1d9j - Revision history

OCA at 11:43, 22 November 2023

2023-11-22T11:43:30Z

←Older revision		Revision as of 11:43, 22 November 2023
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	==SOLUTION STRUCTURE OF CECROPIN A(1-8)-MAGAININ 2(1-12) HYBRID PEPTIDE==		==SOLUTION STRUCTURE OF CECROPIN A(1-8)-MAGAININ 2(1-12) HYBRID PEPTIDE==
-	<StructureSection load='1d9j' size='340' side='right'caption='[[1d9j~~]], [[NMR_Ensembles_of_Models \| 20 NMR models~~]]' scene=''>	+	<StructureSection load='1d9j' size='340' side='right'caption='[[1d9j]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1d9j]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1D9J OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1D9J FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1d9j]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Hyalophora_cecropia Hyalophora cecropia]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1D9J OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1D9J FirstGlance]. <br>
-	</td></tr><tr id='~~NonStdRes~~'><td class="sblockLbl"><b>[[~~Non-Standard_Residue~~\|~~NonStd Res~~:]]</b></td><td class="sblockDat"~~><scene name~~=~~'pdbligand=NH2:AMINO+GROUP'>NH2</scene~~></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
-	<tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"><~~div style~~='~~overflow~~: ~~auto; max-height: 3em;~~'>~~[[1d9l\|1d9l]], [[1d9m\|1d9m]], [[1d9o\|1d9o]], [[1d9p\|1d9p]]~~</~~div~~></td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1d9j FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1d9j OCA], [https://pdbe.org/1d9j PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1d9j RCSB], [https://www.ebi.ac.uk/pdbsum/1d9j PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1d9j ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1d9j FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1d9j OCA], [https://pdbe.org/1d9j PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1d9j RCSB], [https://www.ebi.ac.uk/pdbsum/1d9j PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1d9j ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/CECA_HYACE CECA_HYACE]] Cecropins have lytic and antibacterial activity against several Gram-positive and Gram-negative bacteria.	+	[https://www.uniprot.org/uniprot/MAGA_XENLA MAGA_XENLA] Antimicrobial peptides that inhibit the growth of numerous species of bacteria and fungi and induce osmotic lysis of protozoa. Magainins are membrane lytic agents.[https://www.uniprot.org/uniprot/CECA_HYACE CECA_HYACE] Cecropins have lytic and antibacterial activity against several Gram-positive and Gram-negative bacteria.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 26:		Line 26:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Hyalophora cecropia]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Kim, Y]]	+	[[Category: Kim Y]]
-	[[Category: Oh, D]]	+	[[Category: Oh D]]
-	~~[[Category: Antimicrobial protein]]~~	+
-	~~[[Category: Helix-hinge-helix~~]]	+

OCA at 18:23, 10 March 2021

2021-03-10T18:23:04Z

←Older revision		Revision as of 18:23, 10 March 2021
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	<StructureSection load='1d9j' size='340' side='right'caption='[[1d9j]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>		<StructureSection load='1d9j' size='340' side='right'caption='[[1d9j]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1d9j]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1D9J OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1D9J FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1d9j]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1D9J OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1D9J FirstGlance]. <br>
	</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene></td></tr>		</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1d9l\|1d9l]], [[1d9m\|1d9m]], [[1d9o\|1d9o]], [[1d9p\|1d9p]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1d9l\|1d9l]], [[1d9m\|1d9m]], [[1d9o\|1d9o]], [[1d9p\|1d9p]]</div></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1d9j FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1d9j OCA], [~~http~~://pdbe.org/1d9j PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=1d9j RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/1d9j PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=1d9j ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1d9j FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1d9j OCA], [https://pdbe.org/1d9j PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1d9j RCSB], [https://www.ebi.ac.uk/pdbsum/1d9j PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1d9j ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/CECA_HYACE CECA_HYACE]] Cecropins have lytic and antibacterial activity against several Gram-positive and Gram-negative bacteria.	+	[[https://www.uniprot.org/uniprot/CECA_HYACE CECA_HYACE]] Cecropins have lytic and antibacterial activity against several Gram-positive and Gram-negative bacteria.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==

OCA at 00:08, 6 June 2019

2019-06-06T00:08:05Z

←Older revision		Revision as of 00:08, 6 June 2019
Line 1:		Line 1:

	==SOLUTION STRUCTURE OF CECROPIN A(1-8)-MAGAININ 2(1-12) HYBRID PEPTIDE==		==SOLUTION STRUCTURE OF CECROPIN A(1-8)-MAGAININ 2(1-12) HYBRID PEPTIDE==
-	<StructureSection load='1d9j' size='340' side='right' caption='[[1d9j]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>	+	<StructureSection load='1d9j' size='340' side='right'caption='[[1d9j]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1d9j]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1D9J OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1D9J FirstGlance]. <br>		<table><tr><td colspan='2'>[[1d9j]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1D9J OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1D9J FirstGlance]. <br>
Line 26:		Line 26:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Kim, Y]]		[[Category: Kim, Y]]
	[[Category: Oh, D]]		[[Category: Oh, D]]
	[[Category: Antimicrobial protein]]		[[Category: Antimicrobial protein]]
	[[Category: Helix-hinge-helix]]		[[Category: Helix-hinge-helix]]

