1dd7 - Revision history

OCA at 08:23, 22 May 2024

2024-05-22T08:23:45Z

←Older revision		Revision as of 08:23, 22 May 2024
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1dd7]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1DD7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1DD7 FirstGlance]. <br>		<table><tr><td colspan='2'>[[1dd7]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1DD7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1DD7 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=1PM:METHYL+(3S)-3-{2-[(1,3-BENZODIOXOL-5-YLMETHYL)AMINO]-2-OXOETHYL}-4-[2-(1H-IMIDAZOL-1-YL)PYRIMIDIN-4-YL]PIPERAZINE-1-CARBOXYLATE'>1PM</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=SO3:SULFITE+ION'>SO3</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.25Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=1PM:METHYL+(3S)-3-{2-[(1,3-BENZODIOXOL-5-YLMETHYL)AMINO]-2-OXOETHYL}-4-[2-(1H-IMIDAZOL-1-YL)PYRIMIDIN-4-YL]PIPERAZINE-1-CARBOXYLATE'>1PM</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=SO3:SULFITE+ION'>SO3</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1dd7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1dd7 OCA], [https://pdbe.org/1dd7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1dd7 RCSB], [https://www.ebi.ac.uk/pdbsum/1dd7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1dd7 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1dd7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1dd7 OCA], [https://pdbe.org/1dd7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1dd7 RCSB], [https://www.ebi.ac.uk/pdbsum/1dd7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1dd7 ProSAT]</span></td></tr>
	</table>		</table>

OCA at 09:35, 21 December 2022

2022-12-21T09:35:39Z

←Older revision		Revision as of 09:35, 21 December 2022
Line 3:		Line 3:
	<StructureSection load='1dd7' size='340' side='right'caption='[[1dd7]], [[Resolution\|resolution]] 2.25Å' scene=''>		<StructureSection load='1dd7' size='340' side='right'caption='[[1dd7]], [[Resolution\|resolution]] 2.25Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1dd7]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Lk3_transgenic_mice Lk3 transgenic mice~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1DD7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1DD7 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1dd7]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1DD7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1DD7 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=1PM:METHYL+(3S)-3-{2-[(1,3-BENZODIOXOL-5-YLMETHYL)AMINO]-2-OXOETHYL}-4-[2-(1H-IMIDAZOL-1-YL)PYRIMIDIN-4-YL]PIPERAZINE-1-CARBOXYLATE'>1PM</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=SO3:SULFITE+ION'>SO3</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=1PM:METHYL+(3S)-3-{2-[(1,3-BENZODIOXOL-5-YLMETHYL)AMINO]-2-OXOETHYL}-4-[2-(1H-IMIDAZOL-1-YL)PYRIMIDIN-4-YL]PIPERAZINE-1-CARBOXYLATE'>1PM</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=SO3:SULFITE+ION'>SO3</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1nos\|1nos]], [[1noc\|1noc]], [[1nod\|1nod]], [[2nos\|2nos]], [[1nsi\|1nsi]]</div></td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Nitric-oxide_synthase_(NADPH_dependent) Nitric-oxide synthase (NADPH dependent)], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.14.13.39 1.14.13.39] </span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1dd7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1dd7 OCA], [https://pdbe.org/1dd7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1dd7 RCSB], [https://www.ebi.ac.uk/pdbsum/1dd7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1dd7 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1dd7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1dd7 OCA], [https://pdbe.org/1dd7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1dd7 RCSB], [https://www.ebi.ac.uk/pdbsum/1dd7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1dd7 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/NOS2_MOUSE NOS2_MOUSE]] Produces nitric oxide (NO) which is a messenger molecule with diverse functions throughout the body. In macrophages, NO mediates tumoricidal and bactericidal actions. Also has nitrosylase activity and mediates cysteine S-nitrosylation of cytoplasmic target proteins such COX2.<ref>PMID:16373578</ref>	+	[https://www.uniprot.org/uniprot/NOS2_MOUSE NOS2_MOUSE] Produces nitric oxide (NO) which is a messenger molecule with diverse functions throughout the body. In macrophages, NO mediates tumoricidal and bactericidal actions. Also has nitrosylase activity and mediates cysteine S-nitrosylation of cytoplasmic target proteins such COX2.<ref>PMID:16373578</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Lk3 transgenic mice~~]]	+	[[Category: Mus musculus]]
-	[[Category: Adler, M]]	+	[[Category: Adler M]]
-	[[Category: Whitlow, M]]	+	[[Category: Whitlow M]]
-	~~[[Category: Dimerization]]~~	+
-	~~[[Category: Heme]]~~	+
-	~~[[Category: Inhibitor]]~~	+
-	~~[[Category: L-arginine monooxygenase]]~~	+
-	~~[[Category: Nitric oxide]]~~	+
-	~~[[Category: No]]~~	+
-	~~[[Category: Oxidoreductase~~]]	+

