1et2 - Revision history

OCA at 09:41, 21 July 2021

2021-07-21T09:41:21Z

←Older revision		Revision as of 09:41, 21 July 2021
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	<StructureSection load='1et2' size='340' side='right'caption='[[1et2]]' scene=''>		<StructureSection load='1et2' size='340' side='right'caption='[[1et2]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1ET2 FirstGlance]. <br>	+	<table><tr><td colspan='2'>For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1ET2 FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1et2 FirstGlance], [~~http~~://www.ebi.ac.uk/pdbsum/1et2 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=1et2 ProSAT]</span></td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1et2 FirstGlance], [https://www.ebi.ac.uk/pdbsum/1et2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1et2 ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 11:19, 16 October 2019

2019-10-16T11:19:19Z

←Older revision		Revision as of 11:19, 16 October 2019
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	==MOLECULAR MODEL OF THE CRYSTAL STRUCTURE OF HUMAN PARATHYROID HORMONE 1-34 COMPLEXED WITH PTH/PTHRP RECEPTOR.==		==MOLECULAR MODEL OF THE CRYSTAL STRUCTURE OF HUMAN PARATHYROID HORMONE 1-34 COMPLEXED WITH PTH/PTHRP RECEPTOR.==
-	<StructureSection load='1et2' size='340' side='right' caption='[[1et2]]' scene=''>	+	<StructureSection load='1et2' size='340' side='right'caption='[[1et2]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ET2 FirstGlance]. <br>		<table><tr><td colspan='2'>For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ET2 FirstGlance]. <br>
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	</StructureSection>		</StructureSection>
	[[Category: Theoretical Model]]		[[Category: Theoretical Model]]
		+	[[Category: Large Structures]]
	[[Category: Briggs, S L]]		[[Category: Briggs, S L]]
	[[Category: Chandrasekhar, S]]		[[Category: Chandrasekhar, S]]

OCA at 07:20, 20 December 2017

2017-12-20T07:20:37Z

←Older revision		Revision as of 07:20, 20 December 2017
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	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ET2 FirstGlance]. <br>		<table><tr><td colspan='2'>For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ET2 FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1et2 FirstGlance], [http://www.ebi.ac.uk/pdbsum/1et2 PDBsum]</span></td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1et2 FirstGlance], [http://www.ebi.ac.uk/pdbsum/1et2 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1et2 ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 08:54, 11 February 2016

2016-02-11T08:54:20Z

←Older revision		Revision as of 08:54, 11 February 2016
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		+	{{Theoretical_model}}
		+
	==MOLECULAR MODEL OF THE CRYSTAL STRUCTURE OF HUMAN PARATHYROID HORMONE 1-34 COMPLEXED WITH PTH/PTHRP RECEPTOR.==		==MOLECULAR MODEL OF THE CRYSTAL STRUCTURE OF HUMAN PARATHYROID HORMONE 1-34 COMPLEXED WITH PTH/PTHRP RECEPTOR.==
	<StructureSection load='1et2' size='340' side='right' caption='[[1et2]]' scene=''>		<StructureSection load='1et2' size='340' side='right' caption='[[1et2]]' scene=''>
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Theoretical Model]]
	[[Category: Briggs, S L]]		[[Category: Briggs, S L]]
	[[Category: Chandrasekhar, S]]		[[Category: Chandrasekhar, S]]

OCA at 10:13, 10 September 2015

2015-09-10T10:13:38Z

←Older revision		Revision as of 10:13, 10 September 2015
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	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 1et2" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>

OCA at 12:07, 18 December 2014

2014-12-18T12:07:23Z

←Older revision		Revision as of 12:07, 18 December 2014
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-	~~{{Theoretical_model}}~~	+	==MOLECULAR MODEL OF THE CRYSTAL STRUCTURE OF HUMAN PARATHYROID HORMONE 1-34 COMPLEXED WITH PTH/PTHRP RECEPTOR.==
		+	<StructureSection load='1et2' size='340' side='right' caption='[[1et2]]' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ET2 FirstGlance]. <br>
		+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1et2 FirstGlance], [http://www.ebi.ac.uk/pdbsum/1et2 PDBsum]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The N-terminal fragment 1-34 of parathyroid hormone (PTH), administered intermittently, results in increased bone formation in patients with osteoporosis. PTH and a related molecule, parathyroid hormone-related peptide (PTHrP), act on cells via a common PTH/PTHrP receptor. To define more precisely the ligand-receptor interactions, we have crystallized human PTH (hPTH)-(1-34) and determined the structure to 0.9-A resolution. hPTH-(1-34) crystallizes as a slightly bent, long helical dimer. Analysis reveals that the extended helical conformation of hPTH-(1-34) is the likely bioactive conformation. We have developed molecular models for the interaction of hPTH-(1-34) and hPTHrP-(1-34) with the PTH/PTHrP receptor. A receptor binding pocket for the N terminus of hPTH-(1-34) and a hydrophobic interface with the receptor for the C terminus of hPTH-(1-34) are proposed.

