1e3o - Revision history

OCA at 11:51, 13 December 2023

2023-12-13T11:51:43Z

←Older revision		Revision as of 11:51, 13 December 2023
Line 3:		Line 3:
	<StructureSection load='1e3o' size='340' side='right'caption='[[1e3o]], [[Resolution\|resolution]] 1.90Å' scene=''>		<StructureSection load='1e3o' size='340' side='right'caption='[[1e3o]], [[Resolution\|resolution]] 1.90Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1e3o]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1E3O OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1E3O FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1e3o]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1E3O OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1E3O FirstGlance]. <br>
-	</td></tr><tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat">~~<div style='overflow: auto; max~~-~~height: 3em;'>[[1cqt\|1cqt]]~~, [[~~1oct~~\|~~1oct~~]]~~, [[1pog\|1pog]]</div>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.9Å</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1e3o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1e3o OCA], [https://pdbe.org/1e3o PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1e3o RCSB], [https://www.ebi.ac.uk/pdbsum/1e3o PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1e3o ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1e3o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1e3o OCA], [https://pdbe.org/1e3o PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1e3o RCSB], [https://www.ebi.ac.uk/pdbsum/1e3o PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1e3o ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/PO2F1_HUMAN PO2F1_HUMAN]] Transcription factor that binds to the octamer motif (5'-ATTTGCAT-3') and activates the promoters of the genes for some small nuclear RNAs (snRNA) and of genes such as those for histone H2B and immunoglobulins. Modulates transcription transactivation by NR3C1, AR and PGR (By similarity). In case of human herpes simplex virus (HSV) infection, POU2F1 forms a multiprotein-DNA complex with the viral transactivator protein VP16 and HCFC1 thereby enabling the transcription of the viral immediate early genes.<ref>PMID:1684878</ref>	+	[https://www.uniprot.org/uniprot/PO2F1_HUMAN PO2F1_HUMAN] Transcription factor that binds to the octamer motif (5'-ATTTGCAT-3') and activates the promoters of the genes for some small nuclear RNAs (snRNA) and of genes such as those for histone H2B and immunoglobulins. Modulates transcription transactivation by NR3C1, AR and PGR (By similarity). In case of human herpes simplex virus (HSV) infection, POU2F1 forms a multiprotein-DNA complex with the viral transactivator protein VP16 and HCFC1 thereby enabling the transcription of the viral immediate early genes.<ref>PMID:1684878</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Pohl, E]]	+	[[Category: Pohl E]]
-	[[Category: Remenyi, A]]	+	[[Category: Remenyi A]]
-	[[Category: Schoeler, H]]	+	[[Category: Schoeler H]]
-	[[Category: Tomilin, A]]	+	[[Category: Tomilin A]]
-	[[Category: Wilmanns, M]]	+	[[Category: Wilmanns M]]
-	~~[[Category: Dimer]]~~	+
-	~~[[Category: Dna binding]]~~	+
-	~~[[Category: Pou domain]]~~	+
-	~~[[Category: Transcription~~]]	+

