1cw6 - Revision history

OCA at 11:41, 22 November 2023

2023-11-22T11:41:41Z

←Older revision		Revision as of 11:41, 22 November 2023
Line 1:		Line 1:

	==REFINED SOLUTION STRUCTURE OF LEUCOCIN A==		==REFINED SOLUTION STRUCTURE OF LEUCOCIN A==
-	<StructureSection load='1cw6' size='340' side='right'caption='[[1cw6~~]], [[NMR_Ensembles_of_Models \| 18 NMR models~~]]' scene=''>	+	<StructureSection load='1cw6' size='340' side='right'caption='[[1cw6]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1cw6]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Leuconostoc_gelidum Leuconostoc gelidum]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1CW6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1CW6 FirstGlance]. <br>		<table><tr><td colspan='2'>[[1cw6]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Leuconostoc_gelidum Leuconostoc gelidum]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1CW6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1CW6 FirstGlance]. <br>
-	</td></tr><tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"~~><div style~~=~~'overflow: auto; max-height: 3em;'>[[2leu\|2leu]]</div~~></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1cw6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1cw6 OCA], [https://pdbe.org/1cw6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1cw6 RCSB], [https://www.ebi.ac.uk/pdbsum/1cw6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1cw6 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1cw6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1cw6 OCA], [https://pdbe.org/1cw6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1cw6 RCSB], [https://www.ebi.ac.uk/pdbsum/1cw6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1cw6 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/LCCA_LEUGE LCCA_LEUGE]] Inhibits a wide spectrum of lactic acid bacteria.	+	[https://www.uniprot.org/uniprot/LCCA_LEUGE LCCA_LEUGE] Inhibits a wide spectrum of lactic acid bacteria.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 24:		Line 24:
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Leuconostoc gelidum]]		[[Category: Leuconostoc gelidum]]
-	[[Category: Chai, S]]	+	[[Category: Chai S]]
-	[[Category: Gallagher~~, N L.F~~]]	+	[[Category: Gallagher NLF]]
-	[[Category: Gibbs~~, A C~~]]	+	[[Category: Gibbs AC]]
-	[[Category: Henz~~, M E~~]]	+	[[Category: Henz ME]]
-	[[Category: Stiles~~, M E~~]]	+	[[Category: Stiles ME]]
-	[[Category: Vederas~~, J C~~]]	+	[[Category: Vederas JC]]
-	[[Category: Wang, Y]]	+	[[Category: Wang Y]]
-	[[Category: Wishart~~, D S~~]]	+	[[Category: Wishart DS]]
-	[[Category: Yan~~, L Z]]~~	+	[[Category: Yan LZ]]
-	~~[[Category: Antimicrobial peptide]]~~	+
-	~~[[Category: Bacteriocin]]~~	+
-	~~[[Category: Toxin~~]]	+

OCA at 15:19, 3 March 2021

2021-03-03T15:19:39Z

←Older revision		Revision as of 15:19, 3 March 2021
Line 3:		Line 3:
	<StructureSection load='1cw6' size='340' side='right'caption='[[1cw6]], [[NMR_Ensembles_of_Models \| 18 NMR models]]' scene=''>		<StructureSection load='1cw6' size='340' side='right'caption='[[1cw6]], [[NMR_Ensembles_of_Models \| 18 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1cw6]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Leuconostoc_gelidum Leuconostoc gelidum]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1CW6 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1CW6 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1cw6]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Leuconostoc_gelidum Leuconostoc gelidum]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1CW6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1CW6 FirstGlance]. <br>
-	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2leu\|2leu]]</td></tr>	+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2leu\|2leu]]</div></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1cw6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1cw6 OCA], [~~http~~://pdbe.org/1cw6 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=1cw6 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/1cw6 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=1cw6 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1cw6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1cw6 OCA], [https://pdbe.org/1cw6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1cw6 RCSB], [https://www.ebi.ac.uk/pdbsum/1cw6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1cw6 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/LCCA_LEUGE LCCA_LEUGE]] Inhibits a wide spectrum of lactic acid bacteria.	+	[[https://www.uniprot.org/uniprot/LCCA_LEUGE LCCA_LEUGE]] Inhibits a wide spectrum of lactic acid bacteria.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==

