1ex6 - Revision history

OCA at 09:20, 30 August 2023

2023-08-30T09:20:56Z

←Older revision		Revision as of 09:20, 30 August 2023
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	<StructureSection load='1ex6' size='340' side='right'caption='[[1ex6]], [[Resolution\|resolution]] 2.30Å' scene=''>		<StructureSection load='1ex6' size='340' side='right'caption='[[1ex6]], [[Resolution\|resolution]] 2.30Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1ex6]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1EX6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1EX6 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1ex6]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1EX6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1EX6 FirstGlance]. <br>
-	</td></tr><tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat">~~<div style='overflow: auto; max~~-~~height: 3em;'>[[1gky\|1gky]]~~, [[~~1ex7~~\|~~1ex7~~]]~~</div></td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.3Å</td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Guanylate_kinase Guanylate kinase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.~~7.4.8 2.7.4.8] </span>~~</td></tr>	+
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1ex6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ex6 OCA], [https://pdbe.org/1ex6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1ex6 RCSB], [https://www.ebi.ac.uk/pdbsum/1ex6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1ex6 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1ex6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ex6 OCA], [https://pdbe.org/1ex6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1ex6 RCSB], [https://www.ebi.ac.uk/pdbsum/1ex6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1ex6 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/KGUA_YEAST KGUA_YEAST]] Essential for recycling GMP and indirectly, cGMP.	+	[https://www.uniprot.org/uniprot/KGUA_YEAST KGUA_YEAST] Essential for recycling GMP and indirectly, cGMP.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Guanylate kinase]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Blaszczyk, J~~]]	+	[[Category: Saccharomyces cerevisiae]]
-	[[Category: ~~Ji, X~~]]	+	[[Category: Blaszczyk J]]
-	[[Category: ~~Atp]]~~	+	[[Category: Ji X]]
-	~~[[Category: Domain movement]]~~	+
-	~~[[Category: Gmp]]~~	+
-	~~[[Category: Substrate specificity]]~~	+
-	~~[[Category: Substrate-induced fit]]~~	+
-	~~[[Category: Transferase~~]]	+

OCA at 07:16, 17 March 2021

2021-03-17T07:16:35Z

←Older revision		Revision as of 07:16, 17 March 2021
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	<StructureSection load='1ex6' size='340' side='right'caption='[[1ex6]], [[Resolution\|resolution]] 2.30Å' scene=''>		<StructureSection load='1ex6' size='340' side='right'caption='[[1ex6]], [[Resolution\|resolution]] 2.30Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1ex6]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1EX6 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1EX6 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1ex6]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1EX6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1EX6 FirstGlance]. <br>
-	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1gky\|1gky]], [[1ex7\|1ex7]]</td></tr>	+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1gky\|1gky]], [[1ex7\|1ex7]]</div></td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://en.wikipedia.org/wiki/Guanylate_kinase Guanylate kinase], with EC number [~~http~~://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.4.8 2.7.4.8] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Guanylate_kinase Guanylate kinase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.4.8 2.7.4.8] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1ex6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ex6 OCA], [~~http~~://pdbe.org/1ex6 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=1ex6 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/1ex6 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=1ex6 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1ex6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ex6 OCA], [https://pdbe.org/1ex6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1ex6 RCSB], [https://www.ebi.ac.uk/pdbsum/1ex6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1ex6 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/KGUA_YEAST KGUA_YEAST]] Essential for recycling GMP and indirectly, cGMP.	+	[[https://www.uniprot.org/uniprot/KGUA_YEAST KGUA_YEAST]] Essential for recycling GMP and indirectly, cGMP.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	==See Also==		==See Also==
-	*[[Guanylate kinase\|Guanylate kinase]]	+	*[[Guanylate kinase 3D structures\|Guanylate kinase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 07:16, 12 June 2019

2019-06-12T07:16:57Z

←Older revision		Revision as of 07:16, 12 June 2019
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	==CRYSTAL STRUCTURE OF UNLIGANDED FORM OF GUANYLATE KINASE FROM YEAST==		==CRYSTAL STRUCTURE OF UNLIGANDED FORM OF GUANYLATE KINASE FROM YEAST==
-	<StructureSection load='1ex6' size='340' side='right' caption='[[1ex6]], [[Resolution\|resolution]] 2.30Å' scene=''>	+	<StructureSection load='1ex6' size='340' side='right'caption='[[1ex6]], [[Resolution\|resolution]] 2.30Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1ex6]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1EX6 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1EX6 FirstGlance]. <br>		<table><tr><td colspan='2'>[[1ex6]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1EX6 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1EX6 FirstGlance]. <br>
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	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ex/1ex6_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ex/1ex6_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
Line 37:		Line 37:
	</StructureSection>		</StructureSection>
	[[Category: Guanylate kinase]]		[[Category: Guanylate kinase]]
		+	[[Category: Large Structures]]
	[[Category: Blaszczyk, J]]		[[Category: Blaszczyk, J]]
	[[Category: Ji, X]]		[[Category: Ji, X]]