OCA at 05:45, 28 April 2021

2021-04-28T05:45:23Z

←Older revision		Revision as of 05:45, 28 April 2021
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	<StructureSection load='1e3o' size='340' side='right'caption='[[1e3o]], [[Resolution\|resolution]] 1.90Å' scene=''>		<StructureSection load='1e3o' size='340' side='right'caption='[[1e3o]], [[Resolution\|resolution]] 1.90Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1e3o]] is a 3 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1E3O OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1E3O FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1e3o]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1E3O OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1E3O FirstGlance]. <br>
-	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1cqt\|1cqt]], [[1oct\|1oct]], [[1pog\|1pog]]</td></tr>	+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1cqt\|1cqt]], [[1oct\|1oct]], [[1pog\|1pog]]</div></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1e3o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1e3o OCA], [~~http~~://pdbe.org/1e3o PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=1e3o RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/1e3o PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=1e3o ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1e3o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1e3o OCA], [https://pdbe.org/1e3o PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1e3o RCSB], [https://www.ebi.ac.uk/pdbsum/1e3o PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1e3o ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/PO2F1_HUMAN PO2F1_HUMAN]] Transcription factor that binds to the octamer motif (5'-ATTTGCAT-3') and activates the promoters of the genes for some small nuclear RNAs (snRNA) and of genes such as those for histone H2B and immunoglobulins. Modulates transcription transactivation by NR3C1, AR and PGR (By similarity). In case of human herpes simplex virus (HSV) infection, POU2F1 forms a multiprotein-DNA complex with the viral transactivator protein VP16 and HCFC1 thereby enabling the transcription of the viral immediate early genes.<ref>PMID:1684878</ref>	+	[[https://www.uniprot.org/uniprot/PO2F1_HUMAN PO2F1_HUMAN]] Transcription factor that binds to the octamer motif (5'-ATTTGCAT-3') and activates the promoters of the genes for some small nuclear RNAs (snRNA) and of genes such as those for histone H2B and immunoglobulins. Modulates transcription transactivation by NR3C1, AR and PGR (By similarity). In case of human herpes simplex virus (HSV) infection, POU2F1 forms a multiprotein-DNA complex with the viral transactivator protein VP16 and HCFC1 thereby enabling the transcription of the viral immediate early genes.<ref>PMID:1684878</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]

OCA at 06:35, 24 July 2019

2019-07-24T06:35:33Z

←Older revision		Revision as of 06:35, 24 July 2019
Line 1:		Line 1:

	==Crystal structure of Oct-1 POU dimer bound to MORE==		==Crystal structure of Oct-1 POU dimer bound to MORE==
-	<StructureSection load='1e3o' size='340' side='right' caption='[[1e3o]], [[Resolution\|resolution]] 1.90Å' scene=''>	+	<StructureSection load='1e3o' size='340' side='right'caption='[[1e3o]], [[Resolution\|resolution]] 1.90Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1e3o]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1E3O OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1E3O FirstGlance]. <br>		<table><tr><td colspan='2'>[[1e3o]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1E3O OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1E3O FirstGlance]. <br>
Line 33:		Line 33:
	</StructureSection>		</StructureSection>
	[[Category: Human]]		[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Pohl, E]]		[[Category: Pohl, E]]
	[[Category: Remenyi, A]]		[[Category: Remenyi, A]]

OCA at 05:25, 8 March 2018

2018-03-08T05:25:35Z

←Older revision		Revision as of 05:25, 8 March 2018
Line 3:		Line 3:
	<StructureSection load='1e3o' size='340' side='right' caption='[[1e3o]], [[Resolution\|resolution]] 1.90Å' scene=''>		<StructureSection load='1e3o' size='340' side='right' caption='[[1e3o]], [[Resolution\|resolution]] 1.90Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1e3o]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1E3O OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1E3O FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1e3o]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1E3O OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1E3O FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1cqt\|1cqt]], [[1oct\|1oct]], [[1pog\|1pog]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1cqt\|1cqt]], [[1oct\|1oct]], [[1pog\|1pog]]</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1e3o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1e3o OCA], [http://pdbe.org/1e3o PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1e3o RCSB], [http://www.ebi.ac.uk/pdbsum/1e3o PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1e3o ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1e3o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1e3o OCA], [http://pdbe.org/1e3o PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1e3o RCSB], [http://www.ebi.ac.uk/pdbsum/1e3o PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1e3o ProSAT]</span></td></tr>
Line 13:		Line 13:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/e3/1e3o_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/e3/1e3o_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
Line 32:		Line 32:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Human]]
	[[Category: Pohl, E]]		[[Category: Pohl, E]]
	[[Category: Remenyi, A]]		[[Category: Remenyi, A]]

