1gsm - Revision history

OCA at 12:05, 13 December 2023

2023-12-13T12:05:16Z

←Older revision		Revision as of 12:05, 13 December 2023
Line 3:		Line 3:
	<StructureSection load='1gsm' size='340' side='right'caption='[[1gsm]], [[Resolution\|resolution]] 1.90Å' scene=''>		<StructureSection load='1gsm' size='340' side='right'caption='[[1gsm]], [[Resolution\|resolution]] 1.90Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1gsm]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1GSM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1GSM FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1gsm]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1GSM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1GSM FirstGlance]. <br>
-	</td></tr><tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat">~~<div style='overflow: auto; max~~-~~height: 3em;'>~~[[~~1bqs~~\|~~1bqs~~]]~~</div>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.9Å</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1gsm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1gsm OCA], [https://pdbe.org/1gsm PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1gsm RCSB], [https://www.ebi.ac.uk/pdbsum/1gsm PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1gsm ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1gsm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1gsm OCA], [https://pdbe.org/1gsm PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1gsm RCSB], [https://www.ebi.ac.uk/pdbsum/1gsm PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1gsm ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/MADCA_HUMAN MADCA_HUMAN]] Cell adhesion leukocyte receptor expressed by mucosal venules, helps to direct lymphocyte traffic into mucosal tissues including the Peyer patches and the intestinal lamina propria. It can bind both integrin alpha-4/beta-7 and L-selectin, regulating both the passage and retention of leukocytes. Isoform 2, lacking the mucin-like domain, may be specialized in supporting integrin alpha-4/beta-7-dependent adhesion strengthening, independent of L-selectin binding.	+	[https://www.uniprot.org/uniprot/MADCA_HUMAN MADCA_HUMAN] Cell adhesion leukocyte receptor expressed by mucosal venules, helps to direct lymphocyte traffic into mucosal tissues including the Peyer patches and the intestinal lamina propria. It can bind both integrin alpha-4/beta-7 and L-selectin, regulating both the passage and retention of leukocytes. Isoform 2, lacking the mucin-like domain, may be specialized in supporting integrin alpha-4/beta-7-dependent adhesion strengthening, independent of L-selectin binding.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 32:		Line 32:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Brady~~, R L~~]]	+	[[Category: Brady RL]]
-	[[Category: Dando, J]]	+	[[Category: Dando J]]
-	[[Category: King~~, D J~~]]	+	[[Category: King DJ]]
-	[[Category: Ortlepp, S]]	+	[[Category: Ortlepp S]]
-	[[Category: Wilkinson~~, K W]]~~	+	[[Category: Wilkinson KW]]
-	~~[[Category: Cell adhesion glycoprotein]]~~	+
-	~~[[Category: Cell adhesion protein]]~~	+
-	~~[[Category: I-set fold]]~~	+
-	~~[[Category: Immunoglobulin fold]]~~	+
-	~~[[Category: Integrin recoginition]]~~	+
-	~~[[Category: Madcam-1]]~~	+
-	~~[[Category: Membrane protein~~]]	+

OCA at 05:47, 28 April 2021

2021-04-28T05:47:35Z

←Older revision		Revision as of 05:47, 28 April 2021
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	<StructureSection load='1gsm' size='340' side='right'caption='[[1gsm]], [[Resolution\|resolution]] 1.90Å' scene=''>		<StructureSection load='1gsm' size='340' side='right'caption='[[1gsm]], [[Resolution\|resolution]] 1.90Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1gsm]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1GSM OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1GSM FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1gsm]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1GSM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1GSM FirstGlance]. <br>
-	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1bqs\|1bqs]]</td></tr>	+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1bqs\|1bqs]]</div></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1gsm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1gsm OCA], [~~http~~://pdbe.org/1gsm PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=1gsm RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/1gsm PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=1gsm ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1gsm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1gsm OCA], [https://pdbe.org/1gsm PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1gsm RCSB], [https://www.ebi.ac.uk/pdbsum/1gsm PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1gsm ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/MADCA_HUMAN MADCA_HUMAN]] Cell adhesion leukocyte receptor expressed by mucosal venules, helps to direct lymphocyte traffic into mucosal tissues including the Peyer patches and the intestinal lamina propria. It can bind both integrin alpha-4/beta-7 and L-selectin, regulating both the passage and retention of leukocytes. Isoform 2, lacking the mucin-like domain, may be specialized in supporting integrin alpha-4/beta-7-dependent adhesion strengthening, independent of L-selectin binding.	+	[[https://www.uniprot.org/uniprot/MADCA_HUMAN MADCA_HUMAN]] Cell adhesion leukocyte receptor expressed by mucosal venules, helps to direct lymphocyte traffic into mucosal tissues including the Peyer patches and the intestinal lamina propria. It can bind both integrin alpha-4/beta-7 and L-selectin, regulating both the passage and retention of leukocytes. Isoform 2, lacking the mucin-like domain, may be specialized in supporting integrin alpha-4/beta-7-dependent adhesion strengthening, independent of L-selectin binding.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]

