1drs - Revision history

OCA at 09:53, 20 March 2024

2024-03-20T09:53:01Z

←Older revision		Revision as of 09:53, 20 March 2024
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	==THREE-DIMENSIONAL STRUCTURE OF THE RGD-CONTAINING NEUROTOXIN HOMOLOGUE, DENDROASPIN==		==THREE-DIMENSIONAL STRUCTURE OF THE RGD-CONTAINING NEUROTOXIN HOMOLOGUE, DENDROASPIN==
-	<StructureSection load='1drs' size='340' side='right'caption='[[1drs~~]], [[NMR_Ensembles_of_Models \| 39 NMR models~~]]' scene=''>	+	<StructureSection load='1drs' size='340' side='right'caption='[[1drs]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1drs]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Denja Denja~~]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1DRS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1DRS FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1drs]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Dendroaspis_jamesoni_kaimosae Dendroaspis jamesoni kaimosae]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1DRS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1DRS FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1drs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1drs OCA], [https://pdbe.org/1drs PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1drs RCSB], [https://www.ebi.ac.uk/pdbsum/1drs PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1drs ProSAT]</span></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1drs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1drs OCA], [https://pdbe.org/1drs PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1drs RCSB], [https://www.ebi.ac.uk/pdbsum/1drs PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1drs ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/~~MAMB_DENJA MAMB_DENJA]~~] Inhibits ADP-induced platelet aggregation and inhibits the binding of purified platelet fibrinogen receptor alpha-IIb/beta-3 (ITGA2B/ITGB3) to immobilized fibrinogen.	+	[https://www.uniprot.org/uniprot/3SPM_DENJA 3SPM_DENJA] Inhibits ADP-induced platelet aggregation and inhibits the binding of purified platelet fibrinogen receptor alpha-IIb/beta-3 (ITGA2B/ITGB3) to immobilized fibrinogen (PubMed:1591238). Has also been described to inhibit cell adhesion to fibrinogen, fibronectin, laminin and collagen (PubMed:16798616, PubMed:11336631).<ref>PMID:11336631</ref> <ref>PMID:1591238</ref> <ref>PMID:16798616</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1drs ConSurf].		</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1drs ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
-	<div style="background-color:#fffaf0;">
-	== Publication Abstract from PubMed ==
-	Dendroaspin is a short chain neurotoxin homologue from the venom of Elapidae snakes, which lacks neurotoxicity. Unlike neurotoxins, it contains an Arg-Gly-Asp-(RGD)-motif and functions as an inhibitor of platelet aggregation and platelet adhesion with comparable potency to the disintegrins from the venoms of Viperidae. We have determined the structure of dendroaspin in solution using NMR spectroscopy. The structure contains a core similar to that of short chain neurotoxins, but with a novel arrangement of loops and a solvent-exposed RGD-motif. Dendroaspin is thus an integrin antagonist with a well defined fold different from that of the disintegrins, based on the neurotoxin scaffold.
-
-	Three-dimensional structure of the RGD-containing neurotoxin homologue dendroaspin.,Sutcliffe MJ, Jaseja M, Hyde EI, Lu X, Williams JA Nat Struct Biol. 1994 Nov;1(11):802-7. PMID:7634091<ref>PMID:7634091</ref>
-
-	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	</div>
-	<div class="pdbe-citations 1drs" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Denja~~]]	+	[[Category: Dendroaspis jamesoni kaimosae]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Hyde~~, E I~~]]	+	[[Category: Hyde EI]]
-	[[Category: Jaseja, M]]	+	[[Category: Jaseja M]]
-	[[Category: Lu, X]]	+	[[Category: Lu X]]
-	[[Category: Sutcliffe~~, M J~~]]	+	[[Category: Sutcliffe MJ]]
-	[[Category: Williams~~, J A]]~~	+	[[Category: Williams JA]]
-	~~[[Category: Cell adhesion protein~~]]	+

OCA at 09:30, 21 July 2021

2021-07-21T09:30:41Z

←Older revision		Revision as of 09:30, 21 July 2021
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	<StructureSection load='1drs' size='340' side='right'caption='[[1drs]], [[NMR_Ensembles_of_Models \| 39 NMR models]]' scene=''>		<StructureSection load='1drs' size='340' side='right'caption='[[1drs]], [[NMR_Ensembles_of_Models \| 39 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1drs]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Denja Denja]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1DRS OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1DRS FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1drs]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Denja Denja]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1DRS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1DRS FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1drs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1drs OCA], [~~http~~://pdbe.org/1drs PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=1drs RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/1drs PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=1drs ProSAT]</span></td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1drs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1drs OCA], [https://pdbe.org/1drs PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1drs RCSB], [https://www.ebi.ac.uk/pdbsum/1drs PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1drs ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/MAMB_DENJA MAMB_DENJA]] Inhibits ADP-induced platelet aggregation and inhibits the binding of purified platelet fibrinogen receptor alpha-IIb/beta-3 (ITGA2B/ITGB3) to immobilized fibrinogen.	+	[[https://www.uniprot.org/uniprot/MAMB_DENJA MAMB_DENJA]] Inhibits ADP-induced platelet aggregation and inhibits the binding of purified platelet fibrinogen receptor alpha-IIb/beta-3 (ITGA2B/ITGB3) to immobilized fibrinogen.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]