OCA at 04:16, 30 August 2017

2017-08-30T04:16:25Z

←Older revision		Revision as of 04:16, 30 August 2017
Line 1:		Line 1:
		+
	==Crystal structure of Oct-1 POU dimer bound to MORE==		==Crystal structure of Oct-1 POU dimer bound to MORE==
	<StructureSection load='1e3o' size='340' side='right' caption='[[1e3o]], [[Resolution\|resolution]] 1.90Å' scene=''>		<StructureSection load='1e3o' size='340' side='right' caption='[[1e3o]], [[Resolution\|resolution]] 1.90Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1e3o]] is a 3 chain structure ~~with sequence from [http://en.wikipedia.org/wiki/Human Human]~~. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1E3O OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1E3O FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1e3o]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1E3O OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1E3O FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1cqt\|1cqt]], [[1oct\|1oct]], [[1pog\|1pog]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1cqt\|1cqt]], [[1oct\|1oct]], [[1pog\|1pog]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1e3o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1e3o OCA], [http://pdbe.org/1e3o PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1e3o RCSB], [http://www.ebi.ac.uk/pdbsum/1e3o PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1e3o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1e3o OCA], [http://pdbe.org/1e3o PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1e3o RCSB], [http://www.ebi.ac.uk/pdbsum/1e3o PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1e3o ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 16:		Line 17:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1e3o ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 31:		Line 32:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Human]]
	[[Category: Pohl, E]]		[[Category: Pohl, E]]
	[[Category: Remenyi, A]]		[[Category: Remenyi, A]]

OCA at 15:39, 11 September 2015

2015-09-11T15:39:12Z

←Older revision		Revision as of 15:39, 11 September 2015
Line 2:		Line 2:
	<StructureSection load='1e3o' size='340' side='right' caption='[[1e3o]], [[Resolution\|resolution]] 1.90Å' scene=''>		<StructureSection load='1e3o' size='340' side='right' caption='[[1e3o]], [[Resolution\|resolution]] 1.90Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1e3o]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1E3O OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1E3O FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1e3o]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1E3O OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1E3O FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1cqt\|1cqt]], [[1oct\|1oct]], [[1pog\|1pog]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1cqt\|1cqt]], [[1oct\|1oct]], [[1pog\|1pog]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1e3o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1e3o OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1e3o RCSB], [http://www.ebi.ac.uk/pdbsum/1e3o PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1e3o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1e3o OCA], [http://pdbe.org/1e3o PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1e3o RCSB], [http://www.ebi.ac.uk/pdbsum/1e3o PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 26:		Line 26:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 1e3o" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Homo sapiens~~]]	+	[[Category: Human]]
	[[Category: Pohl, E]]		[[Category: Pohl, E]]
	[[Category: Remenyi, A]]		[[Category: Remenyi, A]]

OCA at 18:30, 25 December 2014

2014-12-25T18:30:39Z

←Older revision		Revision as of 18:30, 25 December 2014
Line 6:		Line 6:
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1e3o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1e3o OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1e3o RCSB], [http://www.ebi.ac.uk/pdbsum/1e3o PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1e3o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1e3o OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1e3o RCSB], [http://www.ebi.ac.uk/pdbsum/1e3o PDBsum]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/PO2F1_HUMAN PO2F1_HUMAN]] Transcription factor that binds to the octamer motif (5'-ATTTGCAT-3') and activates the promoters of the genes for some small nuclear RNAs (snRNA) and of genes such as those for histone H2B and immunoglobulins. Modulates transcription transactivation by NR3C1, AR and PGR (By similarity). In case of human herpes simplex virus (HSV) infection, POU2F1 forms a multiprotein-DNA complex with the viral transactivator protein VP16 and HCFC1 thereby enabling the transcription of the viral immediate early genes.<ref>PMID:1684878</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]

