1dxm - Revision history

OCA at 08:08, 6 December 2023

2023-12-06T08:08:45Z

←Older revision		Revision as of 08:08, 6 December 2023
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	<StructureSection load='1dxm' size='340' side='right'caption='[[1dxm]], [[Resolution\|resolution]] 2.60Å' scene=''>		<StructureSection load='1dxm' size='340' side='right'caption='[[1dxm]], [[Resolution\|resolution]] 2.60Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1dxm]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Garden_pea Garden pea~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1DXM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1DXM FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1dxm]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Pisum_sativum Pisum sativum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1DXM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1DXM FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=RED:DIHYDROLIPOIC+ACID'>RED</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.6Å</td></tr>
-	<tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"><~~div style~~='~~overflow~~: ~~auto; max-height: 3em;~~'>~~[[1hpc\|1hpc]], [[1htp\|1htp]]~~</~~div~~></td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=RED:DIHYDROLIPOIC+ACID'>RED</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1dxm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1dxm OCA], [https://pdbe.org/1dxm PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1dxm RCSB], [https://www.ebi.ac.uk/pdbsum/1dxm PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1dxm ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1dxm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1dxm OCA], [https://pdbe.org/1dxm PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1dxm RCSB], [https://www.ebi.ac.uk/pdbsum/1dxm PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1dxm ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/GCSH_PEA GCSH_PEA]] The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein.	+	[https://www.uniprot.org/uniprot/GCSH_PEA GCSH_PEA] The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Garden pea]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Cohen-Addad, C]]	+	[[Category: Pisum sativum]]
-	[[Category: Douce, R]]	+	[[Category: Cohen-Addad C]]
-	[[Category: Faure, M]]	+	[[Category: Douce R]]
-	[[Category: Neuburger, M]]	+	[[Category: Faure M]]
-	~~[[Category: Glycine decarboxylase]]~~	+	[[Category: Neuburger M]]
-	~~[[Category: Mitochondria~~]]	+

OCA at 09:32, 21 July 2021

2021-07-21T09:32:31Z

←Older revision		Revision as of 09:32, 21 July 2021
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	<StructureSection load='1dxm' size='340' side='right'caption='[[1dxm]], [[Resolution\|resolution]] 2.60Å' scene=''>		<StructureSection load='1dxm' size='340' side='right'caption='[[1dxm]], [[Resolution\|resolution]] 2.60Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1dxm]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Garden_pea Garden pea]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1DXM OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1DXM FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1dxm]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Garden_pea Garden pea]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1DXM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1DXM FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=RED:DIHYDROLIPOIC+ACID'>RED</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=RED:DIHYDROLIPOIC+ACID'>RED</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1hpc\|1hpc]], [[1htp\|1htp]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1hpc\|1hpc]], [[1htp\|1htp]]</div></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1dxm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1dxm OCA], [~~http~~://pdbe.org/1dxm PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=1dxm RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/1dxm PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=1dxm ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1dxm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1dxm OCA], [https://pdbe.org/1dxm PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1dxm RCSB], [https://www.ebi.ac.uk/pdbsum/1dxm PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1dxm ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/GCSH_PEA GCSH_PEA]] The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein.	+	[[https://www.uniprot.org/uniprot/GCSH_PEA GCSH_PEA]] The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]

OCA at 13:21, 16 October 2019

2019-10-16T13:21:15Z

←Older revision		Revision as of 13:21, 16 October 2019
Line 1:		Line 1:

	==Reduced form of the H protein from glycine decarboxylase complex==		==Reduced form of the H protein from glycine decarboxylase complex==
-	<StructureSection load='1dxm' size='340' side='right' caption='[[1dxm]], [[Resolution\|resolution]] 2.60Å' scene=''>	+	<StructureSection load='1dxm' size='340' side='right'caption='[[1dxm]], [[Resolution\|resolution]] 2.60Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1dxm]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Garden_pea Garden pea]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1DXM OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1DXM FirstGlance]. <br>		<table><tr><td colspan='2'>[[1dxm]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Garden_pea Garden pea]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1DXM OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1DXM FirstGlance]. <br>
Line 34:		Line 34:
	</StructureSection>		</StructureSection>
	[[Category: Garden pea]]		[[Category: Garden pea]]
		+	[[Category: Large Structures]]
	[[Category: Cohen-Addad, C]]		[[Category: Cohen-Addad, C]]
	[[Category: Douce, R]]		[[Category: Douce, R]]

