1cv9 - Revision history

OCA at 11:41, 22 November 2023

2023-11-22T11:41:23Z

←Older revision		Revision as of 11:41, 22 November 2023
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	==NMR STUDY OF ITAM PEPTIDE SUBSTRATE==		==NMR STUDY OF ITAM PEPTIDE SUBSTRATE==
-	<StructureSection load='1cv9' size='340' side='right'caption='[[1cv9~~]], [[NMR_Ensembles_of_Models \| 1 NMR models~~]]' scene=''>	+	<StructureSection load='1cv9' size='340' side='right'caption='[[1cv9]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1cv9]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1CV9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1CV9 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1cv9]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1CV9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1CV9 FirstGlance]. <br>
-	</td></tr><tr id='~~NonStdRes~~'><td class="sblockLbl"><b>[[~~Non-Standard_Residue~~\|~~NonStd Res~~:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene>, <scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene>, <scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1cv9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1cv9 OCA], [https://pdbe.org/1cv9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1cv9 RCSB], [https://www.ebi.ac.uk/pdbsum/1cv9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1cv9 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1cv9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1cv9 OCA], [https://pdbe.org/1cv9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1cv9 RCSB], [https://www.ebi.ac.uk/pdbsum/1cv9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1cv9 ProSAT]</span></td></tr>
	</table>		</table>
		+	== Disease ==
		+	[https://www.uniprot.org/uniprot/CD79A_HUMAN CD79A_HUMAN] Autosomal agammaglobulinemia. The disease is caused by variants affecting the gene represented in this entry. Two different mutations, one at the splice donor site of intron 2 and the other at the splice acceptor site for exon 3, have been identified. Both mutations give rise to a truncated protein.
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/CD79A_HUMAN CD79A_HUMAN] Required in cooperation with CD79B for initiation of the signal transduction cascade activated by binding of antigen to the B-cell antigen receptor complex (BCR) which leads to internalization of the complex, trafficking to late endosomes and antigen presentation. Also required for BCR surface expression and for efficient differentiation of pro- and pre-B-cells. Stimulates SYK autophosphorylation and activation. Binds to BLNK, bringing BLNK into proximity with SYK and allowing SYK to phosphorylate BLNK. Also interacts with and increases activity of some Src-family tyrosine kinases. Represses BCR signaling during development of immature B-cells.<ref>PMID:8617796</ref> <ref>PMID:9057631</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 20:		Line 25:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Gaul~~, B S~~]]	+	[[Category: Gaul BS]]
-	[[Category: Geahlen~~, R L~~]]	+	[[Category: Geahlen RL]]
-	[[Category: Harrison~~, M L~~]]	+	[[Category: Harrison ML]]
-	[[Category: Post~~, C B]]~~	+	[[Category: Post CB]]
-	~~[[Category: Immune system]]~~	+
-	~~[[Category: Immunoreceptor tyrosine activation motif]]~~	+
-	~~[[Category: Itam]]~~	+
-	~~[[Category: Lyn tyrosine kinase]]~~	+
-	~~[[Category: Peptide substate~~]]	+

OCA at 15:19, 3 March 2021

2021-03-03T15:19:20Z

←Older revision		Revision as of 15:19, 3 March 2021
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	<StructureSection load='1cv9' size='340' side='right'caption='[[1cv9]], [[NMR_Ensembles_of_Models \| 1 NMR models]]' scene=''>		<StructureSection load='1cv9' size='340' side='right'caption='[[1cv9]], [[NMR_Ensembles_of_Models \| 1 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1cv9]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1CV9 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1CV9 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1cv9]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1CV9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1CV9 FirstGlance]. <br>
	</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene>, <scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene></td></tr>		</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene>, <scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1cv9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1cv9 OCA], [~~http~~://pdbe.org/1cv9 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=1cv9 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/1cv9 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=1cv9 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1cv9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1cv9 OCA], [https://pdbe.org/1cv9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1cv9 RCSB], [https://www.ebi.ac.uk/pdbsum/1cv9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1cv9 ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 07:43, 29 May 2019

