1fu7 - Revision history

OCA at 06:05, 9 August 2023

2023-08-09T06:05:18Z

←Older revision		Revision as of 06:05, 9 August 2023
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1fu7]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Oryctolagus_cuniculus Oryctolagus cuniculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1FU7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1FU7 FirstGlance]. <br>		<table><tr><td colspan='2'>[[1fu7]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Oryctolagus_cuniculus Oryctolagus cuniculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1FU7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1FU7 FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=CR1:1~~-~~DEOXY-1-METHOXYCARBAMIDO-BETA-D-GLUCOPYRANOSE'>CR1</scene>~~, ~~<scene name='pdbligand=PLP:PYRIDOXAL-5-PHOSPHATE'>PLP</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.36Å</td></tr>
-	<tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"><~~div style~~='~~overflow~~: ~~auto; max~~-~~height: 3em;~~'>~~[[1b4d\|1b4d]], [[1ggn\|1ggn]], [[1fs4\|1fs4]], [[1ftq\|1ftq]], [[1ftw\|1ftw]], [[1fty\|1fty]], [[1fu4\|1fu4]], [[1fu8\|1fu8]]~~</~~div~~><~~/td></tr>~~	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CR1:1-DEOXY-1-METHOXYCARBAMIDO-BETA-D-GLUCOPYRANOSE'>CR1</scene>, <scene name='pdbligand=PLP:PYRIDOXAL-5-PHOSPHATE'>PLP</scene></td></tr>
-	~~<tr id~~='~~activity'><td class~~=~~"sblockLbl"><b>Activity~~:~~</b></td><td class="sblockDat"><span class='plainlinks~~'>~~[https://en.wikipedia.org/wiki/Phosphorylase Phosphorylase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.4.1.1 2.4.1.1]~~ </~~span~~></td></tr>	+
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1fu7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1fu7 OCA], [https://pdbe.org/1fu7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1fu7 RCSB], [https://www.ebi.ac.uk/pdbsum/1fu7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1fu7 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1fu7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1fu7 OCA], [https://pdbe.org/1fu7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1fu7 RCSB], [https://www.ebi.ac.uk/pdbsum/1fu7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1fu7 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/PYGM_RABIT PYGM_RABIT]] Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties.	+	[https://www.uniprot.org/uniprot/PYGM_RABIT PYGM_RABIT] Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 39:		Line 38:
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Oryctolagus cuniculus]]		[[Category: Oryctolagus cuniculus]]
-	~~[[Category: Phosphorylase]]~~	+	[[Category: Fleet GW]]
-	[[Category: Fleet~~, G W~~]]	+	[[Category: Gregoriou M]]
-	[[Category: Gregoriou, M]]	+	[[Category: Johnson LN]]
-	[[Category: Johnson~~, L N~~]]	+	[[Category: Oikonomakos NG]]
-	[[Category: Oikonomakos~~, N G~~]]	+	[[Category: Skamnaki VT]]
-	[[Category: Skamnaki~~, V T~~]]	+	[[Category: Tsitsanou KE]]
-	[[Category: Tsitsanou~~, K E~~]]	+	[[Category: Watson KA]]
-	[[Category: Watson~~, K A~~]]	+	[[Category: Zographos SE]]
-	[[Category: Zographos~~, S E]]~~	+
-	~~[[Category: Catalytic site]]~~	+
-	~~[[Category: Design]]~~	+
-	~~[[Category: Glycogen phosphorylase]]~~	+
-	~~[[Category: Inhibitor complex]]~~	+
-	~~[[Category: Transferase~~]]	+

