1gl0 - Revision history

OCA at 11:59, 13 December 2023

2023-12-13T11:59:14Z

←Older revision		Revision as of 11:59, 13 December 2023
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	<StructureSection load='1gl0' size='340' side='right'caption='[[1gl0]], [[Resolution\|resolution]] 3.00Å' scene=''>		<StructureSection load='1gl0' size='340' side='right'caption='[[1gl0]], [[Resolution\|resolution]] 3.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1gl0]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1GL0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1GL0 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1gl0]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Bos_taurus Bos taurus] and [https://en.wikipedia.org/wiki/Locusta_migratoria Locusta migratoria]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1GL0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1GL0 FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=CD:CADMIUM+ION'>CD</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 3Å</td></tr>
-	<tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1ab9\|1ab9]], [[1acb\|1acb]], [[1afq\|1afq]], [[1ca0\|1ca0]], [[1cbw\|1cbw]], [[1cgi\|1cgi]], [[1cgj\|1cgj]], [[1chg\|1chg]], [[1dlk\|1dlk]], [[1ex3\|1ex3]], [[1gcd\|1gcd]], [[1gct\|1gct]], [[1gg6\|1gg6]], [[1ggd\|1ggd]], [[1gha\|1gha]], [[1ghb\|1ghb]], [[1gmc\|1gmc]], [[1gmd\|1gmd]], [[1gmh\|1gmh]], [[1hja\|1hja]], [[1mtn\|1mtn]], [[1vgc\|1vgc]], [[2cga\|2cga]], [[2gch\|2gch]], [[2gct\|2gct]], [[2gmt\|2gmt]], [[2vgc\|2vgc]], [[3gch\|3gch]], [[3gct\|3gct]], [[3vgc\|3vgc]], [[4gch\|4gch]], [[4vgc\|4vgc]], [[5gch\|5gch]], [[6gch\|6gch]], [[7gch\|7gch]], [[8gch\|8gch]], [[1gl1\|1gl1]], [[1pmc\|1pmc]]</div></td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CD:CADMIUM+ION'>CD</scene></td></tr>
-	~~<tr~~ id~~='activity'><td class~~="~~sblockLbl~~"><~~b>Activity:</b></td><td class~~=~~"sblockDat"><span class~~=~~'plainlinks~~'>~~[https://en.wikipedia.org/wiki/Chymotrypsin Chymotrypsin], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.1 3.4.21.1]~~ </~~span~~></td></tr>	+
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1gl0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1gl0 OCA], [https://pdbe.org/1gl0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1gl0 RCSB], [https://www.ebi.ac.uk/pdbsum/1gl0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1gl0 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1gl0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1gl0 OCA], [https://pdbe.org/1gl0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1gl0 RCSB], [https://www.ebi.ac.uk/pdbsum/1gl0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1gl0 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/~~LCM_LOCMI LCM_LOCMI~~]~~] Both LCMI I and II are inhibitors of chymotrypsin and elastase (in vitro). They both inhibit the prophenol oxidase activation cascade.~~	+	[https://www.uniprot.org/uniprot/CTRA_BOVIN CTRA_BOVIN]
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	</StructureSection>		</StructureSection>
	[[Category: Bos taurus]]		[[Category: Bos taurus]]
-	[[Category: Chymotrypsin]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Kellenberger, C~~]]	+	[[Category: Locusta migratoria]]
-	[[Category: ~~Roussel, A~~]]	+	[[Category: Kellenberger C]]
-	[[Category: ~~Hydrolase]]~~	+	[[Category: Roussel A]]
-	~~[[Category: Hydrolase-inhibitor complex]]~~	+
-	~~[[Category: Hydrolase/inhibitor]]~~	+
-	~~[[Category: Serine protease]]~~	+
-	~~[[Category: Serine protease inhibitor~~]]	+