OCA at 07:36, 29 May 2019

2019-05-29T07:36:23Z

←Older revision		Revision as of 07:36, 29 May 2019
Line 1:		Line 1:

	==REFINED SOLUTION STRUCTURE OF LEUCOCIN A==		==REFINED SOLUTION STRUCTURE OF LEUCOCIN A==
-	<StructureSection load='1cw6' size='340' side='right' caption='[[1cw6]], [[NMR_Ensembles_of_Models \| 18 NMR models]]' scene=''>	+	<StructureSection load='1cw6' size='340' side='right'caption='[[1cw6]], [[NMR_Ensembles_of_Models \| 18 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1cw6]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Leuconostoc_gelidum Leuconostoc gelidum]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1CW6 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1CW6 FirstGlance]. <br>		<table><tr><td colspan='2'>[[1cw6]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Leuconostoc_gelidum Leuconostoc gelidum]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1CW6 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1CW6 FirstGlance]. <br>
Line 22:		Line 22:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Leuconostoc gelidum]]		[[Category: Leuconostoc gelidum]]
	[[Category: Chai, S]]		[[Category: Chai, S]]

OCA at 11:18, 24 August 2017

2017-08-24T11:18:36Z

←Older revision		Revision as of 11:18, 24 August 2017
Line 1:		Line 1:
		+
	==REFINED SOLUTION STRUCTURE OF LEUCOCIN A==		==REFINED SOLUTION STRUCTURE OF LEUCOCIN A==
	<StructureSection load='1cw6' size='340' side='right' caption='[[1cw6]], [[NMR_Ensembles_of_Models \| 18 NMR models]]' scene=''>		<StructureSection load='1cw6' size='340' side='right' caption='[[1cw6]], [[NMR_Ensembles_of_Models \| 18 NMR models]]' scene=''>
Line 4:		Line 5:
	<table><tr><td colspan='2'>[[1cw6]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Leuconostoc_gelidum Leuconostoc gelidum]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1CW6 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1CW6 FirstGlance]. <br>		<table><tr><td colspan='2'>[[1cw6]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Leuconostoc_gelidum Leuconostoc gelidum]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1CW6 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1CW6 FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2leu\|2leu]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2leu\|2leu]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1cw6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1cw6 OCA], [http://pdbe.org/1cw6 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1cw6 RCSB], [http://www.ebi.ac.uk/pdbsum/1cw6 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1cw6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1cw6 OCA], [http://pdbe.org/1cw6 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1cw6 RCSB], [http://www.ebi.ac.uk/pdbsum/1cw6 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1cw6 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==

OCA at 14:51, 11 September 2015

2015-09-11T14:51:33Z

←Older revision		Revision as of 14:51, 11 September 2015
Line 4:		Line 4:
	<table><tr><td colspan='2'>[[1cw6]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Leuconostoc_gelidum Leuconostoc gelidum]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1CW6 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1CW6 FirstGlance]. <br>		<table><tr><td colspan='2'>[[1cw6]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Leuconostoc_gelidum Leuconostoc gelidum]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1CW6 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1CW6 FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2leu\|2leu]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2leu\|2leu]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1cw6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1cw6 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1cw6 RCSB], [http://www.ebi.ac.uk/pdbsum/1cw6 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1cw6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1cw6 OCA], [http://pdbe.org/1cw6 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1cw6 RCSB], [http://www.ebi.ac.uk/pdbsum/1cw6 PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 16:		Line 16:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 1cw6" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>

OCA at 17:58, 25 December 2014

2014-12-25T17:58:48Z

←Older revision		Revision as of 17:58, 25 December 2014
Line 6:		Line 6:
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1cw6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1cw6 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1cw6 RCSB], [http://www.ebi.ac.uk/pdbsum/1cw6 PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1cw6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1cw6 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1cw6 RCSB], [http://www.ebi.ac.uk/pdbsum/1cw6 PDBsum]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/LCCA_LEUGE LCCA_LEUGE]] Inhibits a wide spectrum of lactic acid bacteria.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==

