1cya - Revision history

OCA at 08:48, 7 December 2022

2022-12-07T08:48:16Z

←Older revision		Revision as of 08:48, 7 December 2022
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	==NMR STUDIES OF (U-13C)CYCLOSPORIN A BOUND TO CYCLOPHILIN: BOUND CONFORMATION AND PORTIONS OF CYCLOSPORIN INVOLVED IN BINDING==		==NMR STUDIES OF (U-13C)CYCLOSPORIN A BOUND TO CYCLOPHILIN: BOUND CONFORMATION AND PORTIONS OF CYCLOSPORIN INVOLVED IN BINDING==
-	<StructureSection load='1cya' size='340' side='right'caption='[[1cya~~]], [[NMR_Ensembles_of_Models \| 1 NMR models~~]]' scene=''>	+	<StructureSection load='1cya' size='340' side='right'caption='[[1cya]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1cya]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1CYA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1CYA FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1cya]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Tolypocladium_inflatum Tolypocladium inflatum]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1CYA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1CYA FirstGlance]. <br>
-	</td></tr><tr id='~~NonStdRes~~'><td class="sblockLbl"><b>[[~~Non-Standard_Residue~~\|~~NonStd Res~~:]]</b></td><td class="sblockDat"><scene name='pdbligand=ABA:ALPHA-AMINOBUTYRIC+ACID'>ABA</scene>, <scene name='pdbligand=BMT:4-METHYL-4-[(E)-2-BUTENYL]-4,N-METHYL-THREONINE'>BMT</scene>, <scene name='pdbligand=DAL:D-ALANINE'>DAL</scene>, <scene name='pdbligand=MLE:N-METHYLLEUCINE'>MLE</scene>, <scene name='pdbligand=MVA:N-METHYLVALINE'>MVA</scene>, <scene name='pdbligand=~~SAR~~:~~SARCOSINE~~'>~~SAR~~</scene><~~/td></tr>~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ABA:ALPHA-AMINOBUTYRIC+ACID'>ABA</scene>, <scene name='pdbligand=BMT:4-METHYL-4-[(E)-2-BUTENYL]-4,N-METHYL-THREONINE'>BMT</scene>, <scene name='pdbligand=DAL:D-ALANINE'>DAL</scene>, <scene name='pdbligand=MLE:N-METHYLLEUCINE'>MLE</scene>, <scene name='pdbligand=MVA:N-METHYLVALINE'>MVA</scene>, <scene name='pdbligand=PRD_000142:Cyclosporin+A'>PRD_000142</scene>, <scene name='pdbligand=SAR:SARCOSINE'>SAR</scene></td></tr>
-	~~<tr id~~='~~related'><td class~~=~~"sblockLbl"><b>[[Related_structure\|Related~~:~~]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;~~'>[[1bck\|1bck]], [[1c5f\|1c5f]], [[1csa\|1csa]], [[1cwa\|1cwa]], [[1cwb\|1cwb]], [[1cwc\|1cwc]], [[1cwf\|1cwf]], [[1cwh\|1cwh]], [[1cwi\|1cwi]], [[1cwj\|1cwj]], [[1cwk\|1cwk]], [[1cwl\|1cwl]], [[1cwm\|1cwm]], [[1cwo\|1cwo]], [[1cyb\|1cyb]], [[1cyn\|1cyn]], [[1ikf\|1ikf]], [[1m63\|1m63]], [[1mf8\|1mf8]], [[1mik\|1mik]], [[1qng\|1qng]], [[1qnh\|1qnh]], [[1xq7\|1xq7]], [[2esl\|2esl]], [[2oju\|2oju]], [[2poy\|2poy]], [[2rma\|2rma]], [[2rmb\|2rmb]], [[2rmc\|2rmc]], [[2wfj\|2wfj]], [[2x2c\|2x2c]], [[2x7k\|2x7k]], [[2z6w\|2z6w]], [[3bo7\|3bo7]], [[3cys\|3cys]], [[3eov\|3eov]]</~~div~~></td></tr>	+
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1cya FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1cya OCA], [https://pdbe.org/1cya PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1cya RCSB], [https://www.ebi.ac.uk/pdbsum/1cya PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1cya ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1cya FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1cya OCA], [https://pdbe.org/1cya PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1cya RCSB], [https://www.ebi.ac.uk/pdbsum/1cya PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1cya ProSAT]</span></td></tr>
	</table>		</table>
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	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Fesik, S W~~]]	+	[[Category: Tolypocladium inflatum]]
-	[[Category: ~~Cyclosporin some]]~~	+	[[Category: Fesik SW]]
-	~~[[Category: Immunosuppressant~~]]	+