OCA at 11:25, 28 July 2021

2021-07-28T11:25:13Z

←Older revision		Revision as of 11:25, 28 July 2021
Line 3:		Line 3:
	<StructureSection load='1gl0' size='340' side='right'caption='[[1gl0]], [[Resolution\|resolution]] 3.00Å' scene=''>		<StructureSection load='1gl0' size='340' side='right'caption='[[1gl0]], [[Resolution\|resolution]] 3.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1gl0]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1GL0 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1GL0 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1gl0]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1GL0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1GL0 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CD:CADMIUM+ION'>CD</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CD:CADMIUM+ION'>CD</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1ab9\|1ab9]], [[1acb\|1acb]], [[1afq\|1afq]], [[1ca0\|1ca0]], [[1cbw\|1cbw]], [[1cgi\|1cgi]], [[1cgj\|1cgj]], [[1chg\|1chg]], [[1dlk\|1dlk]], [[1ex3\|1ex3]], [[1gcd\|1gcd]], [[1gct\|1gct]], [[1gg6\|1gg6]], [[1ggd\|1ggd]], [[1gha\|1gha]], [[1ghb\|1ghb]], [[1gmc\|1gmc]], [[1gmd\|1gmd]], [[1gmh\|1gmh]], [[1hja\|1hja]], [[1mtn\|1mtn]], [[1vgc\|1vgc]], [[2cga\|2cga]], [[2gch\|2gch]], [[2gct\|2gct]], [[2gmt\|2gmt]], [[2vgc\|2vgc]], [[3gch\|3gch]], [[3gct\|3gct]], [[3vgc\|3vgc]], [[4gch\|4gch]], [[4vgc\|4vgc]], [[5gch\|5gch]], [[6gch\|6gch]], [[7gch\|7gch]], [[8gch\|8gch]], [[1gl1\|1gl1]], [[1pmc\|1pmc]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1ab9\|1ab9]], [[1acb\|1acb]], [[1afq\|1afq]], [[1ca0\|1ca0]], [[1cbw\|1cbw]], [[1cgi\|1cgi]], [[1cgj\|1cgj]], [[1chg\|1chg]], [[1dlk\|1dlk]], [[1ex3\|1ex3]], [[1gcd\|1gcd]], [[1gct\|1gct]], [[1gg6\|1gg6]], [[1ggd\|1ggd]], [[1gha\|1gha]], [[1ghb\|1ghb]], [[1gmc\|1gmc]], [[1gmd\|1gmd]], [[1gmh\|1gmh]], [[1hja\|1hja]], [[1mtn\|1mtn]], [[1vgc\|1vgc]], [[2cga\|2cga]], [[2gch\|2gch]], [[2gct\|2gct]], [[2gmt\|2gmt]], [[2vgc\|2vgc]], [[3gch\|3gch]], [[3gct\|3gct]], [[3vgc\|3vgc]], [[4gch\|4gch]], [[4vgc\|4vgc]], [[5gch\|5gch]], [[6gch\|6gch]], [[7gch\|7gch]], [[8gch\|8gch]], [[1gl1\|1gl1]], [[1pmc\|1pmc]]</div></td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://en.wikipedia.org/wiki/Chymotrypsin Chymotrypsin], with EC number [~~http~~://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.1 3.4.21.1] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Chymotrypsin Chymotrypsin], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.1 3.4.21.1] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1gl0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1gl0 OCA], [~~http~~://pdbe.org/1gl0 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=1gl0 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/1gl0 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=1gl0 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1gl0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1gl0 OCA], [https://pdbe.org/1gl0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1gl0 RCSB], [https://www.ebi.ac.uk/pdbsum/1gl0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1gl0 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/LCM_LOCMI LCM_LOCMI]] Both LCMI I and II are inhibitors of chymotrypsin and elastase (in vitro). They both inhibit the prophenol oxidase activation cascade.	+	[[https://www.uniprot.org/uniprot/LCM_LOCMI LCM_LOCMI]] Both LCMI I and II are inhibitors of chymotrypsin and elastase (in vitro). They both inhibit the prophenol oxidase activation cascade.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]

OCA at 08:40, 23 October 2019

2019-10-23T08:40:12Z

←Older revision		Revision as of 08:40, 23 October 2019
Line 1:		Line 1:

	==structure of the complex between bovine alpha-chymotrypsin and PMP-D2v, an inhibitor from the insect Locusta migratoria==		==structure of the complex between bovine alpha-chymotrypsin and PMP-D2v, an inhibitor from the insect Locusta migratoria==
-	<StructureSection load='1gl0' size='340' side='right' caption='[[1gl0]], [[Resolution\|resolution]] 3.00Å' scene=''>	+	<StructureSection load='1gl0' size='340' side='right'caption='[[1gl0]], [[Resolution\|resolution]] 3.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1gl0]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1GL0 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1GL0 FirstGlance]. <br>		<table><tr><td colspan='2'>[[1gl0]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1GL0 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1GL0 FirstGlance]. <br>
Line 30:		Line 30:
	</div>		</div>
	<div class="pdbe-citations 1gl0" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 1gl0" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Chymotrypsin 3D structures\|Chymotrypsin 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
Line 36:		Line 39:
	[[Category: Bos taurus]]		[[Category: Bos taurus]]
	[[Category: Chymotrypsin]]		[[Category: Chymotrypsin]]
		+	[[Category: Large Structures]]
	[[Category: Kellenberger, C]]		[[Category: Kellenberger, C]]
	[[Category: Roussel, A]]		[[Category: Roussel, A]]