OCA at 06:40, 24 July 2019

2019-07-24T06:40:41Z

←Older revision		Revision as of 06:40, 24 July 2019
Line 1:		Line 1:

	==A reassessment of the MAdCAM-1 structure and its role in integrin recognition.==		==A reassessment of the MAdCAM-1 structure and its role in integrin recognition.==
-	<StructureSection load='1gsm' size='340' side='right' caption='[[1gsm]], [[Resolution\|resolution]] 1.90Å' scene=''>	+	<StructureSection load='1gsm' size='340' side='right'caption='[[1gsm]], [[Resolution\|resolution]] 1.90Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1gsm]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1GSM OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1GSM FirstGlance]. <br>		<table><tr><td colspan='2'>[[1gsm]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1GSM OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1GSM FirstGlance]. <br>
Line 33:		Line 33:
	</StructureSection>		</StructureSection>
	[[Category: Human]]		[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Brady, R L]]		[[Category: Brady, R L]]
	[[Category: Dando, J]]		[[Category: Dando, J]]

OCA at 06:33, 3 January 2018

2018-01-03T06:33:38Z

←Older revision		Revision as of 06:33, 3 January 2018
Line 1:		Line 1:
-	==A ~~REASSESSMENT OF THE MADCAM~~-1 ~~STRUCTURE AND ITS ROLE IN INTEGRIN RECOGNITION~~.==	+
		+	==A reassessment of the MAdCAM-1 structure and its role in integrin recognition.==
	<StructureSection load='1gsm' size='340' side='right' caption='[[1gsm]], [[Resolution\|resolution]] 1.90Å' scene=''>		<StructureSection load='1gsm' size='340' side='right' caption='[[1gsm]], [[Resolution\|resolution]] 1.90Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1gsm]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1GSM OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1GSM FirstGlance]. <br>		<table><tr><td colspan='2'>[[1gsm]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1GSM OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1GSM FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1bqs\|1bqs]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1bqs\|1bqs]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1gsm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1gsm OCA], [http://pdbe.org/1gsm PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1gsm RCSB], [http://www.ebi.ac.uk/pdbsum/1gsm PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1gsm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1gsm OCA], [http://pdbe.org/1gsm PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1gsm RCSB], [http://www.ebi.ac.uk/pdbsum/1gsm PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1gsm ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 12:		Line 13:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/gs/1gsm_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/gs/1gsm_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>

OCA at 04:35, 9 February 2016

2016-02-09T04:35:43Z

←Older revision		Revision as of 04:35, 9 February 2016
Line 16:		Line 16:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1gsm ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 18:41, 10 September 2015

2015-09-10T18:41:31Z

←Older revision		Revision as of 18:41, 10 September 2015
Line 2:		Line 2:
	<StructureSection load='1gsm' size='340' side='right' caption='[[1gsm]], [[Resolution\|resolution]] 1.90Å' scene=''>		<StructureSection load='1gsm' size='340' side='right' caption='[[1gsm]], [[Resolution\|resolution]] 1.90Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1gsm]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1GSM OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1GSM FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1gsm]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1GSM OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1GSM FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1bqs\|1bqs]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1bqs\|1bqs]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1gsm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1gsm OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1gsm RCSB], [http://www.ebi.ac.uk/pdbsum/1gsm PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1gsm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1gsm OCA], [http://pdbe.org/1gsm PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1gsm RCSB], [http://www.ebi.ac.uk/pdbsum/1gsm PDBsum]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/MADCA_HUMAN MADCA_HUMAN]] Cell adhesion leukocyte receptor expressed by mucosal venules, helps to direct lymphocyte traffic into mucosal tissues including the Peyer patches and the intestinal lamina propria. It can bind both integrin alpha-4/beta-7 and L-selectin, regulating both the passage and retention of leukocytes. Isoform 2, lacking the mucin-like domain, may be specialized in supporting integrin alpha-4/beta-7-dependent adhesion strengthening, independent of L-selectin binding.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 24:		Line 26:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 1gsm" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Homo sapiens~~]]	+	[[Category: Human]]
	[[Category: Brady, R L]]		[[Category: Brady, R L]]
	[[Category: Dando, J]]		[[Category: Dando, J]]

