1dzb - Revision history

OCA at 08:09, 6 December 2023

2023-12-06T08:09:29Z

←Older revision		Revision as of 08:09, 6 December 2023
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	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1dzb]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Meleagris_gallopavo Meleagris gallopavo] and [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1DZB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1DZB FirstGlance]. <br>		<table><tr><td colspan='2'>[[1dzb]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Meleagris_gallopavo Meleagris gallopavo] and [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1DZB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1DZB FirstGlance]. <br>
-	</td></tr><tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat">~~<div style='overflow: auto; max~~-~~height: 3em;'>[[1lz2\|1lz2]]~~, [[~~2lz2~~\|~~2lz2~~]]~~, [[3lz2\|3lz2]], [[1lz3\|1lz3]], [[1lzy\|1lzy]], [[1jef\|1jef]], [[1tew\|1tew]], [[1jse\|1jse]]</div></td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2Å</td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Lysozyme Lysozyme], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2~~.1.17 3.2.1.17] </span>~~</td></tr>	+
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1dzb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1dzb OCA], [https://pdbe.org/1dzb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1dzb RCSB], [https://www.ebi.ac.uk/pdbsum/1dzb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1dzb ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1dzb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1dzb OCA], [https://pdbe.org/1dzb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1dzb RCSB], [https://www.ebi.ac.uk/pdbsum/1dzb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1dzb ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/LYSC_MELGA LYSC_MELGA]] Lysozymes have primarily a bacteriolytic function; those in tissues and body fluids are associated with the monocyte-macrophage system and enhance the activity of immunoagents.	+	[https://www.uniprot.org/uniprot/LYSC_MELGA LYSC_MELGA] Lysozymes have primarily a bacteriolytic function; those in tissues and body fluids are associated with the monocyte-macrophage system and enhance the activity of immunoagents.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Lysozyme]]
	[[Category: Meleagris gallopavo]]		[[Category: Meleagris gallopavo]]
	[[Category: Mus musculus]]		[[Category: Mus musculus]]
-	[[Category: Ay, J]]	+	[[Category: Ay J]]
-	[[Category: Hahn, M]]	+	[[Category: Hahn M]]
-	[[Category: Hoehne, W]]	+	[[Category: Hoehne W]]
-	[[Category: Keitel, T]]	+	[[Category: Keitel T]]
-	[[Category: Kuettner, G]]	+	[[Category: Kuettner G]]
-	[[Category: Scholz, C]]	+	[[Category: Scholz C]]
-	[[Category: Wessner, H]]	+	[[Category: Wessner H]]
-	~~[[Category: Antibody- protein complex]]~~	+
-	~~[[Category: Immune system]]~~	+
-	~~[[Category: Single-chain fv fragment]]~~	+
-	~~[[Category: Single-domain antibody]]~~	+
-	~~[[Category: Turkey egg-white lysozyme~~]]	+

OCA at 05:44, 28 April 2021

2021-04-28T05:44:40Z

←Older revision		Revision as of 05:44, 28 April 2021
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	<StructureSection load='1dzb' size='340' side='right'caption='[[1dzb]], [[Resolution\|resolution]] 2.00Å' scene=''>		<StructureSection load='1dzb' size='340' side='right'caption='[[1dzb]], [[Resolution\|resolution]] 2.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1dzb]] is a 4 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Meleagris_gallopavo Meleagris gallopavo] and [~~http~~://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1DZB OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1DZB FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1dzb]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Meleagris_gallopavo Meleagris gallopavo] and [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1DZB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1DZB FirstGlance]. <br>
-	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1lz2\|1lz2]], [[2lz2\|2lz2]], [[3lz2\|3lz2]], [[1lz3\|1lz3]], [[1lzy\|1lzy]], [[1jef\|1jef]], [[1tew\|1tew]], [[1jse\|1jse]]</td></tr>	+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1lz2\|1lz2]], [[2lz2\|2lz2]], [[3lz2\|3lz2]], [[1lz3\|1lz3]], [[1lzy\|1lzy]], [[1jef\|1jef]], [[1tew\|1tew]], [[1jse\|1jse]]</div></td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://en.wikipedia.org/wiki/Lysozyme Lysozyme], with EC number [~~http~~://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.17 3.2.1.17] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Lysozyme Lysozyme], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.17 3.2.1.17] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1dzb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1dzb OCA], [~~http~~://pdbe.org/1dzb PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=1dzb RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/1dzb PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=1dzb ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1dzb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1dzb OCA], [https://pdbe.org/1dzb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1dzb RCSB], [https://www.ebi.ac.uk/pdbsum/1dzb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1dzb ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/LYSC_MELGA LYSC_MELGA]] Lysozymes have primarily a bacteriolytic function; those in tissues and body fluids are associated with the monocyte-macrophage system and enhance the activity of immunoagents.	+	[[https://www.uniprot.org/uniprot/LYSC_MELGA LYSC_MELGA]] Lysozymes have primarily a bacteriolytic function; those in tissues and body fluids are associated with the monocyte-macrophage system and enhance the activity of immunoagents.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	*[[Lysozyme 3D structures\|Lysozyme 3D structures]]		*[[Lysozyme 3D structures\|Lysozyme 3D structures]]
	*[[Monoclonal Antibodies 3D structures\|Monoclonal Antibodies 3D structures]]		*[[Monoclonal Antibodies 3D structures\|Monoclonal Antibodies 3D structures]]
		+	*[[3D structures of non-human antibody\|3D structures of non-human antibody]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 06:34, 24 July 2019