OCA at 06:25, 3 January 2018

2018-01-03T06:25:15Z

←Older revision		Revision as of 06:25, 3 January 2018
Line 1:		Line 1:
-	==~~STRUCTURE OF THE COMPLEX BETWEEN BOVINE ALPHA~~-~~CHYMOTRYPSIN AND~~ PMP-~~D2V~~, ~~AN INHIBITOR FROM THE INSECT LOCUSTA MIGRATORIA~~==	+
		+	==structure of the complex between bovine alpha-chymotrypsin and PMP-D2v, an inhibitor from the insect Locusta migratoria==
	<StructureSection load='1gl0' size='340' side='right' caption='[[1gl0]], [[Resolution\|resolution]] 3.00Å' scene=''>		<StructureSection load='1gl0' size='340' side='right' caption='[[1gl0]], [[Resolution\|resolution]] 3.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
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	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1ab9\|1ab9]], [[1acb\|1acb]], [[1afq\|1afq]], [[1ca0\|1ca0]], [[1cbw\|1cbw]], [[1cgi\|1cgi]], [[1cgj\|1cgj]], [[1chg\|1chg]], [[1dlk\|1dlk]], [[1ex3\|1ex3]], [[1gcd\|1gcd]], [[1gct\|1gct]], [[1gg6\|1gg6]], [[1ggd\|1ggd]], [[1gha\|1gha]], [[1ghb\|1ghb]], [[1gmc\|1gmc]], [[1gmd\|1gmd]], [[1gmh\|1gmh]], [[1hja\|1hja]], [[1mtn\|1mtn]], [[1vgc\|1vgc]], [[2cga\|2cga]], [[2gch\|2gch]], [[2gct\|2gct]], [[2gmt\|2gmt]], [[2vgc\|2vgc]], [[3gch\|3gch]], [[3gct\|3gct]], [[3vgc\|3vgc]], [[4gch\|4gch]], [[4vgc\|4vgc]], [[5gch\|5gch]], [[6gch\|6gch]], [[7gch\|7gch]], [[8gch\|8gch]], [[1gl1\|1gl1]], [[1pmc\|1pmc]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1ab9\|1ab9]], [[1acb\|1acb]], [[1afq\|1afq]], [[1ca0\|1ca0]], [[1cbw\|1cbw]], [[1cgi\|1cgi]], [[1cgj\|1cgj]], [[1chg\|1chg]], [[1dlk\|1dlk]], [[1ex3\|1ex3]], [[1gcd\|1gcd]], [[1gct\|1gct]], [[1gg6\|1gg6]], [[1ggd\|1ggd]], [[1gha\|1gha]], [[1ghb\|1ghb]], [[1gmc\|1gmc]], [[1gmd\|1gmd]], [[1gmh\|1gmh]], [[1hja\|1hja]], [[1mtn\|1mtn]], [[1vgc\|1vgc]], [[2cga\|2cga]], [[2gch\|2gch]], [[2gct\|2gct]], [[2gmt\|2gmt]], [[2vgc\|2vgc]], [[3gch\|3gch]], [[3gct\|3gct]], [[3vgc\|3vgc]], [[4gch\|4gch]], [[4vgc\|4vgc]], [[5gch\|5gch]], [[6gch\|6gch]], [[7gch\|7gch]], [[8gch\|8gch]], [[1gl1\|1gl1]], [[1pmc\|1pmc]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Chymotrypsin Chymotrypsin], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.1 3.4.21.1] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Chymotrypsin Chymotrypsin], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.1 3.4.21.1] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1gl0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1gl0 OCA], [http://pdbe.org/1gl0 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1gl0 RCSB], [http://www.ebi.ac.uk/pdbsum/1gl0 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1gl0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1gl0 OCA], [http://pdbe.org/1gl0 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1gl0 RCSB], [http://www.ebi.ac.uk/pdbsum/1gl0 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1gl0 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 14:		Line 15:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/gl/1gl0_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/gl/1gl0_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
Line 29:		Line 30:
	</div>		</div>
	<div class="pdbe-citations 1gl0" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 1gl0" style="background-color:#fffaf0;"></div>
-
-	==See Also==
-	*[[Chymotrypsin\|Chymotrypsin]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 18:36, 9 February 2016