OCA at 11:15, 28 July 2021

2021-07-28T11:15:13Z

←Older revision		Revision as of 11:15, 28 July 2021
Line 3:		Line 3:
	<StructureSection load='1fu7' size='340' side='right'caption='[[1fu7]], [[Resolution\|resolution]] 2.36Å' scene=''>		<StructureSection load='1fu7' size='340' side='right'caption='[[1fu7]], [[Resolution\|resolution]] 2.36Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1fu7]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Oryctolagus_cuniculus Oryctolagus cuniculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1FU7 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1FU7 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1fu7]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Oryctolagus_cuniculus Oryctolagus cuniculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1FU7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1FU7 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CR1:1-DEOXY-1-METHOXYCARBAMIDO-BETA-D-GLUCOPYRANOSE'>CR1</scene>, <scene name='pdbligand=PLP:PYRIDOXAL-5-PHOSPHATE'>PLP</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CR1:1-DEOXY-1-METHOXYCARBAMIDO-BETA-D-GLUCOPYRANOSE'>CR1</scene>, <scene name='pdbligand=PLP:PYRIDOXAL-5-PHOSPHATE'>PLP</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1b4d\|1b4d]], [[1ggn\|1ggn]], [[1fs4\|1fs4]], [[1ftq\|1ftq]], [[1ftw\|1ftw]], [[1fty\|1fty]], [[1fu4\|1fu4]], [[1fu8\|1fu8]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1b4d\|1b4d]], [[1ggn\|1ggn]], [[1fs4\|1fs4]], [[1ftq\|1ftq]], [[1ftw\|1ftw]], [[1fty\|1fty]], [[1fu4\|1fu4]], [[1fu8\|1fu8]]</div></td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://en.wikipedia.org/wiki/Phosphorylase Phosphorylase], with EC number [~~http~~://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.4.1.1 2.4.1.1] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Phosphorylase Phosphorylase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.4.1.1 2.4.1.1] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1fu7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1fu7 OCA], [~~http~~://pdbe.org/1fu7 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=1fu7 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/1fu7 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=1fu7 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1fu7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1fu7 OCA], [https://pdbe.org/1fu7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1fu7 RCSB], [https://www.ebi.ac.uk/pdbsum/1fu7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1fu7 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/PYGM_RABIT PYGM_RABIT]] Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties.	+	[[https://www.uniprot.org/uniprot/PYGM_RABIT PYGM_RABIT]] Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]

OCA at 08:36, 23 October 2019

2019-10-23T08:36:25Z

←Older revision		Revision as of 08:36, 23 October 2019
Line 1:		Line 1:

	==STRUCTURES OF GLYCOGEN PHOSPHORYLASE-INHIBITOR COMPLEXES AND THE IMPLICATIONS FOR STRUCTURE-BASED DRUG DESIGN==		==STRUCTURES OF GLYCOGEN PHOSPHORYLASE-INHIBITOR COMPLEXES AND THE IMPLICATIONS FOR STRUCTURE-BASED DRUG DESIGN==
-	<StructureSection load='1fu7' size='340' side='right' caption='[[1fu7]], [[Resolution\|resolution]] 2.36Å' scene=''>	+	<StructureSection load='1fu7' size='340' side='right'caption='[[1fu7]], [[Resolution\|resolution]] 2.36Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1fu7]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Oryctolagus_cuniculus Oryctolagus cuniculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1FU7 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1FU7 FirstGlance]. <br>		<table><tr><td colspan='2'>[[1fu7]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Oryctolagus_cuniculus Oryctolagus cuniculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1FU7 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1FU7 FirstGlance]. <br>
Line 30:		Line 30:
	</div>		</div>
	<div class="pdbe-citations 1fu7" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 1fu7" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Glycogen phosphorylase 3D structures\|Glycogen phosphorylase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Oryctolagus cuniculus]]		[[Category: Oryctolagus cuniculus]]
	[[Category: Phosphorylase]]		[[Category: Phosphorylase]]

