1dr0 - Revision history

OCA at 05:57, 9 August 2023

2023-08-09T05:57:44Z

←Older revision		Revision as of 05:57, 9 August 2023
Line 3:		Line 3:
	<StructureSection load='1dr0' size='340' side='right'caption='[[1dr0]], [[Resolution\|resolution]] 2.20Å' scene=''>		<StructureSection load='1dr0' size='340' side='right'caption='[[1dr0]], [[Resolution\|resolution]] 2.20Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1dr0]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Thet8 Thet8~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1DR0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1DR0 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1dr0]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Thermus_thermophilus_HB8 Thermus thermophilus HB8]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1DR0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1DR0 FirstGlance]. <br>
-	</td></tr><tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"~~><div style='overflow: auto; max-height: 3em;'>[[1osj\|1osj]], [[1dpz\|1dpz]], [[1dr8\|1dr8]]</div></td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.2Å</td></tr>
-	~~<tr~~ id~~='gene'><td class~~="~~sblockLbl~~">~~<b>~~[[~~Gene~~\|~~Gene:~~]]~~</b></td><td class="sblockDat">LEUB ([https://www~~.~~ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info~~&~~srchmode=5&id=300852 THET8])</td></tr>~~	+
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/3-isopropylmalate_dehydrogenase 3-isopropylmalate dehydrogenase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.1.85 1.1.1.85] </span></td></tr>	+
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1dr0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1dr0 OCA], [https://pdbe.org/1dr0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1dr0 RCSB], [https://www.ebi.ac.uk/pdbsum/1dr0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1dr0 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1dr0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1dr0 OCA], [https://pdbe.org/1dr0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1dr0 RCSB], [https://www.ebi.ac.uk/pdbsum/1dr0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1dr0 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/LEU3_THET8 LEU3_THET8]] Catalyzes the oxidation of 3-carboxy-2-hydroxy-4-methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2-oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate.[HAMAP-Rule:MF_01033]	+	[https://www.uniprot.org/uniprot/LEU3_THET8 LEU3_THET8] Catalyzes the oxidation of 3-carboxy-2-hydroxy-4-methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2-oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate.[HAMAP-Rule:MF_01033]
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 37:		Line 35:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: 3-isopropylmalate dehydrogenase]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Thet8~~]]	+	[[Category: Thermus thermophilus HB8]]
-	[[Category: Akanuma, S]]	+	[[Category: Akanuma S]]
-	[[Category: Nurachman, Z]]	+	[[Category: Nurachman Z]]
-	[[Category: Oshima, T]]	+	[[Category: Oshima T]]
-	[[Category: Sato, T]]	+	[[Category: Sato T]]
-	[[Category: Tanaka, N]]	+	[[Category: Tanaka N]]
-	~~[[Category: Dehydrogenase]]~~	+
-	~~[[Category: Minor groove]]~~	+
-	~~[[Category: Oxidoreductase]]~~	+
-	~~[[Category: Paperclip motion~~]]	+

OCA at 18:33, 10 March 2021

2021-03-10T18:33:18Z

←Older revision		Revision as of 18:33, 10 March 2021
Line 3:		Line 3:
	<StructureSection load='1dr0' size='340' side='right'caption='[[1dr0]], [[Resolution\|resolution]] 2.20Å' scene=''>		<StructureSection load='1dr0' size='340' side='right'caption='[[1dr0]], [[Resolution\|resolution]] 2.20Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1dr0]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Thet8 Thet8]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1DR0 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1DR0 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1dr0]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Thet8 Thet8]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1DR0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1DR0 FirstGlance]. <br>
-	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1osj\|1osj]], [[1dpz\|1dpz]], [[1dr8\|1dr8]]</td></tr>	+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1osj\|1osj]], [[1dpz\|1dpz]], [[1dr8\|1dr8]]</div></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">LEUB ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=300852 THET8])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">LEUB ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=300852 THET8])</td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://en.wikipedia.org/wiki/3-isopropylmalate_dehydrogenase 3-isopropylmalate dehydrogenase], with EC number [~~http~~://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.1.85 1.1.1.85] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/3-isopropylmalate_dehydrogenase 3-isopropylmalate dehydrogenase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.1.85 1.1.1.85] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1dr0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1dr0 OCA], [~~http~~://pdbe.org/1dr0 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=1dr0 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/1dr0 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=1dr0 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1dr0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1dr0 OCA], [https://pdbe.org/1dr0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1dr0 RCSB], [https://www.ebi.ac.uk/pdbsum/1dr0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1dr0 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/LEU3_THET8 LEU3_THET8]] Catalyzes the oxidation of 3-carboxy-2-hydroxy-4-methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2-oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate.[HAMAP-Rule:MF_01033]	+	[[https://www.uniprot.org/uniprot/LEU3_THET8 LEU3_THET8]] Catalyzes the oxidation of 3-carboxy-2-hydroxy-4-methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2-oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate.[HAMAP-Rule:MF_01033]
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]