OCA at 10:00, 7 July 2021

2021-07-07T10:00:13Z

←Older revision		Revision as of 10:00, 7 July 2021
Line 3:		Line 3:
	<StructureSection load='1dd7' size='340' side='right'caption='[[1dd7]], [[Resolution\|resolution]] 2.25Å' scene=''>		<StructureSection load='1dd7' size='340' side='right'caption='[[1dd7]], [[Resolution\|resolution]] 2.25Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1dd7]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1DD7 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1DD7 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1dd7]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1DD7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1DD7 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=1PM:METHYL+(3S)-3-{2-[(1,3-BENZODIOXOL-5-YLMETHYL)AMINO]-2-OXOETHYL}-4-[2-(1H-IMIDAZOL-1-YL)PYRIMIDIN-4-YL]PIPERAZINE-1-CARBOXYLATE'>1PM</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=SO3:SULFITE+ION'>SO3</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=1PM:METHYL+(3S)-3-{2-[(1,3-BENZODIOXOL-5-YLMETHYL)AMINO]-2-OXOETHYL}-4-[2-(1H-IMIDAZOL-1-YL)PYRIMIDIN-4-YL]PIPERAZINE-1-CARBOXYLATE'>1PM</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=SO3:SULFITE+ION'>SO3</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1nos\|1nos]], [[1noc\|1noc]], [[1nod\|1nod]], [[2nos\|2nos]], [[1nsi\|1nsi]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1nos\|1nos]], [[1noc\|1noc]], [[1nod\|1nod]], [[2nos\|2nos]], [[1nsi\|1nsi]]</div></td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://en.wikipedia.org/wiki/Nitric-oxide_synthase_(NADPH_dependent) Nitric-oxide synthase (NADPH dependent)], with EC number [~~http~~://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.14.13.39 1.14.13.39] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Nitric-oxide_synthase_(NADPH_dependent) Nitric-oxide synthase (NADPH dependent)], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.14.13.39 1.14.13.39] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1dd7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1dd7 OCA], [~~http~~://pdbe.org/1dd7 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=1dd7 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/1dd7 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=1dd7 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1dd7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1dd7 OCA], [https://pdbe.org/1dd7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1dd7 RCSB], [https://www.ebi.ac.uk/pdbsum/1dd7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1dd7 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/NOS2_MOUSE NOS2_MOUSE]] Produces nitric oxide (NO) which is a messenger molecule with diverse functions throughout the body. In macrophages, NO mediates tumoricidal and bactericidal actions. Also has nitrosylase activity and mediates cysteine S-nitrosylation of cytoplasmic target proteins such COX2.<ref>PMID:16373578</ref>	+	[[https://www.uniprot.org/uniprot/NOS2_MOUSE NOS2_MOUSE]] Produces nitric oxide (NO) which is a messenger molecule with diverse functions throughout the body. In macrophages, NO mediates tumoricidal and bactericidal actions. Also has nitrosylase activity and mediates cysteine S-nitrosylation of cytoplasmic target proteins such COX2.<ref>PMID:16373578</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 32:		Line 32:

	==See Also==		==See Also==
-	*[[Nitric Oxide Synthase\|Nitric Oxide Synthase]]	+	*[[Nitric Oxide Synthase 3D structures\|Nitric Oxide Synthase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 06:41, 10 October 2019

2019-10-10T06:41:29Z

←Older revision		Revision as of 06:41, 10 October 2019
Line 1:		Line 1:

	==MURINE INDUCIBLE NITRIC OXIDE SYNTHASE OXYGENASE DOMAIN (DELTA 114) (N-[(1,3-BENZODIOXOL-5-YL)METHYL]-1-[2-(1H-IMIDAZOL-1-YL)PYRIMIDIN-4-YL]-4-(METHOXYCARBONYL)-PIPERAZINE-2-ACETAMIDE COMPLEX==		==MURINE INDUCIBLE NITRIC OXIDE SYNTHASE OXYGENASE DOMAIN (DELTA 114) (N-[(1,3-BENZODIOXOL-5-YL)METHYL]-1-[2-(1H-IMIDAZOL-1-YL)PYRIMIDIN-4-YL]-4-(METHOXYCARBONYL)-PIPERAZINE-2-ACETAMIDE COMPLEX==
-	<StructureSection load='1dd7' size='340' side='right' caption='[[1dd7]], [[Resolution\|resolution]] 2.25Å' scene=''>	+	<StructureSection load='1dd7' size='340' side='right'caption='[[1dd7]], [[Resolution\|resolution]] 2.25Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1dd7]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1DD7 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1DD7 FirstGlance]. <br>		<table><tr><td colspan='2'>[[1dd7]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1DD7 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1DD7 FirstGlance]. <br>
Line 30:		Line 30:
	</div>		</div>
	<div class="pdbe-citations 1dd7" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 1dd7" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Nitric Oxide Synthase\|Nitric Oxide Synthase]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Lk3 transgenic mice]]		[[Category: Lk3 transgenic mice]]
	[[Category: Adler, M]]		[[Category: Adler, M]]