OCA at 00:01, 23 December 2014

2014-12-23T00:01:12Z

←Older revision		Revision as of 00:01, 23 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1e3o]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1E3O OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1E3O FirstGlance]. <br>		<table><tr><td colspan='2'>[[1e3o]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1E3O OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1E3O FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1cqt\|1cqt]], [[1oct\|1oct]], [[1pog\|1pog]]</td></tr>	+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1cqt\|1cqt]], [[1oct\|1oct]], [[1pog\|1pog]]</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1e3o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1e3o OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1e3o RCSB], [http://www.ebi.ac.uk/pdbsum/1e3o PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1e3o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1e3o OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1e3o RCSB], [http://www.ebi.ac.uk/pdbsum/1e3o PDBsum]</span></td></tr>
-	<table>	+	</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 29:		Line 29:
	</StructureSection>		</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
-	[[Category: Pohl, E.]]	+	[[Category: Pohl, E]]
-	[[Category: Remenyi, A.]]	+	[[Category: Remenyi, A]]
-	[[Category: Schoeler, H.]]	+	[[Category: Schoeler, H]]
-	[[Category: Tomilin, A.]]	+	[[Category: Tomilin, A]]
-	[[Category: Wilmanns, M.]]	+	[[Category: Wilmanns, M]]
	[[Category: Dimer]]		[[Category: Dimer]]
	[[Category: Dna binding]]		[[Category: Dna binding]]
	[[Category: Pou domain]]		[[Category: Pou domain]]
	[[Category: Transcription]]		[[Category: Transcription]]

OCA at 10:55, 10 September 2014

2014-09-10T10:55:41Z

←Older revision		Revision as of 10:55, 10 September 2014
Line 1:		Line 1:
-	[[~~Image:~~1e3o.~~png~~\|~~left~~\|200px]]	+	==Crystal structure of Oct-1 POU dimer bound to MORE==
		+	<StructureSection load='1e3o' size='340' side='right' caption='[[1e3o]], [[Resolution\|resolution]] 1.90Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[1e3o]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1E3O OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1E3O FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1cqt\|1cqt]], [[1oct\|1oct]], [[1pog\|1pog]]</td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1e3o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1e3o OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1e3o RCSB], [http://www.ebi.ac.uk/pdbsum/1e3o PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/e3/1e3o_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Two crystal structures of Oct-1 POU domain bound to DNA provide a rationale for differential, conformation-dependent recruitment of transcription cofactors. The POU-homeo and POU-specific subdomains of Oct-1 contain two different nonoverlapping pairs of surface patches that are capable of forming unrelated protein-protein interfaces. Members of the POU factor family contain one or two conserved sequence motifs in the interface that are known to be phosphorylated, as noted for Oct-1 and Pit-1. Modeling of Oct-4 reveals the unique case where the same conserved sequence is located in both interfaces. Our studies provide the basis for two distinct dimeric POU factor arrangements that are dictated by the architecture of each DNA response element. We suggest interface swapping in dimers could be a general mechanism of modulating the activity of transcription factors.

-	~~{{STRUCTURE_1e3o\| PDB=1e3o \| SCENE= }}~~	+	Differential dimer activities of the transcription factor Oct-1 by DNA-induced interface swapping.,Remenyi A, Tomilin A, Pohl E, Lins K, Philippsen A, Reinbold R, Scholer HR, Wilmanns M Mol Cell. 2001 Sep;8(3):569-80. PMID:11583619<ref>PMID:11583619</ref>

-	~~===Crystal structure~~ of ~~Oct-1 POU dimer bound to MORE===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_11583619}}~~	+	== References ==
-		+	<references/>
-	~~==About this Structure==~~	+	__TOC__
-	~~[[1e3o]] is a 3 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Homo_sapiens Homo sapiens]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=1E3O OCA].~~	+	</StructureSection>
-		+
-	==~~Reference~~==	+
-	<~~ref group="xtra">PMID:011583619<~~/~~ref~~><~~references group="xtra"~~/>	+
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Pohl, E.]]		[[Category: Pohl, E.]]

OCA at 10:40, 14 November 2012

2012-11-14T10:40:01Z

←Older revision		Revision as of 10:40, 14 November 2012
Line 5:		Line 5:
	===Crystal structure of Oct-1 POU dimer bound to MORE===		===Crystal structure of Oct-1 POU dimer bound to MORE===

		+	{{ABSTRACT_PUBMED_11583619}}

	==About this Structure==		==About this Structure==