OCA at 06:22, 3 January 2018

2018-01-03T06:22:56Z

←Older revision		Revision as of 06:22, 3 January 2018
Line 1:		Line 1:
		+
	==STRUCTURES OF GLYCOGEN PHOSPHORYLASE-INHIBITOR COMPLEXES AND THE IMPLICATIONS FOR STRUCTURE-BASED DRUG DESIGN==		==STRUCTURES OF GLYCOGEN PHOSPHORYLASE-INHIBITOR COMPLEXES AND THE IMPLICATIONS FOR STRUCTURE-BASED DRUG DESIGN==
	<StructureSection load='1fu7' size='340' side='right' caption='[[1fu7]], [[Resolution\|resolution]] 2.36Å' scene=''>		<StructureSection load='1fu7' size='340' side='right' caption='[[1fu7]], [[Resolution\|resolution]] 2.36Å' scene=''>
Line 6:		Line 7:
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1b4d\|1b4d]], [[1ggn\|1ggn]], [[1fs4\|1fs4]], [[1ftq\|1ftq]], [[1ftw\|1ftw]], [[1fty\|1fty]], [[1fu4\|1fu4]], [[1fu8\|1fu8]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1b4d\|1b4d]], [[1ggn\|1ggn]], [[1fs4\|1fs4]], [[1ftq\|1ftq]], [[1ftw\|1ftw]], [[1fty\|1fty]], [[1fu4\|1fu4]], [[1fu8\|1fu8]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Phosphorylase Phosphorylase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.4.1.1 2.4.1.1] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Phosphorylase Phosphorylase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.4.1.1 2.4.1.1] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1fu7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1fu7 OCA], [http://pdbe.org/1fu7 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1fu7 RCSB], [http://www.ebi.ac.uk/pdbsum/1fu7 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1fu7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1fu7 OCA], [http://pdbe.org/1fu7 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1fu7 RCSB], [http://www.ebi.ac.uk/pdbsum/1fu7 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1fu7 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 14:		Line 15:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/fu/1fu7_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/fu/1fu7_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
Line 29:		Line 30:
	</div>		</div>
	<div class="pdbe-citations 1fu7" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 1fu7" style="background-color:#fffaf0;"></div>
-
-	==See Also==
-	*[[Glycogen Phosphorylase\|Glycogen Phosphorylase]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 02:28, 9 February 2016

2016-02-09T02:28:18Z

←Older revision		Revision as of 02:28, 9 February 2016
Line 18:		Line 18:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1fu7 ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 17:43, 10 September 2015

2015-09-10T17:43:25Z

←Older revision		Revision as of 17:43, 10 September 2015
Line 6:		Line 6:
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1b4d\|1b4d]], [[1ggn\|1ggn]], [[1fs4\|1fs4]], [[1ftq\|1ftq]], [[1ftw\|1ftw]], [[1fty\|1fty]], [[1fu4\|1fu4]], [[1fu8\|1fu8]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1b4d\|1b4d]], [[1ggn\|1ggn]], [[1fs4\|1fs4]], [[1ftq\|1ftq]], [[1ftw\|1ftw]], [[1fty\|1fty]], [[1fu4\|1fu4]], [[1fu8\|1fu8]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Phosphorylase Phosphorylase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.4.1.1 2.4.1.1] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Phosphorylase Phosphorylase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.4.1.1 2.4.1.1] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1fu7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1fu7 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1fu7 RCSB], [http://www.ebi.ac.uk/pdbsum/1fu7 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1fu7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1fu7 OCA], [http://pdbe.org/1fu7 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1fu7 RCSB], [http://www.ebi.ac.uk/pdbsum/1fu7 PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 28:		Line 28:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 1fu7" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==

OCA at 03:46, 25 December 2014

2014-12-25T03:46:50Z

←Older revision		Revision as of 03:46, 25 December 2014
Line 8:		Line 8:
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1fu7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1fu7 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1fu7 RCSB], [http://www.ebi.ac.uk/pdbsum/1fu7 PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1fu7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1fu7 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1fu7 RCSB], [http://www.ebi.ac.uk/pdbsum/1fu7 PDBsum]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/PYGM_RABIT PYGM_RABIT]] Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]