OCA at 08:22, 6 December 2017

2017-12-06T08:22:26Z

←Older revision		Revision as of 08:22, 6 December 2017
Line 1:		Line 1:
		+
	==MURINE INDUCIBLE NITRIC OXIDE SYNTHASE OXYGENASE DOMAIN (DELTA 114) (N-[(1,3-BENZODIOXOL-5-YL)METHYL]-1-[2-(1H-IMIDAZOL-1-YL)PYRIMIDIN-4-YL]-4-(METHOXYCARBONYL)-PIPERAZINE-2-ACETAMIDE COMPLEX==		==MURINE INDUCIBLE NITRIC OXIDE SYNTHASE OXYGENASE DOMAIN (DELTA 114) (N-[(1,3-BENZODIOXOL-5-YL)METHYL]-1-[2-(1H-IMIDAZOL-1-YL)PYRIMIDIN-4-YL]-4-(METHOXYCARBONYL)-PIPERAZINE-2-ACETAMIDE COMPLEX==
	<StructureSection load='1dd7' size='340' side='right' caption='[[1dd7]], [[Resolution\|resolution]] 2.25Å' scene=''>		<StructureSection load='1dd7' size='340' side='right' caption='[[1dd7]], [[Resolution\|resolution]] 2.25Å' scene=''>
Line 6:		Line 7:
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1nos\|1nos]], [[1noc\|1noc]], [[1nod\|1nod]], [[2nos\|2nos]], [[1nsi\|1nsi]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1nos\|1nos]], [[1noc\|1noc]], [[1nod\|1nod]], [[2nos\|2nos]], [[1nsi\|1nsi]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Nitric-oxide_synthase_(NADPH_dependent) Nitric-oxide synthase (NADPH dependent)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.14.13.39 1.14.13.39] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Nitric-oxide_synthase_(NADPH_dependent) Nitric-oxide synthase (NADPH dependent)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.14.13.39 1.14.13.39] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1dd7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1dd7 OCA], [http://pdbe.org/1dd7 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1dd7 RCSB], [http://www.ebi.ac.uk/pdbsum/1dd7 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1dd7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1dd7 OCA], [http://pdbe.org/1dd7 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1dd7 RCSB], [http://www.ebi.ac.uk/pdbsum/1dd7 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1dd7 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 14:		Line 15:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/dd/1dd7_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/dd/1dd7_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
Line 29:		Line 30:
	</div>		</div>
	<div class="pdbe-citations 1dd7" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 1dd7" style="background-color:#fffaf0;"></div>
-
-	==See Also==
-	*[[Nitric Oxide Synthase\|Nitric Oxide Synthase]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 19:35, 8 February 2016

2016-02-08T19:35:16Z

←Older revision		Revision as of 19:35, 8 February 2016
Line 18:		Line 18:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1dd7 ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 14:44, 10 September 2015