OCA at 03:58, 6 September 2017

2017-09-06T03:58:16Z

←Older revision		Revision as of 03:58, 6 September 2017
Line 1:		Line 1:
		+
	==CRYSTAL STRUCTURE OF UNLIGANDED FORM OF GUANYLATE KINASE FROM YEAST==		==CRYSTAL STRUCTURE OF UNLIGANDED FORM OF GUANYLATE KINASE FROM YEAST==
	<StructureSection load='1ex6' size='340' side='right' caption='[[1ex6]], [[Resolution\|resolution]] 2.30Å' scene=''>		<StructureSection load='1ex6' size='340' side='right' caption='[[1ex6]], [[Resolution\|resolution]] 2.30Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1ex6]] is a 2 chain structure ~~with sequence from [http://en.wikipedia.org/wiki/Atcc_18824 Atcc 18824]~~. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1EX6 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1EX6 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1ex6]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1EX6 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1EX6 FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1gky\|1gky]], [[1ex7\|1ex7]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1gky\|1gky]], [[1ex7\|1ex7]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Guanylate_kinase Guanylate kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.4.8 2.7.4.8] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Guanylate_kinase Guanylate kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.4.8 2.7.4.8] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ex6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ex6 OCA], [http://pdbe.org/1ex6 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1ex6 RCSB], [http://www.ebi.ac.uk/pdbsum/1ex6 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ex6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ex6 OCA], [http://pdbe.org/1ex6 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1ex6 RCSB], [http://www.ebi.ac.uk/pdbsum/1ex6 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1ex6 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
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	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1ex6 ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Atcc 18824]]
	[[Category: Guanylate kinase]]		[[Category: Guanylate kinase]]
	[[Category: Blaszczyk, J]]		[[Category: Blaszczyk, J]]
	[[Category: Ji, X]]		[[Category: Ji, X]]
		+	[[Category: Atp]]
	[[Category: Domain movement]]		[[Category: Domain movement]]
	[[Category: Gmp]]		[[Category: Gmp]]

OCA at 07:16, 11 September 2015

2015-09-11T07:16:06Z

←Older revision		Revision as of 07:16, 11 September 2015
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	<StructureSection load='1ex6' size='340' side='right' caption='[[1ex6]], [[Resolution\|resolution]] 2.30Å' scene=''>		<StructureSection load='1ex6' size='340' side='right' caption='[[1ex6]], [[Resolution\|resolution]] 2.30Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1ex6]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Saccharomyces_cerevisiae Saccharomyces cerevisiae~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1EX6 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1EX6 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1ex6]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Atcc_18824 Atcc 18824]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1EX6 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1EX6 FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1gky\|1gky]], [[1ex7\|1ex7]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1gky\|1gky]], [[1ex7\|1ex7]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Guanylate_kinase Guanylate kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.4.8 2.7.4.8] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Guanylate_kinase Guanylate kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.4.8 2.7.4.8] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ex6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ex6 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1ex6 RCSB], [http://www.ebi.ac.uk/pdbsum/1ex6 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ex6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ex6 OCA], [http://pdbe.org/1ex6 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1ex6 RCSB], [http://www.ebi.ac.uk/pdbsum/1ex6 PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
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	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 1ex6" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 34:		Line 35:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Atcc 18824]]
	[[Category: Guanylate kinase]]		[[Category: Guanylate kinase]]
-	[[Category: Saccharomyces cerevisiae]]
	[[Category: Blaszczyk, J]]		[[Category: Blaszczyk, J]]
	[[Category: Ji, X]]		[[Category: Ji, X]]

OCA at 13:06, 25 December 2014

2014-12-25T13:06:25Z

←Older revision		Revision as of 13:06, 25 December 2014
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	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ex6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ex6 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1ex6 RCSB], [http://www.ebi.ac.uk/pdbsum/1ex6 PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ex6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ex6 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1ex6 RCSB], [http://www.ebi.ac.uk/pdbsum/1ex6 PDBsum]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/KGUA_YEAST KGUA_YEAST]] Essential for recycling GMP and indirectly, cGMP.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]

OCA at 21:38, 22 December 2014

2014-12-22T21:38:03Z

←Older revision		Revision as of 21:38, 22 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1ex6]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1EX6 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1EX6 FirstGlance]. <br>		<table><tr><td colspan='2'>[[1ex6]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1EX6 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1EX6 FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1gky\|1gky]], [[1ex7\|1ex7]]</td></tr>	+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1gky\|1gky]], [[1ex7\|1ex7]]</td></tr>
-	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Guanylate_kinase Guanylate kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.4.8 2.7.4.8] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Guanylate_kinase Guanylate kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.4.8 2.7.4.8] </span></td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ex6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ex6 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1ex6 RCSB], [http://www.ebi.ac.uk/pdbsum/1ex6 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ex6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ex6 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1ex6 RCSB], [http://www.ebi.ac.uk/pdbsum/1ex6 PDBsum]</span></td></tr>
-	<table>	+	</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 34:		Line 34:
	[[Category: Guanylate kinase]]		[[Category: Guanylate kinase]]
	[[Category: Saccharomyces cerevisiae]]		[[Category: Saccharomyces cerevisiae]]
-	[[Category: Blaszczyk, J.]]	+	[[Category: Blaszczyk, J]]
-	[[Category: Ji, X.]]	+	[[Category: Ji, X]]
	[[Category: Domain movement]]		[[Category: Domain movement]]
	[[Category: Gmp]]		[[Category: Gmp]]
-	[[Category: Guanylate kinase]]
	[[Category: Substrate specificity]]		[[Category: Substrate specificity]]
	[[Category: Substrate-induced fit]]		[[Category: Substrate-induced fit]]
	[[Category: Transferase]]		[[Category: Transferase]]