OCA at 23:14, 22 December 2014

2014-12-22T23:14:21Z

←Older revision		Revision as of 23:14, 22 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1cw6]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Leuconostoc_gelidum Leuconostoc gelidum]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1CW6 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1CW6 FirstGlance]. <br>		<table><tr><td colspan='2'>[[1cw6]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Leuconostoc_gelidum Leuconostoc gelidum]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1CW6 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1CW6 FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2leu\|2leu]]</td></tr>	+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2leu\|2leu]]</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1cw6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1cw6 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1cw6 RCSB], [http://www.ebi.ac.uk/pdbsum/1cw6 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1cw6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1cw6 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1cw6 RCSB], [http://www.ebi.ac.uk/pdbsum/1cw6 PDBsum]</span></td></tr>
-	<table>	+	</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 19:		Line 19:
	</StructureSection>		</StructureSection>
	[[Category: Leuconostoc gelidum]]		[[Category: Leuconostoc gelidum]]
-	[[Category: Chai, S.]]	+	[[Category: Chai, S]]
-	[[Category: Gallagher, N L.F.]]	+	[[Category: Gallagher, N L.F]]
-	[[Category: Gibbs, A C.]]	+	[[Category: Gibbs, A C]]
-	[[Category: Henz, M E.]]	+	[[Category: Henz, M E]]
-	[[Category: Stiles, M E.]]	+	[[Category: Stiles, M E]]
-	[[Category: Vederas, J C.]]	+	[[Category: Vederas, J C]]
-	[[Category: Wang, Y.]]	+	[[Category: Wang, Y]]
-	[[Category: Wishart, D S.]]	+	[[Category: Wishart, D S]]
-	[[Category: Yan, L Z.]]	+	[[Category: Yan, L Z]]
	[[Category: Antimicrobial peptide]]		[[Category: Antimicrobial peptide]]
	[[Category: Bacteriocin]]		[[Category: Bacteriocin]]
	[[Category: Toxin]]		[[Category: Toxin]]

OCA at 09:22, 27 August 2014

2014-08-27T09:22:43Z

←Older revision		Revision as of 09:22, 27 August 2014
Line 1:		Line 1:
-	[[~~Image:~~1cw6.~~png~~\|~~left~~\|~~200px~~]]	+	==REFINED SOLUTION STRUCTURE OF LEUCOCIN A==
		+	<StructureSection load='1cw6' size='340' side='right' caption='[[1cw6]], [[NMR_Ensembles_of_Models \| 18 NMR models]]' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[1cw6]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Leuconostoc_gelidum Leuconostoc gelidum]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1CW6 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1CW6 FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2leu\|2leu]]</td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1cw6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1cw6 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1cw6 RCSB], [http://www.ebi.ac.uk/pdbsum/1cw6 PDBsum]</span></td></tr>
		+	<table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Carnobacteriocin B2 (CbnB2), a type IIa bacteriocin, is a 48 residue antimicrobial peptide from the lactic acid bacterium Carnobacterium pisicola LV17B. Type IIa bacteriocins have a conserved YGNGVXC sequence near the N-terminus and usually contain a disulfide bridge. CbnB2 seemed to be unique in that its two cysteines (Cys9 and Cys14) could be isolated as free thiols [Quadri et al. (1994) J. Biol. Chem. 26, 12204-12211]. To establish the structural consequences of the presence or absence of a disulfide bridge and to investigate if the YGNGVXC sequence is a receptor-binding motif [Fleury et al. (1996) J. Biol. Chem. 271, 14421-14429], the three-dimensional solution structure of CbnB2 was determined by two-dimensional (1)H nuclear magnetic resonance (NMR) techniques. Mass spectroscopic and thiol modification experiments on CbnB2 and on model peptides, in conjunction with activity measurements, were used to verify the redox status of CbnB2. The results show that CbnB2 readily forms a disulfide bond and that this peptide has full antimicrobial activity. NMR results indicate that CbnB2 in trifluoroethanol (TFE) has a well-defined central helical structure (residues 18-39) but a disordered N terminus. Comparison of the CbnB2 structure with the refined solution structure of leucocin A (LeuA), another type IIa bacteriocin, indicates that the central helical structure is conserved between the two peptides despite differences in sequence but that the N-terminal structure (a proposed receptor binding site) is not. This is unexpected because LeuA and CbnB2 exhibit >66% sequence identity in the first 24 residues. This suggests that the N-terminus, which had been proposed [Fleury et al. (1996) J. Biol. Chem. 271, 14421-14429] to be a receptor binding site of type IIa bacteriocins, may not be directly involved and that recognition of the amphiphilic helical portion is the critical feature.

