1dc9 - Revision history

OCA at 06:51, 7 February 2024

2024-02-07T06:51:57Z

←Older revision		Revision as of 06:51, 7 February 2024
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	<StructureSection load='1dc9' size='340' side='right'caption='[[1dc9]], [[Resolution\|resolution]] 2.10Å' scene=''>		<StructureSection load='1dc9' size='340' side='right'caption='[[1dc9]], [[Resolution\|resolution]] 2.10Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1dc9]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Buffalo_rat Buffalo rat~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1DC9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1DC9 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1dc9]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1DC9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1DC9 FirstGlance]. <br>
-	</td></tr><tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat">~~<div style='overflow: auto; max~~-~~height: 3em;'>[[1icm\|1icm]]~~, [[~~1icn~~\|~~1icn~~]]~~, [[1ifc\|1ifc]], [[1ifb\|1ifb]], [[2ifb\|2ifb]]</div>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.1Å</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1dc9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1dc9 OCA], [https://pdbe.org/1dc9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1dc9 RCSB], [https://www.ebi.ac.uk/pdbsum/1dc9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1dc9 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1dc9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1dc9 OCA], [https://pdbe.org/1dc9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1dc9 RCSB], [https://www.ebi.ac.uk/pdbsum/1dc9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1dc9 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/FABPI_RAT FABPI_RAT]] FABP are thought to play a role in the intracellular transport of long-chain fatty acids and their acyl-CoA esters. FABP2 is probably involved in triglyceride-rich lipoprotein synthesis. Binds saturated long-chain fatty acids with a high affinity, but binds with a lower affinity to unsaturated long-chain fatty acids. FABP2 may also help maintain energy homeostasis by functioning as a lipid sensor (By similarity).	+	[https://www.uniprot.org/uniprot/FABPI_RAT FABPI_RAT] FABP are thought to play a role in the intracellular transport of long-chain fatty acids and their acyl-CoA esters. FABP2 is probably involved in triglyceride-rich lipoprotein synthesis. Binds saturated long-chain fatty acids with a high affinity, but binds with a lower affinity to unsaturated long-chain fatty acids. FABP2 may also help maintain energy homeostasis by functioning as a lipid sensor (By similarity).
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1dc9 ConSurf].		</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1dc9 ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
-	<div style="background-color:#fffaf0;">
-	== Publication Abstract from PubMed ==
-	A mutant of a beta-barrel protein, rat intestinal fatty acid binding protein, was predicted to be more stable than the wild-type protein due to a novel hydrogen bond. Equilibrium denaturation studies indicated the opposite: the V60N mutant protein was less stable. The folding transitions followed by CD and fluorescence were reversible and two-state for both mutant and wild-type protein. However, the rates of denaturation and renaturation of V60N were faster. During unfolding, the initial rate was associated with 75-80% of the fluorescence and all of the CD amplitude change. A subsequent rate accounted for the remaining fluorescence change for both proteins; thus the intermediate state lacked secondary structure. During folding, one rate was detected by both fluorescence and CD after an initial burst phase for both wild-type and mutant. An additional slower folding rate was detected by fluorescence for the mutant protein. The structure of the V60N mutant has been obtained and is nearly identical to prior crystal structures of IFABP. Analysis of mean differences in hydrogen bond and van der Waals interactions did not readily account for the stability loss due to the mutation. However, significant average differences of the solvent accessible surface and crystallographic displacement factors suggest entropic destabilization.
-
-	Properties and crystal structure of a beta-barrel folding mutant.,Ropson IJ, Yowler BC, Dalessio PM, Banaszak L, Thompson J Biophys J. 2000 Mar;78(3):1551-60. PMID:10692339<ref>PMID:10692339</ref>
-
-	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	</div>
-	<div class="pdbe-citations 1dc9" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
	*[[Fatty acid-binding protein 3D structures\|Fatty acid-binding protein 3D structures]]		*[[Fatty acid-binding protein 3D structures\|Fatty acid-binding protein 3D structures]]
-	== References ==
-	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Buffalo rat]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Banaszak, L]]	+	[[Category: Rattus norvegicus]]
-	[[Category: Dalessio~~, P M~~]]	+	[[Category: Banaszak L]]
-	[[Category: Ropson~~, I J~~]]	+	[[Category: Dalessio PM]]
-	[[Category: Thompson, J]]	+	[[Category: Ropson IJ]]
-	[[Category: Yowler~~, B C]]~~	+	[[Category: Thompson J]]
-	~~[[Category: Beta- barrel]]~~	+	[[Category: Yowler BC]]
-	~~[[Category: Fatty acid binding protein]]~~	+
-	~~[[Category: Intracellular lipid binding protein]]~~	+
-	~~[[Category: Lipid binding protein]]~~	+
-	~~[[Category: Mutant~~]]	+