OCA at 04:08, 30 August 2017

2017-08-30T04:08:37Z

←Older revision		Revision as of 04:08, 30 August 2017
Line 1:		Line 1:
		+
	==SOLUTION STRUCTURE OF CECROPIN A(1-8)-MAGAININ 2(1-12) HYBRID PEPTIDE==		==SOLUTION STRUCTURE OF CECROPIN A(1-8)-MAGAININ 2(1-12) HYBRID PEPTIDE==
	<StructureSection load='1d9j' size='340' side='right' caption='[[1d9j]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>		<StructureSection load='1d9j' size='340' side='right' caption='[[1d9j]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
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	</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene></td></tr>		</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1d9l\|1d9l]], [[1d9m\|1d9m]], [[1d9o\|1d9o]], [[1d9p\|1d9p]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1d9l\|1d9l]], [[1d9m\|1d9m]], [[1d9o\|1d9o]], [[1d9p\|1d9p]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1d9j FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1d9j OCA], [http://pdbe.org/1d9j PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1d9j RCSB], [http://www.ebi.ac.uk/pdbsum/1d9j PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1d9j FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1d9j OCA], [http://pdbe.org/1d9j PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1d9j RCSB], [http://www.ebi.ac.uk/pdbsum/1d9j PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1d9j ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 18:		Line 19:
	</div>		</div>
	<div class="pdbe-citations 1d9j" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 1d9j" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Magainin 2\|Magainin 2]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 22:26, 11 September 2015

2015-09-11T22:26:45Z

←Older revision		Revision as of 22:26, 11 September 2015
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	</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene></td></tr>		</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1d9l\|1d9l]], [[1d9m\|1d9m]], [[1d9o\|1d9o]], [[1d9p\|1d9p]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1d9l\|1d9l]], [[1d9m\|1d9m]], [[1d9o\|1d9o]], [[1d9p\|1d9p]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1d9j FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1d9j OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1d9j RCSB], [http://www.ebi.ac.uk/pdbsum/1d9j PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1d9j FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1d9j OCA], [http://pdbe.org/1d9j PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1d9j RCSB], [http://www.ebi.ac.uk/pdbsum/1d9j PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 17:		Line 17:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 1d9j" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>

OCA at 20:17, 25 December 2014

2014-12-25T20:17:20Z

←Older revision		Revision as of 20:17, 25 December 2014
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	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1d9j FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1d9j OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1d9j RCSB], [http://www.ebi.ac.uk/pdbsum/1d9j PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1d9j FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1d9j OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1d9j RCSB], [http://www.ebi.ac.uk/pdbsum/1d9j PDBsum]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/CECA_HYACE CECA_HYACE]] Cecropins have lytic and antibacterial activity against several Gram-positive and Gram-negative bacteria.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==

OCA at 20:37, 22 December 2014

2014-12-22T20:37:24Z

←Older revision		Revision as of 20:37, 22 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1d9j]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1D9J OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1D9J FirstGlance]. <br>		<table><tr><td colspan='2'>[[1d9j]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1D9J OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1D9J FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene></td></tr>	+	</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1d9l\|1d9l]], [[1d9m\|1d9m]], [[1d9o\|1d9o]], [[1d9p\|1d9p]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1d9l\|1d9l]], [[1d9m\|1d9m]], [[1d9o\|1d9o]], [[1d9p\|1d9p]]</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1d9j FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1d9j OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1d9j RCSB], [http://www.ebi.ac.uk/pdbsum/1d9j PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1d9j FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1d9j OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1d9j RCSB], [http://www.ebi.ac.uk/pdbsum/1d9j PDBsum]</span></td></tr>
-	<table>	+	</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 19:		Line 19:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Kim, Y.]]	+	[[Category: Kim, Y]]
-	[[Category: Oh, D.]]	+	[[Category: Oh, D]]
	[[Category: Antimicrobial protein]]		[[Category: Antimicrobial protein]]
	[[Category: Helix-hinge-helix]]		[[Category: Helix-hinge-helix]]