OCA at 15:20, 3 March 2021

2021-03-03T15:20:12Z

←Older revision		Revision as of 15:20, 3 March 2021
Line 3:		Line 3:
	<StructureSection load='1cya' size='340' side='right'caption='[[1cya]], [[NMR_Ensembles_of_Models \| 1 NMR models]]' scene=''>		<StructureSection load='1cya' size='340' side='right'caption='[[1cya]], [[NMR_Ensembles_of_Models \| 1 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1cya]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1CYA OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1CYA FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1cya]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1CYA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1CYA FirstGlance]. <br>
	</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=ABA:ALPHA-AMINOBUTYRIC+ACID'>ABA</scene>, <scene name='pdbligand=BMT:4-METHYL-4-[(E)-2-BUTENYL]-4,N-METHYL-THREONINE'>BMT</scene>, <scene name='pdbligand=DAL:D-ALANINE'>DAL</scene>, <scene name='pdbligand=MLE:N-METHYLLEUCINE'>MLE</scene>, <scene name='pdbligand=MVA:N-METHYLVALINE'>MVA</scene>, <scene name='pdbligand=SAR:SARCOSINE'>SAR</scene></td></tr>		</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=ABA:ALPHA-AMINOBUTYRIC+ACID'>ABA</scene>, <scene name='pdbligand=BMT:4-METHYL-4-[(E)-2-BUTENYL]-4,N-METHYL-THREONINE'>BMT</scene>, <scene name='pdbligand=DAL:D-ALANINE'>DAL</scene>, <scene name='pdbligand=MLE:N-METHYLLEUCINE'>MLE</scene>, <scene name='pdbligand=MVA:N-METHYLVALINE'>MVA</scene>, <scene name='pdbligand=SAR:SARCOSINE'>SAR</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1bck\|1bck]], [[1c5f\|1c5f]], [[1csa\|1csa]], [[1cwa\|1cwa]], [[1cwb\|1cwb]], [[1cwc\|1cwc]], [[1cwf\|1cwf]], [[1cwh\|1cwh]], [[1cwi\|1cwi]], [[1cwj\|1cwj]], [[1cwk\|1cwk]], [[1cwl\|1cwl]], [[1cwm\|1cwm]], [[1cwo\|1cwo]], [[1cyb\|1cyb]], [[1cyn\|1cyn]], [[1ikf\|1ikf]], [[1m63\|1m63]], [[1mf8\|1mf8]], [[1mik\|1mik]], [[1qng\|1qng]], [[1qnh\|1qnh]], [[1xq7\|1xq7]], [[2esl\|2esl]], [[2oju\|2oju]], [[2poy\|2poy]], [[2rma\|2rma]], [[2rmb\|2rmb]], [[2rmc\|2rmc]], [[2wfj\|2wfj]], [[2x2c\|2x2c]], [[2x7k\|2x7k]], [[2z6w\|2z6w]], [[3bo7\|3bo7]], [[3cys\|3cys]], [[3eov\|3eov]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1bck\|1bck]], [[1c5f\|1c5f]], [[1csa\|1csa]], [[1cwa\|1cwa]], [[1cwb\|1cwb]], [[1cwc\|1cwc]], [[1cwf\|1cwf]], [[1cwh\|1cwh]], [[1cwi\|1cwi]], [[1cwj\|1cwj]], [[1cwk\|1cwk]], [[1cwl\|1cwl]], [[1cwm\|1cwm]], [[1cwo\|1cwo]], [[1cyb\|1cyb]], [[1cyn\|1cyn]], [[1ikf\|1ikf]], [[1m63\|1m63]], [[1mf8\|1mf8]], [[1mik\|1mik]], [[1qng\|1qng]], [[1qnh\|1qnh]], [[1xq7\|1xq7]], [[2esl\|2esl]], [[2oju\|2oju]], [[2poy\|2poy]], [[2rma\|2rma]], [[2rmb\|2rmb]], [[2rmc\|2rmc]], [[2wfj\|2wfj]], [[2x2c\|2x2c]], [[2x7k\|2x7k]], [[2z6w\|2z6w]], [[3bo7\|3bo7]], [[3cys\|3cys]], [[3eov\|3eov]]</div></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1cya FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1cya OCA], [~~http~~://pdbe.org/1cya PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=1cya RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/1cya PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=1cya ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1cya FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1cya OCA], [https://pdbe.org/1cya PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1cya RCSB], [https://www.ebi.ac.uk/pdbsum/1cya PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1cya ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 07:40, 29 May 2019