OCA at 20:15, 22 December 2014

2014-12-22T20:15:07Z

←Older revision		Revision as of 20:15, 22 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1fu7]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Oryctolagus_cuniculus Oryctolagus cuniculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1FU7 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1FU7 FirstGlance]. <br>		<table><tr><td colspan='2'>[[1fu7]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Oryctolagus_cuniculus Oryctolagus cuniculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1FU7 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1FU7 FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CR1:1-DEOXY-1-METHOXYCARBAMIDO-BETA-D-GLUCOPYRANOSE'>CR1</scene>, <scene name='pdbligand=PLP:PYRIDOXAL-5-PHOSPHATE'>PLP</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CR1:1-DEOXY-1-METHOXYCARBAMIDO-BETA-D-GLUCOPYRANOSE'>CR1</scene>, <scene name='pdbligand=PLP:PYRIDOXAL-5-PHOSPHATE'>PLP</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1b4d\|1b4d]], [[1ggn\|1ggn]], [[1fs4\|1fs4]], [[1ftq\|1ftq]], [[1ftw\|1ftw]], [[1fty\|1fty]], [[1fu4\|1fu4]], [[1fu8\|1fu8]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1b4d\|1b4d]], [[1ggn\|1ggn]], [[1fs4\|1fs4]], [[1ftq\|1ftq]], [[1ftw\|1ftw]], [[1fty\|1fty]], [[1fu4\|1fu4]], [[1fu8\|1fu8]]</td></tr>
-	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Phosphorylase Phosphorylase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.4.1.1 2.4.1.1] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Phosphorylase Phosphorylase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.4.1.1 2.4.1.1] </span></td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1fu7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1fu7 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1fu7 RCSB], [http://www.ebi.ac.uk/pdbsum/1fu7 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1fu7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1fu7 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1fu7 RCSB], [http://www.ebi.ac.uk/pdbsum/1fu7 PDBsum]</span></td></tr>
-	<table>	+	</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 35:		Line 35:
	[[Category: Oryctolagus cuniculus]]		[[Category: Oryctolagus cuniculus]]
	[[Category: Phosphorylase]]		[[Category: Phosphorylase]]
-	[[Category: Fleet, G W.]]	+	[[Category: Fleet, G W]]
-	[[Category: Gregoriou, M.]]	+	[[Category: Gregoriou, M]]
-	[[Category: Johnson, L N.]]	+	[[Category: Johnson, L N]]
-	[[Category: Oikonomakos, N G.]]	+	[[Category: Oikonomakos, N G]]
-	[[Category: Skamnaki, V T.]]	+	[[Category: Skamnaki, V T]]
-	[[Category: Tsitsanou, K E.]]	+	[[Category: Tsitsanou, K E]]
-	[[Category: Watson, K A.]]	+	[[Category: Watson, K A]]
-	[[Category: Zographos, S E.]]	+	[[Category: Zographos, S E]]
	[[Category: Catalytic site]]		[[Category: Catalytic site]]
	[[Category: Design]]		[[Category: Design]]