2019-07-24T06:34:08Z

←Older revision		Revision as of 06:34, 24 July 2019
Line 1:		Line 1:

	==Crystal structure of phage library-derived single-chain Fv fragment 1F9 in complex with turkey egg-white lysozyme==		==Crystal structure of phage library-derived single-chain Fv fragment 1F9 in complex with turkey egg-white lysozyme==
-	<StructureSection load='1dzb' size='340' side='right' caption='[[1dzb]], [[Resolution\|resolution]] 2.00Å' scene=''>	+	<StructureSection load='1dzb' size='340' side='right'caption='[[1dzb]], [[Resolution\|resolution]] 2.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1dzb]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Meleagris_gallopavo Meleagris gallopavo] and [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1DZB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1DZB FirstGlance]. <br>		<table><tr><td colspan='2'>[[1dzb]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Meleagris_gallopavo Meleagris gallopavo] and [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1DZB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1DZB FirstGlance]. <br>
Line 31:		Line 31:

	==See Also==		==See Also==
		+	*[[Antibody 3D structures\|Antibody 3D structures]]
	*[[Lysozyme 3D structures\|Lysozyme 3D structures]]		*[[Lysozyme 3D structures\|Lysozyme 3D structures]]
		+	*[[Monoclonal Antibodies 3D structures\|Monoclonal Antibodies 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Lysozyme]]		[[Category: Lysozyme]]
	[[Category: Meleagris gallopavo]]		[[Category: Meleagris gallopavo]]

OCA at 08:06, 13 December 2017

2017-12-13T08:06:30Z

←Older revision		Revision as of 08:06, 13 December 2017
Line 1:		Line 1:
-	==~~CRYSTAL STRUCTURE OF PHAGE LIBRARY~~-~~DERIVED SINGLE~~-~~CHAIN FV FRAGMENT~~ 1F9 ~~IN COMPLEX WITH TURKEY EGG~~-~~WHITE LYSOZYME~~==	+
		+	==Crystal structure of phage library-derived single-chain Fv fragment 1F9 in complex with turkey egg-white lysozyme==
	<StructureSection load='1dzb' size='340' side='right' caption='[[1dzb]], [[Resolution\|resolution]] 2.00Å' scene=''>		<StructureSection load='1dzb' size='340' side='right' caption='[[1dzb]], [[Resolution\|resolution]] 2.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
Line 5:		Line 6:
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1lz2\|1lz2]], [[2lz2\|2lz2]], [[3lz2\|3lz2]], [[1lz3\|1lz3]], [[1lzy\|1lzy]], [[1jef\|1jef]], [[1tew\|1tew]], [[1jse\|1jse]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1lz2\|1lz2]], [[2lz2\|2lz2]], [[3lz2\|3lz2]], [[1lz3\|1lz3]], [[1lzy\|1lzy]], [[1jef\|1jef]], [[1tew\|1tew]], [[1jse\|1jse]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Lysozyme Lysozyme], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.17 3.2.1.17] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Lysozyme Lysozyme], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.17 3.2.1.17] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1dzb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1dzb OCA], [http://pdbe.org/1dzb PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1dzb RCSB], [http://www.ebi.ac.uk/pdbsum/1dzb PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1dzb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1dzb OCA], [http://pdbe.org/1dzb PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1dzb RCSB], [http://www.ebi.ac.uk/pdbsum/1dzb PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1dzb ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
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	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/dz/1dzb_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/dz/1dzb_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>