2019-05-29T07:40:13Z

←Older revision		Revision as of 07:40, 29 May 2019
Line 1:		Line 1:

	==NMR STUDIES OF (U-13C)CYCLOSPORIN A BOUND TO CYCLOPHILIN: BOUND CONFORMATION AND PORTIONS OF CYCLOSPORIN INVOLVED IN BINDING==		==NMR STUDIES OF (U-13C)CYCLOSPORIN A BOUND TO CYCLOPHILIN: BOUND CONFORMATION AND PORTIONS OF CYCLOSPORIN INVOLVED IN BINDING==
-	<StructureSection load='1cya' size='340' side='right' caption='[[1cya]], [[NMR_Ensembles_of_Models \| 1 NMR models]]' scene=''>	+	<StructureSection load='1cya' size='340' side='right'caption='[[1cya]], [[NMR_Ensembles_of_Models \| 1 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1cya]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1CYA OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1CYA FirstGlance]. <br>		<table><tr><td colspan='2'>[[1cya]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1CYA OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1CYA FirstGlance]. <br>
Line 21:		Line 21:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Fesik, S W]]		[[Category: Fesik, S W]]
	[[Category: Cyclosporin some]]		[[Category: Cyclosporin some]]
	[[Category: Immunosuppressant]]		[[Category: Immunosuppressant]]