OCA at 13:45, 16 October 2019

2019-10-16T13:45:30Z

←Older revision		Revision as of 13:45, 16 October 2019
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	==THREE-DIMENSIONAL STRUCTURE OF THE RGD-CONTAINING NEUROTOXIN HOMOLOGUE, DENDROASPIN==		==THREE-DIMENSIONAL STRUCTURE OF THE RGD-CONTAINING NEUROTOXIN HOMOLOGUE, DENDROASPIN==
-	<StructureSection load='1drs' size='340' side='right' caption='[[1drs]], [[NMR_Ensembles_of_Models \| 39 NMR models]]' scene=''>	+	<StructureSection load='1drs' size='340' side='right'caption='[[1drs]], [[NMR_Ensembles_of_Models \| 39 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1drs]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Denja Denja]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1DRS OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1DRS FirstGlance]. <br>		<table><tr><td colspan='2'>[[1drs]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Denja Denja]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1DRS OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1DRS FirstGlance]. <br>
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	</StructureSection>		</StructureSection>
	[[Category: Denja]]		[[Category: Denja]]
		+	[[Category: Large Structures]]
	[[Category: Hyde, E I]]		[[Category: Hyde, E I]]
	[[Category: Jaseja, M]]		[[Category: Jaseja, M]]

OCA at 07:54, 13 December 2017

2017-12-13T07:54:41Z

←Older revision		Revision as of 07:54, 13 December 2017
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		+
	==THREE-DIMENSIONAL STRUCTURE OF THE RGD-CONTAINING NEUROTOXIN HOMOLOGUE, DENDROASPIN==		==THREE-DIMENSIONAL STRUCTURE OF THE RGD-CONTAINING NEUROTOXIN HOMOLOGUE, DENDROASPIN==
	<StructureSection load='1drs' size='340' side='right' caption='[[1drs]], [[NMR_Ensembles_of_Models \| 39 NMR models]]' scene=''>		<StructureSection load='1drs' size='340' side='right' caption='[[1drs]], [[NMR_Ensembles_of_Models \| 39 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1drs]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Denja Denja]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1DRS OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1DRS FirstGlance]. <br>		<table><tr><td colspan='2'>[[1drs]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Denja Denja]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1DRS OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1DRS FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1drs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1drs OCA], [http://pdbe.org/1drs PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1drs RCSB], [http://www.ebi.ac.uk/pdbsum/1drs PDBsum]</span></td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1drs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1drs OCA], [http://pdbe.org/1drs PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1drs RCSB], [http://www.ebi.ac.uk/pdbsum/1drs PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1drs ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
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	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/dr/1drs_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/dr/1drs_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>

OCA at 07:26, 7 February 2016

2016-02-07T07:26:24Z

←Older revision		Revision as of 07:26, 7 February 2016
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	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1drs ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 23:10, 9 September 2015

2015-09-09T23:10:22Z

←Older revision		Revision as of 23:10, 9 September 2015
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	<StructureSection load='1drs' size='340' side='right' caption='[[1drs]], [[NMR_Ensembles_of_Models \| 39 NMR models]]' scene=''>		<StructureSection load='1drs' size='340' side='right' caption='[[1drs]], [[NMR_Ensembles_of_Models \| 39 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1drs]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Dendroaspis_jamesoni_kaimosae Dendroaspis jamesoni kaimosae~~]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1DRS OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1DRS FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1drs]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Denja Denja]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1DRS OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1DRS FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1drs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1drs OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1drs RCSB], [http://www.ebi.ac.uk/pdbsum/1drs PDBsum]</span></td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1drs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1drs OCA], [http://pdbe.org/1drs PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1drs RCSB], [http://www.ebi.ac.uk/pdbsum/1drs PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
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	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 1drs" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Dendroaspis jamesoni kaimosae~~]]	+	[[Category: Denja]]
	[[Category: Hyde, E I]]		[[Category: Hyde, E I]]
	[[Category: Jaseja, M]]		[[Category: Jaseja, M]]

OCA at 08:58, 24 December 2014

2014-12-24T08:58:49Z

←Older revision		Revision as of 08:58, 24 December 2014
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	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1drs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1drs OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1drs RCSB], [http://www.ebi.ac.uk/pdbsum/1drs PDBsum]</span></td></tr>		</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1drs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1drs OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1drs RCSB], [http://www.ebi.ac.uk/pdbsum/1drs PDBsum]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/MAMB_DENJA MAMB_DENJA]] Inhibits ADP-induced platelet aggregation and inhibits the binding of purified platelet fibrinogen receptor alpha-IIb/beta-3 (ITGA2B/ITGB3) to immobilized fibrinogen.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]