2019-05-29T07:43:11Z

←Older revision		Revision as of 07:43, 29 May 2019
Line 1:		Line 1:

	==NMR STUDY OF ITAM PEPTIDE SUBSTRATE==		==NMR STUDY OF ITAM PEPTIDE SUBSTRATE==
-	<StructureSection load='1cv9' size='340' side='right' caption='[[1cv9]], [[NMR_Ensembles_of_Models \| 1 NMR models]]' scene=''>	+	<StructureSection load='1cv9' size='340' side='right'caption='[[1cv9]], [[NMR_Ensembles_of_Models \| 1 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1cv9]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1CV9 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1CV9 FirstGlance]. <br>		<table><tr><td colspan='2'>[[1cv9]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1CV9 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1CV9 FirstGlance]. <br>
Line 20:		Line 20:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Gaul, B S]]		[[Category: Gaul, B S]]
	[[Category: Geahlen, R L]]		[[Category: Geahlen, R L]]

OCA at 11:22, 24 August 2017

2017-08-24T11:22:22Z

←Older revision		Revision as of 11:22, 24 August 2017
Line 1:		Line 1:
		+
	==NMR STUDY OF ITAM PEPTIDE SUBSTRATE==		==NMR STUDY OF ITAM PEPTIDE SUBSTRATE==
	<StructureSection load='1cv9' size='340' side='right' caption='[[1cv9]], [[NMR_Ensembles_of_Models \| 1 NMR models]]' scene=''>		<StructureSection load='1cv9' size='340' side='right' caption='[[1cv9]], [[NMR_Ensembles_of_Models \| 1 NMR models]]' scene=''>
Line 4:		Line 5:
	<table><tr><td colspan='2'>[[1cv9]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1CV9 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1CV9 FirstGlance]. <br>		<table><tr><td colspan='2'>[[1cv9]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1CV9 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1CV9 FirstGlance]. <br>
	</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene>, <scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene></td></tr>		</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene>, <scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1cv9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1cv9 OCA], [http://pdbe.org/1cv9 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1cv9 RCSB], [http://www.ebi.ac.uk/pdbsum/1cv9 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1cv9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1cv9 OCA], [http://pdbe.org/1cv9 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1cv9 RCSB], [http://www.ebi.ac.uk/pdbsum/1cv9 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1cv9 ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 00:42, 11 September 2015

2015-09-11T00:42:33Z

←Older revision		Revision as of 00:42, 11 September 2015
Line 4:		Line 4:
	<table><tr><td colspan='2'>[[1cv9]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1CV9 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1CV9 FirstGlance]. <br>		<table><tr><td colspan='2'>[[1cv9]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1CV9 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1CV9 FirstGlance]. <br>
	</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene>, <scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene></td></tr>		</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene>, <scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1cv9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1cv9 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1cv9 RCSB], [http://www.ebi.ac.uk/pdbsum/1cv9 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1cv9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1cv9 OCA], [http://pdbe.org/1cv9 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1cv9 RCSB], [http://www.ebi.ac.uk/pdbsum/1cv9 PDBsum]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 14:		Line 14:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 1cv9" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>

OCA at 20:51, 22 December 2014

2014-12-22T20:51:36Z

←Older revision		Revision as of 20:51, 22 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1cv9]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1CV9 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1CV9 FirstGlance]. <br>		<table><tr><td colspan='2'>[[1cv9]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1CV9 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1CV9 FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene>, <scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene></td></tr>	+	</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene>, <scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene></td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1cv9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1cv9 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1cv9 RCSB], [http://www.ebi.ac.uk/pdbsum/1cv9 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1cv9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1cv9 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1cv9 RCSB], [http://www.ebi.ac.uk/pdbsum/1cv9 PDBsum]</span></td></tr>
-	<table>	+	</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 18:		Line 18:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Gaul, B S.]]	+	[[Category: Gaul, B S]]
-	[[Category: Geahlen, R L.]]	+	[[Category: Geahlen, R L]]
-	[[Category: Harrison, M L.]]	+	[[Category: Harrison, M L]]
-	[[Category: Post, C B.]]	+	[[Category: Post, C B]]
	[[Category: Immune system]]		[[Category: Immune system]]
	[[Category: Immunoreceptor tyrosine activation motif]]		[[Category: Immunoreceptor tyrosine activation motif]]