OCA at 11:20, 24 August 2017

2017-08-24T11:20:24Z

←Older revision		Revision as of 11:20, 24 August 2017
Line 1:		Line 1:
		+
	==NMR STUDIES OF (U-13C)CYCLOSPORIN A BOUND TO CYCLOPHILIN: BOUND CONFORMATION AND PORTIONS OF CYCLOSPORIN INVOLVED IN BINDING==		==NMR STUDIES OF (U-13C)CYCLOSPORIN A BOUND TO CYCLOPHILIN: BOUND CONFORMATION AND PORTIONS OF CYCLOSPORIN INVOLVED IN BINDING==
	<StructureSection load='1cya' size='340' side='right' caption='[[1cya]], [[NMR_Ensembles_of_Models \| 1 NMR models]]' scene=''>		<StructureSection load='1cya' size='340' side='right' caption='[[1cya]], [[NMR_Ensembles_of_Models \| 1 NMR models]]' scene=''>
Line 5:		Line 6:
	</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=ABA:ALPHA-AMINOBUTYRIC+ACID'>ABA</scene>, <scene name='pdbligand=BMT:4-METHYL-4-[(E)-2-BUTENYL]-4,N-METHYL-THREONINE'>BMT</scene>, <scene name='pdbligand=DAL:D-ALANINE'>DAL</scene>, <scene name='pdbligand=MLE:N-METHYLLEUCINE'>MLE</scene>, <scene name='pdbligand=MVA:N-METHYLVALINE'>MVA</scene>, <scene name='pdbligand=SAR:SARCOSINE'>SAR</scene></td></tr>		</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=ABA:ALPHA-AMINOBUTYRIC+ACID'>ABA</scene>, <scene name='pdbligand=BMT:4-METHYL-4-[(E)-2-BUTENYL]-4,N-METHYL-THREONINE'>BMT</scene>, <scene name='pdbligand=DAL:D-ALANINE'>DAL</scene>, <scene name='pdbligand=MLE:N-METHYLLEUCINE'>MLE</scene>, <scene name='pdbligand=MVA:N-METHYLVALINE'>MVA</scene>, <scene name='pdbligand=SAR:SARCOSINE'>SAR</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1bck\|1bck]], [[1c5f\|1c5f]], [[1csa\|1csa]], [[1cwa\|1cwa]], [[1cwb\|1cwb]], [[1cwc\|1cwc]], [[1cwf\|1cwf]], [[1cwh\|1cwh]], [[1cwi\|1cwi]], [[1cwj\|1cwj]], [[1cwk\|1cwk]], [[1cwl\|1cwl]], [[1cwm\|1cwm]], [[1cwo\|1cwo]], [[1cyb\|1cyb]], [[1cyn\|1cyn]], [[1ikf\|1ikf]], [[1m63\|1m63]], [[1mf8\|1mf8]], [[1mik\|1mik]], [[1qng\|1qng]], [[1qnh\|1qnh]], [[1xq7\|1xq7]], [[2esl\|2esl]], [[2oju\|2oju]], [[2poy\|2poy]], [[2rma\|2rma]], [[2rmb\|2rmb]], [[2rmc\|2rmc]], [[2wfj\|2wfj]], [[2x2c\|2x2c]], [[2x7k\|2x7k]], [[2z6w\|2z6w]], [[3bo7\|3bo7]], [[3cys\|3cys]], [[3eov\|3eov]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1bck\|1bck]], [[1c5f\|1c5f]], [[1csa\|1csa]], [[1cwa\|1cwa]], [[1cwb\|1cwb]], [[1cwc\|1cwc]], [[1cwf\|1cwf]], [[1cwh\|1cwh]], [[1cwi\|1cwi]], [[1cwj\|1cwj]], [[1cwk\|1cwk]], [[1cwl\|1cwl]], [[1cwm\|1cwm]], [[1cwo\|1cwo]], [[1cyb\|1cyb]], [[1cyn\|1cyn]], [[1ikf\|1ikf]], [[1m63\|1m63]], [[1mf8\|1mf8]], [[1mik\|1mik]], [[1qng\|1qng]], [[1qnh\|1qnh]], [[1xq7\|1xq7]], [[2esl\|2esl]], [[2oju\|2oju]], [[2poy\|2poy]], [[2rma\|2rma]], [[2rmb\|2rmb]], [[2rmc\|2rmc]], [[2wfj\|2wfj]], [[2x2c\|2x2c]], [[2x7k\|2x7k]], [[2z6w\|2z6w]], [[3bo7\|3bo7]], [[3cys\|3cys]], [[3eov\|3eov]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1cya FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1cya OCA], [http://pdbe.org/1cya PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1cya RCSB], [http://www.ebi.ac.uk/pdbsum/1cya PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1cya FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1cya OCA], [http://pdbe.org/1cya PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1cya RCSB], [http://www.ebi.ac.uk/pdbsum/1cya PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1cya ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 13:03, 10 September 2015