-	~~{{STRUCTURE_1cw6\| PDB=1cw6 \| SCENE= }}~~	+	Solution structure of carnobacteriocin B2 and implications for structure-activity relationships among type IIa bacteriocins from lactic acid bacteria.,Wang Y, Henz ME, Gallagher NL, Chai S, Gibbs AC, Yan LZ, Stiles ME, Wishart DS, Vederas JC Biochemistry. 1999 Nov 23;38(47):15438-47. PMID:10569926<ref>PMID:10569926</ref>

-	~~===REFINED SOLUTION STRUCTURE OF LEUCOCIN A===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_10569926}}~~	+	== References ==
-		+	<references/>
-	==~~About this Structure~~==	+	__TOC__
-	~~[[1cw6]] is a 1 chain structure with sequence from [http:~~//~~en.wikipedia.org/wiki/Leuconostoc_gelidum Leuconostoc gelidum]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1CW6 OCA].~~	+	</StructureSection>
	[[Category: Leuconostoc gelidum]]		[[Category: Leuconostoc gelidum]]
	[[Category: Chai, S.]]		[[Category: Chai, S.]]

OCA: Protected "1cw6" [edit=sysop:move=sysop]

2012-10-21T20:47:24Z

Protected "1cw6" [edit=sysop:move=sysop]

←Older revision

Revision as of 20:47, 21 October 2012

OCA at 20:47, 21 October 2012

2012-10-21T20:47:21Z

←Older revision		Revision as of 20:47, 21 October 2012
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-	{{Seed}}
	[[Image:1cw6.png\|left\|200px]]		[[Image:1cw6.png\|left\|200px]]

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	{{STRUCTURE_1cw6\| PDB=1cw6 \| SCENE= }}		{{STRUCTURE_1cw6\| PDB=1cw6 \| SCENE= }}

	===REFINED SOLUTION STRUCTURE OF LEUCOCIN A===		===REFINED SOLUTION STRUCTURE OF LEUCOCIN A===

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	{{ABSTRACT_PUBMED_10569926}}		{{ABSTRACT_PUBMED_10569926}}

	==About this Structure==		==About this Structure==
-	~~1CW6 is a~~ [[~~Single protein~~]] structure of sequence from [http://en.wikipedia.org/wiki/Leuconostoc_gelidum Leuconostoc gelidum]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1CW6 OCA].	+	[[1cw6]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Leuconostoc_gelidum Leuconostoc gelidum]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1CW6 OCA].
-		+
-	~~==Reference==~~	+
-	Solution structure of carnobacteriocin B2 and implications for structure-activity relationships among type IIa bacteriocins from lactic acid bacteria., Wang Y, Henz ME, Gallagher NL, Chai S, Gibbs AC, Yan LZ, Stiles ME, Wishart DS, Vederas JC, Biochemistry. 1999 Nov 23;38(47):15438-47. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/10569926 10569926]	+
	[[Category: Leuconostoc gelidum]]		[[Category: Leuconostoc gelidum]]
-	[[Category: Single protein]]
	[[Category: Chai, S.]]		[[Category: Chai, S.]]
	[[Category: Gallagher, N L.F.]]		[[Category: Gallagher, N L.F.]]
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	[[Category: Antimicrobial peptide]]		[[Category: Antimicrobial peptide]]
	[[Category: Bacteriocin]]		[[Category: Bacteriocin]]
-		+	[[Category: Toxin]]
-	~~''Page seeded by~~ [~~http~~:~~//oca.weizmann.ac.il/oca OCA~~ ] ~~on Mon Jun 30 21:36:03 2008''~~	+