OCA at 09:26, 27 August 2014

2014-08-27T09:26:55Z

←Older revision		Revision as of 09:26, 27 August 2014
Line 1:		Line 1:
-	[[~~Image:~~1cv9.~~png~~\|~~left\|200px~~]]	+	==NMR STUDY OF ITAM PEPTIDE SUBSTRATE==
		+	<StructureSection load='1cv9' size='340' side='right' caption='[[1cv9]], [[NMR_Ensembles_of_Models \| 1 NMR models]]' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[1cv9]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1CV9 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1CV9 FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene>, <scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene></td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1cv9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1cv9 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1cv9 RCSB], [http://www.ebi.ac.uk/pdbsum/1cv9 PDBsum]</span></td></tr>
		+	<table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The immunoreceptor tyrosine-based activation motif (ITAM) plays a central role in transmembrane signal transduction in hematopoietic cells by mediating responses leading to proliferation and differentiation. An initial signaling event following activation of the B cell antigen receptor is phosphorylation of the CD79a (Ig-alpha) ITAM by Lyn, a Src family protein-tyrosine kinase. To elucidate the structural basis for recognition between the ITAM substrate and activated Lyn kinase, the structure of an ITAM-derived peptide bound to Lyn was determined using exchange-transferred nuclear Overhauser NMR spectroscopy. The bound substrate structure has an irregular helix-like character. Docking based on the NMR data into the active site of the closely related Lck kinase strongly favors ITAM binding in an orientation similar to binding of cyclic AMP-dependent protein kinase rather than that of insulin receptor tyrosine kinase. The model of the complex provides a rationale for conserved ITAM residues, substrate specificity, and suggests that substrate binds only the active conformation of the Src family tyrosine kinase, unlike the ATP cofactor, which can bind the inactive form.

-	~~{{STRUCTURE_1cv9\| PDB=1cv9 \| SCENE= }}~~	+	Substrate recognition by the Lyn protein-tyrosine kinase. NMR structure of the immunoreceptor tyrosine-based activation motif signaling region of the B cell antigen receptor.,Gaul BS, Harrison ML, Geahlen RL, Burton RA, Post CB J Biol Chem. 2000 May 26;275(21):16174-82. PMID:10748115<ref>PMID:10748115</ref>

-	~~===NMR STUDY OF ITAM PEPTIDE SUBSTRATE===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_10748115}}~~	+	== References ==
-		+	<references/>
-	==~~About this Structure~~==	+	__TOC__
-	~~[[1cv9]] is a 1 chain structure. Full experimental information is available from [http:~~//~~oca.weizmann.ac.il/oca-bin/ocashort?id=1CV9 OCA].~~	+	</StructureSection>
	[[Category: Gaul, B S.]]		[[Category: Gaul, B S.]]
	[[Category: Geahlen, R L.]]		[[Category: Geahlen, R L.]]

OCA: Protected "1cv9" [edit=sysop:move=sysop]

2012-10-21T20:54:00Z

Protected "1cv9" [edit=sysop:move=sysop]

←Older revision

Revision as of 20:54, 21 October 2012

OCA at 20:53, 21 October 2012

2012-10-21T20:53:56Z

←Older revision		Revision as of 20:53, 21 October 2012
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-	{{Seed}}
	[[Image:1cv9.png\|left\|200px]]		[[Image:1cv9.png\|left\|200px]]

-	<!--
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	{{STRUCTURE_1cv9\| PDB=1cv9 \| SCENE= }}		{{STRUCTURE_1cv9\| PDB=1cv9 \| SCENE= }}

