1cwb - Revision history

OCA at 15:43, 13 March 2024

2024-03-13T15:43:58Z

←Older revision		Revision as of 15:43, 13 March 2024
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	<StructureSection load='1cwb' size='340' side='right'caption='[[1cwb]], [[Resolution\|resolution]] 2.20Å' scene=''>		<StructureSection load='1cwb' size='340' side='right'caption='[[1cwb]], [[Resolution\|resolution]] 2.20Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1cwb]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1CWB OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=1CWB FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1cwb]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Tolypocladium_inflatum Tolypocladium inflatum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1CWB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1CWB FirstGlance]. <br>
-	</td></tr><tr id='~~NonStdRes~~'><td class="sblockLbl"><b>[[~~Non-Standard_Residue~~\|~~NonStd Res~~:]]</b></td><td class="sblockDat"><~~scene name~~='~~pdbligand~~=~~ABA~~:~~ALPHA-AMINOBUTYRIC+ACID'~~>~~ABA~~</~~scene~~>, <scene name='pdbligand=~~BMT~~:4-~~METHYL-4-[(E)-2-BUTENYL]-4,N-METHYL-THREONINE~~'>~~BMT~~</scene>, <scene name='pdbligand=DAL:D-ALANINE'>DAL</scene>, <scene name='pdbligand=DMT:3-HYDROXY-4,4-DIMETHYL-2-(METHYLAMINO)-6-OCTENOIC+ACID'>DMT</scene>, <scene name='pdbligand=MLE:N-METHYLLEUCINE'>MLE</scene>, <scene name='pdbligand=MVA:N-METHYLVALINE'>MVA</scene>, <scene name='pdbligand=SAR:SARCOSINE'>SAR</scene~~></td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.2Å</td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1bck\|1bck]], [[1c5f\|1c5f]], [[1csa\|1csa]], [[1cwa\|1cwa]], [[1cwc\|1cwc]], [[1cwf\|1cwf]], [[1cwh\|1cwh]], [[1cwi\|1cwi]], [[1cwj\|1cwj]], [[1cwk\|1cwk]], [[1cwl\|1cwl]], [[1cwm\|1cwm]], [[1cwo\|1cwo]], [[1cya\|1cya]], [[1cyb\|1cyb]], [[1cyn\|1cyn]], [[1ikf\|1ikf]], [[1m63\|1m63]], [[1mf8\|1mf8]], [[1mik\|1mik]], [[1qng\|1qng]], [[1qnh\|1qnh]], [[1xq7\|1xq7]], [[2esl\|2esl]], [[2oju\|2oju]], [[2poy\|2poy]], [[2rma\|2rma]], [[2rmb\|2rmb]], [[2rmc\|2rmc]], [[2wfj\|2wfj]], [[2x2c\|2x2c]], [[2x7k\|2x7k]], [[2z6w\|2z6w]], [[3bo7\|3bo7]], [[3cys\|3cys]], [[3eov\|3eov]]</td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ABA:ALPHA-AMINOBUTYRIC+ACID'>ABA</scene>, <scene name='pdbligand=DAL:D-ALANINE'>DAL</scene>, <scene name='pdbligand=DMT:3-HYDROXY-4,4-DIMETHYL-2-(METHYLAMINO)-6-OCTENOIC+ACID'>DMT</scene>, <scene name='pdbligand=MLE:N-METHYLLEUCINE'>MLE</scene>, <scene name='pdbligand=MVA:N-METHYLVALINE'>MVA</scene>, <scene name='pdbligand=SAR:SARCOSINE'>SAR</scene></td></tr>
-	~~<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CYCLOPHILIN ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>~~	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1cwb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1cwb OCA], [https://pdbe.org/1cwb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1cwb RCSB], [https://www.ebi.ac.uk/pdbsum/1cwb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1cwb ProSAT]</span></td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Peptidylprolyl_isomerase Peptidylprolyl isomerase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.2.1.8 5.2.1.8] </span></td></tr>	+