OCA at 11:30, 8 February 2016

2016-02-08T11:30:01Z

←Older revision		Revision as of 11:30, 8 February 2016
Line 17:		Line 17:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1dzb ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 11:07, 10 September 2015

2015-09-10T11:07:14Z

←Older revision		Revision as of 11:07, 10 September 2015
Line 5:		Line 5:
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1lz2\|1lz2]], [[2lz2\|2lz2]], [[3lz2\|3lz2]], [[1lz3\|1lz3]], [[1lzy\|1lzy]], [[1jef\|1jef]], [[1tew\|1tew]], [[1jse\|1jse]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1lz2\|1lz2]], [[2lz2\|2lz2]], [[3lz2\|3lz2]], [[1lz3\|1lz3]], [[1lzy\|1lzy]], [[1jef\|1jef]], [[1tew\|1tew]], [[1jse\|1jse]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Lysozyme Lysozyme], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.17 3.2.1.17] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Lysozyme Lysozyme], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.17 3.2.1.17] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1dzb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1dzb OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1dzb RCSB], [http://www.ebi.ac.uk/pdbsum/1dzb PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1dzb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1dzb OCA], [http://pdbe.org/1dzb PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1dzb RCSB], [http://www.ebi.ac.uk/pdbsum/1dzb PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
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	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 1dzb" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==

OCA at 22:59, 24 December 2014

2014-12-24T22:59:24Z

←Older revision		Revision as of 22:59, 24 December 2014
Line 7:		Line 7:
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1dzb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1dzb OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1dzb RCSB], [http://www.ebi.ac.uk/pdbsum/1dzb PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1dzb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1dzb OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1dzb RCSB], [http://www.ebi.ac.uk/pdbsum/1dzb PDBsum]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/LYSC_MELGA LYSC_MELGA]] Lysozymes have primarily a bacteriolytic function; those in tissues and body fluids are associated with the monocyte-macrophage system and enhance the activity of immunoagents.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]

OCA at 19:33, 22 December 2014

2014-12-22T19:33:42Z

←Older revision		Revision as of 19:33, 22 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1dzb]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Meleagris_gallopavo Meleagris gallopavo] and [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1DZB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1DZB FirstGlance]. <br>		<table><tr><td colspan='2'>[[1dzb]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Meleagris_gallopavo Meleagris gallopavo] and [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1DZB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1DZB FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1lz2\|1lz2]], [[2lz2\|2lz2]], [[3lz2\|3lz2]], [[1lz3\|1lz3]], [[1lzy\|1lzy]], [[1jef\|1jef]], [[1tew\|1tew]], [[1jse\|1jse]]</td></tr>	+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1lz2\|1lz2]], [[2lz2\|2lz2]], [[3lz2\|3lz2]], [[1lz3\|1lz3]], [[1lzy\|1lzy]], [[1jef\|1jef]], [[1tew\|1tew]], [[1jse\|1jse]]</td></tr>
-	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Lysozyme Lysozyme], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.17 3.2.1.17] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Lysozyme Lysozyme], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.17 3.2.1.17] </span></td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1dzb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1dzb OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1dzb RCSB], [http://www.ebi.ac.uk/pdbsum/1dzb PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1dzb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1dzb OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1dzb RCSB], [http://www.ebi.ac.uk/pdbsum/1dzb PDBsum]</span></td></tr>
-	<table>	+	</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 35:		Line 35:
	[[Category: Meleagris gallopavo]]		[[Category: Meleagris gallopavo]]
	[[Category: Mus musculus]]		[[Category: Mus musculus]]
-	[[Category: Ay, J.]]	+	[[Category: Ay, J]]
-	[[Category: Hahn, M.]]	+	[[Category: Hahn, M]]
-	[[Category: Hoehne, W.]]	+	[[Category: Hoehne, W]]
-	[[Category: Keitel, T.]]	+	[[Category: Keitel, T]]
-	[[Category: Kuettner, G.]]	+	[[Category: Kuettner, G]]
-	[[Category: Scholz, C.]]	+	[[Category: Scholz, C]]
-	[[Category: Wessner, H.]]	+	[[Category: Wessner, H]]
	[[Category: Antibody- protein complex]]		[[Category: Antibody- protein complex]]
	[[Category: Immune system]]		[[Category: Immune system]]

