1g19 - Revision history

OCA at 06:06, 9 August 2023

2023-08-09T06:06:32Z

←Older revision		Revision as of 06:06, 9 August 2023
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1g19]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1G19 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1G19 FirstGlance]. <br>		<table><tr><td colspan='2'>[[1g19]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1G19 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1G19 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 3Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1g19 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1g19 OCA], [https://pdbe.org/1g19 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1g19 RCSB], [https://www.ebi.ac.uk/pdbsum/1g19 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1g19 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1g19 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1g19 OCA], [https://pdbe.org/1g19 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1g19 RCSB], [https://www.ebi.ac.uk/pdbsum/1g19 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1g19 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/RECA_MYCTU RECA_MYCTU]] Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage.[HAMAP-Rule:MF_00268] PI-MtuI is an endonuclease.[HAMAP-Rule:MF_00268]	+	[https://www.uniprot.org/uniprot/RECA_MYCTU RECA_MYCTU] Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage.[HAMAP-Rule:MF_00268] PI-MtuI is an endonuclease.[HAMAP-Rule:MF_00268]
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 30:		Line 31:

	==See Also==		==See Also==
-	*[[~~Recombinase~~ A\|~~Recombinase~~ A]]	+	*[[3D structures of recombinase A\|3D structures of recombinase A]]
	== References ==		== References ==
	<references/>		<references/>
Line 37:		Line 38:
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Mycobacterium tuberculosis]]		[[Category: Mycobacterium tuberculosis]]
-	[[Category: Chandra~~, N R~~]]	+	[[Category: Chandra NR]]
-	[[Category: Datta, S]]	+	[[Category: Datta S]]
-	[[Category: Ganesh, N]]	+	[[Category: Ganesh N]]
-	[[Category: Muniyappa, K]]	+	[[Category: Muniyappa K]]
-	[[Category: Prabu~~, M M]]~~	+	[[Category: Prabu MM]]
-	~~[[Category: Structural genomic~~]]	+	[[Category: Vaze MB]]
-	[[Category: Vaze~~, M B~~]]	+	[[Category: Vijayan M]]
-	[[Category: Vijayan, M]]	+
-	~~[[Category: Dna-repair]]~~	+
-	~~[[Category: Hydrolase]]~~	+
-	~~[[Category: PSI, Protein structure initiative]]~~	+
-	~~[[Category: Recombination]]~~	+
-	~~[[Category: Tbsgc~~]]	+

OCA at 13:12, 13 October 2021

2021-10-13T13:12:55Z

←Older revision		Revision as of 13:12, 13 October 2021
Line 3:		Line 3:
	<StructureSection load='1g19' size='340' side='right'caption='[[1g19]], [[Resolution\|resolution]] 3.00Å' scene=''>		<StructureSection load='1g19' size='340' side='right'caption='[[1g19]], [[Resolution\|resolution]] 3.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1g19]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1G19 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1G19 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1g19]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1G19 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1G19 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1g19 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1g19 OCA], [~~http~~://pdbe.org/1g19 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=1g19 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/1g19 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=1g19 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1g19 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1g19 OCA], [https://pdbe.org/1g19 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1g19 RCSB], [https://www.ebi.ac.uk/pdbsum/1g19 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1g19 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/RECA_MYCTU RECA_MYCTU]] Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage.[HAMAP-Rule:MF_00268] PI-MtuI is an endonuclease.[HAMAP-Rule:MF_00268]	+	[[https://www.uniprot.org/uniprot/RECA_MYCTU RECA_MYCTU]] Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage.[HAMAP-Rule:MF_00268] PI-MtuI is an endonuclease.[HAMAP-Rule:MF_00268]
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]

OCA at 10:23, 8 January 2020

2020-01-08T10:23:48Z

←Older revision		Revision as of 10:23, 8 January 2020
Line 1:		Line 1:

	==STRUCTURE OF RECA PROTEIN==		==STRUCTURE OF RECA PROTEIN==
-	<StructureSection load='1g19' size='340' side='right' caption='[[1g19]], [[Resolution\|resolution]] 3.00Å' scene=''>	+	<StructureSection load='1g19' size='340' side='right'caption='[[1g19]], [[Resolution\|resolution]] 3.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1g19]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1G19 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1G19 FirstGlance]. <br>		<table><tr><td colspan='2'>[[1g19]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1G19 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1G19 FirstGlance]. <br>
Line 35:		Line 35:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Mycobacterium tuberculosis]]		[[Category: Mycobacterium tuberculosis]]
	[[Category: Chandra, N R]]		[[Category: Chandra, N R]]