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=1cwb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1cwb OCA], [~~http~~://pdbe.org/1cwb PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=1cwb RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/1cwb PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=1cwb ProSAT]</span></td></tr>	+
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/PPIA_HUMAN PPIA_HUMAN] PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1cwb ConSurf].		</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1cwb ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
-	<div style="background-color:#fffaf0;">
-	== Publication Abstract from PubMed ==
-	For most of the cyclosporin A (CsA) analogs, there is generally a good correlation between cyclophilin binding and immunosuppression. However, this relationship does not seem to hold for 4-[(E)-2-butenyl]-4,4,N-trimethyl-L-threonine1 (MeBm2t)1-CsA. Its affinity for cyclophilin was reported to be approximately 1% that of CsA and its immunosuppressive activity in vitro was shown to be approximately 30% that of CsA. We report here the crystal structure of a complex between recombinant human cyclophilin A (CypA) and (MeBm2t)1-CsA which has been determined by X-ray crystallography at 2.2 A resolution and refined to an R-factor of 16.3%. (MeBm2t)1-CsA shows a similar bound conformation and network of interactions to CypA as CsA. The measured lower affinity for CypA cannot therefore be explained by a different mode of binding. We propose that the poor affinity to CypA could be accounted for by the existence of an equilibrium in aqueous solution between a 'cyclophilin bound conformation' and a 'non-binding conformation' of (MeBm2t)1-CsA. The relatively high immunosuppressive activity is suggested to result from slight conformational differences observed in the effector domain.
-
-	The X-ray structure of (MeBm2t)1-cyclosporin complexed with cyclophilin A provides an explanation for its anomalously high immunosuppressive activity.,Mikol V, Kallen J, Walkinshaw MD Protein Eng. 1994 May;7(5):597-603. PMID:8073029<ref>PMID:8073029</ref>
-
-	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	</div>
-	<div class="pdbe-citations 1cwb" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
	*[[Cyclophilin 3D structures\|Cyclophilin 3D structures]]		*[[Cyclophilin 3D structures\|Cyclophilin 3D structures]]
-	== References ==
-	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Peptidylprolyl isomerase~~]]	+	[[Category: Tolypocladium inflatum]]
-	[[Category: Kallen, J]]	+	[[Category: Kallen J]]
-	[[Category: Mikol, V]]	+	[[Category: Mikol V]]
-	[[Category: Walkinshaw~~, M D]]~~	+	[[Category: Walkinshaw MD]]
-	~~[[Category: Cyclophilin]]~~	+
-	~~[[Category: Cyclophilin-cyclosporin complex]]~~	+
-	~~[[Category: Cyclosporin some]]~~	+
-	~~[[Category: Immunosuppressant]]~~	+
-	~~[[Category: Isomerase-immunosuppressant complex~~]]	+