OCA at 07:52, 13 December 2017

2017-12-13T07:52:14Z

←Older revision		Revision as of 07:52, 13 December 2017
Line 1:		Line 1:
-	==~~REDUCED FORM OF THE~~ H ~~PROTEIN FROM GLYCINE DECARBOXYLASE COMPLEX~~==	+
		+	==Reduced form of the H protein from glycine decarboxylase complex==
	<StructureSection load='1dxm' size='340' side='right' caption='[[1dxm]], [[Resolution\|resolution]] 2.60Å' scene=''>		<StructureSection load='1dxm' size='340' side='right' caption='[[1dxm]], [[Resolution\|resolution]] 2.60Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
Line 5:		Line 6:
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=RED:DIHYDROLIPOIC+ACID'>RED</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=RED:DIHYDROLIPOIC+ACID'>RED</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1hpc\|1hpc]], [[1htp\|1htp]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1hpc\|1hpc]], [[1htp\|1htp]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1dxm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1dxm OCA], [http://pdbe.org/1dxm PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1dxm RCSB], [http://www.ebi.ac.uk/pdbsum/1dxm PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1dxm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1dxm OCA], [http://pdbe.org/1dxm PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1dxm RCSB], [http://www.ebi.ac.uk/pdbsum/1dxm PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1dxm ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 13:		Line 14:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/dx/1dxm_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/dx/1dxm_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>

OCA at 08:28, 10 February 2016

2016-02-10T08:28:39Z

←Older revision		Revision as of 08:28, 10 February 2016
Line 17:		Line 17:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1dxm ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 07:05, 11 September 2015

2015-09-11T07:05:50Z

←Older revision		Revision as of 07:05, 11 September 2015
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	<StructureSection load='1dxm' size='340' side='right' caption='[[1dxm]], [[Resolution\|resolution]] 2.60Å' scene=''>		<StructureSection load='1dxm' size='340' side='right' caption='[[1dxm]], [[Resolution\|resolution]] 2.60Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1dxm]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Pisum_sativum Pisum sativum~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1DXM OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1DXM FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1dxm]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Garden_pea Garden pea]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1DXM OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1DXM FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=RED:DIHYDROLIPOIC+ACID'>RED</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=RED:DIHYDROLIPOIC+ACID'>RED</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1hpc\|1hpc]], [[1htp\|1htp]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1hpc\|1hpc]], [[1htp\|1htp]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1dxm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1dxm OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1dxm RCSB], [http://www.ebi.ac.uk/pdbsum/1dxm PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1dxm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1dxm OCA], [http://pdbe.org/1dxm PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1dxm RCSB], [http://www.ebi.ac.uk/pdbsum/1dxm PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 27:		Line 27:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 1dxm" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Pisum sativum~~]]	+	[[Category: Garden pea]]
	[[Category: Cohen-Addad, C]]		[[Category: Cohen-Addad, C]]
	[[Category: Douce, R]]		[[Category: Douce, R]]

OCA at 12:59, 25 December 2014

2014-12-25T12:59:59Z

←Older revision		Revision as of 12:59, 25 December 2014
Line 7:		Line 7:
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1dxm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1dxm OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1dxm RCSB], [http://www.ebi.ac.uk/pdbsum/1dxm PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1dxm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1dxm OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1dxm RCSB], [http://www.ebi.ac.uk/pdbsum/1dxm PDBsum]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/GCSH_PEA GCSH_PEA]] The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]

OCA at 21:28, 22 December 2014

2014-12-22T21:28:11Z

←Older revision		Revision as of 21:28, 22 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1dxm]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Pisum_sativum Pisum sativum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1DXM OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1DXM FirstGlance]. <br>		<table><tr><td colspan='2'>[[1dxm]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Pisum_sativum Pisum sativum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1DXM OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1DXM FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=RED:DIHYDROLIPOIC+ACID'>RED</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=RED:DIHYDROLIPOIC+ACID'>RED</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1hpc\|1hpc]], [[1htp\|1htp]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1hpc\|1hpc]], [[1htp\|1htp]]</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1dxm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1dxm OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1dxm RCSB], [http://www.ebi.ac.uk/pdbsum/1dxm PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1dxm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1dxm OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1dxm RCSB], [http://www.ebi.ac.uk/pdbsum/1dxm PDBsum]</span></td></tr>
-	<table>	+	</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 30:		Line 30:
	</StructureSection>		</StructureSection>
	[[Category: Pisum sativum]]		[[Category: Pisum sativum]]
-	[[Category: Cohen-Addad, C.]]	+	[[Category: Cohen-Addad, C]]
-	[[Category: Douce, R.]]	+	[[Category: Douce, R]]
-	[[Category: Faure, M.]]	+	[[Category: Faure, M]]
-	[[Category: Neuburger, M.]]	+	[[Category: Neuburger, M]]
	[[Category: Glycine decarboxylase]]		[[Category: Glycine decarboxylase]]
	[[Category: Mitochondria]]		[[Category: Mitochondria]]