2016-02-09T18:36:39Z

←Older revision		Revision as of 18:36, 9 February 2016
Line 18:		Line 18:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1gl0 ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 00:57, 11 September 2015

2015-09-11T00:57:31Z

←Older revision		Revision as of 00:57, 11 September 2015
Line 6:		Line 6:
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1ab9\|1ab9]], [[1acb\|1acb]], [[1afq\|1afq]], [[1ca0\|1ca0]], [[1cbw\|1cbw]], [[1cgi\|1cgi]], [[1cgj\|1cgj]], [[1chg\|1chg]], [[1dlk\|1dlk]], [[1ex3\|1ex3]], [[1gcd\|1gcd]], [[1gct\|1gct]], [[1gg6\|1gg6]], [[1ggd\|1ggd]], [[1gha\|1gha]], [[1ghb\|1ghb]], [[1gmc\|1gmc]], [[1gmd\|1gmd]], [[1gmh\|1gmh]], [[1hja\|1hja]], [[1mtn\|1mtn]], [[1vgc\|1vgc]], [[2cga\|2cga]], [[2gch\|2gch]], [[2gct\|2gct]], [[2gmt\|2gmt]], [[2vgc\|2vgc]], [[3gch\|3gch]], [[3gct\|3gct]], [[3vgc\|3vgc]], [[4gch\|4gch]], [[4vgc\|4vgc]], [[5gch\|5gch]], [[6gch\|6gch]], [[7gch\|7gch]], [[8gch\|8gch]], [[1gl1\|1gl1]], [[1pmc\|1pmc]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1ab9\|1ab9]], [[1acb\|1acb]], [[1afq\|1afq]], [[1ca0\|1ca0]], [[1cbw\|1cbw]], [[1cgi\|1cgi]], [[1cgj\|1cgj]], [[1chg\|1chg]], [[1dlk\|1dlk]], [[1ex3\|1ex3]], [[1gcd\|1gcd]], [[1gct\|1gct]], [[1gg6\|1gg6]], [[1ggd\|1ggd]], [[1gha\|1gha]], [[1ghb\|1ghb]], [[1gmc\|1gmc]], [[1gmd\|1gmd]], [[1gmh\|1gmh]], [[1hja\|1hja]], [[1mtn\|1mtn]], [[1vgc\|1vgc]], [[2cga\|2cga]], [[2gch\|2gch]], [[2gct\|2gct]], [[2gmt\|2gmt]], [[2vgc\|2vgc]], [[3gch\|3gch]], [[3gct\|3gct]], [[3vgc\|3vgc]], [[4gch\|4gch]], [[4vgc\|4vgc]], [[5gch\|5gch]], [[6gch\|6gch]], [[7gch\|7gch]], [[8gch\|8gch]], [[1gl1\|1gl1]], [[1pmc\|1pmc]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Chymotrypsin Chymotrypsin], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.1 3.4.21.1] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Chymotrypsin Chymotrypsin], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.1 3.4.21.1] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1gl0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1gl0 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1gl0 RCSB], [http://www.ebi.ac.uk/pdbsum/1gl0 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1gl0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1gl0 OCA], [http://pdbe.org/1gl0 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1gl0 RCSB], [http://www.ebi.ac.uk/pdbsum/1gl0 PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 28:		Line 28:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 1gl0" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==

OCA at 08:43, 25 December 2014

2014-12-25T08:43:44Z

←Older revision		Revision as of 08:43, 25 December 2014
Line 8:		Line 8:
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1gl0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1gl0 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1gl0 RCSB], [http://www.ebi.ac.uk/pdbsum/1gl0 PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1gl0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1gl0 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1gl0 RCSB], [http://www.ebi.ac.uk/pdbsum/1gl0 PDBsum]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/LCM_LOCMI LCM_LOCMI]] Both LCMI I and II are inhibitors of chymotrypsin and elastase (in vitro). They both inhibit the prophenol oxidase activation cascade.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]