OCA at 10:19, 18 November 2020

2020-11-18T10:19:04Z

←Older revision		Revision as of 10:19, 18 November 2020
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	==THE X-RAY STRUCTURE OF (MEBM2T)1-CYCLOSPORIN COMPLEXED WITH CYCLOPHILIN A PROVIDES AN EXPLANATION FOR ITS ANOMALOUSLY HIGH IMMUNOSUPPRESSIVE ACTIVITY==		==THE X-RAY STRUCTURE OF (MEBM2T)1-CYCLOSPORIN COMPLEXED WITH CYCLOPHILIN A PROVIDES AN EXPLANATION FOR ITS ANOMALOUSLY HIGH IMMUNOSUPPRESSIVE ACTIVITY==
-	<StructureSection load='1cwb' size='340' side='right' caption='[[1cwb]], [[Resolution\|resolution]] 2.20Å' scene=''>	+	<StructureSection load='1cwb' size='340' side='right'caption='[[1cwb]], [[Resolution\|resolution]] 2.20Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1cwb]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1CWB OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1CWB FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1cwb]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1CWB OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=1CWB FirstGlance]. <br>
	</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=ABA:ALPHA-AMINOBUTYRIC+ACID'>ABA</scene>, <scene name='pdbligand=BMT:4-METHYL-4-[(E)-2-BUTENYL]-4,N-METHYL-THREONINE'>BMT</scene>, <scene name='pdbligand=DAL:D-ALANINE'>DAL</scene>, <scene name='pdbligand=DMT:3-HYDROXY-4,4-DIMETHYL-2-(METHYLAMINO)-6-OCTENOIC+ACID'>DMT</scene>, <scene name='pdbligand=MLE:N-METHYLLEUCINE'>MLE</scene>, <scene name='pdbligand=MVA:N-METHYLVALINE'>MVA</scene>, <scene name='pdbligand=SAR:SARCOSINE'>SAR</scene></td></tr>		</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=ABA:ALPHA-AMINOBUTYRIC+ACID'>ABA</scene>, <scene name='pdbligand=BMT:4-METHYL-4-[(E)-2-BUTENYL]-4,N-METHYL-THREONINE'>BMT</scene>, <scene name='pdbligand=DAL:D-ALANINE'>DAL</scene>, <scene name='pdbligand=DMT:3-HYDROXY-4,4-DIMETHYL-2-(METHYLAMINO)-6-OCTENOIC+ACID'>DMT</scene>, <scene name='pdbligand=MLE:N-METHYLLEUCINE'>MLE</scene>, <scene name='pdbligand=MVA:N-METHYLVALINE'>MVA</scene>, <scene name='pdbligand=SAR:SARCOSINE'>SAR</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1bck\|1bck]], [[1c5f\|1c5f]], [[1csa\|1csa]], [[1cwa\|1cwa]], [[1cwc\|1cwc]], [[1cwf\|1cwf]], [[1cwh\|1cwh]], [[1cwi\|1cwi]], [[1cwj\|1cwj]], [[1cwk\|1cwk]], [[1cwl\|1cwl]], [[1cwm\|1cwm]], [[1cwo\|1cwo]], [[1cya\|1cya]], [[1cyb\|1cyb]], [[1cyn\|1cyn]], [[1ikf\|1ikf]], [[1m63\|1m63]], [[1mf8\|1mf8]], [[1mik\|1mik]], [[1qng\|1qng]], [[1qnh\|1qnh]], [[1xq7\|1xq7]], [[2esl\|2esl]], [[2oju\|2oju]], [[2poy\|2poy]], [[2rma\|2rma]], [[2rmb\|2rmb]], [[2rmc\|2rmc]], [[2wfj\|2wfj]], [[2x2c\|2x2c]], [[2x7k\|2x7k]], [[2z6w\|2z6w]], [[3bo7\|3bo7]], [[3cys\|3cys]], [[3eov\|3eov]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1bck\|1bck]], [[1c5f\|1c5f]], [[1csa\|1csa]], [[1cwa\|1cwa]], [[1cwc\|1cwc]], [[1cwf\|1cwf]], [[1cwh\|1cwh]], [[1cwi\|1cwi]], [[1cwj\|1cwj]], [[1cwk\|1cwk]], [[1cwl\|1cwl]], [[1cwm\|1cwm]], [[1cwo\|1cwo]], [[1cya\|1cya]], [[1cyb\|1cyb]], [[1cyn\|1cyn]], [[1ikf\|1ikf]], [[1m63\|1m63]], [[1mf8\|1mf8]], [[1mik\|1mik]], [[1qng\|1qng]], [[1qnh\|1qnh]], [[1xq7\|1xq7]], [[2esl\|2esl]], [[2oju\|2oju]], [[2poy\|2poy]], [[2rma\|2rma]], [[2rmb\|2rmb]], [[2rmc\|2rmc]], [[2wfj\|2wfj]], [[2x2c\|2x2c]], [[2x7k\|2x7k]], [[2z6w\|2z6w]], [[3bo7\|3bo7]], [[3cys\|3cys]], [[3eov\|3eov]]</td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CYCLOPHILIN ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CYCLOPHILIN ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Peptidylprolyl_isomerase Peptidylprolyl isomerase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.2.1.8 5.2.1.8] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Peptidylprolyl_isomerase Peptidylprolyl isomerase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.2.1.8 5.2.1.8] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1cwb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1cwb OCA], [http://pdbe.org/1cwb PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1cwb RCSB], [http://www.ebi.ac.uk/pdbsum/1cwb PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1cwb ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=1cwb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1cwb OCA], [http://pdbe.org/1cwb PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1cwb RCSB], [http://www.ebi.ac.uk/pdbsum/1cwb PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1cwb ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
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	</div>		</div>
	<div class="pdbe-citations 1cwb" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 1cwb" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Cyclophilin 3D structures\|Cyclophilin 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
Line 34:		Line 37:
	</StructureSection>		</StructureSection>
	[[Category: Human]]		[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Peptidylprolyl isomerase]]		[[Category: Peptidylprolyl isomerase]]
	[[Category: Kallen, J]]		[[Category: Kallen, J]]