OCA at 10:05, 28 September 2014

2014-09-28T10:05:53Z

←Older revision		Revision as of 10:05, 28 September 2014
Line 1:		Line 1:
-	[[~~Image:~~1fu7.~~png~~\|~~left~~\|200px]]	+	==STRUCTURES OF GLYCOGEN PHOSPHORYLASE-INHIBITOR COMPLEXES AND THE IMPLICATIONS FOR STRUCTURE-BASED DRUG DESIGN==
		+	<StructureSection load='1fu7' size='340' side='right' caption='[[1fu7]], [[Resolution\|resolution]] 2.36Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[1fu7]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Oryctolagus_cuniculus Oryctolagus cuniculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1FU7 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1FU7 FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CR1:1-DEOXY-1-METHOXYCARBAMIDO-BETA-D-GLUCOPYRANOSE'>CR1</scene>, <scene name='pdbligand=PLP:PYRIDOXAL-5-PHOSPHATE'>PLP</scene><br>
		+	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1b4d\|1b4d]], [[1ggn\|1ggn]], [[1fs4\|1fs4]], [[1ftq\|1ftq]], [[1ftw\|1ftw]], [[1fty\|1fty]], [[1fu4\|1fu4]], [[1fu8\|1fu8]]</td></tr>
		+	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Phosphorylase Phosphorylase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.4.1.1 2.4.1.1] </span></td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1fu7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1fu7 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1fu7 RCSB], [http://www.ebi.ac.uk/pdbsum/1fu7 PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/fu/1fu7_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Glycogen phosphorylase (GP) is currently exploited as a target for inhibition of hepatic glycogenolysis under high glucose conditions. Spirohydantoin of glucopyranose and N-acetyl-beta-D-glucopyranosylamine have been identified as the most potent inhibitors of GP that bind at the catalytic site. Four spirohydantoin and three beta-D-glucopyranosylamine analogs have been designed, synthesized and tested for inhibition of GP in kinetic experiments. Depending on the functional group introduced, the K(i) values varied from 16.5 microM to 1200 microM. In order to rationalize the kinetic results, we determined the crystal structures of the analogs in complex with GP. All the inhibitors bound at the catalytic site of the enzyme, by making direct and water-mediated hydrogen bonds with the protein and by inducing minor movements of the side chains of Asp283 and Asn284, of the 280s loop that blocks access of the substrate glycogen to the catalytic site, and changes in the water structure in the vicinity of the site. The differences observed in the Ki values of the analogs can be interpreted in terms of variations in hydrogen bonding and van der Waals interactions, desolvation effects, ligand conformational entropy, and displacement of water molecules on ligand binding to the catalytic site.

-	~~{{STRUCTURE_1fu7\| PDB=1fu7 \| SCENE= }}~~	+	Kinetic and crystallographic studies of glucopyranose spirohydantoin and glucopyranosylamine analogs inhibitors of glycogen phosphorylase.,Watson KA, Chrysina ED, Tsitsanou KE, Zographos SE, Archontis G, Fleet GW, Oikonomakos NG Proteins. 2005 Dec 1;61(4):966-83. PMID:16222658<ref>PMID:16222658</ref>

-	~~===STRUCTURES OF GLYCOGEN PHOSPHORYLASE-INHIBITOR COMPLEXES AND THE IMPLICATIONS FOR STRUCTURE-BASED DRUG DESIGN===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_16222658}}~~	+
-		+
-	~~==About this Structure==~~	+
-	~~[[1fu7]] is~~ a ~~1 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Oryctolagus_cuniculus Oryctolagus cuniculus]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=1FU7 OCA].~~	+

	==See Also==		==See Also==
	*[[Glycogen Phosphorylase\|Glycogen Phosphorylase]]		*[[Glycogen Phosphorylase\|Glycogen Phosphorylase]]
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	<~~ref group="xtra">PMID:016222658<~~/~~ref~~><~~references group="xtra"~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Oryctolagus cuniculus]]		[[Category: Oryctolagus cuniculus]]
	[[Category: Phosphorylase]]		[[Category: Phosphorylase]]

OCA at 12:19, 20 October 2012

2012-10-20T12:19:25Z

←Older revision		Revision as of 12:19, 20 October 2012
Line 8:		Line 8:

	==About this Structure==		==About this Structure==
-	[[1fu7]] is a 1 chain structure ~~of [[Glycogen Phosphorylase]]~~ with sequence from [http://en.wikipedia.org/wiki/Oryctolagus_cuniculus Oryctolagus cuniculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1FU7 OCA].	+	[[1fu7]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Oryctolagus_cuniculus Oryctolagus cuniculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1FU7 OCA].

	==See Also==		==See Also==