OCA at 06:11, 4 April 2018

2018-04-04T06:11:40Z

←Older revision		Revision as of 06:11, 4 April 2018
Line 28:		Line 28:
	</div>		</div>
	<div class="pdbe-citations 1g19" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 1g19" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Recombinase A\|Recombinase A]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 06:31, 3 January 2018

2018-01-03T06:31:58Z

←Older revision		Revision as of 06:31, 3 January 2018
Line 1:		Line 1:
		+
	==STRUCTURE OF RECA PROTEIN==		==STRUCTURE OF RECA PROTEIN==
	<StructureSection load='1g19' size='340' side='right' caption='[[1g19]], [[Resolution\|resolution]] 3.00Å' scene=''>		<StructureSection load='1g19' size='340' side='right' caption='[[1g19]], [[Resolution\|resolution]] 3.00Å' scene=''>
Line 4:		Line 5:
	<table><tr><td colspan='2'>[[1g19]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1G19 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1G19 FirstGlance]. <br>		<table><tr><td colspan='2'>[[1g19]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1G19 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1G19 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1g19 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1g19 OCA], [http://pdbe.org/1g19 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1g19 RCSB], [http://www.ebi.ac.uk/pdbsum/1g19 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1g19 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1g19 OCA], [http://pdbe.org/1g19 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1g19 RCSB], [http://www.ebi.ac.uk/pdbsum/1g19 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1g19 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 12:		Line 13:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/g1/1g19_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/g1/1g19_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
Line 27:		Line 28:
	</div>		</div>
	<div class="pdbe-citations 1g19" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 1g19" style="background-color:#fffaf0;"></div>
-
-	==See Also==
-	*[[Recombinase A\|Recombinase A]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 04:46, 10 February 2016

2016-02-10T04:46:11Z

←Older revision		Revision as of 04:46, 10 February 2016
Line 16:		Line 16:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1g19 ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 05:30, 11 September 2015

2015-09-11T05:30:45Z

←Older revision		Revision as of 05:30, 11 September 2015
Line 4:		Line 4:
	<table><tr><td colspan='2'>[[1g19]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1G19 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1G19 FirstGlance]. <br>		<table><tr><td colspan='2'>[[1g19]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1G19 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1G19 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1g19 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1g19 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1g19 RCSB], [http://www.ebi.ac.uk/pdbsum/1g19 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1g19 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1g19 OCA], [http://pdbe.org/1g19 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1g19 RCSB], [http://www.ebi.ac.uk/pdbsum/1g19 PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 26:		Line 26:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 1g19" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==

OCA at 11:52, 25 December 2014

2014-12-25T11:52:56Z

←Older revision		Revision as of 11:52, 25 December 2014
Line 6:		Line 6:
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1g19 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1g19 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1g19 RCSB], [http://www.ebi.ac.uk/pdbsum/1g19 PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1g19 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1g19 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1g19 RCSB], [http://www.ebi.ac.uk/pdbsum/1g19 PDBsum]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/RECA_MYCTU RECA_MYCTU]] Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage.[HAMAP-Rule:MF_00268] PI-MtuI is an endonuclease.[HAMAP-Rule:MF_00268]
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]