OCA at 00:17, 6 June 2019

2019-06-06T00:17:07Z

←Older revision		Revision as of 00:17, 6 June 2019
Line 1:		Line 1:

	==STRUCTURE OF MODIFIED 3-ISOPROPYLMALATE DEHYDROGENASE AT THE C-TERMINUS, HD708==		==STRUCTURE OF MODIFIED 3-ISOPROPYLMALATE DEHYDROGENASE AT THE C-TERMINUS, HD708==
-	<StructureSection load='1dr0' size='340' side='right' caption='[[1dr0]], [[Resolution\|resolution]] 2.20Å' scene=''>	+	<StructureSection load='1dr0' size='340' side='right'caption='[[1dr0]], [[Resolution\|resolution]] 2.20Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1dr0]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1DR0 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1DR0 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1dr0]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Thet8 Thet8]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1DR0 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1DR0 FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1osj\|1osj]], [[1dpz\|1dpz]], [[1dr8\|1dr8]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1osj\|1osj]], [[1dpz\|1dpz]], [[1dr8\|1dr8]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">LEUB ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=300852 THET8])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/3-isopropylmalate_dehydrogenase 3-isopropylmalate dehydrogenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.1.85 1.1.1.85] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/3-isopropylmalate_dehydrogenase 3-isopropylmalate dehydrogenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.1.85 1.1.1.85] </span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1dr0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1dr0 OCA], [http://pdbe.org/1dr0 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1dr0 RCSB], [http://www.ebi.ac.uk/pdbsum/1dr0 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1dr0 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1dr0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1dr0 OCA], [http://pdbe.org/1dr0 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1dr0 RCSB], [http://www.ebi.ac.uk/pdbsum/1dr0 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1dr0 ProSAT]</span></td></tr>
Line 14:		Line 15:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/dr/1dr0_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/dr/1dr0_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
Line 37:		Line 38:
	</StructureSection>		</StructureSection>
	[[Category: 3-isopropylmalate dehydrogenase]]		[[Category: 3-isopropylmalate dehydrogenase]]
		+	[[Category: Large Structures]]
		+	[[Category: Thet8]]
	[[Category: Akanuma, S]]		[[Category: Akanuma, S]]
	[[Category: Nurachman, Z]]		[[Category: Nurachman, Z]]

OCA at 04:12, 30 August 2017

2017-08-30T04:12:57Z

←Older revision		Revision as of 04:12, 30 August 2017
Line 1:		Line 1:
		+
	==STRUCTURE OF MODIFIED 3-ISOPROPYLMALATE DEHYDROGENASE AT THE C-TERMINUS, HD708==		==STRUCTURE OF MODIFIED 3-ISOPROPYLMALATE DEHYDROGENASE AT THE C-TERMINUS, HD708==
	<StructureSection load='1dr0' size='340' side='right' caption='[[1dr0]], [[Resolution\|resolution]] 2.20Å' scene=''>		<StructureSection load='1dr0' size='340' side='right' caption='[[1dr0]], [[Resolution\|resolution]] 2.20Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1dr0]] is a 2 chain structure ~~with sequence from [http://en.wikipedia.org/wiki/Thet8 Thet8]~~. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1DR0 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1DR0 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1dr0]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1DR0 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1DR0 FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1osj\|1osj]], [[1dpz\|1dpz]], [[1dr8\|1dr8]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1osj\|1osj]], [[1dpz\|1dpz]], [[1dr8\|1dr8]]</td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">LEUB ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=300852 THET8])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/3-isopropylmalate_dehydrogenase 3-isopropylmalate dehydrogenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.1.85 1.1.1.85] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/3-isopropylmalate_dehydrogenase 3-isopropylmalate dehydrogenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.1.85 1.1.1.85] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1dr0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1dr0 OCA], [http://pdbe.org/1dr0 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1dr0 RCSB], [http://www.ebi.ac.uk/pdbsum/1dr0 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1dr0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1dr0 OCA], [http://pdbe.org/1dr0 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1dr0 RCSB], [http://www.ebi.ac.uk/pdbsum/1dr0 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1dr0 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 18:		Line 18:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1dr0 ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 37:		Line 37:
	</StructureSection>		</StructureSection>
	[[Category: 3-isopropylmalate dehydrogenase]]		[[Category: 3-isopropylmalate dehydrogenase]]
-	[[Category: Thet8]]
	[[Category: Akanuma, S]]		[[Category: Akanuma, S]]
	[[Category: Nurachman, Z]]		[[Category: Nurachman, Z]]