OCA at 08:29, 6 December 2017

2017-12-06T08:29:18Z

←Older revision		Revision as of 08:29, 6 December 2017
Line 1:		Line 1:
		+
	==THE X-RAY STRUCTURE OF (MEBM2T)1-CYCLOSPORIN COMPLEXED WITH CYCLOPHILIN A PROVIDES AN EXPLANATION FOR ITS ANOMALOUSLY HIGH IMMUNOSUPPRESSIVE ACTIVITY==		==THE X-RAY STRUCTURE OF (MEBM2T)1-CYCLOSPORIN COMPLEXED WITH CYCLOPHILIN A PROVIDES AN EXPLANATION FOR ITS ANOMALOUSLY HIGH IMMUNOSUPPRESSIVE ACTIVITY==
	<StructureSection load='1cwb' size='340' side='right' caption='[[1cwb]], [[Resolution\|resolution]] 2.20Å' scene=''>		<StructureSection load='1cwb' size='340' side='right' caption='[[1cwb]], [[Resolution\|resolution]] 2.20Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1cwb]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1CWB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1CWB FirstGlance]. <br>		<table><tr><td colspan='2'>[[1cwb]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1CWB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1CWB FirstGlance]. <br>
-	</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=ABA:ALPHA-AMINOBUTYRIC+ACID'>ABA</scene>, <scene name='pdbligand=DAL:D-ALANINE'>DAL</scene>, <scene name='pdbligand=DMT:3-HYDROXY-4,4-DIMETHYL-2-(METHYLAMINO)-6-OCTENOIC+ACID'>DMT</scene>, <scene name='pdbligand=MLE:N-METHYLLEUCINE'>MLE</scene>, <scene name='pdbligand=MVA:N-METHYLVALINE'>MVA</scene>, <scene name='pdbligand=SAR:SARCOSINE'>SAR</scene></td></tr>	+	</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=ABA:ALPHA-AMINOBUTYRIC+ACID'>ABA</scene>, <scene name='pdbligand=BMT:4-METHYL-4-[(E)-2-BUTENYL]-4,N-METHYL-THREONINE'>BMT</scene>, <scene name='pdbligand=DAL:D-ALANINE'>DAL</scene>, <scene name='pdbligand=DMT:3-HYDROXY-4,4-DIMETHYL-2-(METHYLAMINO)-6-OCTENOIC+ACID'>DMT</scene>, <scene name='pdbligand=MLE:N-METHYLLEUCINE'>MLE</scene>, <scene name='pdbligand=MVA:N-METHYLVALINE'>MVA</scene>, <scene name='pdbligand=SAR:SARCOSINE'>SAR</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1bck\|1bck]], [[1c5f\|1c5f]], [[1csa\|1csa]], [[1cwa\|1cwa]], [[1cwc\|1cwc]], [[1cwf\|1cwf]], [[1cwh\|1cwh]], [[1cwi\|1cwi]], [[1cwj\|1cwj]], [[1cwk\|1cwk]], [[1cwl\|1cwl]], [[1cwm\|1cwm]], [[1cwo\|1cwo]], [[1cya\|1cya]], [[1cyb\|1cyb]], [[1cyn\|1cyn]], [[1ikf\|1ikf]], [[1m63\|1m63]], [[1mf8\|1mf8]], [[1mik\|1mik]], [[1qng\|1qng]], [[1qnh\|1qnh]], [[1xq7\|1xq7]], [[2esl\|2esl]], [[2oju\|2oju]], [[2poy\|2poy]], [[2rma\|2rma]], [[2rmb\|2rmb]], [[2rmc\|2rmc]], [[2wfj\|2wfj]], [[2x2c\|2x2c]], [[2x7k\|2x7k]], [[2z6w\|2z6w]], [[3bo7\|3bo7]], [[3cys\|3cys]], [[3eov\|3eov]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1bck\|1bck]], [[1c5f\|1c5f]], [[1csa\|1csa]], [[1cwa\|1cwa]], [[1cwc\|1cwc]], [[1cwf\|1cwf]], [[1cwh\|1cwh]], [[1cwi\|1cwi]], [[1cwj\|1cwj]], [[1cwk\|1cwk]], [[1cwl\|1cwl]], [[1cwm\|1cwm]], [[1cwo\|1cwo]], [[1cya\|1cya]], [[1cyb\|1cyb]], [[1cyn\|1cyn]], [[1ikf\|1ikf]], [[1m63\|1m63]], [[1mf8\|1mf8]], [[1mik\|1mik]], [[1qng\|1qng]], [[1qnh\|1qnh]], [[1xq7\|1xq7]], [[2esl\|2esl]], [[2oju\|2oju]], [[2poy\|2poy]], [[2rma\|2rma]], [[2rmb\|2rmb]], [[2rmc\|2rmc]], [[2wfj\|2wfj]], [[2x2c\|2x2c]], [[2x7k\|2x7k]], [[2z6w\|2z6w]], [[3bo7\|3bo7]], [[3cys\|3cys]], [[3eov\|3eov]]</td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CYCLOPHILIN ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CYCLOPHILIN ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Peptidylprolyl_isomerase Peptidylprolyl isomerase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.2.1.8 5.2.1.8] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Peptidylprolyl_isomerase Peptidylprolyl isomerase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.2.1.8 5.2.1.8] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1cwb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1cwb OCA], [http://pdbe.org/1cwb PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1cwb RCSB], [http://www.ebi.ac.uk/pdbsum/1cwb PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1cwb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1cwb OCA], [http://pdbe.org/1cwb PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1cwb RCSB], [http://www.ebi.ac.uk/pdbsum/1cwb PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1cwb ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 13:		Line 14:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/cw/1cwb_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/cw/1cwb_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
Line 28:		Line 29:
	</div>		</div>
	<div class="pdbe-citations 1cwb" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 1cwb" style="background-color:#fffaf0;"></div>
-
-	==See Also==
-	*[[Cyclophilin\|Cyclophilin]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 06:05, 10 February 2016

2016-02-10T06:05:23Z

←Older revision		Revision as of 06:05, 10 February 2016
Line 17:		Line 17:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1cwb ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 06:05, 11 September 2015