OCA at 15:39, 29 September 2014

2014-09-29T15:39:22Z

←Older revision		Revision as of 15:39, 29 September 2014
Line 1:		Line 1:
-	[[~~Image:~~1dxm.~~png~~\|~~left~~\|200px]]	+	==REDUCED FORM OF THE H PROTEIN FROM GLYCINE DECARBOXYLASE COMPLEX==
		+	<StructureSection load='1dxm' size='340' side='right' caption='[[1dxm]], [[Resolution\|resolution]] 2.60Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[1dxm]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Pisum_sativum Pisum sativum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1DXM OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1DXM FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=RED:DIHYDROLIPOIC+ACID'>RED</scene><br>
		+	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1hpc\|1hpc]], [[1htp\|1htp]]</td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1dxm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1dxm OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1dxm RCSB], [http://www.ebi.ac.uk/pdbsum/1dxm PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/dx/1dxm_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The glycine decarboxylase complex consists of four different component enzymes (P-, H-, T- and L-proteins). The 14-kDa lipoamide-containing H-protein plays a pivotal role in the complete sequence of reactions as its prosthetic group (lipoic acid) interacts successively with the three other components of the complex and undergoes a cycle of reductive methylamination, methylamine transfer and electron transfer. With the aim to understand the interaction between the H-protein and its different partners, we have previously determined the crystal structure of the oxidized and methylaminated forms of the H-protein. In the present study, we have crystallized the H-protein in its reduced state and the L-protein (lipoamide dehydrogenase or dihydrolipoamide dehydrogenase). The L-protein has been overexpressed in Escherichia coli and refolded from inclusion bodies in an active form. Crystals were obtained from the refolded L-protein and the structure has been determined by X-ray crystallography. This first crystal structure of a plant dihydrolipoamide dehydrogenase is similar to other known dihydrolipoamide dehydrogenase structures. The crystal structure of the H-protein in its reduced form has been determined and compared to the structure of the other forms of the protein. It is isomorphous to the structure of the oxidized form. In contrast with methylaminated H-protein where the loaded lipoamide arm was locked into a cavity of the protein, the reduced lipoamide arm appeared freely exposed to the solvent. Such a freedom is required to allow its targeting inside the hollow active site of L-protein. Our results strongly suggest that a direct interaction between the H- and L-proteins is not necessary for the reoxidation of the reduced lipoamide arm bound to the H-protein. This hypothesis is supported by biochemical data [Neuburger, M., Polidori, A.M., Pietre, E., Faure, M., Jourdain, A., Bourguignon, J., Pucci, B. & Douce, R. (2000) Eur. J. Biochem. 267, 2882-2889] and by small angle X-ray scattering experiments reported herein.

-	~~{{STRUCTURE_1dxm\| PDB=1dxm \| SCENE= }}~~	+	Interaction between the lipoamide-containing H-protein and the lipoamide dehydrogenase (L-protein) of the glycine decarboxylase multienzyme system 2. Crystal structures of H- and L-proteins.,Faure M, Bourguignon J, Neuburger M, MacHerel D, Sieker L, Ober R, Kahn R, Cohen-Addad C, Douce R Eur J Biochem. 2000 May;267(10):2890-8. PMID:10806386<ref>PMID:10806386</ref>

-	~~===REDUCED FORM OF THE H PROTEIN FROM GLYCINE DECARBOXYLASE COMPLEX===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_10806386}}~~	+	== References ==
-		+	<references/>
-	~~==About this Structure==~~	+	__TOC__
-	~~[[1dxm]] is~~ a ~~2 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Pisum_sativum Pisum sativum]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=1DXM OCA].~~	+	</StructureSection>
-		+
-	==~~Reference~~==	+
-	<~~ref group="xtra">PMID:010806386<~~/~~ref~~><~~ref group="xtra">PMID:015299773</ref><references group="xtra"~~/>	+
	[[Category: Pisum sativum]]		[[Category: Pisum sativum]]
	[[Category: Cohen-Addad, C.]]		[[Category: Cohen-Addad, C.]]

OCA at 09:32, 16 January 2013

2013-01-16T09:32:58Z

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	[[Image:1dxm.png\|left\|200px]]		[[Image:1dxm.png\|left\|200px]]

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	===REDUCED FORM OF THE H PROTEIN FROM GLYCINE DECARBOXYLASE COMPLEX===		===REDUCED FORM OF THE H PROTEIN FROM GLYCINE DECARBOXYLASE COMPLEX===

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	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~10806386~~</ref><ref group="xtra">PMID:~~9479445</ref><ref group="xtra">PMID:7719855</ref><ref group="xtra">PMID:15299773~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:010806386</ref><ref group="xtra">PMID:015299773</ref><references group="xtra"/>
	[[Category: Pisum sativum]]		[[Category: Pisum sativum]]
	[[Category: Cohen-Addad, C.]]		[[Category: Cohen-Addad, C.]]