OCA at 20:37, 22 December 2014

2014-12-22T20:37:29Z

←Older revision		Revision as of 20:37, 22 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1drs]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Dendroaspis_jamesoni_kaimosae Dendroaspis jamesoni kaimosae]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1DRS OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1DRS FirstGlance]. <br>		<table><tr><td colspan='2'>[[1drs]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Dendroaspis_jamesoni_kaimosae Dendroaspis jamesoni kaimosae]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1DRS OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1DRS FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1drs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1drs OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1drs RCSB], [http://www.ebi.ac.uk/pdbsum/1drs PDBsum]</span></td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1drs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1drs OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1drs RCSB], [http://www.ebi.ac.uk/pdbsum/1drs PDBsum]</span></td></tr>
-	<table>	+	</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	</StructureSection>		</StructureSection>
	[[Category: Dendroaspis jamesoni kaimosae]]		[[Category: Dendroaspis jamesoni kaimosae]]
-	[[Category: Hyde, E I.]]	+	[[Category: Hyde, E I]]
-	[[Category: Jaseja, M.]]	+	[[Category: Jaseja, M]]
-	[[Category: Lu, X.]]	+	[[Category: Lu, X]]
-	[[Category: Sutcliffe, M J.]]	+	[[Category: Sutcliffe, M J]]
-	[[Category: Williams, J A.]]	+	[[Category: Williams, J A]]
	[[Category: Cell adhesion protein]]		[[Category: Cell adhesion protein]]

OCA at 10:45, 10 September 2014

2014-09-10T10:45:00Z

←Older revision		Revision as of 10:45, 10 September 2014
Line 1:		Line 1:
-	[[~~Image~~:1drs.~~png\|left~~\|200px]]	+	==THREE-DIMENSIONAL STRUCTURE OF THE RGD-CONTAINING NEUROTOXIN HOMOLOGUE, DENDROASPIN==
		+	<StructureSection load='1drs' size='340' side='right' caption='[[1drs]], [[NMR_Ensembles_of_Models \| 39 NMR models]]' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[1drs]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Dendroaspis_jamesoni_kaimosae Dendroaspis jamesoni kaimosae]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1DRS OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1DRS FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1drs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1drs OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1drs RCSB], [http://www.ebi.ac.uk/pdbsum/1drs PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/dr/1drs_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Dendroaspin is a short chain neurotoxin homologue from the venom of Elapidae snakes, which lacks neurotoxicity. Unlike neurotoxins, it contains an Arg-Gly-Asp-(RGD)-motif and functions as an inhibitor of platelet aggregation and platelet adhesion with comparable potency to the disintegrins from the venoms of Viperidae. We have determined the structure of dendroaspin in solution using NMR spectroscopy. The structure contains a core similar to that of short chain neurotoxins, but with a novel arrangement of loops and a solvent-exposed RGD-motif. Dendroaspin is thus an integrin antagonist with a well defined fold different from that of the disintegrins, based on the neurotoxin scaffold.

-	~~{{STRUCTURE_1drs\| PDB=1drs \| SCENE= }}~~	+	Three-dimensional structure of the RGD-containing neurotoxin homologue dendroaspin.,Sutcliffe MJ, Jaseja M, Hyde EI, Lu X, Williams JA Nat Struct Biol. 1994 Nov;1(11):802-7. PMID:7634091<ref>PMID:7634091</ref>

-	~~===THREE-DIMENSIONAL STRUCTURE OF THE RGD-CONTAINING NEUROTOXIN HOMOLOGUE~~, ~~DENDROASPIN===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_7634091}}~~	+	== References ==
-		+	<references/>
-	~~==About this Structure==~~	+	__TOC__
-	~~[[1drs]] is~~ a ~~1 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Dendroaspis_jamesoni_kaimosae Dendroaspis jamesoni kaimosae]~~. ~~Full experimental information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=1DRS OCA].~~	+	</StructureSection>
-		+
-	==~~Reference~~==	+
-	<~~ref group="xtra">PMID:007634091<~~/~~ref~~><~~references group="xtra"~~/>	+
	[[Category: Dendroaspis jamesoni kaimosae]]		[[Category: Dendroaspis jamesoni kaimosae]]
	[[Category: Hyde, E I.]]		[[Category: Hyde, E I.]]

OCA: Protected "1drs" [edit=sysop:move=sysop]

2012-10-31T09:54:03Z

Protected "1drs" [edit=sysop:move=sysop]

←Older revision

Revision as of 09:54, 31 October 2012