OCA at 18:24, 10 March 2021

2021-03-10T18:24:32Z

←Older revision		Revision as of 18:24, 10 March 2021
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	<StructureSection load='1dc9' size='340' side='right'caption='[[1dc9]], [[Resolution\|resolution]] 2.10Å' scene=''>		<StructureSection load='1dc9' size='340' side='right'caption='[[1dc9]], [[Resolution\|resolution]] 2.10Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1dc9]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Buffalo_rat Buffalo rat]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1DC9 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1DC9 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1dc9]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Buffalo_rat Buffalo rat]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1DC9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1DC9 FirstGlance]. <br>
-	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1icm\|1icm]], [[1icn\|1icn]], [[1ifc\|1ifc]], [[1ifb\|1ifb]], [[2ifb\|2ifb]]</td></tr>	+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1icm\|1icm]], [[1icn\|1icn]], [[1ifc\|1ifc]], [[1ifb\|1ifb]], [[2ifb\|2ifb]]</div></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1dc9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1dc9 OCA], [~~http~~://pdbe.org/1dc9 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=1dc9 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/1dc9 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=1dc9 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1dc9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1dc9 OCA], [https://pdbe.org/1dc9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1dc9 RCSB], [https://www.ebi.ac.uk/pdbsum/1dc9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1dc9 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/FABPI_RAT FABPI_RAT]] FABP are thought to play a role in the intracellular transport of long-chain fatty acids and their acyl-CoA esters. FABP2 is probably involved in triglyceride-rich lipoprotein synthesis. Binds saturated long-chain fatty acids with a high affinity, but binds with a lower affinity to unsaturated long-chain fatty acids. FABP2 may also help maintain energy homeostasis by functioning as a lipid sensor (By similarity).	+	[[https://www.uniprot.org/uniprot/FABPI_RAT FABPI_RAT]] FABP are thought to play a role in the intracellular transport of long-chain fatty acids and their acyl-CoA esters. FABP2 is probably involved in triglyceride-rich lipoprotein synthesis. Binds saturated long-chain fatty acids with a high affinity, but binds with a lower affinity to unsaturated long-chain fatty acids. FABP2 may also help maintain energy homeostasis by functioning as a lipid sensor (By similarity).
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	==See Also==		==See Also==
-	*[[Fatty acid-binding protein\|Fatty acid-binding protein]]	+	*[[Fatty acid-binding protein 3D structures\|Fatty acid-binding protein 3D structures]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 23:24, 5 June 2019

2019-06-05T23:24:33Z

←Older revision		Revision as of 23:24, 5 June 2019
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	==PROPERTIES AND CRYSTAL STRUCTURE OF A BETA-BARREL FOLDING MUTANT, V60N INTESTINAL FATTY ACID BINDING PROTEIN (IFABP)==		==PROPERTIES AND CRYSTAL STRUCTURE OF A BETA-BARREL FOLDING MUTANT, V60N INTESTINAL FATTY ACID BINDING PROTEIN (IFABP)==
-	<StructureSection load='1dc9' size='340' side='right' caption='[[1dc9]], [[Resolution\|resolution]] 2.10Å' scene=''>	+	<StructureSection load='1dc9' size='340' side='right'caption='[[1dc9]], [[Resolution\|resolution]] 2.10Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1dc9]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1DC9 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1DC9 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1dc9]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Buffalo_rat Buffalo rat]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1DC9 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1DC9 FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1icm\|1icm]], [[1icn\|1icn]], [[1ifc\|1ifc]], [[1ifb\|1ifb]], [[2ifb\|2ifb]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1icm\|1icm]], [[1icn\|1icn]], [[1ifc\|1ifc]], [[1ifb\|1ifb]], [[2ifb\|2ifb]]</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1dc9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1dc9 OCA], [http://pdbe.org/1dc9 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1dc9 RCSB], [http://www.ebi.ac.uk/pdbsum/1dc9 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1dc9 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1dc9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1dc9 OCA], [http://pdbe.org/1dc9 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1dc9 RCSB], [http://www.ebi.ac.uk/pdbsum/1dc9 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1dc9 ProSAT]</span></td></tr>
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	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/dc/1dc9_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/dc/1dc9_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Buffalo rat]]
		+	[[Category: Large Structures]]
	[[Category: Banaszak, L]]		[[Category: Banaszak, L]]
	[[Category: Dalessio, P M]]		[[Category: Dalessio, P M]]