OCA at 10:58, 10 September 2014

2014-09-10T10:58:29Z

←Older revision		Revision as of 10:58, 10 September 2014
Line 1:		Line 1:
-	[[~~Image:~~1dzb.~~png~~\|~~left~~\|200px]]	+	==CRYSTAL STRUCTURE OF PHAGE LIBRARY-DERIVED SINGLE-CHAIN FV FRAGMENT 1F9 IN COMPLEX WITH TURKEY EGG-WHITE LYSOZYME==
		+	<StructureSection load='1dzb' size='340' side='right' caption='[[1dzb]], [[Resolution\|resolution]] 2.00Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[1dzb]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Meleagris_gallopavo Meleagris gallopavo] and [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1DZB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1DZB FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1lz2\|1lz2]], [[2lz2\|2lz2]], [[3lz2\|3lz2]], [[1lz3\|1lz3]], [[1lzy\|1lzy]], [[1jef\|1jef]], [[1tew\|1tew]], [[1jse\|1jse]]</td></tr>
		+	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Lysozyme Lysozyme], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.17 3.2.1.17] </span></td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1dzb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1dzb OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1dzb RCSB], [http://www.ebi.ac.uk/pdbsum/1dzb PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/dz/1dzb_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The three-dimensional structure of the single-chain Fv fragment 1F9 in complex with turkey egg-white lysozyme (TEL) has been determined to a nominal resolution of 2.0 A by X-ray diffraction. The scFv fragment 1F9 was derived from phage-display libraries in two steps and binds both hen and turkey egg-white lysozyme, although the level of binding affinity is two orders of magnitude greater for the turkey lysozyme. The comparison of the crystal structure with a model of the single-chain Fv fragment 1F9 in complex with hen egg-white lysozyme (HEL) reveals that in the latter a clash between Asp101 in lysozyme and Trp98 of the complementarity determining region H3 of the heavy chain variable domain occurs. This is the only explanation apparent from the crystal structure for the better binding of TEL compared to HEL.The binding site topology on the paratope is not simply a planar surface as is usually found in antibody-protein interfaces, but includes a cleft between the light chain variable domain and heavy chain variable domain large enough to accommodate a loop from the lysozyme. The scFv fragment 1F9 recognizes an epitope on TEL that differs from the three antigenic determinants recognized in other known crystal structures of monoclonal antibodies in complex with lysozyme.

-	~~{{STRUCTURE_1dzb\| PDB=1dzb \| SCENE= }}~~	+	Crystal structure of a phage library-derived single-chain Fv fragment complexed with turkey egg-white lysozyme at 2.0 A resolution.,Ay J, Keitel T, Kuttner G, Wessner H, Scholz C, Hahn M, Hohne W J Mol Biol. 2000 Aug 11;301(2):239-46. PMID:10926506<ref>PMID:10926506</ref>

-	~~===CRYSTAL STRUCTURE OF PHAGE LIBRARY-DERIVED SINGLE-CHAIN FV FRAGMENT 1F9 IN COMPLEX WITH TURKEY EGG-WHITE LYSOZYME===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_10926506}}~~	+
-		+
-	~~==About this Structure==~~	+
-	~~[[1dzb]] is~~ a ~~4 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Meleagris_gallopavo Meleagris gallopavo] and [http://en~~.~~wikipedia.org~~/~~wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1DZB OCA].~~	+

	==See Also==		==See Also==
-	*[[~~Hen Egg-White (HEW)~~ Lysozyme\|~~Hen Egg-White (HEW)~~ Lysozyme]]	+	*[[Lysozyme 3D structures\|Lysozyme 3D structures]]
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	<~~ref group="xtra">PMID:010926506<~~/~~ref~~><~~ref group="xtra">PMID:009694519</ref><references group="xtra"~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Lysozyme]]		[[Category: Lysozyme]]
	[[Category: Meleagris gallopavo]]		[[Category: Meleagris gallopavo]]

OCA at 09:59, 20 October 2012

2012-10-20T09:59:41Z

←Older revision		Revision as of 09:59, 20 October 2012
Line 8:		Line 8:

	==About this Structure==		==About this Structure==
-	[[1dzb]] is a 4 chain structure ~~of [[Hen Egg-White (HEW) Lysozyme]]~~ with sequence from [http://en.wikipedia.org/wiki/Meleagris_gallopavo Meleagris gallopavo] and [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1DZB OCA].	+	[[1dzb]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Meleagris_gallopavo Meleagris gallopavo] and [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1DZB OCA].

	==See Also==		==See Also==