OCA at 21:19, 22 December 2014

2014-12-22T21:19:58Z

←Older revision		Revision as of 21:19, 22 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1gsm]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1GSM OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1GSM FirstGlance]. <br>		<table><tr><td colspan='2'>[[1gsm]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1GSM OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1GSM FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1bqs\|1bqs]]</td></tr>	+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1bqs\|1bqs]]</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1gsm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1gsm OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1gsm RCSB], [http://www.ebi.ac.uk/pdbsum/1gsm PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1gsm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1gsm OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1gsm RCSB], [http://www.ebi.ac.uk/pdbsum/1gsm PDBsum]</span></td></tr>
-	<table>	+	</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 29:		Line 29:
	</StructureSection>		</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
-	[[Category: Brady, R L.]]	+	[[Category: Brady, R L]]
-	[[Category: Dando, J.]]	+	[[Category: Dando, J]]
-	[[Category: King, D J.]]	+	[[Category: King, D J]]
-	[[Category: Ortlepp, S.]]	+	[[Category: Ortlepp, S]]
-	[[Category: Wilkinson, K W.]]	+	[[Category: Wilkinson, K W]]
	[[Category: Cell adhesion glycoprotein]]		[[Category: Cell adhesion glycoprotein]]
	[[Category: Cell adhesion protein]]		[[Category: Cell adhesion protein]]

OCA at 11:11, 28 September 2014

2014-09-28T11:11:19Z

←Older revision		Revision as of 11:11, 28 September 2014
Line 1:		Line 1:
-	[[~~Image:~~1gsm.~~png~~\|~~left~~\|200px]]	+	==A REASSESSMENT OF THE MADCAM-1 STRUCTURE AND ITS ROLE IN INTEGRIN RECOGNITION.==
		+	<StructureSection load='1gsm' size='340' side='right' caption='[[1gsm]], [[Resolution\|resolution]] 1.90Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[1gsm]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1GSM OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1GSM FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1bqs\|1bqs]]</td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1gsm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1gsm OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1gsm RCSB], [http://www.ebi.ac.uk/pdbsum/1gsm PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/gs/1gsm_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Mucosal addressin cell-adhesion molecule (MAdCAM-1) is a membrane-bound leukocyte receptor regulating both the passage and retention of leukocytes in mucosal tissues. A crystal structure for the two extracellular amino-terminal domains of human MAdCAM-1 has previously been reported, confirming their expected immunoglobulin superfamily topology. In this study, a second crystal structure of this fragment is described. Although the overall structure is similar to that previously reported, one edge strand in the amino-terminal domain is instead located on the opposite sheet. This alters the arrangement and conformation of amino acids in this region that have previously been shown to be crucial for ligand binding. MAdCAM-1 is also seen to form dimers within the crystal lattice, raising the possibility that oligomerization may influence the biological role of this adhesion molecule.

-	~~{{STRUCTURE_1gsm\| PDB=1gsm \| SCENE= }}~~	+	A reassessment of the MAdCAM-1 structure and its role in integrin recognition.,Dando J, Wilkinson KW, Ortlepp S, King DJ, Brady RL Acta Crystallogr D Biol Crystallogr. 2002 Feb;58(Pt 2):233-41. Epub 2002, Jan 24. PMID:11807247<ref>PMID:11807247</ref>

-	~~===A REASSESSMENT OF THE MADCAM-1 STRUCTURE AND ITS ROLE IN INTEGRIN RECOGNITION.===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_11807247}}~~	+	== References ==
-		+	<references/>
-	~~==About this Structure==~~	+	__TOC__
-	~~[[1gsm]] is~~ a ~~1 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Homo_sapiens Homo sapiens]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=1GSM OCA].~~	+	</StructureSection>
-		+
-	==~~Reference~~==	+
-	<~~ref group="xtra">PMID:011807247<~~/~~ref~~><~~references group="xtra"~~/>	+
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Brady, R L.]]		[[Category: Brady, R L.]]

OCA: Protected "1gsm" [edit=sysop:move=sysop]

2012-11-21T15:57:07Z

Protected "1gsm" [edit=sysop:move=sysop]

←Older revision

Revision as of 15:57, 21 November 2012

OCA at 15:57, 21 November 2012

2012-11-21T15:57:03Z

←Older revision		Revision as of 15:57, 21 November 2012
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-	{{Seed}}
	[[Image:1gsm.png\|left\|200px]]		[[Image:1gsm.png\|left\|200px]]

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	{{STRUCTURE_1gsm\| PDB=1gsm \| SCENE= }}		{{STRUCTURE_1gsm\| PDB=1gsm \| SCENE= }}

	===A REASSESSMENT OF THE MADCAM-1 STRUCTURE AND ITS ROLE IN INTEGRIN RECOGNITION.===		===A REASSESSMENT OF THE MADCAM-1 STRUCTURE AND ITS ROLE IN INTEGRIN RECOGNITION.===

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	{{ABSTRACT_PUBMED_11807247}}		{{ABSTRACT_PUBMED_11807247}}

	==About this Structure==		==About this Structure==
-	~~1GSM~~ is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1GSM OCA].	+	[[1gsm]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1GSM OCA].

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~11807247~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:011807247</ref><references group="xtra"/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Brady, R L.]]		[[Category: Brady, R L.]]
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	[[Category: Madcam-1]]		[[Category: Madcam-1]]
	[[Category: Membrane protein]]		[[Category: Membrane protein]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 06:31:19 2009''