OCA at 04:02, 30 August 2017

2017-08-30T04:02:07Z

←Older revision		Revision as of 04:02, 30 August 2017
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		+
	==PROPERTIES AND CRYSTAL STRUCTURE OF A BETA-BARREL FOLDING MUTANT, V60N INTESTINAL FATTY ACID BINDING PROTEIN (IFABP)==		==PROPERTIES AND CRYSTAL STRUCTURE OF A BETA-BARREL FOLDING MUTANT, V60N INTESTINAL FATTY ACID BINDING PROTEIN (IFABP)==
	<StructureSection load='1dc9' size='340' side='right' caption='[[1dc9]], [[Resolution\|resolution]] 2.10Å' scene=''>		<StructureSection load='1dc9' size='340' side='right' caption='[[1dc9]], [[Resolution\|resolution]] 2.10Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1dc9]] is a 1 chain structure ~~with sequence from [http://en.wikipedia.org/wiki/Buffalo_rat Buffalo rat]~~. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1DC9 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1DC9 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1dc9]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1DC9 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1DC9 FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1icm\|1icm]], [[1icn\|1icn]], [[1ifc\|1ifc]], [[1ifb\|1ifb]], [[2ifb\|2ifb]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1icm\|1icm]], [[1icn\|1icn]], [[1ifc\|1ifc]], [[1ifb\|1ifb]], [[2ifb\|2ifb]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1dc9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1dc9 OCA], [http://pdbe.org/1dc9 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1dc9 RCSB], [http://www.ebi.ac.uk/pdbsum/1dc9 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1dc9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1dc9 OCA], [http://pdbe.org/1dc9 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1dc9 RCSB], [http://www.ebi.ac.uk/pdbsum/1dc9 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1dc9 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 16:		Line 17:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1dc9 ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 34:		Line 35:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Buffalo rat]]
	[[Category: Banaszak, L]]		[[Category: Banaszak, L]]
	[[Category: Dalessio, P M]]		[[Category: Dalessio, P M]]

OCA at 01:59, 12 September 2015

2015-09-12T01:59:54Z

←Older revision		Revision as of 01:59, 12 September 2015
Line 2:		Line 2:
	<StructureSection load='1dc9' size='340' side='right' caption='[[1dc9]], [[Resolution\|resolution]] 2.10Å' scene=''>		<StructureSection load='1dc9' size='340' side='right' caption='[[1dc9]], [[Resolution\|resolution]] 2.10Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1dc9]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Rattus_norvegicus Rattus norvegicus~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1DC9 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1DC9 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1dc9]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Buffalo_rat Buffalo rat]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1DC9 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1DC9 FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1icm\|1icm]], [[1icn\|1icn]], [[1ifc\|1ifc]], [[1ifb\|1ifb]], [[2ifb\|2ifb]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1icm\|1icm]], [[1icn\|1icn]], [[1ifc\|1ifc]], [[1ifb\|1ifb]], [[2ifb\|2ifb]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1dc9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1dc9 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1dc9 RCSB], [http://www.ebi.ac.uk/pdbsum/1dc9 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1dc9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1dc9 OCA], [http://pdbe.org/1dc9 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1dc9 RCSB], [http://www.ebi.ac.uk/pdbsum/1dc9 PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 26:		Line 26:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 1dc9" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 33:		Line 34:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Rattus norvegicus~~]]	+	[[Category: Buffalo rat]]
	[[Category: Banaszak, L]]		[[Category: Banaszak, L]]
	[[Category: Dalessio, P M]]		[[Category: Dalessio, P M]]

OCA at 22:22, 25 December 2014

2014-12-25T22:22:47Z

←Older revision		Revision as of 22:22, 25 December 2014
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	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1dc9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1dc9 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1dc9 RCSB], [http://www.ebi.ac.uk/pdbsum/1dc9 PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1dc9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1dc9 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1dc9 RCSB], [http://www.ebi.ac.uk/pdbsum/1dc9 PDBsum]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/FABPI_RAT FABPI_RAT]] FABP are thought to play a role in the intracellular transport of long-chain fatty acids and their acyl-CoA esters. FABP2 is probably involved in triglyceride-rich lipoprotein synthesis. Binds saturated long-chain fatty acids with a high affinity, but binds with a lower affinity to unsaturated long-chain fatty acids. FABP2 may also help maintain energy homeostasis by functioning as a lipid sensor (By similarity).
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]

OCA at 00:06, 23 December 2014

2014-12-23T00:06:07Z

←Older revision		Revision as of 00:06, 23 December 2014
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	</StructureSection>		</StructureSection>
	[[Category: Rattus norvegicus]]		[[Category: Rattus norvegicus]]
-	[[Category: Banaszak, L.]]	+	[[Category: Banaszak, L]]
-	[[Category: Dalessio, P M.]]	+	[[Category: Dalessio, P M]]
-	[[Category: Ropson, I J.]]	+	[[Category: Ropson, I J]]
-	[[Category: Thompson, J.]]	+	[[Category: Thompson, J]]
-	[[Category: Yowler, B C.]]	+	[[Category: Yowler, B C]]
	[[Category: Beta- barrel]]		[[Category: Beta- barrel]]
	[[Category: Fatty acid binding protein]]		[[Category: Fatty acid binding protein]]