2015-09-10T13:03:29Z

←Older revision		Revision as of 13:03, 10 September 2015
Line 5:		Line 5:
	</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=ABA:ALPHA-AMINOBUTYRIC+ACID'>ABA</scene>, <scene name='pdbligand=BMT:4-METHYL-4-[(E)-2-BUTENYL]-4,N-METHYL-THREONINE'>BMT</scene>, <scene name='pdbligand=DAL:D-ALANINE'>DAL</scene>, <scene name='pdbligand=MLE:N-METHYLLEUCINE'>MLE</scene>, <scene name='pdbligand=MVA:N-METHYLVALINE'>MVA</scene>, <scene name='pdbligand=SAR:SARCOSINE'>SAR</scene></td></tr>		</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=ABA:ALPHA-AMINOBUTYRIC+ACID'>ABA</scene>, <scene name='pdbligand=BMT:4-METHYL-4-[(E)-2-BUTENYL]-4,N-METHYL-THREONINE'>BMT</scene>, <scene name='pdbligand=DAL:D-ALANINE'>DAL</scene>, <scene name='pdbligand=MLE:N-METHYLLEUCINE'>MLE</scene>, <scene name='pdbligand=MVA:N-METHYLVALINE'>MVA</scene>, <scene name='pdbligand=SAR:SARCOSINE'>SAR</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1bck\|1bck]], [[1c5f\|1c5f]], [[1csa\|1csa]], [[1cwa\|1cwa]], [[1cwb\|1cwb]], [[1cwc\|1cwc]], [[1cwf\|1cwf]], [[1cwh\|1cwh]], [[1cwi\|1cwi]], [[1cwj\|1cwj]], [[1cwk\|1cwk]], [[1cwl\|1cwl]], [[1cwm\|1cwm]], [[1cwo\|1cwo]], [[1cyb\|1cyb]], [[1cyn\|1cyn]], [[1ikf\|1ikf]], [[1m63\|1m63]], [[1mf8\|1mf8]], [[1mik\|1mik]], [[1qng\|1qng]], [[1qnh\|1qnh]], [[1xq7\|1xq7]], [[2esl\|2esl]], [[2oju\|2oju]], [[2poy\|2poy]], [[2rma\|2rma]], [[2rmb\|2rmb]], [[2rmc\|2rmc]], [[2wfj\|2wfj]], [[2x2c\|2x2c]], [[2x7k\|2x7k]], [[2z6w\|2z6w]], [[3bo7\|3bo7]], [[3cys\|3cys]], [[3eov\|3eov]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1bck\|1bck]], [[1c5f\|1c5f]], [[1csa\|1csa]], [[1cwa\|1cwa]], [[1cwb\|1cwb]], [[1cwc\|1cwc]], [[1cwf\|1cwf]], [[1cwh\|1cwh]], [[1cwi\|1cwi]], [[1cwj\|1cwj]], [[1cwk\|1cwk]], [[1cwl\|1cwl]], [[1cwm\|1cwm]], [[1cwo\|1cwo]], [[1cyb\|1cyb]], [[1cyn\|1cyn]], [[1ikf\|1ikf]], [[1m63\|1m63]], [[1mf8\|1mf8]], [[1mik\|1mik]], [[1qng\|1qng]], [[1qnh\|1qnh]], [[1xq7\|1xq7]], [[2esl\|2esl]], [[2oju\|2oju]], [[2poy\|2poy]], [[2rma\|2rma]], [[2rmb\|2rmb]], [[2rmc\|2rmc]], [[2wfj\|2wfj]], [[2x2c\|2x2c]], [[2x7k\|2x7k]], [[2z6w\|2z6w]], [[3bo7\|3bo7]], [[3cys\|3cys]], [[3eov\|3eov]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1cya FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1cya OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1cya RCSB], [http://www.ebi.ac.uk/pdbsum/1cya PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1cya FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1cya OCA], [http://pdbe.org/1cya PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1cya RCSB], [http://www.ebi.ac.uk/pdbsum/1cya PDBsum]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 15:		Line 15:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 1cya" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>

