1gv4 - Revision history

OCA at 12:08, 13 December 2023

2023-12-13T12:08:10Z

←Older revision		Revision as of 12:08, 13 December 2023
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	<StructureSection load='1gv4' size='340' side='right'caption='[[1gv4]], [[Resolution\|resolution]] 2.00Å' scene=''>		<StructureSection load='1gv4' size='340' side='right'caption='[[1gv4]], [[Resolution\|resolution]] 2.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1gv4]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Lk3_transgenic_mice Lk3 transgenic mice~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1GV4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1GV4 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1gv4]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1GV4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1GV4 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1gv4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1gv4 OCA], [https://pdbe.org/1gv4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1gv4 RCSB], [https://www.ebi.ac.uk/pdbsum/1gv4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1gv4 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1gv4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1gv4 OCA], [https://pdbe.org/1gv4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1gv4 RCSB], [https://www.ebi.ac.uk/pdbsum/1gv4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1gv4 ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/AIFM1_MOUSE AIFM1_MOUSE] Functions both as NADH oxidoreductase and as regulator of apoptosis. In response to apoptotic stimuli, it is released from the mitochondrion intermembrane space into the cytosol and to the nucleus, where it functions as a proapoptotic factor in a caspase-independent pathway. In contrast, functions as an antiapoptotic factor in normal mitochondria via its NADH oxidoreductase activity. The soluble form (AIFsol) found in the nucleus induces 'parthanatos' i.e. caspase-independent fragmentation of chromosomal DNA. Interacts with EIF3G,and thereby inhibits the EIF3 machinery and protein synthesis,and activates casapse-7 to amplify apoptosis. Plays a critical role in caspase-independent, pyknotic cell death in hydrogen peroxide-exposed cells. Binds to DNA in a sequence-independent manner (By similarity).
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Lk3 transgenic mice~~]]	+	[[Category: Mus musculus]]
-	[[Category: Alzari~~, P M~~]]	+	[[Category: Alzari PM]]
-	[[Category: Mate~~, M J]]~~	+	[[Category: Mate MJ]]
-	~~[[Category: Apoptosi]]~~	+
-	~~[[Category: Fad]]~~	+
-	~~[[Category: Flavoprotein]]~~	+
-	~~[[Category: Nuclear protein]]~~	+
-	~~[[Category: Oxidoreductase~~]]	+

OCA at 11:29, 28 July 2021

2021-07-28T11:29:03Z

←Older revision		Revision as of 11:29, 28 July 2021
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	<StructureSection load='1gv4' size='340' side='right'caption='[[1gv4]], [[Resolution\|resolution]] 2.00Å' scene=''>		<StructureSection load='1gv4' size='340' side='right'caption='[[1gv4]], [[Resolution\|resolution]] 2.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1gv4]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1GV4 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1GV4 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1gv4]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1GV4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1GV4 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1gv4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1gv4 OCA], [~~http~~://pdbe.org/1gv4 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=1gv4 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/1gv4 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=1gv4 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1gv4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1gv4 OCA], [https://pdbe.org/1gv4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1gv4 RCSB], [https://www.ebi.ac.uk/pdbsum/1gv4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1gv4 ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 28:		Line 28:

	==See Also==		==See Also==
-	*[[Cell death protein\|Cell death protein]]	+	*[[Cell death protein 3D structures\|Cell death protein 3D structures]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 08:29, 23 October 2019

2019-10-23T08:29:36Z

←Older revision		Revision as of 08:29, 23 October 2019
Line 1:		Line 1:

	==Murine apoptosis-inducing factor (AIF)==		==Murine apoptosis-inducing factor (AIF)==
-	<StructureSection load='1gv4' size='340' side='right' caption='[[1gv4]], [[Resolution\|resolution]] 2.00Å' scene=''>	+	<StructureSection load='1gv4' size='340' side='right'caption='[[1gv4]], [[Resolution\|resolution]] 2.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1gv4]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1GV4 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1GV4 FirstGlance]. <br>		<table><tr><td colspan='2'>[[1gv4]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1GV4 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1GV4 FirstGlance]. <br>
Line 26:		Line 26:
	</div>		</div>
	<div class="pdbe-citations 1gv4" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 1gv4" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Cell death protein\|Cell death protein]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Lk3 transgenic mice]]		[[Category: Lk3 transgenic mice]]
	[[Category: Alzari, P M]]		[[Category: Alzari, P M]]