OCA at 06:21, 10 October 2014

2014-10-10T06:21:41Z

←Older revision		Revision as of 06:21, 10 October 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1dc9]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1DC9 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1DC9 FirstGlance]. <br>		<table><tr><td colspan='2'>[[1dc9]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1DC9 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1DC9 FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1icm\|1icm]], [[1icn\|1icn]], [[1ifc\|1ifc]], [[1ifb\|1ifb]], [[2ifb\|2ifb]]</td></tr>	+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1icm\|1icm]], [[1icn\|1icn]], [[1ifc\|1ifc]], [[1ifb\|1ifb]], [[2ifb\|2ifb]]</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1dc9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1dc9 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1dc9 RCSB], [http://www.ebi.ac.uk/pdbsum/1dc9 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1dc9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1dc9 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1dc9 RCSB], [http://www.ebi.ac.uk/pdbsum/1dc9 PDBsum]</span></td></tr>
-	<table>	+	</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]

OCA at 06:29, 4 September 2014

2014-09-04T06:29:17Z

←Older revision		Revision as of 06:29, 4 September 2014
Line 1:		Line 1:
-	[[~~Image:~~1dc9.~~png~~\|~~left~~\|200px]]	+	==PROPERTIES AND CRYSTAL STRUCTURE OF A BETA-BARREL FOLDING MUTANT, V60N INTESTINAL FATTY ACID BINDING PROTEIN (IFABP)==
		+	<StructureSection load='1dc9' size='340' side='right' caption='[[1dc9]], [[Resolution\|resolution]] 2.10Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[1dc9]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1DC9 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1DC9 FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1icm\|1icm]], [[1icn\|1icn]], [[1ifc\|1ifc]], [[1ifb\|1ifb]], [[2ifb\|2ifb]]</td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1dc9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1dc9 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1dc9 RCSB], [http://www.ebi.ac.uk/pdbsum/1dc9 PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/dc/1dc9_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	A mutant of a beta-barrel protein, rat intestinal fatty acid binding protein, was predicted to be more stable than the wild-type protein due to a novel hydrogen bond. Equilibrium denaturation studies indicated the opposite: the V60N mutant protein was less stable. The folding transitions followed by CD and fluorescence were reversible and two-state for both mutant and wild-type protein. However, the rates of denaturation and renaturation of V60N were faster. During unfolding, the initial rate was associated with 75-80% of the fluorescence and all of the CD amplitude change. A subsequent rate accounted for the remaining fluorescence change for both proteins; thus the intermediate state lacked secondary structure. During folding, one rate was detected by both fluorescence and CD after an initial burst phase for both wild-type and mutant. An additional slower folding rate was detected by fluorescence for the mutant protein. The structure of the V60N mutant has been obtained and is nearly identical to prior crystal structures of IFABP. Analysis of mean differences in hydrogen bond and van der Waals interactions did not readily account for the stability loss due to the mutation. However, significant average differences of the solvent accessible surface and crystallographic displacement factors suggest entropic destabilization.

-	~~{{STRUCTURE_1dc9\| PDB=1dc9 \| SCENE= }}~~	+	Properties and crystal structure of a beta-barrel folding mutant.,Ropson IJ, Yowler BC, Dalessio PM, Banaszak L, Thompson J Biophys J. 2000 Mar;78(3):1551-60. PMID:10692339<ref>PMID:10692339</ref>

-	~~===PROPERTIES AND CRYSTAL STRUCTURE OF A BETA-BARREL FOLDING MUTANT~~, ~~V60N INTESTINAL FATTY ACID BINDING PROTEIN (IFABP)===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>

-	~~{{ABSTRACT_PUBMED_10692339}}~~	+	==See Also==
-		+	*[[Fatty acid-binding protein\|Fatty acid-binding protein]]
-	==~~About this Structure~~==	+	== References ==
-	[[~~1dc9~~]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1DC9 OCA].	+	<references/>
-		+	__TOC__
-	==~~Reference~~==	+	</StructureSection>
-	<~~ref group="xtra">PMID:010692339<~~/~~ref~~><~~references group="xtra"~~/>	+
	[[Category: Rattus norvegicus]]		[[Category: Rattus norvegicus]]
	[[Category: Banaszak, L.]]		[[Category: Banaszak, L.]]

OCA: Protected "1dc9" [edit=sysop:move=sysop]

2012-10-21T19:58:26Z

Protected "1dc9" [edit=sysop:move=sysop]

←Older revision

Revision as of 19:58, 21 October 2012