OCA at 06:48, 22 December 2014

2014-12-22T06:48:31Z

←Older revision		Revision as of 06:48, 22 December 2014
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-	~~{{STRUCTURE_1cya\| PDB=1cya \| SCENE= }}~~	+	==NMR STUDIES OF (U-13C)CYCLOSPORIN A BOUND TO CYCLOPHILIN: BOUND CONFORMATION AND PORTIONS OF CYCLOSPORIN INVOLVED IN BINDING==
-	===NMR STUDIES OF (U-13C)CYCLOSPORIN A BOUND TO CYCLOPHILIN: BOUND CONFORMATION AND PORTIONS OF CYCLOSPORIN INVOLVED IN BINDING===	+	<StructureSection load='1cya' size='340' side='right' caption='[[1cya]], [[NMR_Ensembles_of_Models \| 1 NMR models]]' scene=''>
-	~~{{ABSTRACT_PUBMED_2054356}}~~	+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[1cya]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1CYA OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1CYA FirstGlance]. <br>
		+	</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=ABA:ALPHA-AMINOBUTYRIC+ACID'>ABA</scene>, <scene name='pdbligand=BMT:4-METHYL-4-[(E)-2-BUTENYL]-4,N-METHYL-THREONINE'>BMT</scene>, <scene name='pdbligand=DAL:D-ALANINE'>DAL</scene>, <scene name='pdbligand=MLE:N-METHYLLEUCINE'>MLE</scene>, <scene name='pdbligand=MVA:N-METHYLVALINE'>MVA</scene>, <scene name='pdbligand=SAR:SARCOSINE'>SAR</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1bck\|1bck]], [[1c5f\|1c5f]], [[1csa\|1csa]], [[1cwa\|1cwa]], [[1cwb\|1cwb]], [[1cwc\|1cwc]], [[1cwf\|1cwf]], [[1cwh\|1cwh]], [[1cwi\|1cwi]], [[1cwj\|1cwj]], [[1cwk\|1cwk]], [[1cwl\|1cwl]], [[1cwm\|1cwm]], [[1cwo\|1cwo]], [[1cyb\|1cyb]], [[1cyn\|1cyn]], [[1ikf\|1ikf]], [[1m63\|1m63]], [[1mf8\|1mf8]], [[1mik\|1mik]], [[1qng\|1qng]], [[1qnh\|1qnh]], [[1xq7\|1xq7]], [[2esl\|2esl]], [[2oju\|2oju]], [[2poy\|2poy]], [[2rma\|2rma]], [[2rmb\|2rmb]], [[2rmc\|2rmc]], [[2wfj\|2wfj]], [[2x2c\|2x2c]], [[2x7k\|2x7k]], [[2z6w\|2z6w]], [[3bo7\|3bo7]], [[3cys\|3cys]], [[3eov\|3eov]]</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1cya FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1cya OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1cya RCSB], [http://www.ebi.ac.uk/pdbsum/1cya PDBsum]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Cyclosporin A (CsA), a potent immunosuppressant, is known to bind with high specificity to cyclophilin (CyP), a 17.7 kDa protein with peptidyl-prolyl isomerase activity. In order to investigate the three-dimensional structure of the CsA/CyP complex, we have applied a variety of multidimensional NMR methods in the study of uniformly 13C-labeled CsA bound to cyclophilin. The 1H and 13C NMR signals of cyclosporin A in the bound state have been assigned, and from a quantitative interpretation of the 3D NOE data, the bound conformation of CsA has been determined. Three-dimensional structures of CsA calculated from the NOE data by using a distance geometry/simulated appealing protocol were found to be very different from previously determined crystalline and solution conformations of uncomplexed CsA. In addition, from CsA/CyP NOEs, the portions of CsA that interact with cyclophilin were identified. For the most part, those CsA residues with NOEs to cyclophilin were the same residues important for cyclophilin binding and immunosuppressive activity as determined from structure/activity relationships. The structural information derived in this study together with the known structure/activity relationships for CsA analogues may prove useful in the design of improved immunosuppressants. Moreover, the approach that is described for obtaining the structural information is widely applicable to the study of small molecule/large molecule interactions.