OCA at 01:02, 12 September 2015

2015-09-12T01:02:02Z

←Older revision		Revision as of 01:02, 12 September 2015
Line 2:		Line 2:
	<StructureSection load='1dr0' size='340' side='right' caption='[[1dr0]], [[Resolution\|resolution]] 2.20Å' scene=''>		<StructureSection load='1dr0' size='340' side='right' caption='[[1dr0]], [[Resolution\|resolution]] 2.20Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1dr0]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Thermus_thermophilus_hb8 Thermus thermophilus hb8~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1DR0 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1DR0 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1dr0]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Thet8 Thet8]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1DR0 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1DR0 FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1osj\|1osj]], [[1dpz\|1dpz]], [[1dr8\|1dr8]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1osj\|1osj]], [[1dpz\|1dpz]], [[1dr8\|1dr8]]</td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">LEUB ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=300852 ~~Thermus thermophilus HB8~~])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">LEUB ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=300852 THET8])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/3-isopropylmalate_dehydrogenase 3-isopropylmalate dehydrogenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.1.85 1.1.1.85] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/3-isopropylmalate_dehydrogenase 3-isopropylmalate dehydrogenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.1.85 1.1.1.85] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1dr0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1dr0 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1dr0 RCSB], [http://www.ebi.ac.uk/pdbsum/1dr0 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1dr0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1dr0 OCA], [http://pdbe.org/1dr0 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1dr0 RCSB], [http://www.ebi.ac.uk/pdbsum/1dr0 PDBsum]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/LEU3_THET8 LEU3_THET8]] Catalyzes the oxidation of 3-carboxy-2-hydroxy-4-methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2-oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate.[HAMAP-Rule:MF_01033]
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 26:		Line 28:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 1dr0" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 34:		Line 37:
	</StructureSection>		</StructureSection>
	[[Category: 3-isopropylmalate dehydrogenase]]		[[Category: 3-isopropylmalate dehydrogenase]]
-	[[Category: ~~Thermus thermophilus hb8~~]]	+	[[Category: Thet8]]
	[[Category: Akanuma, S]]		[[Category: Akanuma, S]]
	[[Category: Nurachman, Z]]		[[Category: Nurachman, Z]]