2015-09-11T06:05:57Z

←Older revision		Revision as of 06:05, 11 September 2015
Line 2:		Line 2:
	<StructureSection load='1cwb' size='340' side='right' caption='[[1cwb]], [[Resolution\|resolution]] 2.20Å' scene=''>		<StructureSection load='1cwb' size='340' side='right' caption='[[1cwb]], [[Resolution\|resolution]] 2.20Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1cwb]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1CWB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1CWB FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1cwb]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1CWB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1CWB FirstGlance]. <br>
	</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=ABA:ALPHA-AMINOBUTYRIC+ACID'>ABA</scene>, <scene name='pdbligand=DAL:D-ALANINE'>DAL</scene>, <scene name='pdbligand=DMT:3-HYDROXY-4,4-DIMETHYL-2-(METHYLAMINO)-6-OCTENOIC+ACID'>DMT</scene>, <scene name='pdbligand=MLE:N-METHYLLEUCINE'>MLE</scene>, <scene name='pdbligand=MVA:N-METHYLVALINE'>MVA</scene>, <scene name='pdbligand=SAR:SARCOSINE'>SAR</scene></td></tr>		</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=ABA:ALPHA-AMINOBUTYRIC+ACID'>ABA</scene>, <scene name='pdbligand=DAL:D-ALANINE'>DAL</scene>, <scene name='pdbligand=DMT:3-HYDROXY-4,4-DIMETHYL-2-(METHYLAMINO)-6-OCTENOIC+ACID'>DMT</scene>, <scene name='pdbligand=MLE:N-METHYLLEUCINE'>MLE</scene>, <scene name='pdbligand=MVA:N-METHYLVALINE'>MVA</scene>, <scene name='pdbligand=SAR:SARCOSINE'>SAR</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1bck\|1bck]], [[1c5f\|1c5f]], [[1csa\|1csa]], [[1cwa\|1cwa]], [[1cwc\|1cwc]], [[1cwf\|1cwf]], [[1cwh\|1cwh]], [[1cwi\|1cwi]], [[1cwj\|1cwj]], [[1cwk\|1cwk]], [[1cwl\|1cwl]], [[1cwm\|1cwm]], [[1cwo\|1cwo]], [[1cya\|1cya]], [[1cyb\|1cyb]], [[1cyn\|1cyn]], [[1ikf\|1ikf]], [[1m63\|1m63]], [[1mf8\|1mf8]], [[1mik\|1mik]], [[1qng\|1qng]], [[1qnh\|1qnh]], [[1xq7\|1xq7]], [[2esl\|2esl]], [[2oju\|2oju]], [[2poy\|2poy]], [[2rma\|2rma]], [[2rmb\|2rmb]], [[2rmc\|2rmc]], [[2wfj\|2wfj]], [[2x2c\|2x2c]], [[2x7k\|2x7k]], [[2z6w\|2z6w]], [[3bo7\|3bo7]], [[3cys\|3cys]], [[3eov\|3eov]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1bck\|1bck]], [[1c5f\|1c5f]], [[1csa\|1csa]], [[1cwa\|1cwa]], [[1cwc\|1cwc]], [[1cwf\|1cwf]], [[1cwh\|1cwh]], [[1cwi\|1cwi]], [[1cwj\|1cwj]], [[1cwk\|1cwk]], [[1cwl\|1cwl]], [[1cwm\|1cwm]], [[1cwo\|1cwo]], [[1cya\|1cya]], [[1cyb\|1cyb]], [[1cyn\|1cyn]], [[1ikf\|1ikf]], [[1m63\|1m63]], [[1mf8\|1mf8]], [[1mik\|1mik]], [[1qng\|1qng]], [[1qnh\|1qnh]], [[1xq7\|1xq7]], [[2esl\|2esl]], [[2oju\|2oju]], [[2poy\|2poy]], [[2rma\|2rma]], [[2rmb\|2rmb]], [[2rmc\|2rmc]], [[2wfj\|2wfj]], [[2x2c\|2x2c]], [[2x7k\|2x7k]], [[2z6w\|2z6w]], [[3bo7\|3bo7]], [[3cys\|3cys]], [[3eov\|3eov]]</td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CYCLOPHILIN ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 ~~Homo sapiens~~])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CYCLOPHILIN ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Peptidylprolyl_isomerase Peptidylprolyl isomerase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.2.1.8 5.2.1.8] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Peptidylprolyl_isomerase Peptidylprolyl isomerase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.2.1.8 5.2.1.8] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1cwb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1cwb OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1cwb RCSB], [http://www.ebi.ac.uk/pdbsum/1cwb PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1cwb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1cwb OCA], [http://pdbe.org/1cwb PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1cwb RCSB], [http://www.ebi.ac.uk/pdbsum/1cwb PDBsum]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 27:		Line 27:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 1cwb" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 34:		Line 35:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Homo sapiens~~]]	+	[[Category: Human]]
	[[Category: Peptidylprolyl isomerase]]		[[Category: Peptidylprolyl isomerase]]
	[[Category: Kallen, J]]		[[Category: Kallen, J]]