-	~~==About this Structure==~~	+	NMR studies of [U-13C]cyclosporin A bound to cyclophilin: bound conformation and portions of cyclosporin involved in binding.,Fesik SW, Gampe RT Jr, Eaton HL, Gemmecker G, Olejniczak ET, Neri P, Holzman TF, Egan DA, Edalji R, Simmer R, et al. Biochemistry. 1991 Jul 2;30(26):6574-83. PMID:2054356<ref>PMID:2054356</ref>
-	[~~[1cya~~]~~] is a 1 chain structure. Full experimental information is available from [http~~:~~//oca~~.~~weizmann~~.ac.~~il/oca~~-~~bin~~/~~ocashort?id=1CYA OCA].~~	+

-	==~~Reference~~==	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~<ref group="xtra">PMID:002054356</ref>~~<references ~~group="xtra"~~/><~~references~~/>	+	</div>
-	[[Category: Fesik, S W.]]	+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Fesik, S W]]
	[[Category: Cyclosporin some]]		[[Category: Cyclosporin some]]
	[[Category: Immunosuppressant]]		[[Category: Immunosuppressant]]

OCA at 06:30, 10 April 2014

2014-04-10T06:30:42Z

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-	[[Image:1cya.png\|left\|200px]]
-
-	<!--
-	The line below this paragraph, containing "STRUCTURE_1cya", creates the "Structure Box" on the page.
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-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_1cya\| PDB=1cya \| SCENE= }}		{{STRUCTURE_1cya\| PDB=1cya \| SCENE= }}
-
	===NMR STUDIES OF (U-13C)CYCLOSPORIN A BOUND TO CYCLOPHILIN: BOUND CONFORMATION AND PORTIONS OF CYCLOSPORIN INVOLVED IN BINDING===		===NMR STUDIES OF (U-13C)CYCLOSPORIN A BOUND TO CYCLOPHILIN: BOUND CONFORMATION AND PORTIONS OF CYCLOSPORIN INVOLVED IN BINDING===
-
-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_2054356}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 2054356 is the PubMed ID number.
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	{{ABSTRACT_PUBMED_2054356}}		{{ABSTRACT_PUBMED_2054356}}

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	==Reference==		==Reference==
-	<ref group="xtra">PMID:002054356</ref><references group="xtra"/>	+	<ref group="xtra">PMID:002054356</ref><references group="xtra"/><references/>
	[[Category: Fesik, S W.]]		[[Category: Fesik, S W.]]
	[[Category: Cyclosporin some]]		[[Category: Cyclosporin some]]
	[[Category: Immunosuppressant]]		[[Category: Immunosuppressant]]

OCA: Protected "1cya" [edit=sysop:move=sysop]

2011-07-27T05:18:54Z

Protected "1cya" [edit=sysop:move=sysop]

←Older revision

Revision as of 05:18, 27 July 2011

OCA at 05:18, 27 July 2011

2011-07-27T05:18:52Z

←Older revision		Revision as of 05:18, 27 July 2011
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-	{{Seed}}
	[[Image:1cya.png\|left\|200px]]		[[Image:1cya.png\|left\|200px]]

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	==About this Structure==		==About this Structure==
-	Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1CYA OCA].	+	[[1cya]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1CYA OCA].

