1gt6 - Revision history

OCA at 12:05, 13 December 2023

2023-12-13T12:05:50Z

←Older revision		Revision as of 12:05, 13 December 2023
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	<StructureSection load='1gt6' size='340' side='right'caption='[[1gt6]], [[Resolution\|resolution]] 2.20Å' scene=''>		<StructureSection load='1gt6' size='340' side='right'caption='[[1gt6]], [[Resolution\|resolution]] 2.20Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1gt6]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Cbs_632.91 Cbs 632.91~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1GT6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1GT6 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1gt6]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Thermomyces_lanuginosus Thermomyces lanuginosus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1GT6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1GT6 FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=OLA:OLEIC+ACID'>OLA</scene></td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.2Å</td></tr>
-	~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max~~-~~height: 3em;'>[[1dt3\|1dt3]]~~, [[~~1dt5~~\|~~1dt5]], [[1dte\|1dte]], [[1du4\|1du4~~]]~~</div>~~</td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=OLA:OLEIC+ACID'>OLA</scene></td></tr>
-	<tr id='~~gene~~'><td class="sblockLbl"><b>[[~~Gene~~\|~~Gene~~:]]</b></td><td class="sblockDat"~~>LIP ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&~~id=~~5541 CBS 632.91])</td~~><~~/tr>~~	+
-	~~<tr id~~='~~activity'><td class~~=~~"sblockLbl"><b>Activity~~:~~</b></td><td class="sblockDat"><span class='plainlinks~~'>~~[https://en.wikipedia.org/wiki/Triacylglycerol_lipase Triacylglycerol lipase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.1.3 3.1.1.3]~~ </~~span~~></td></tr>	+
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1gt6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1gt6 OCA], [https://pdbe.org/1gt6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1gt6 RCSB], [https://www.ebi.ac.uk/pdbsum/1gt6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1gt6 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1gt6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1gt6 OCA], [https://pdbe.org/1gt6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1gt6 RCSB], [https://www.ebi.ac.uk/pdbsum/1gt6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1gt6 ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/LIP_THELA LIP_THELA]
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 36:		Line 36:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Cbs 632 91]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Triacylglycerol lipase~~]]	+	[[Category: Thermomyces lanuginosus]]
-	[[Category: Brzozowski~~, A M~~]]	+	[[Category: Brzozowski AM]]
-	[[Category: Ivanova~~, M G~~]]	+	[[Category: Ivanova MG]]
-	[[Category: Patkar~~, S A~~]]	+	[[Category: Patkar SA]]
-	[[Category: Svendsen, A]]	+	[[Category: Svendsen A]]
-	[[Category: Verger, R]]	+	[[Category: Verger R]]
-	[[Category: Vind, J]]	+	[[Category: Vind J]]
-	[[Category: Yapoudjian, S]]	+	[[Category: Yapoudjian S]]
-	~~[[Category: Hydrolase]]~~	+
-	~~[[Category: Lipase]]~~	+
-	~~[[Category: Lipid degradation]]~~	+
-	~~[[Category: Zymogen~~]]	+

OCA at 10:47, 14 July 2021

2021-07-14T10:47:28Z

←Older revision		Revision as of 10:47, 14 July 2021
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	<StructureSection load='1gt6' size='340' side='right'caption='[[1gt6]], [[Resolution\|resolution]] 2.20Å' scene=''>		<StructureSection load='1gt6' size='340' side='right'caption='[[1gt6]], [[Resolution\|resolution]] 2.20Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1gt6]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Cbs_632.91 Cbs 632.91]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1GT6 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1GT6 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1gt6]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Cbs_632.91 Cbs 632.91]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1GT6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1GT6 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=OLA:OLEIC+ACID'>OLA</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=OLA:OLEIC+ACID'>OLA</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1dt3\|1dt3]], [[1dt5\|1dt5]], [[1dte\|1dte]], [[1du4\|1du4]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1dt3\|1dt3]], [[1dt5\|1dt5]], [[1dte\|1dte]], [[1du4\|1du4]]</div></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">LIP ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=5541 CBS 632.91])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">LIP ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=5541 CBS 632.91])</td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://en.wikipedia.org/wiki/Triacylglycerol_lipase Triacylglycerol lipase], with EC number [~~http~~://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.1.3 3.1.1.3] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Triacylglycerol_lipase Triacylglycerol lipase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.1.3 3.1.1.3] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1gt6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1gt6 OCA], [~~http~~://pdbe.org/1gt6 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=1gt6 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/1gt6 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=1gt6 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1gt6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1gt6 OCA], [https://pdbe.org/1gt6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1gt6 RCSB], [https://www.ebi.ac.uk/pdbsum/1gt6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1gt6 ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 31:		Line 31:

	==See Also==		==See Also==
-	*[[Lipase\|Lipase]]	+	*[[Lipase 3D Structures\|Lipase 3D Structures]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 05:31, 10 October 2019

2019-10-10T05:31:23Z

←Older revision		Revision as of 05:31, 10 October 2019
Line 1:		Line 1:

	==S146A mutant of Thermomyces (Humicola) lanuginosa lipase complex with oleic acid==		==S146A mutant of Thermomyces (Humicola) lanuginosa lipase complex with oleic acid==
-	<StructureSection load='1gt6' size='340' side='right' caption='[[1gt6]], [[Resolution\|resolution]] 2.20Å' scene=''>	+	<StructureSection load='1gt6' size='340' side='right'caption='[[1gt6]], [[Resolution\|resolution]] 2.20Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1gt6]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Cbs_632.91 Cbs 632.91]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1GT6 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1GT6 FirstGlance]. <br>		<table><tr><td colspan='2'>[[1gt6]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Cbs_632.91 Cbs 632.91]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1GT6 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1GT6 FirstGlance]. <br>
Line 37:		Line 37:
	</StructureSection>		</StructureSection>
	[[Category: Cbs 632 91]]		[[Category: Cbs 632 91]]
		+	[[Category: Large Structures]]
	[[Category: Triacylglycerol lipase]]		[[Category: Triacylglycerol lipase]]
	[[Category: Brzozowski, A M]]		[[Category: Brzozowski, A M]]

OCA at 08:25, 14 November 2018

2018-11-14T08:25:00Z

←Older revision		Revision as of 08:25, 14 November 2018
Line 3:		Line 3:
	<StructureSection load='1gt6' size='340' side='right' caption='[[1gt6]], [[Resolution\|resolution]] 2.20Å' scene=''>		<StructureSection load='1gt6' size='340' side='right' caption='[[1gt6]], [[Resolution\|resolution]] 2.20Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1gt6]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Thermomyces_lanuginosus Thermomyces lanuginosus~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1GT6 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1GT6 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1gt6]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Cbs_632.91 Cbs 632.91]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1GT6 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1GT6 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=OLA:OLEIC+ACID'>OLA</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=OLA:OLEIC+ACID'>OLA</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1dt3\|1dt3]], [[1dt5\|1dt5]], [[1dte\|1dte]], [[1du4\|1du4]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1dt3\|1dt3]], [[1dt5\|1dt5]], [[1dte\|1dte]], [[1du4\|1du4]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">LIP ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=5541 CBS 632.91])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Triacylglycerol_lipase Triacylglycerol lipase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.1.3 3.1.1.3] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Triacylglycerol_lipase Triacylglycerol lipase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.1.3 3.1.1.3] </span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1gt6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1gt6 OCA], [http://pdbe.org/1gt6 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1gt6 RCSB], [http://www.ebi.ac.uk/pdbsum/1gt6 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1gt6 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1gt6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1gt6 OCA], [http://pdbe.org/1gt6 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1gt6 RCSB], [http://www.ebi.ac.uk/pdbsum/1gt6 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1gt6 ProSAT]</span></td></tr>
Line 28:		Line 29:
	</div>		</div>
	<div class="pdbe-citations 1gt6" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 1gt6" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Lipase\|Lipase]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Thermomyces lanuginosus~~]]	+	[[Category: Cbs 632 91]]
	[[Category: Triacylglycerol lipase]]		[[Category: Triacylglycerol lipase]]
	[[Category: Brzozowski, A M]]		[[Category: Brzozowski, A M]]