OCA at 21:07, 22 December 2014

2014-12-22T21:07:31Z

←Older revision		Revision as of 21:07, 22 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1gl0]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1GL0 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1GL0 FirstGlance]. <br>		<table><tr><td colspan='2'>[[1gl0]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1GL0 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1GL0 FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CD:CADMIUM+ION'>CD</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CD:CADMIUM+ION'>CD</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1ab9\|1ab9]], [[1acb\|1acb]], [[1afq\|1afq]], [[1ca0\|1ca0]], [[1cbw\|1cbw]], [[1cgi\|1cgi]], [[1cgj\|1cgj]], [[1chg\|1chg]], [[1dlk\|1dlk]], [[1ex3\|1ex3]], [[1gcd\|1gcd]], [[1gct\|1gct]], [[1gg6\|1gg6]], [[1ggd\|1ggd]], [[1gha\|1gha]], [[1ghb\|1ghb]], [[1gmc\|1gmc]], [[1gmd\|1gmd]], [[1gmh\|1gmh]], [[1hja\|1hja]], [[1mtn\|1mtn]], [[1vgc\|1vgc]], [[2cga\|2cga]], [[2gch\|2gch]], [[2gct\|2gct]], [[2gmt\|2gmt]], [[2vgc\|2vgc]], [[3gch\|3gch]], [[3gct\|3gct]], [[3vgc\|3vgc]], [[4gch\|4gch]], [[4vgc\|4vgc]], [[5gch\|5gch]], [[6gch\|6gch]], [[7gch\|7gch]], [[8gch\|8gch]], [[1gl1\|1gl1]], [[1pmc\|1pmc]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1ab9\|1ab9]], [[1acb\|1acb]], [[1afq\|1afq]], [[1ca0\|1ca0]], [[1cbw\|1cbw]], [[1cgi\|1cgi]], [[1cgj\|1cgj]], [[1chg\|1chg]], [[1dlk\|1dlk]], [[1ex3\|1ex3]], [[1gcd\|1gcd]], [[1gct\|1gct]], [[1gg6\|1gg6]], [[1ggd\|1ggd]], [[1gha\|1gha]], [[1ghb\|1ghb]], [[1gmc\|1gmc]], [[1gmd\|1gmd]], [[1gmh\|1gmh]], [[1hja\|1hja]], [[1mtn\|1mtn]], [[1vgc\|1vgc]], [[2cga\|2cga]], [[2gch\|2gch]], [[2gct\|2gct]], [[2gmt\|2gmt]], [[2vgc\|2vgc]], [[3gch\|3gch]], [[3gct\|3gct]], [[3vgc\|3vgc]], [[4gch\|4gch]], [[4vgc\|4vgc]], [[5gch\|5gch]], [[6gch\|6gch]], [[7gch\|7gch]], [[8gch\|8gch]], [[1gl1\|1gl1]], [[1pmc\|1pmc]]</td></tr>
-	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Chymotrypsin Chymotrypsin], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.1 3.4.21.1] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Chymotrypsin Chymotrypsin], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.1 3.4.21.1] </span></td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1gl0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1gl0 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1gl0 RCSB], [http://www.ebi.ac.uk/pdbsum/1gl0 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1gl0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1gl0 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1gl0 RCSB], [http://www.ebi.ac.uk/pdbsum/1gl0 PDBsum]</span></td></tr>
-	<table>	+	</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 35:		Line 35:
	[[Category: Bos taurus]]		[[Category: Bos taurus]]
	[[Category: Chymotrypsin]]		[[Category: Chymotrypsin]]
-	[[Category: Kellenberger, C.]]	+	[[Category: Kellenberger, C]]
-	[[Category: Roussel, A.]]	+	[[Category: Roussel, A]]
	[[Category: Hydrolase]]		[[Category: Hydrolase]]
	[[Category: Hydrolase-inhibitor complex]]		[[Category: Hydrolase-inhibitor complex]]

