], [[1cuq\|1cuq]], [[1cv0\|1cv0]], [[1cv1\|1cv1]], [[1qsq\|1qsq]], [[1cv3\|1cv3]], [[1cv5\|1cv5]], [[1cv6\|1cv6]], [[1cvk\|1cvk]], [[1d2w\|1d2w]], [[1d2y\|1d2y]], [[1d3f\|1d3f]], [[1d3j\|1d3j]]</td></tr>
		+	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">GENE E ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10665 Enterobacteria phage T4])</td></tr>
		+	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Lysozyme Lysozyme], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.17 3.2.1.17] </span></td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1cv4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1cv4 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1cv4 RCSB], [http://www.ebi.ac.uk/pdbsum/1cv4 PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/cv/1cv4_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	In an attempt to identify a systematic relation between the structure of a protein and its folding kinetics, the rate of folding was determined for 20 mutants of T4 lysozyme in which a bulky, buried, nonpolar wild-type residue (Leu, Ile, Phe, Val, or Met) was substituted with alanine. Methionine, which approximated the size of the original side chain but which is of different shape and flexibility, was also substituted at most of the same sites. Mutations that substantially destabilize the protein and are located in the carboxy-terminal domain generally slow the rate of folding. Destabilizing mutations in the amino-terminal domain, however, have little effect on the rate of folding. Mutations that have little effect on stability tend to have little effect on the rate, no matter where they are located. These results suggest that, at the rate-limiting step, elements of structure in the C-terminal domain are formed and have a structure similar to that of the fully folded protein. Consistent with this, two variants that somewhat increase the rate of folding (Phe104 --> Met and Val149 --> Met) are located within the carboxy-terminal domain and maintain or improve packing with very little perturbation of the wild-type structure.

-	~~{{STRUCTURE_1cv4\| PDB=1cv4 \| SCENE= }}~~	+	Methionine and alanine substitutions show that the formation of wild-type-like structure in the carboxy-terminal domain of T4 lysozyme is a rate-limiting step in folding.,Gassner NC, Baase WA, Lindstrom JD, Lu J, Dahlquist FW, Matthews BW Biochemistry. 1999 Nov 2;38(44):14451-60. PMID:10545167<ref>PMID:10545167</ref>

-	~~===T4 LYSOZYME MUTANT L118M===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_10545167}}~~	+
-		+
-	~~==About this Structure==~~	+
-	~~[[1cv4]] is~~ a ~~1 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Enterobacteria_phage_t4 Enterobacteria phage t4]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=1CV4 OCA].~~	+

	==See Also==		==See Also==
-	*[[~~Hen Egg-White (HEW)~~ Lysozyme\|~~Hen Egg-White (HEW)~~ Lysozyme]]	+	*[[Lysozyme 3D structures\|Lysozyme 3D structures]]
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	<~~ref group="xtra">PMID:010545167<~~/~~ref~~><~~references group="xtra"~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Enterobacteria phage t4]]		[[Category: Enterobacteria phage t4]]
	[[Category: Lysozyme]]		[[Category: Lysozyme]]

←Older revision		Revision as of 14:56, 3 November 2021
Line 3:		Line 3:
	<StructureSection load='1cv4' size='340' side='right'caption='[[1cv4]], [[Resolution\|resolution]] 1.90Å' scene=''>		<StructureSection load='1cv4' size='340' side='right'caption='[[1cv4]], [[Resolution\|resolution]] 1.90Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1cv4]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Bpt4 Bpt4]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1CV4 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=1CV4 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1cv4]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Bpt4 Bpt4]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1CV4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1CV4 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=HED:2-HYDROXYETHYL+DISULFIDE'>HED</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=HED:2-HYDROXYETHYL+DISULFIDE'>HED</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1ctw\|1ctw]], [[1cu0\|1cu0]], [[1cu2\|1cu2]], [[1cu3\|1cu3]], [[1cu6\|1cu6]], [[1cu5\|1cu5]], [[1cup\|1cup]], [[1cuq\|1cuq]], [[1cv0\|1cv0]], [[1cv1\|1cv1]], [[1qsq\|1qsq]], [[1cv3\|1cv3]], [[1cv5\|1cv5]], [[1cv6\|1cv6]], [[1cvk\|1cvk]], [[1d2w\|1d2w]], [[1d2y\|1d2y]], [[1d3f\|1d3f]], [[1d3j\|1d3j]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1ctw\|1ctw]], [[1cu0\|1cu0]], [[1cu2\|1cu2]], [[1cu3\|1cu3]], [[1cu6\|1cu6]], [[1cu5\|1cu5]], [[1cup\|1cup]], [[1cuq\|1cuq]], [[1cv0\|1cv0]], [[1cv1\|1cv1]], [[1qsq\|1qsq]], [[1cv3\|1cv3]], [[1cv5\|1cv5]], [[1cv6\|1cv6]], [[1cvk\|1cvk]], [[1d2w\|1d2w]], [[1d2y\|1d2y]], [[1d3f\|1d3f]], [[1d3j\|1d3j]]</div></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">GENE E ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10665 BPT4])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">GENE E ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10665 BPT4])</td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://en.wikipedia.org/wiki/Lysozyme Lysozyme], with EC number [~~http~~://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.17 3.2.1.17] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Lysozyme Lysozyme], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.17 3.2.1.17] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=1cv4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1cv4 OCA], [~~http~~://pdbe.org/1cv4 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=1cv4 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/1cv4 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=1cv4 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1cv4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1cv4 OCA], [https://pdbe.org/1cv4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1cv4 RCSB], [https://www.ebi.ac.uk/pdbsum/1cv4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1cv4 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/LYS_BPT4 LYS_BPT4]] Helps to release the mature phage particles from the cell wall by breaking down the peptidoglycan.	+	[[https://www.uniprot.org/uniprot/LYS_BPT4 LYS_BPT4]] Helps to release the mature phage particles from the cell wall by breaking down the peptidoglycan.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]