-	~~{{STRUCTURE_1et2\| PDB=1et2 \| SCENE= }}~~	+	Crystal structure of human parathyroid hormone 1-34 at 0.9-A resolution.,Jin L, Briggs SL, Chandrasekhar S, Chirgadze NY, Clawson DK, Schevitz RW, Smiley DL, Tashjian AH, Zhang F J Biol Chem. 2000 Sep 1;275(35):27238-44. PMID:10837469<ref>PMID:10837469</ref>
-	~~===MOLECULAR MODEL OF THE CRYSTAL STRUCTURE OF HUMAN PARATHYROID HORMONE~~ 1-34 ~~COMPLEXED WITH PTH/PTHRP RECEPTOR~~.~~===~~	+
-	~~{{ABSTRACT_PUBMED_10837469}}~~	+

-	==~~Reference~~==	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~<ref group="xtra">PMID:010837469</ref>~~<references ~~group="xtra"~~/><~~references~~/>	+	</div>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
	[[Category: Briggs, S L]]		[[Category: Briggs, S L]]
	[[Category: Chandrasekhar, S]]		[[Category: Chandrasekhar, S]]

OCA at 09:33, 24 March 2013

2013-03-24T09:33:25Z

←Older revision		Revision as of 09:33, 24 March 2013
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	{{Theoretical_model}}		{{Theoretical_model}}
-
-	[[Image:1et2.png\|left\|200px]]

	{{STRUCTURE_1et2\| PDB=1et2 \| SCENE= }}		{{STRUCTURE_1et2\| PDB=1et2 \| SCENE= }}
-
	===MOLECULAR MODEL OF THE CRYSTAL STRUCTURE OF HUMAN PARATHYROID HORMONE 1-34 COMPLEXED WITH PTH/PTHRP RECEPTOR.===		===MOLECULAR MODEL OF THE CRYSTAL STRUCTURE OF HUMAN PARATHYROID HORMONE 1-34 COMPLEXED WITH PTH/PTHRP RECEPTOR.===
-
	{{ABSTRACT_PUBMED_10837469}}		{{ABSTRACT_PUBMED_10837469}}

	==Reference==		==Reference==
-	<ref group="xtra">PMID:010837469</ref><references group="xtra"/>	+	<ref group="xtra">PMID:010837469</ref><references group="xtra"/><references/>
	[[Category: Briggs, S L]]		[[Category: Briggs, S L]]
	[[Category: Chandrasekhar, S]]		[[Category: Chandrasekhar, S]]

OCA: Protected "1et2" [edit=sysop:move=sysop]

2012-10-21T08:59:59Z

Protected "1et2" [edit=sysop:move=sysop]

←Older revision

Revision as of 08:59, 21 October 2012

OCA at 08:59, 21 October 2012

2012-10-21T08:59:57Z

←Older revision		Revision as of 08:59, 21 October 2012
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	{{Theoretical_model}}		{{Theoretical_model}}
-	~~{{Seed}}~~	+
	[[Image:1et2.png\|left\|200px]]		[[Image:1et2.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_1et2", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_1et2\| PDB=1et2 \| SCENE= }}		{{STRUCTURE_1et2\| PDB=1et2 \| SCENE= }}

	===MOLECULAR MODEL OF THE CRYSTAL STRUCTURE OF HUMAN PARATHYROID HORMONE 1-34 COMPLEXED WITH PTH/PTHRP RECEPTOR.===		===MOLECULAR MODEL OF THE CRYSTAL STRUCTURE OF HUMAN PARATHYROID HORMONE 1-34 COMPLEXED WITH PTH/PTHRP RECEPTOR.===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_10837469}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 10837469 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_10837469}}		{{ABSTRACT_PUBMED_10837469}}
-
-	==About this Structure==
-	Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ET2 OCA].

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~10837469~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:010837469</ref><references group="xtra"/>
	[[Category: Briggs, S L]]		[[Category: Briggs, S L]]
	[[Category: Chandrasekhar, S]]		[[Category: Chandrasekhar, S]]
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	[[Category: Tashjian, A H]]		[[Category: Tashjian, A H]]
	[[Category: Zhang, F]]		[[Category: Zhang, F]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Apr 8 07:25:55 2010''

OCA at 04:25, 8 April 2010

2010-04-08T04:25:55Z

←Older revision		Revision as of 04:25, 8 April 2010
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-	~~'''Theoretical Model'''~~	+	{{Theoretical_model}}
		+	{{Seed}}
		+	[[Image:1et2.png\|left\|200px]]

-	The ~~entry 1ET2~~ is ~~a Theoretical Model titled 'MOLECULAR MODEL OF THE CRYSTAL STRUCTURE OF HUMAN PARATHYROID HORMONE 1-34 COMPLEXED WITH PTH/PTHRP RECEPTOR.'~~.	+	<!--
		+	The line below this paragraph, containing "STRUCTURE_1et2", creates the "Structure Box" on the page.
		+	You may change the PDB parameter (which sets the PDB file loaded into the applet)
		+	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
		+	or leave the SCENE parameter empty for the default display.
		+	-->
		+	{{STRUCTURE_1et2\| PDB=1et2 \| SCENE= }}

-	~~[[Category:Theoretical Model]]~~	+	===MOLECULAR MODEL OF THE CRYSTAL STRUCTURE OF HUMAN PARATHYROID HORMONE 1-34 COMPLEXED WITH PTH/PTHRP RECEPTOR.===


-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Wed Jul 30 09~~:49:~~35 2008~~''	+	<!--
		+	The line below this paragraph, {{ABSTRACT_PUBMED_10837469}}, adds the Publication Abstract to the page
		+	(as it appears on PubMed at http://www.pubmed.gov), where 10837469 is the PubMed ID number.
		+	-->
		+	{{ABSTRACT_PUBMED_10837469}}
		+
		+	==About this Structure==
		+	Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ET2 OCA].
		+
		+	==Reference==
		+	<ref group="xtra">PMID:10837469</ref><references group="xtra"/>
		+	[[Category: Briggs, S L]]
		+	[[Category: Chandrasekhar, S]]
		+	[[Category: Chirgadze, N Y]]
		+	[[Category: Clawson, D K]]
		+	[[Category: Jin, L]]
		+	[[Category: Schevitz, R W]]
		+	[[Category: Smiley, D L]]
		+	[[Category: Tashjian, A H]]
		+	[[Category: Zhang, F]]
		+
		+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Apr 8 07:25:55 2010''