OCA at 10:58, 28 September 2014

2014-09-28T10:58:59Z

←Older revision		Revision as of 10:58, 28 September 2014
Line 1:		Line 1:
-	[[~~Image:~~1gl0.~~png~~\|~~left~~\|200px]]	+	==STRUCTURE OF THE COMPLEX BETWEEN BOVINE ALPHA-CHYMOTRYPSIN AND PMP-D2V, AN INHIBITOR FROM THE INSECT LOCUSTA MIGRATORIA==
		+	<StructureSection load='1gl0' size='340' side='right' caption='[[1gl0]], [[Resolution\|resolution]] 3.00Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[1gl0]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1GL0 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1GL0 FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CD:CADMIUM+ION'>CD</scene><br>
		+	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1ab9\|1ab9]], [[1acb\|1acb]], [[1afq\|1afq]], [[1ca0\|1ca0]], [[1cbw\|1cbw]], [[1cgi\|1cgi]], [[1cgj\|1cgj]], [[1chg\|1chg]], [[1dlk\|1dlk]], [[1ex3\|1ex3]], [[1gcd\|1gcd]], [[1gct\|1gct]], [[1gg6\|1gg6]], [[1ggd\|1ggd]], [[1gha\|1gha]], [[1ghb\|1ghb]], [[1gmc\|1gmc]], [[1gmd\|1gmd]], [[1gmh\|1gmh]], [[1hja\|1hja]], [[1mtn\|1mtn]], [[1vgc\|1vgc]], [[2cga\|2cga]], [[2gch\|2gch]], [[2gct\|2gct]], [[2gmt\|2gmt]], [[2vgc\|2vgc]], [[3gch\|3gch]], [[3gct\|3gct]], [[3vgc\|3vgc]], [[4gch\|4gch]], [[4vgc\|4vgc]], [[5gch\|5gch]], [[6gch\|6gch]], [[7gch\|7gch]], [[8gch\|8gch]], [[1gl1\|1gl1]], [[1pmc\|1pmc]]</td></tr>
		+	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Chymotrypsin Chymotrypsin], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.1 3.4.21.1] </span></td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1gl0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1gl0 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1gl0 RCSB], [http://www.ebi.ac.uk/pdbsum/1gl0 PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/gl/1gl0_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The crystal structures of two homologous inhibitors (PMP-C and PMP-D2v) from the insect Locusta migratoria have been determined in complex with bovine alpha-chymotrypsin at 2.1- and 3.0-A resolution, respectively. PMP-C is a potent bovine alpha-chymotrypsin inhibitor whereas native PMP-D2 is a weak inhibitor of bovine trypsin. One unique mutation at the P1 position converts PMP-D2 into a potent bovine alpha-chymotrypsin inhibitor. The two peptides have a similar overall conformation, which consists of a triple-stranded antiparallel beta-sheet connected by three disulfide bridges, thus defining a novel family of serine protease inhibitors. They have in common the protease interaction site, which is composed of the classical protease binding loop (position P5 to P'4, corresponding to residues 26-34) and of an internal segment (residues 15-18), held together by two disulfide bridges. Structural divergences between the two inhibitors result in an additional interaction site between PMP-D2v (position P10 to P6, residues 21-25) and the residues 172-175 of alpha-chymotrypsin. This unusual interaction may be responsible for species selectivity. A careful comparison of data on bound and free inhibitors (from this study and previous NMR studies, respectively) suggests that complexation to the protease stabilizes the flexible binding loop (from P5 to P'4).

-	~~{{STRUCTURE_1gl0\| PDB=1gl0 \| SCENE= }}~~	+	Complexation of two proteic insect inhibitors to the active site of chymotrypsin suggests decoupled roles for binding and selectivity.,Roussel A, Mathieu M, Dobbs A, Luu B, Cambillau C, Kellenberger C J Biol Chem. 2001 Oct 19;276(42):38893-8. Epub 2001 Aug 8. PMID:11495915<ref>PMID:11495915</ref>

-	~~===STRUCTURE OF THE COMPLEX BETWEEN BOVINE ALPHA-CHYMOTRYPSIN AND PMP-D2V~~, ~~AN INHIBITOR FROM THE INSECT LOCUSTA MIGRATORIA===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_11495915}}~~	+
-		+
-	~~==About this Structure==~~	+
-	~~[[1gl0]] is~~ a ~~2 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Bos_taurus Bos taurus]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=1GL0 OCA].~~	+

	==See Also==		==See Also==
	*[[Chymotrypsin\|Chymotrypsin]]		*[[Chymotrypsin\|Chymotrypsin]]
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	<~~ref group="xtra">PMID:011495915<~~/~~ref~~><~~references group="xtra"~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Bos taurus]]		[[Category: Bos taurus]]
	[[Category: Chymotrypsin]]		[[Category: Chymotrypsin]]

OCA at 14:45, 20 October 2012

2012-10-20T14:45:24Z

←Older revision		Revision as of 14:45, 20 October 2012
Line 8:		Line 8:

	==About this Structure==		==About this Structure==
-	[[1gl0]] is a 2 chain structure ~~of [[Chymotrypsin]]~~ with sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1GL0 OCA].	+	[[1gl0]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1GL0 OCA].

	==See Also==		==See Also==