OCA at 11:28, 28 September 2014

2014-09-28T11:28:14Z

←Older revision		Revision as of 11:28, 28 September 2014
Line 1:		Line 1:
-	[[~~Image:~~1ex6.~~png~~\|~~left~~\|200px]]	+	==CRYSTAL STRUCTURE OF UNLIGANDED FORM OF GUANYLATE KINASE FROM YEAST==
		+	<StructureSection load='1ex6' size='340' side='right' caption='[[1ex6]], [[Resolution\|resolution]] 2.30Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[1ex6]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1EX6 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1EX6 FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1gky\|1gky]], [[1ex7\|1ex7]]</td></tr>
		+	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Guanylate_kinase Guanylate kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.4.8 2.7.4.8] </span></td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ex6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ex6 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1ex6 RCSB], [http://www.ebi.ac.uk/pdbsum/1ex6 PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ex/1ex6_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The crystal structure of guanylate kinase (GK) from yeast (Saccharomyces cerevisiae) with a non-acetylated N terminus has been determined in its unligated form (apo-GK) as well as in complex with GMP (GK.GMP). The structure of apo-GK was solved with multiwavelength anomalous diffraction data and refined to an R-factor of 0.164 (R(free)=0.199) at 2.3 A resolution. The structure of GK.GMP was determined using the crystal structure of GK with an acetylated N terminus as the search model and refined to an R-factor of 0.156 (R(free)=0.245) at 1.9 A. GK belongs to the family of nucleoside monophosphate (NMP) kinases and catalyzes the reversible phosphoryl transfer from ATP to GMP. Like other NMP kinases, GK consists of three dynamic domains: the CORE, LID, and NMP-binding domains. Dramatic movements of the GMP-binding domain and smaller but significant movements of the LID domain have been revealed by comparing the structures of apo-GK and GK.GMP. apo-GK has a much more open conformation than the GK.GMP complex. Systematic analysis of the domain movements using the program DynDom shows that the large movements of the GMP-binding domain involve a rotation around an effective hinge axis approximately parallel with helix 3, which connects the GMP-binding and CORE domains. The C-terminal portion of helix 3, which connects to the CORE domain, has strikingly higher temperature factors in GK.GMP than in apo-GK, indicating that these residues become more mobile upon GMP binding. The results suggest that helix 3 plays an important role in domain movement. Unlike the GMP-binding domain, which moves toward the active center of the enzyme upon GMP binding, the LID domain moves away from the active center and makes the presumed ATP-binding site more open. Therefore, the LID domain movement may facilitate the binding of MgATP. The structure of the recombinant GK.GMP complex superimposes very well with that of the native GK.GMP complex, indicating that N-terminal acetylation does not have significant impact on the three-dimensional structure of GK.

-	~~{{STRUCTURE_1ex6\| PDB=1ex6 \| SCENE= }}~~	+	Crystal structure of unligated guanylate kinase from yeast reveals GMP-induced conformational changes.,Blaszczyk J, Li Y, Yan H, Ji X J Mol Biol. 2001 Mar 16;307(1):247-57. PMID:11243817<ref>PMID:11243817</ref>

-	~~===CRYSTAL STRUCTURE OF UNLIGANDED FORM OF GUANYLATE KINASE FROM YEAST===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_11243817}}~~	+
-		+
-	~~==About this Structure==~~	+
-	~~[[1ex6]] is~~ a ~~2 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=1EX6 OCA].~~	+

	==See Also==		==See Also==
	*[[Guanylate kinase\|Guanylate kinase]]		*[[Guanylate kinase\|Guanylate kinase]]
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	<~~ref group="xtra">PMID:011243817<~~/~~ref~~><~~references group="xtra"~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Guanylate kinase]]		[[Category: Guanylate kinase]]
	[[Category: Saccharomyces cerevisiae]]		[[Category: Saccharomyces cerevisiae]]

OCA at 17:02, 20 October 2012

2012-10-20T17:02:10Z

←Older revision		Revision as of 17:02, 20 October 2012
Line 8:		Line 8:

	==About this Structure==		==About this Structure==
-	[[1ex6]] is a 2 chain structure ~~of [[Guanylate kinase]]~~ with sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1EX6 OCA].	+	[[1ex6]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1EX6 OCA].

	==See Also==		==See Also==

OCA: Protected "1ex6" [edit=sysop:move=sysop]

2012-07-26T23:36:54Z

Protected "1ex6" [edit=sysop:move=sysop]

←Older revision

Revision as of 23:36, 26 July 2012