OCA at 19:32, 22 December 2014

2014-12-22T19:32:35Z

←Older revision		Revision as of 19:32, 22 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1g19]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1G19 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1G19 FirstGlance]. <br>		<table><tr><td colspan='2'>[[1g19]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1G19 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1G19 FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1g19 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1g19 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1g19 RCSB], [http://www.ebi.ac.uk/pdbsum/1g19 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1g19 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1g19 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1g19 RCSB], [http://www.ebi.ac.uk/pdbsum/1g19 PDBsum]</span></td></tr>
-	<table>	+	</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 32:		Line 32:
	</StructureSection>		</StructureSection>
	[[Category: Mycobacterium tuberculosis]]		[[Category: Mycobacterium tuberculosis]]
-	[[Category: Chandra, N R.]]	+	[[Category: Chandra, N R]]
-	[[Category: Datta, S.]]	+	[[Category: Datta, S]]
-	[[Category: Ganesh, N.]]	+	[[Category: Ganesh, N]]
-	[[Category: Muniyappa, K.]]	+	[[Category: Muniyappa, K]]
-	[[Category: Prabu, M M.]]	+	[[Category: Prabu, M M]]
-	[[Category: ~~TBSGC, TB~~ Structural ~~Genomics Consortium.~~]]	+	[[Category: Structural genomic]]
-	[[Category: Vaze, M B.]]	+	[[Category: Vaze, M B]]
-	[[Category: Vijayan, M.]]	+	[[Category: Vijayan, M]]
	[[Category: Dna-repair]]		[[Category: Dna-repair]]
	[[Category: Hydrolase]]		[[Category: Hydrolase]]
-	[[Category: Protein structure initiative]]	+	[[Category: PSI, Protein structure initiative]]
-	~~[[Category: Psi~~]]	+
	[[Category: Recombination]]		[[Category: Recombination]]
-	[[Category: Structural genomic]]
-	[[Category: Tb structural genomics consortium]]
	[[Category: Tbsgc]]		[[Category: Tbsgc]]

OCA at 09:24, 28 September 2014

2014-09-28T09:24:58Z

←Older revision		Revision as of 09:24, 28 September 2014
Line 1:		Line 1:
-	[[~~Image~~:1g19.~~png\|left~~\|200px]]	+	==STRUCTURE OF RECA PROTEIN==
		+	<StructureSection load='1g19' size='340' side='right' caption='[[1g19]], [[Resolution\|resolution]] 3.00Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[1g19]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1G19 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1G19 FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene><br>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1g19 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1g19 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1g19 RCSB], [http://www.ebi.ac.uk/pdbsum/1g19 PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/g1/1g19_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Sequencing of the complete genome of Mycobacterium tuberculosis, combined with the rapidly increasing need to improve tuberculosis management through better drugs and vaccines, has initiated extensive research on several key proteins from the pathogen. RecA, a ubiquitous multifunctional protein, is a key component of the processes of homologous genetic recombination and DNA repair. Structural knowledge of MtRecA is imperative for a full understanding of both these activities and any ensuing application. The crystal structure of MtRecA, presented here, has six molecules in the unit cell forming a 6(1) helical filament with a deep groove capable of binding DNA. The observed weakening in the higher order aggregation of filaments into bundles may have implications for recombination in mycobacteria. The structure of the complex reveals the atomic interactions of ADP-AlF(4), an ATP analogue, with the P-loop-containing binding pocket. The structures explain reduced levels of interactions of MtRecA with ATP, despite sharing the same fold, topology and high sequence similarity with EcRecA. The formation of a helical filament with a deep groove appears to be an inherent property of MtRecA. The histidine in loop L1 appears to be positioned appropriately for DNA interaction.

-	~~{{STRUCTURE_1g19\| PDB=1g19 \| SCENE= }}~~	+	Crystal structures of Mycobacterium tuberculosis RecA and its complex with ADP-AlF(4): implications for decreased ATPase activity and molecular aggregation.,Datta S, Prabu MM, Vaze MB, Ganesh N, Chandra NR, Muniyappa K, Vijayan M Nucleic Acids Res. 2000 Dec 15;28(24):4964-73. PMID:11121488<ref>PMID:11121488</ref>

-	~~===STRUCTURE OF RECA PROTEIN===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_11121488}}~~	+
-		+
-	~~==About this Structure==~~	+
-	~~[[1g19]] is~~ a ~~1 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=1G19 OCA].~~	+

	==See Also==		==See Also==
	*[[Recombinase A\|Recombinase A]]		*[[Recombinase A\|Recombinase A]]
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	<~~ref group="xtra">PMID:011121488<~~/~~ref~~><~~ref group="xtra">PMID:008639660</ref><references group="xtra"~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Mycobacterium tuberculosis]]		[[Category: Mycobacterium tuberculosis]]
	[[Category: Chandra, N R.]]		[[Category: Chandra, N R.]]