2015-09-10T14:44:13Z

←Older revision		Revision as of 14:44, 10 September 2015
Line 2:		Line 2:
	<StructureSection load='1dd7' size='340' side='right' caption='[[1dd7]], [[Resolution\|resolution]] 2.25Å' scene=''>		<StructureSection load='1dd7' size='340' side='right' caption='[[1dd7]], [[Resolution\|resolution]] 2.25Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1dd7]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Mus_musculus Mus musculus~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1DD7 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1DD7 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1dd7]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1DD7 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1DD7 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=1PM:METHYL+(3S)-3-{2-[(1,3-BENZODIOXOL-5-YLMETHYL)AMINO]-2-OXOETHYL}-4-[2-(1H-IMIDAZOL-1-YL)PYRIMIDIN-4-YL]PIPERAZINE-1-CARBOXYLATE'>1PM</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=SO3:SULFITE+ION'>SO3</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=1PM:METHYL+(3S)-3-{2-[(1,3-BENZODIOXOL-5-YLMETHYL)AMINO]-2-OXOETHYL}-4-[2-(1H-IMIDAZOL-1-YL)PYRIMIDIN-4-YL]PIPERAZINE-1-CARBOXYLATE'>1PM</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=SO3:SULFITE+ION'>SO3</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1nos\|1nos]], [[1noc\|1noc]], [[1nod\|1nod]], [[2nos\|2nos]], [[1nsi\|1nsi]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1nos\|1nos]], [[1noc\|1noc]], [[1nod\|1nod]], [[2nos\|2nos]], [[1nsi\|1nsi]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Nitric-oxide_synthase_(NADPH_dependent) Nitric-oxide synthase (NADPH dependent)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.14.13.39 1.14.13.39] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Nitric-oxide_synthase_(NADPH_dependent) Nitric-oxide synthase (NADPH dependent)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.14.13.39 1.14.13.39] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1dd7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1dd7 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1dd7 RCSB], [http://www.ebi.ac.uk/pdbsum/1dd7 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1dd7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1dd7 OCA], [http://pdbe.org/1dd7 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1dd7 RCSB], [http://www.ebi.ac.uk/pdbsum/1dd7 PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 28:		Line 28:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 1dd7" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 35:		Line 36:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Mus musculus~~]]	+	[[Category: Lk3 transgenic mice]]
	[[Category: Adler, M]]		[[Category: Adler, M]]
	[[Category: Whitlow, M]]		[[Category: Whitlow, M]]

OCA at 01:40, 25 December 2014

2014-12-25T01:40:54Z

←Older revision		Revision as of 01:40, 25 December 2014
Line 8:		Line 8:
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1dd7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1dd7 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1dd7 RCSB], [http://www.ebi.ac.uk/pdbsum/1dd7 PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1dd7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1dd7 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1dd7 RCSB], [http://www.ebi.ac.uk/pdbsum/1dd7 PDBsum]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/NOS2_MOUSE NOS2_MOUSE]] Produces nitric oxide (NO) which is a messenger molecule with diverse functions throughout the body. In macrophages, NO mediates tumoricidal and bactericidal actions. Also has nitrosylase activity and mediates cysteine S-nitrosylation of cytoplasmic target proteins such COX2.<ref>PMID:16373578</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]

OCA at 23:26, 22 December 2014

2014-12-22T23:26:04Z

←Older revision		Revision as of 23:26, 22 December 2014
Line 34:		Line 34:
	</StructureSection>		</StructureSection>
	[[Category: Mus musculus]]		[[Category: Mus musculus]]
-	[[Category: Adler, M.]]	+	[[Category: Adler, M]]
-	[[Category: Whitlow, M.]]	+	[[Category: Whitlow, M]]
	[[Category: Dimerization]]		[[Category: Dimerization]]
	[[Category: Heme]]		[[Category: Heme]]

OCA at 05:50, 10 October 2014

2014-10-10T05:50:29Z

←Older revision		Revision as of 05:50, 10 October 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1dd7]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1DD7 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1DD7 FirstGlance]. <br>		<table><tr><td colspan='2'>[[1dd7]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1DD7 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1DD7 FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=1PM:METHYL+(3S)-3-{2-[(1,3-BENZODIOXOL-5-YLMETHYL)AMINO]-2-OXOETHYL}-4-[2-(1H-IMIDAZOL-1-YL)PYRIMIDIN-4-YL]PIPERAZINE-1-CARBOXYLATE'>1PM</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=SO3:SULFITE+ION'>SO3</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=1PM:METHYL+(3S)-3-{2-[(1,3-BENZODIOXOL-5-YLMETHYL)AMINO]-2-OXOETHYL}-4-[2-(1H-IMIDAZOL-1-YL)PYRIMIDIN-4-YL]PIPERAZINE-1-CARBOXYLATE'>1PM</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=SO3:SULFITE+ION'>SO3</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1nos\|1nos]], [[1noc\|1noc]], [[1nod\|1nod]], [[2nos\|2nos]], [[1nsi\|1nsi]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1nos\|1nos]], [[1noc\|1noc]], [[1nod\|1nod]], [[2nos\|2nos]], [[1nsi\|1nsi]]</td></tr>
-	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Nitric-oxide_synthase_(NADPH_dependent) Nitric-oxide synthase (NADPH dependent)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.14.13.39 1.14.13.39] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Nitric-oxide_synthase_(NADPH_dependent) Nitric-oxide synthase (NADPH dependent)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.14.13.39 1.14.13.39] </span></td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1dd7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1dd7 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1dd7 RCSB], [http://www.ebi.ac.uk/pdbsum/1dd7 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1dd7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1dd7 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1dd7 RCSB], [http://www.ebi.ac.uk/pdbsum/1dd7 PDBsum]</span></td></tr>
-	<table>	+	</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]