OCA at 23:13, 22 December 2014

2014-12-22T23:13:36Z

←Older revision		Revision as of 23:13, 22 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1dr0]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Thermus_thermophilus_hb8 Thermus thermophilus hb8]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1DR0 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1DR0 FirstGlance]. <br>		<table><tr><td colspan='2'>[[1dr0]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Thermus_thermophilus_hb8 Thermus thermophilus hb8]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1DR0 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1DR0 FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1osj\|1osj]], [[1dpz\|1dpz]], [[1dr8\|1dr8]]</td></tr>	+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1osj\|1osj]], [[1dpz\|1dpz]], [[1dr8\|1dr8]]</td></tr>
-	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">LEUB ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=300852 Thermus thermophilus HB8])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">LEUB ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=300852 Thermus thermophilus HB8])</td></tr>
-	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/3-isopropylmalate_dehydrogenase 3-isopropylmalate dehydrogenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.1.85 1.1.1.85] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/3-isopropylmalate_dehydrogenase 3-isopropylmalate dehydrogenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.1.85 1.1.1.85] </span></td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1dr0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1dr0 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1dr0 RCSB], [http://www.ebi.ac.uk/pdbsum/1dr0 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1dr0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1dr0 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1dr0 RCSB], [http://www.ebi.ac.uk/pdbsum/1dr0 PDBsum]</span></td></tr>
-	<table>	+	</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 35:		Line 35:
	[[Category: 3-isopropylmalate dehydrogenase]]		[[Category: 3-isopropylmalate dehydrogenase]]
	[[Category: Thermus thermophilus hb8]]		[[Category: Thermus thermophilus hb8]]
-	[[Category: Akanuma, S.]]	+	[[Category: Akanuma, S]]
-	[[Category: Nurachman, Z.]]	+	[[Category: Nurachman, Z]]
-	[[Category: Oshima, T.]]	+	[[Category: Oshima, T]]
-	[[Category: Sato, T.]]	+	[[Category: Sato, T]]
-	[[Category: Tanaka, N.]]	+	[[Category: Tanaka, N]]
	[[Category: Dehydrogenase]]		[[Category: Dehydrogenase]]
	[[Category: Minor groove]]		[[Category: Minor groove]]
	[[Category: Oxidoreductase]]		[[Category: Oxidoreductase]]
	[[Category: Paperclip motion]]		[[Category: Paperclip motion]]

OCA at 10:52, 10 September 2014

2014-09-10T10:52:01Z

←Older revision		Revision as of 10:52, 10 September 2014
Line 1:		Line 1:
-	[[~~Image:~~1dr0.~~png~~\|~~left~~\|200px]]	+	==STRUCTURE OF MODIFIED 3-ISOPROPYLMALATE DEHYDROGENASE AT THE C-TERMINUS, HD708==
		+	<StructureSection load='1dr0' size='340' side='right' caption='[[1dr0]], [[Resolution\|resolution]] 2.20Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[1dr0]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Thermus_thermophilus_hb8 Thermus thermophilus hb8]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1DR0 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1DR0 FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1osj\|1osj]], [[1dpz\|1dpz]], [[1dr8\|1dr8]]</td></tr>
		+	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">LEUB ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=300852 Thermus thermophilus HB8])</td></tr>
		+	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/3-isopropylmalate_dehydrogenase 3-isopropylmalate dehydrogenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.1.85 1.1.1.85] </span></td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1dr0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1dr0 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1dr0 RCSB], [http://www.ebi.ac.uk/pdbsum/1dr0 PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/dr/1dr0_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Thermal stability of the Thermus thermophilus isopropylmalate dehydrogenase enzyme was substantially lost upon the deletion of three residues from the C-terminus. However, the stability was partly recovered by the addition of two, four and seven amino acid residues (called HD177, HD708 and HD711, respectively) to the C-terminal region of the truncated enzyme. Three structures of these mutant enzymes were determined by an X-ray diffraction method. All protein crystals belong to space group P2(1) and their structures were solved by a standard molecular replacement method where the original dimer structure of the A172L mutant was used as a search model. Thermal stability of these mutant enzymes is discussed based on the 3D structure with special attention to the width of the active-site groove and the minor groove, distortion of beta-sheet pillar structure and size of cavity in the domain-domain interface around the C-terminus. Our previous studies revealed that the thermal stability of isopropylmalate dehydrogenase increases when the active-site cleft is closed (the closed form). In the present study it is shown that the active-site cleft can be regulated by open-close movement of the minor groove located at the opposite side to the active-site groove on the same subunit, through a paperclip-like motion.

-	~~{{STRUCTURE_1dr0\| PDB=1dr0 \| SCENE= }}~~	+	Crystal structures of 3-isopropylmalate dehydrogenases with mutations at the C-terminus: crystallographic analyses of structure-stability relationships.,Nurachman Z, Akanuma S, Sato T, Oshima T, Tanaka N Protein Eng. 2000 Apr;13(4):253-8. PMID:10810156<ref>PMID:10810156</ref>

-	~~===STRUCTURE OF MODIFIED 3-ISOPROPYLMALATE DEHYDROGENASE AT THE C-TERMINUS~~, ~~HD708===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_10810156}}~~	+
-		+
-	~~==About this Structure==~~	+
-	~~[[1dr0]] is~~ a ~~2 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Thermus_thermophilus_hb8 Thermus thermophilus hb8]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=1DR0 OCA].~~	+