OCA at 20:17, 22 December 2014

2014-12-22T20:17:19Z

←Older revision		Revision as of 20:17, 22 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1cwb]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1CWB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1CWB FirstGlance]. <br>		<table><tr><td colspan='2'>[[1cwb]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1CWB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1CWB FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=ABA:ALPHA-AMINOBUTYRIC+ACID'>ABA</scene>, <scene name='pdbligand=DAL:D-ALANINE'>DAL</scene>, <scene name='pdbligand=DMT:3-HYDROXY-4,4-DIMETHYL-2-(METHYLAMINO)-6-OCTENOIC+ACID'>DMT</scene>, <scene name='pdbligand=MLE:N-METHYLLEUCINE'>MLE</scene>, <scene name='pdbligand=MVA:N-METHYLVALINE'>MVA</scene>, <scene name='pdbligand=SAR:SARCOSINE'>SAR</scene></td></tr>	+	</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=ABA:ALPHA-AMINOBUTYRIC+ACID'>ABA</scene>, <scene name='pdbligand=DAL:D-ALANINE'>DAL</scene>, <scene name='pdbligand=DMT:3-HYDROXY-4,4-DIMETHYL-2-(METHYLAMINO)-6-OCTENOIC+ACID'>DMT</scene>, <scene name='pdbligand=MLE:N-METHYLLEUCINE'>MLE</scene>, <scene name='pdbligand=MVA:N-METHYLVALINE'>MVA</scene>, <scene name='pdbligand=SAR:SARCOSINE'>SAR</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1bck\|1bck]], [[1c5f\|1c5f]], [[1csa\|1csa]], [[1cwa\|1cwa]], [[1cwc\|1cwc]], [[1cwf\|1cwf]], [[1cwh\|1cwh]], [[1cwi\|1cwi]], [[1cwj\|1cwj]], [[1cwk\|1cwk]], [[1cwl\|1cwl]], [[1cwm\|1cwm]], [[1cwo\|1cwo]], [[1cya\|1cya]], [[1cyb\|1cyb]], [[1cyn\|1cyn]], [[1ikf\|1ikf]], [[1m63\|1m63]], [[1mf8\|1mf8]], [[1mik\|1mik]], [[1qng\|1qng]], [[1qnh\|1qnh]], [[1xq7\|1xq7]], [[2esl\|2esl]], [[2oju\|2oju]], [[2poy\|2poy]], [[2rma\|2rma]], [[2rmb\|2rmb]], [[2rmc\|2rmc]], [[2wfj\|2wfj]], [[2x2c\|2x2c]], [[2x7k\|2x7k]], [[2z6w\|2z6w]], [[3bo7\|3bo7]], [[3cys\|3cys]], [[3eov\|3eov]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1bck\|1bck]], [[1c5f\|1c5f]], [[1csa\|1csa]], [[1cwa\|1cwa]], [[1cwc\|1cwc]], [[1cwf\|1cwf]], [[1cwh\|1cwh]], [[1cwi\|1cwi]], [[1cwj\|1cwj]], [[1cwk\|1cwk]], [[1cwl\|1cwl]], [[1cwm\|1cwm]], [[1cwo\|1cwo]], [[1cya\|1cya]], [[1cyb\|1cyb]], [[1cyn\|1cyn]], [[1ikf\|1ikf]], [[1m63\|1m63]], [[1mf8\|1mf8]], [[1mik\|1mik]], [[1qng\|1qng]], [[1qnh\|1qnh]], [[1xq7\|1xq7]], [[2esl\|2esl]], [[2oju\|2oju]], [[2poy\|2poy]], [[2rma\|2rma]], [[2rmb\|2rmb]], [[2rmc\|2rmc]], [[2wfj\|2wfj]], [[2x2c\|2x2c]], [[2x7k\|2x7k]], [[2z6w\|2z6w]], [[3bo7\|3bo7]], [[3cys\|3cys]], [[3eov\|3eov]]</td></tr>
-	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CYCLOPHILIN ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CYCLOPHILIN ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
-	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Peptidylprolyl_isomerase Peptidylprolyl isomerase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.2.1.8 5.2.1.8] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Peptidylprolyl_isomerase Peptidylprolyl isomerase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.2.1.8 5.2.1.8] </span></td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1cwb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1cwb OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1cwb RCSB], [http://www.ebi.ac.uk/pdbsum/1cwb PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1cwb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1cwb OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1cwb RCSB], [http://www.ebi.ac.uk/pdbsum/1cwb PDBsum]</span></td></tr>
-	<table>	+	</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 36:		Line 36:
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Peptidylprolyl isomerase]]		[[Category: Peptidylprolyl isomerase]]
-	[[Category: Kallen, J.]]	+	[[Category: Kallen, J]]
-	[[Category: Mikol, V.]]	+	[[Category: Mikol, V]]
-	[[Category: Walkinshaw, M D.]]	+	[[Category: Walkinshaw, M D]]
	[[Category: Cyclophilin]]		[[Category: Cyclophilin]]
	[[Category: Cyclophilin-cyclosporin complex]]		[[Category: Cyclophilin-cyclosporin complex]]