OCA at 06:53, 3 January 2018

2018-01-03T06:53:33Z

←Older revision		Revision as of 06:53, 3 January 2018
Line 1:		Line 1:
-	==S146A ~~MUTANT OF THERMOMYCES~~ (~~HUMICOLA~~) ~~LANUGINOSA LIPASE COMPLEX WITH OLEIC ACID~~==	+
		+	==S146A mutant of Thermomyces (Humicola) lanuginosa lipase complex with oleic acid==
	<StructureSection load='1gt6' size='340' side='right' caption='[[1gt6]], [[Resolution\|resolution]] 2.20Å' scene=''>		<StructureSection load='1gt6' size='340' side='right' caption='[[1gt6]], [[Resolution\|resolution]] 2.20Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
Line 6:		Line 7:
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1dt3\|1dt3]], [[1dt5\|1dt5]], [[1dte\|1dte]], [[1du4\|1du4]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1dt3\|1dt3]], [[1dt5\|1dt5]], [[1dte\|1dte]], [[1du4\|1du4]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Triacylglycerol_lipase Triacylglycerol lipase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.1.3 3.1.1.3] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Triacylglycerol_lipase Triacylglycerol lipase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.1.3 3.1.1.3] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1gt6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1gt6 OCA], [http://pdbe.org/1gt6 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1gt6 RCSB], [http://www.ebi.ac.uk/pdbsum/1gt6 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1gt6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1gt6 OCA], [http://pdbe.org/1gt6 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1gt6 RCSB], [http://www.ebi.ac.uk/pdbsum/1gt6 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1gt6 ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 12:		Line 13:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/gt/1gt6_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/gt/1gt6_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
Line 27:		Line 28:
	</div>		</div>
	<div class="pdbe-citations 1gt6" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 1gt6" style="background-color:#fffaf0;"></div>
-
-	==See Also==
-	*[[Lipase\|Lipase]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 16:06, 9 February 2016

2016-02-09T16:06:10Z

←Older revision		Revision as of 16:06, 9 February 2016
Line 16:		Line 16:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1gt6 ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 23:51, 10 September 2015

2015-09-10T23:51:17Z

←Older revision		Revision as of 23:51, 10 September 2015
Line 6:		Line 6:
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1dt3\|1dt3]], [[1dt5\|1dt5]], [[1dte\|1dte]], [[1du4\|1du4]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1dt3\|1dt3]], [[1dt5\|1dt5]], [[1dte\|1dte]], [[1du4\|1du4]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Triacylglycerol_lipase Triacylglycerol lipase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.1.3 3.1.1.3] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Triacylglycerol_lipase Triacylglycerol lipase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.1.3 3.1.1.3] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1gt6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1gt6 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1gt6 RCSB], [http://www.ebi.ac.uk/pdbsum/1gt6 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1gt6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1gt6 OCA], [http://pdbe.org/1gt6 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1gt6 RCSB], [http://www.ebi.ac.uk/pdbsum/1gt6 PDBsum]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 26:		Line 26:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 1gt6" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==

OCA at 20:00, 22 December 2014

2014-12-22T20:00:22Z

←Older revision		Revision as of 20:00, 22 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1gt6]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Thermomyces_lanuginosus Thermomyces lanuginosus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1GT6 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1GT6 FirstGlance]. <br>		<table><tr><td colspan='2'>[[1gt6]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Thermomyces_lanuginosus Thermomyces lanuginosus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1GT6 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1GT6 FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=OLA:OLEIC+ACID'>OLA</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=OLA:OLEIC+ACID'>OLA</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1dt3\|1dt3]], [[1dt5\|1dt5]], [[1dte\|1dte]], [[1du4\|1du4]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1dt3\|1dt3]], [[1dt5\|1dt5]], [[1dte\|1dte]], [[1du4\|1du4]]</td></tr>
-	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Triacylglycerol_lipase Triacylglycerol lipase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.1.3 3.1.1.3] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Triacylglycerol_lipase Triacylglycerol lipase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.1.3 3.1.1.3] </span></td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1gt6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1gt6 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1gt6 RCSB], [http://www.ebi.ac.uk/pdbsum/1gt6 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1gt6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1gt6 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1gt6 RCSB], [http://www.ebi.ac.uk/pdbsum/1gt6 PDBsum]</span></td></tr>
-	<table>	+	</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 35:		Line 35:
	[[Category: Thermomyces lanuginosus]]		[[Category: Thermomyces lanuginosus]]
	[[Category: Triacylglycerol lipase]]		[[Category: Triacylglycerol lipase]]
-	[[Category: Brzozowski, A M.]]	+	[[Category: Brzozowski, A M]]
-	[[Category: Ivanova, M G.]]	+	[[Category: Ivanova, M G]]
-	[[Category: Patkar, S A.]]	+	[[Category: Patkar, S A]]
-	[[Category: Svendsen, A.]]	+	[[Category: Svendsen, A]]
-	[[Category: Verger, R.]]	+	[[Category: Verger, R]]
-	[[Category: Vind, J.]]	+	[[Category: Vind, J]]
-	[[Category: Yapoudjian, S.]]	+	[[Category: Yapoudjian, S]]
	[[Category: Hydrolase]]		[[Category: Hydrolase]]
	[[Category: Lipase]]		[[Category: Lipase]]
	[[Category: Lipid degradation]]		[[Category: Lipid degradation]]
	[[Category: Zymogen]]		[[Category: Zymogen]]