	==See Also==		==See Also==
	*[[Isopropylmalate dehydrogenase\|Isopropylmalate dehydrogenase]]		*[[Isopropylmalate dehydrogenase\|Isopropylmalate dehydrogenase]]
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	<~~ref group="xtra">PMID:010810156<~~/~~ref~~><~~references group="xtra"~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: 3-isopropylmalate dehydrogenase]]		[[Category: 3-isopropylmalate dehydrogenase]]
	[[Category: Thermus thermophilus hb8]]		[[Category: Thermus thermophilus hb8]]

OCA at 22:01, 20 October 2012

2012-10-20T22:01:43Z

←Older revision		Revision as of 22:01, 20 October 2012
Line 8:		Line 8:

	==About this Structure==		==About this Structure==
-	[[1dr0]] is a 2 chain structure ~~of [[Isopropylmalate dehydrogenase]]~~ with sequence from [http://en.wikipedia.org/wiki/~~Thermus_thermophilus~~ Thermus thermophilus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1DR0 OCA].	+	[[1dr0]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Thermus_thermophilus_hb8 Thermus thermophilus hb8]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1DR0 OCA].

	==See Also==		==See Also==
Line 16:		Line 16:
	<ref group="xtra">PMID:010810156</ref><references group="xtra"/>		<ref group="xtra">PMID:010810156</ref><references group="xtra"/>
	[[Category: 3-isopropylmalate dehydrogenase]]		[[Category: 3-isopropylmalate dehydrogenase]]
-	[[Category: Thermus thermophilus]]	+	[[Category: Thermus thermophilus hb8]]
	[[Category: Akanuma, S.]]		[[Category: Akanuma, S.]]
	[[Category: Nurachman, Z.]]		[[Category: Nurachman, Z.]]

OCA: Protected "1dr0" [edit=sysop:move=sysop]

2012-07-27T15:00:48Z

Protected "1dr0" [edit=sysop:move=sysop]

←Older revision

Revision as of 15:00, 27 July 2012

OCA at 15:00, 27 July 2012

2012-07-27T15:00:44Z

←Older revision		Revision as of 15:00, 27 July 2012
Line 1:		Line 1:
-	{{Seed}}
	[[Image:1dr0.png\|left\|200px]]		[[Image:1dr0.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_1dr0", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_1dr0\| PDB=1dr0 \| SCENE= }}		{{STRUCTURE_1dr0\| PDB=1dr0 \| SCENE= }}

	===STRUCTURE OF MODIFIED 3-ISOPROPYLMALATE DEHYDROGENASE AT THE C-TERMINUS, HD708===		===STRUCTURE OF MODIFIED 3-ISOPROPYLMALATE DEHYDROGENASE AT THE C-TERMINUS, HD708===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_10810156}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 10810156 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_10810156}}		{{ABSTRACT_PUBMED_10810156}}

	==About this Structure==		==About this Structure==
-	~~1DR0~~ is a 2 ~~chains~~ structure of ~~sequences~~ from [http://en.wikipedia.org/wiki/Thermus_thermophilus Thermus thermophilus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1DR0 OCA].	+	[[1dr0]] is a 2 chain structure of [[Isopropylmalate dehydrogenase]] with sequence from [http://en.wikipedia.org/wiki/Thermus_thermophilus Thermus thermophilus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1DR0 OCA].
		+
		+	==See Also==
		+	*[[Isopropylmalate dehydrogenase\|Isopropylmalate dehydrogenase]]

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~10810156~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:010810156</ref><references group="xtra"/>
	[[Category: 3-isopropylmalate dehydrogenase]]		[[Category: 3-isopropylmalate dehydrogenase]]
	[[Category: Thermus thermophilus]]		[[Category: Thermus thermophilus]]
Line 33:		Line 24:
	[[Category: Dehydrogenase]]		[[Category: Dehydrogenase]]
	[[Category: Minor groove]]		[[Category: Minor groove]]
		+	[[Category: Oxidoreductase]]
	[[Category: Paperclip motion]]		[[Category: Paperclip motion]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Feb 18 08:51:08 2009''