OCA at 09:19, 27 August 2014

2014-08-27T09:19:04Z

←Older revision		Revision as of 09:19, 27 August 2014
Line 1:		Line 1:
-	[[~~Image:~~1cwb.~~png~~\|~~left~~\|200px]]	+	==THE X-RAY STRUCTURE OF (MEBM2T)1-CYCLOSPORIN COMPLEXED WITH CYCLOPHILIN A PROVIDES AN EXPLANATION FOR ITS ANOMALOUSLY HIGH IMMUNOSUPPRESSIVE ACTIVITY==
		+	<StructureSection load='1cwb' size='340' side='right' caption='[[1cwb]], [[Resolution\|resolution]] 2.20Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[1cwb]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1CWB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1CWB FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=ABA:ALPHA-AMINOBUTYRIC+ACID'>ABA</scene>, <scene name='pdbligand=DAL:D-ALANINE'>DAL</scene>, <scene name='pdbligand=DMT:3-HYDROXY-4,4-DIMETHYL-2-(METHYLAMINO)-6-OCTENOIC+ACID'>DMT</scene>, <scene name='pdbligand=MLE:N-METHYLLEUCINE'>MLE</scene>, <scene name='pdbligand=MVA:N-METHYLVALINE'>MVA</scene>, <scene name='pdbligand=SAR:SARCOSINE'>SAR</scene></td></tr>
		+	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1bck\|1bck]], [[1c5f\|1c5f]], [[1csa\|1csa]], [[1cwa\|1cwa]], [[1cwc\|1cwc]], [[1cwf\|1cwf]], [[1cwh\|1cwh]], [[1cwi\|1cwi]], [[1cwj\|1cwj]], [[1cwk\|1cwk]], [[1cwl\|1cwl]], [[1cwm\|1cwm]], [[1cwo\|1cwo]], [[1cya\|1cya]], [[1cyb\|1cyb]], [[1cyn\|1cyn]], [[1ikf\|1ikf]], [[1m63\|1m63]], [[1mf8\|1mf8]], [[1mik\|1mik]], [[1qng\|1qng]], [[1qnh\|1qnh]], [[1xq7\|1xq7]], [[2esl\|2esl]], [[2oju\|2oju]], [[2poy\|2poy]], [[2rma\|2rma]], [[2rmb\|2rmb]], [[2rmc\|2rmc]], [[2wfj\|2wfj]], [[2x2c\|2x2c]], [[2x7k\|2x7k]], [[2z6w\|2z6w]], [[3bo7\|3bo7]], [[3cys\|3cys]], [[3eov\|3eov]]</td></tr>
		+	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CYCLOPHILIN ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
		+	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Peptidylprolyl_isomerase Peptidylprolyl isomerase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.2.1.8 5.2.1.8] </span></td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1cwb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1cwb OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1cwb RCSB], [http://www.ebi.ac.uk/pdbsum/1cwb PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/cw/1cwb_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	For most of the cyclosporin A (CsA) analogs, there is generally a good correlation between cyclophilin binding and immunosuppression. However, this relationship does not seem to hold for 4-[(E)-2-butenyl]-4,4,N-trimethyl-L-threonine1 (MeBm2t)1-CsA. Its affinity for cyclophilin was reported to be approximately 1% that of CsA and its immunosuppressive activity in vitro was shown to be approximately 30% that of CsA. We report here the crystal structure of a complex between recombinant human cyclophilin A (CypA) and (MeBm2t)1-CsA which has been determined by X-ray crystallography at 2.2 A resolution and refined to an R-factor of 16.3%. (MeBm2t)1-CsA shows a similar bound conformation and network of interactions to CypA as CsA. The measured lower affinity for CypA cannot therefore be explained by a different mode of binding. We propose that the poor affinity to CypA could be accounted for by the existence of an equilibrium in aqueous solution between a 'cyclophilin bound conformation' and a 'non-binding conformation' of (MeBm2t)1-CsA. The relatively high immunosuppressive activity is suggested to result from slight conformational differences observed in the effector domain.