OCA at 09:51, 28 September 2014

2014-09-28T09:51:06Z

←Older revision		Revision as of 09:51, 28 September 2014
Line 1:		Line 1:
-	[[~~Image:~~1gt6.~~png~~\|~~left~~\|200px]]	+	==S146A MUTANT OF THERMOMYCES (HUMICOLA) LANUGINOSA LIPASE COMPLEX WITH OLEIC ACID==
		+	<StructureSection load='1gt6' size='340' side='right' caption='[[1gt6]], [[Resolution\|resolution]] 2.20Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[1gt6]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Thermomyces_lanuginosus Thermomyces lanuginosus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1GT6 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1GT6 FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=OLA:OLEIC+ACID'>OLA</scene><br>
		+	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1dt3\|1dt3]], [[1dt5\|1dt5]], [[1dte\|1dte]], [[1du4\|1du4]]</td></tr>
		+	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Triacylglycerol_lipase Triacylglycerol lipase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.1.3 3.1.1.3] </span></td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1gt6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1gt6 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1gt6 RCSB], [http://www.ebi.ac.uk/pdbsum/1gt6 PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/gt/1gt6_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The binding of Thermomyces lanuginosa lipase and its mutants [TLL(S146A), TLL(W89L), TLL(W117F, W221H, W260H)] to the mixed micelles of cis-parinaric acid/sodium taurodeoxycholate at pH 5.0 led to the quenching of the intrinsic tryptophan fluorescence emission (300-380 nm) and to a simultaneous increase in the cis-parinaric acid fluorescence emission (380-500 nm). These findings were used to characterize the Thermomyces lanuginosa lipase/cis-parinaric acid interactions occurring in the presence of sodium taurodeoxycholate.The fluorescence resonance energy transfer and Stern-Volmer quenching constant values obtained were correlated with the accessibility of the tryptophan residues to the cis-parinaric acid and with the lid opening ability of Thermomyces lanuginosa lipase (and its mutants). TLL(S146A) was found to have the highest fluorescence resonance energy transfer. In addition, a TLL(S146A)/oleic acid complex was crystallised and its three-dimensional structure was solved. Surprisingly, two possible binding modes (sn-1 and antisn1) were found to exist between oleic acid and the catalytic cleft of the open conformation of TLL(S146A). Both binding modes involved an interaction with tryptophan 89 of the lipase lid, in agreement with fluorescence resonance energy transfer experiments.As a consequence, we concluded that TLL(S146A) mutant is not an appropriate substitute for the wild-type Thermomyces lanuginosa lipase for mimicking the interaction between the wild-type enzyme and lipids.

-	~~{{STRUCTURE_1gt6\| PDB=1gt6 \| SCENE= }}~~	+	Binding of Thermomyces (Humicola) lanuginosa lipase to the mixed micelles of cis-parinaric acid/NaTDC.,Yapoudjian S, Ivanova MG, Brzozowski AM, Patkar SA, Vind J, Svendsen A, Verger R Eur J Biochem. 2002 Mar;269(6):1613-21. PMID:11895431<ref>PMID:11895431</ref>

-	~~===S146A MUTANT OF THERMOMYCES (HUMICOLA) LANUGINOSA LIPASE COMPLEX WITH OLEIC ACID===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_11895431}}~~	+
-		+
-	~~==About this Structure==~~	+
-	~~[[1gt6]] is~~ a ~~2 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Thermomyces_lanuginosus Thermomyces lanuginosus]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=1GT6 OCA].~~	+

	==See Also==		==See Also==
	*[[Lipase\|Lipase]]		*[[Lipase\|Lipase]]
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	<~~ref group="xtra">PMID:011895431<~~/~~ref~~><~~references group="xtra"~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Thermomyces lanuginosus]]		[[Category: Thermomyces lanuginosus]]
	[[Category: Triacylglycerol lipase]]		[[Category: Triacylglycerol lipase]]

OCA at 14:23, 20 October 2012

2012-10-20T14:23:35Z

←Older revision		Revision as of 14:23, 20 October 2012
Line 8:		Line 8:

	==About this Structure==		==About this Structure==
-	[[1gt6]] is a 2 chain structure ~~of [[Lipase]]~~ with sequence from [http://en.wikipedia.org/wiki/Thermomyces_lanuginosus Thermomyces lanuginosus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1GT6 OCA].	+	[[1gt6]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Thermomyces_lanuginosus Thermomyces lanuginosus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1GT6 OCA].

	==See Also==		==See Also==