OCA at 06:37, 4 September 2014

2014-09-04T06:37:38Z

←Older revision		Revision as of 06:37, 4 September 2014
Line 1:		Line 1:
-	[[~~Image:~~1d9j.~~png~~\|~~left~~\|~~200px~~]]	+	==SOLUTION STRUCTURE OF CECROPIN A(1-8)-MAGAININ 2(1-12) HYBRID PEPTIDE==
		+	<StructureSection load='1d9j' size='340' side='right' caption='[[1d9j]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[1d9j]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1D9J OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1D9J FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene></td></tr>
		+	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1d9l\|1d9l]], [[1d9m\|1d9m]], [[1d9o\|1d9o]], [[1d9p\|1d9p]]</td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1d9j FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1d9j OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1d9j RCSB], [http://www.ebi.ac.uk/pdbsum/1d9j PDBsum]</span></td></tr>
		+	<table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	In order to elucidate the structure-antibiotic activity relationships of the peptides, the three-dimensional structures of two hybrid peptides, CA(1-8) - MA(1-12) and CA(1-8) - ME(1-12) in trifluoroethanol-containing aqueous solution were investigated by NMR spectroscopy. Both CA(1-8) - MA(1-12) and CA(1-8) - ME(1-12) have strong antibacterial activity but only CA(1-8) - ME(1-12) has hemolytic activity against human erythrocytes. CA(1-8) - MA(1-12) has a hydrophobic 310-helix of only two turns combined with one short helix in the N-terminus with a flexible hinge section in between. CA(1-8) - MA(1-12) has a severely bent structure in the middle of the peptide. These structural features as well as the low hydrophobicity of CA(1-8) - MA(1-12) seem to be crucial for the selective lysis against the membrane of prokaryotic cells. CA(1-8) - ME(1-12) has an alpha-helical structure of about three turns in the melittin domain and a flexible structure with one turn in the cecropin domain connected with a flexible hinge section in between, and these might be the structural features required for membrane disruption against prokaryotic and eukaryotic cells. The central hinge region (Gly9-Ile10-Gly11) in an amphipathic antibacterial peptide is considered to play an important role in providing the conformational flexibility required for ion channel formation of the C-terminal hydrophobic alpha-helix on cell membrane.

-	~~{{STRUCTURE_1d9j\| PDB=1d9j \| SCENE= }}~~	+	NMR structural characterization of cecropin A(1-8) - magainin 2(1-12) and cecropin A (1-8) - melittin (1-12) hybrid peptides.,Oh D, Shin SY, Kang JH, Hahm KS, Kim KL, Kim Y J Pept Res. 1999 May;53(5):578-89. PMID:10424354<ref>PMID:10424354</ref>

-	~~===SOLUTION STRUCTURE OF CECROPIN A(1-8)-MAGAININ 2(1-12) HYBRID PEPTIDE===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_10424354}}~~	+	== References ==
-		+	<references/>
-	~~==About this Structure==~~	+	__TOC__
-	~~[[1d9j]] is~~ a ~~1 chain structure~~. ~~Full experimental information is available from [http://oca~~.~~weizmann~~.~~ac.il~~/~~oca-bin/ocashort?id=1D9J OCA].~~	+	</StructureSection>
-		+
-	==~~Reference~~==	+
-	<~~ref group="xtra">PMID:010424354<~~/~~ref~~><~~references group="xtra"~~/>	+
	[[Category: Kim, Y.]]		[[Category: Kim, Y.]]
	[[Category: Oh, D.]]		[[Category: Oh, D.]]
	[[Category: Antimicrobial protein]]		[[Category: Antimicrobial protein]]
	[[Category: Helix-hinge-helix]]		[[Category: Helix-hinge-helix]]

OCA: Protected "1d9j" [edit=sysop:move=sysop]

2012-10-21T20:38:25Z

Protected "1d9j" [edit=sysop:move=sysop]

←Older revision

Revision as of 20:38, 21 October 2012

OCA at 20:38, 21 October 2012

2012-10-21T20:38:23Z

←Older revision		Revision as of 20:38, 21 October 2012
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-	{{Seed}}
	[[Image:1d9j.png\|left\|200px]]		[[Image:1d9j.png\|left\|200px]]

-	<!--
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	{{STRUCTURE_1d9j\| PDB=1d9j \| SCENE= }}		{{STRUCTURE_1d9j\| PDB=1d9j \| SCENE= }}

	===SOLUTION STRUCTURE OF CECROPIN A(1-8)-MAGAININ 2(1-12) HYBRID PEPTIDE===		===SOLUTION STRUCTURE OF CECROPIN A(1-8)-MAGAININ 2(1-12) HYBRID PEPTIDE===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_10424354}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 10424354 is the PubMed ID number.
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	{{ABSTRACT_PUBMED_10424354}}		{{ABSTRACT_PUBMED_10424354}}

	==About this Structure==		==About this Structure==
-	~~1D9J is a~~ [[~~Single protein~~]] structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1D9J OCA].	+	[[1d9j]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1D9J OCA].

	==Reference==		==Reference==
-	NMR structural characterization of cecropin A(1-8) - magainin 2(1-12) and cecropin A (1-8) - melittin (1-12) hybrid peptides., Oh D, Shin SY, Kang JH, Hahm KS, Kim KL, Kim Y, J Pept Res. 1999 May;53(5):578-89. PMID:~~[http:~~//~~www.ncbi.nlm.nih.gov/pubmed/10424354 10424354]~~	+	<ref group="xtra">PMID:010424354</ref><references group="xtra"/>
-	~~[[Category: Single protein]]~~	+
	[[Category: Kim, Y.]]		[[Category: Kim, Y.]]
	[[Category: Oh, D.]]		[[Category: Oh, D.]]
		+	[[Category: Antimicrobial protein]]
	[[Category: Helix-hinge-helix]]		[[Category: Helix-hinge-helix]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 22:42:37 2008''