-	~~{{STRUCTURE_1cwb\| PDB=1cwb \| SCENE= }}~~	+	The X-ray structure of (MeBm2t)1-cyclosporin complexed with cyclophilin A provides an explanation for its anomalously high immunosuppressive activity.,Mikol V, Kallen J, Walkinshaw MD Protein Eng. 1994 May;7(5):597-603. PMID:8073029<ref>PMID:8073029</ref>

-	~~===THE X-RAY STRUCTURE OF (MEBM2T)1-CYCLOSPORIN COMPLEXED WITH CYCLOPHILIN A PROVIDES AN EXPLANATION FOR ITS ANOMALOUSLY HIGH IMMUNOSUPPRESSIVE ACTIVITY===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_8073029}}~~	+
-		+
-	~~==About this Structure==~~	+
-	~~[[1cwb]] is~~ a ~~2 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Homo_sapiens Homo sapiens]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=1CWB OCA].~~	+

	==See Also==		==See Also==
	*[[Cyclophilin\|Cyclophilin]]		*[[Cyclophilin\|Cyclophilin]]
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	<~~ref group="xtra">PMID:008073029<~~/~~ref~~><~~ref group="xtra">PMID:015299416</ref><ref group="xtra">PMID:008263916</ref><ref group="xtra">PMID:008421501</ref><references group="xtra"~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Peptidylprolyl isomerase]]		[[Category: Peptidylprolyl isomerase]]

OCA at 16:35, 20 October 2012

2012-10-20T16:35:26Z

←Older revision		Revision as of 16:35, 20 October 2012
Line 8:		Line 8:

	==About this Structure==		==About this Structure==
-	[[1cwb]] is a 2 chain structure ~~of [[Cyclophilin]]~~ with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1CWB OCA].	+	[[1cwb]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1CWB OCA].

	==See Also==		==See Also==
Line 14:		Line 14:

	==Reference==		==Reference==
-	<ref group="xtra">PMID:008073029</ref><ref group="xtra">PMID:015299416~~</ref><ref group="xtra">PMID:007966126~~</ref><ref group="xtra">PMID:008263916</ref><ref group="xtra">PMID:008421501</ref><references group="xtra"/>	+	<ref group="xtra">PMID:008073029</ref><ref group="xtra">PMID:015299416</ref><ref group="xtra">PMID:008263916</ref><ref group="xtra">PMID:008421501</ref><references group="xtra"/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Peptidylprolyl isomerase]]		[[Category: Peptidylprolyl isomerase]]

OCA at 22:09, 26 July 2012

2012-07-26T22:09:54Z

←Older revision		Revision as of 22:09, 26 July 2012
Line 1:		Line 1:
	[[Image:1cwb.png\|left\|200px]]		[[Image:1cwb.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_1cwb", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_1cwb\| PDB=1cwb \| SCENE= }}		{{STRUCTURE_1cwb\| PDB=1cwb \| SCENE= }}

	===THE X-RAY STRUCTURE OF (MEBM2T)1-CYCLOSPORIN COMPLEXED WITH CYCLOPHILIN A PROVIDES AN EXPLANATION FOR ITS ANOMALOUSLY HIGH IMMUNOSUPPRESSIVE ACTIVITY===		===THE X-RAY STRUCTURE OF (MEBM2T)1-CYCLOSPORIN COMPLEXED WITH CYCLOPHILIN A PROVIDES AN EXPLANATION FOR ITS ANOMALOUSLY HIGH IMMUNOSUPPRESSIVE ACTIVITY===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_8073029}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 8073029 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_8073029}}		{{ABSTRACT_PUBMED_8073029}}

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	==See Also==		==See Also==
-	*[[Cyclophilin]]	+	*[[Cyclophilin\|Cyclophilin]]

	==Reference==		==Reference==

OCA at 05:05, 27 July 2011

2011-07-27T05:05:05Z

←Older revision		Revision as of 05:05, 27 July 2011
Line 25:		Line 25:

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~8073029~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:008073029</ref><ref group="xtra">PMID:015299416</ref><ref group="xtra">PMID:007966126</ref><ref group="xtra">PMID:008263916</ref><ref group="xtra">PMID:008421501</ref><references group="xtra"/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
		+	[[Category: Peptidylprolyl isomerase]]
	[[Category: Kallen, J.]]		[[Category: Kallen, J.]]
	[[Category: Mikol, V.]]		[[Category: Mikol, V.]]
	[[Category: Walkinshaw, M D.]]		[[Category: Walkinshaw, M D.]]
		+	[[Category: Cyclophilin]]
		+	[[Category: Cyclophilin-cyclosporin complex]]
		+	[[Category: Cyclosporin some]]
		+	[[Category: Immunosuppressant]]
		+	[[Category: Isomerase-immunosuppressant complex]]