	===NMR STUDY OF ITAM PEPTIDE SUBSTRATE===		===NMR STUDY OF ITAM PEPTIDE SUBSTRATE===

-
-	<!--
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	{{ABSTRACT_PUBMED_10748115}}		{{ABSTRACT_PUBMED_10748115}}

	==About this Structure==		==About this Structure==
-	Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1CV9 OCA].	+	[[1cv9]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1CV9 OCA].
-		+
-	~~==Reference==~~	+
-	Substrate recognition by the Lyn protein-tyrosine kinase. NMR structure of the immunoreceptor tyrosine-based activation motif signaling region of the B cell antigen receptor., Gaul BS, Harrison ML, Geahlen RL, Burton RA, Post CB, J Biol Chem. 2000 May 26;275(21):16174-82. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/10748115 10748115]	+
	[[Category: Gaul, B S.]]		[[Category: Gaul, B S.]]
	[[Category: Geahlen, R L.]]		[[Category: Geahlen, R L.]]
	[[Category: Harrison, M L.]]		[[Category: Harrison, M L.]]
	[[Category: Post, C B.]]		[[Category: Post, C B.]]
		+	[[Category: Immune system]]
	[[Category: Immunoreceptor tyrosine activation motif]]		[[Category: Immunoreceptor tyrosine activation motif]]
	[[Category: Itam]]		[[Category: Itam]]
	[[Category: Lyn tyrosine kinase]]		[[Category: Lyn tyrosine kinase]]
	[[Category: Peptide substate]]		[[Category: Peptide substate]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 21:27:58 2008''

OCA at 18:28, 30 June 2008

2008-06-30T18:28:00Z

←Older revision		Revision as of 18:28, 30 June 2008
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-	[[Image:1cv9.~~gif~~\|left\|200px]]	+	{{Seed}}
		+	[[Image:1cv9.png\|left\|200px]]

	<!--		<!--
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	{{STRUCTURE_1cv9\| PDB=1cv9 \| SCENE= }}		{{STRUCTURE_1cv9\| PDB=1cv9 \| SCENE= }}

-	~~'''~~NMR STUDY OF ITAM PEPTIDE SUBSTRATE~~'''~~	+	===NMR STUDY OF ITAM PEPTIDE SUBSTRATE===


-	~~==Overview==~~	+	<!--
-	The ~~immunoreceptor tyrosine-based activation motif (ITAM) plays a central role in transmembrane signal transduction in hematopoietic cells by mediating responses leading~~ to ~~proliferation and differentiation. An initial signaling event following activation of~~ the ~~B cell antigen receptor is phosphorylation of the CD79a~~ (~~Ig-alpha~~) ~~ITAM by Lyn~~, ~~a Src family protein-tyrosine kinase. To elucidate~~ the structural basis for recognition between the ITAM substrate and activated Lyn kinase, the structure of an ITAM-derived peptide bound to Lyn was determined using exchange-transferred nuclear Overhauser NMR spectroscopy. ~~The bound substrate structure has an irregular helix~~-~~like character. Docking based on the NMR data into the active site of the closely related Lck kinase strongly favors ITAM binding in an orientation similar to binding of cyclic AMP~~-dependent protein kinase rather than that of insulin receptor tyrosine kinase. The model of the complex provides a rationale for conserved ITAM residues, substrate specificity, and suggests that substrate binds only the active conformation of the Src family tyrosine kinase, unlike the ATP cofactor, which can bind the inactive form.	+	The line below this paragraph, {{ABSTRACT_PUBMED_10748115}}, adds the Publication Abstract to the page
		+	(as it appears on PubMed at http://www.pubmed.gov), where 10748115 is the PubMed ID number.
		+	-->
		+	{{ABSTRACT_PUBMED_10748115}}

	==About this Structure==		==About this Structure==
-	Full ~~crystallographic~~ information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1CV9 OCA].	+	Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1CV9 OCA].

	==Reference==		==Reference==
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	[[Category: Lyn tyrosine kinase]]		[[Category: Lyn tyrosine kinase]]
	[[Category: Peptide substate]]		[[Category: Peptide substate]]
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Fri May 2 13~~:08:54 2008''	+
		+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 21:27:58 2008''