	==Reference==		==Reference==
-	NMR studies of [U-13C]cyclosporin A bound to cyclophilin: bound conformation and portions of cyclosporin involved in binding., Fesik SW, Gampe RT Jr, Eaton HL, Gemmecker G, Olejniczak ET, Neri P, Holzman TF, Egan DA, Edalji R, Simmer R, et al., Biochemistry. 1991 Jul 2;30(26):6574-83. PMID:~~[http://www.ncbi.nlm.nih.gov~~/~~pubmed~~/~~2054356 2054356]~~	+	<ref group="xtra">PMID:002054356</ref><references group="xtra"/>
	[[Category: Fesik, S W.]]		[[Category: Fesik, S W.]]
-	[[Category: ~~Isomerase~~]]	+	[[Category: Cyclosporin some]]
-		+	[[Category: Immunosuppressant]]
-	~~''Page seeded by~~ [~~http~~:~~//oca.weizmann.ac.il/oca OCA~~ ] ~~on Mon Jun 30 21:46:48 2008''~~	+

OCA at 18:46, 30 June 2008

2008-06-30T18:46:53Z

←Older revision		Revision as of 18:46, 30 June 2008
Line 1:		Line 1:
-	[[Image:1cya.~~gif~~\|left\|200px]]	+	{{Seed}}
		+	[[Image:1cya.png\|left\|200px]]

	<!--		<!--
Line 9:		Line 10:
	{{STRUCTURE_1cya\| PDB=1cya \| SCENE= }}		{{STRUCTURE_1cya\| PDB=1cya \| SCENE= }}

-	~~'''~~NMR STUDIES OF (U-13C)CYCLOSPORIN A BOUND TO CYCLOPHILIN: BOUND CONFORMATION AND PORTIONS OF CYCLOSPORIN INVOLVED IN BINDING~~'''~~	+	===NMR STUDIES OF (U-13C)CYCLOSPORIN A BOUND TO CYCLOPHILIN: BOUND CONFORMATION AND PORTIONS OF CYCLOSPORIN INVOLVED IN BINDING===


-	~~==Overview==~~	+	<!--
-	~~Cyclosporin A (CsA), a potent immunosuppressant, is known to bind with high specificity to cyclophilin (CyP), a 17.7 kDa protein with peptidyl~~-~~prolyl isomerase activity. In order to investigate the three~~-~~dimensional structure of the CsA/CyP complex, we have applied a variety of multidimensional NMR methods in the study of uniformly 13C-labeled CsA bound to cyclophilin.~~ The ~~1H and 13C NMR signals of cyclosporin A in the bound state have been assigned~~, ~~and from a quantitative interpretation of the 3D NOE data~~, the ~~bound conformation of CsA has been determined. Three-dimensional structures of CsA calculated from the NOE data by using a distance geometry/simulated appealing protocol were found~~ to ~~be very different from previously determined crystalline and solution conformations of uncomplexed CsA. In addition, from CsA/CyP NOEs,~~ the portions of CsA that interact with cyclophilin were identified. For the most part, those CsA residues with NOEs to cyclophilin were the same residues important for cyclophilin binding and immunosuppressive activity as ~~determined from structure~~/~~activity relationships~~. ~~The structural information derived in this study together with the known structure/activity relationships for CsA analogues may prove useful in the design of improved immunosuppressants~~. ~~Moreover~~, ~~the approach that~~ is ~~described for obtaining~~ the ~~structural information is widely applicable to the study of small molecule/large molecule interactions~~.	+	The line below this paragraph, {{ABSTRACT_PUBMED_2054356}}, adds the Publication Abstract to the page
		+	(as it appears on PubMed at http://www.pubmed.gov), where 2054356 is the PubMed ID number.
		+	-->
		+	{{ABSTRACT_PUBMED_2054356}}

	==About this Structure==		==About this Structure==
-	Full ~~crystallographic~~ information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1CYA OCA].	+	Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1CYA OCA].

	==Reference==		==Reference==
Line 22:		Line 26:
	[[Category: Fesik, S W.]]		[[Category: Fesik, S W.]]
	[[Category: Isomerase]]		[[Category: Isomerase]]
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Fri May 2 13~~:14:27 2008''	+
		+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 21:46:48 2008''