OCA at 06:17, 3 January 2018

2018-01-03T06:17:33Z

←Older revision		Revision as of 06:17, 3 January 2018
Line 1:		Line 1:
-	==~~MURINE APOPTOSIS~~-~~INDUCING FACTOR~~ (AIF)==	+
		+	==Murine apoptosis-inducing factor (AIF)==
	<StructureSection load='1gv4' size='340' side='right' caption='[[1gv4]], [[Resolution\|resolution]] 2.00Å' scene=''>		<StructureSection load='1gv4' size='340' side='right' caption='[[1gv4]], [[Resolution\|resolution]] 2.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1gv4]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1GV4 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1GV4 FirstGlance]. <br>		<table><tr><td colspan='2'>[[1gv4]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1GV4 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1GV4 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1gv4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1gv4 OCA], [http://pdbe.org/1gv4 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1gv4 RCSB], [http://www.ebi.ac.uk/pdbsum/1gv4 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1gv4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1gv4 OCA], [http://pdbe.org/1gv4 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1gv4 RCSB], [http://www.ebi.ac.uk/pdbsum/1gv4 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1gv4 ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 10:		Line 11:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/gv/1gv4_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/gv/1gv4_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
Line 25:		Line 26:
	</div>		</div>
	<div class="pdbe-citations 1gv4" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 1gv4" style="background-color:#fffaf0;"></div>
-
-	==See Also==
-	*[[Cell death protein\|Cell death protein]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 14:26, 9 February 2016

2016-02-09T14:26:25Z

←Older revision		Revision as of 14:26, 9 February 2016
Line 14:		Line 14:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1gv4 ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 23:08, 10 September 2015

2015-09-10T23:08:30Z

←Older revision		Revision as of 23:08, 10 September 2015
Line 2:		Line 2:
	<StructureSection load='1gv4' size='340' side='right' caption='[[1gv4]], [[Resolution\|resolution]] 2.00Å' scene=''>		<StructureSection load='1gv4' size='340' side='right' caption='[[1gv4]], [[Resolution\|resolution]] 2.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1gv4]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Mus_musculus Mus musculus~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1GV4 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1GV4 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1gv4]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1GV4 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1GV4 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1gv4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1gv4 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1gv4 RCSB], [http://www.ebi.ac.uk/pdbsum/1gv4 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1gv4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1gv4 OCA], [http://pdbe.org/1gv4 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1gv4 RCSB], [http://www.ebi.ac.uk/pdbsum/1gv4 PDBsum]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 24:		Line 24:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 1gv4" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 31:		Line 32:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Mus musculus~~]]	+	[[Category: Lk3 transgenic mice]]
	[[Category: Alzari, P M]]		[[Category: Alzari, P M]]
	[[Category: Mate, M J]]		[[Category: Mate, M J]]

OCA at 19:14, 22 December 2014

2014-12-22T19:14:25Z

←Older revision		Revision as of 19:14, 22 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1gv4]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1GV4 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1GV4 FirstGlance]. <br>		<table><tr><td colspan='2'>[[1gv4]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1GV4 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1GV4 FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene></td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1gv4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1gv4 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1gv4 RCSB], [http://www.ebi.ac.uk/pdbsum/1gv4 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1gv4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1gv4 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1gv4 RCSB], [http://www.ebi.ac.uk/pdbsum/1gv4 PDBsum]</span></td></tr>
-	<table>	+	</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 32:		Line 32:
	</StructureSection>		</StructureSection>
	[[Category: Mus musculus]]		[[Category: Mus musculus]]
-	[[Category: Alzari, P M.]]	+	[[Category: Alzari, P M]]
-	[[Category: Mate, M J.]]	+	[[Category: Mate, M J]]
	[[Category: Apoptosi]]		[[Category: Apoptosi]]
	[[Category: Fad]]		[[Category: Fad]]

OCA at 09:11, 28 September 2014

2014-09-28T09:11:51Z

←Older revision		Revision as of 09:11, 28 September 2014
Line 1:		Line 1:
-	[[~~Image~~:1gv4.~~png\|left~~\|200px]]	+	==MURINE APOPTOSIS-INDUCING FACTOR (AIF)==
		+	<StructureSection load='1gv4' size='340' side='right' caption='[[1gv4]], [[Resolution\|resolution]] 2.00Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[1gv4]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1GV4 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1GV4 FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene><br>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1gv4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1gv4 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1gv4 RCSB], [http://www.ebi.ac.uk/pdbsum/1gv4 PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/gv/1gv4_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Mitochondria play a key role in apoptosis due to their capacity to release potentially lethal proteins. One of these latent death factors is cytochrome c, which can stimulate the proteolytic activation of caspase zymogens. Another important protein is apoptosis-inducing factor (AIF), a flavoprotein that can stimulate a caspase-independent cell-death pathway required for early embryonic morphogenesis. Here, we report the crystal structure of mouse AIF at 2.0 A. Its active site structure and redox properties suggest that AIF functions as an electron transferase with a mechanism similar to that of the bacterial ferredoxin reductases, its closest evolutionary homologs. However, AIF structurally differs from these proteins in some essential features, including a long insertion in a C-terminal beta-hairpin loop, which may be related to its apoptogenic functions.

-	~~{{STRUCTURE_1gv4\| PDB=1gv4 \| SCENE= }}~~	+	The crystal structure of the mouse apoptosis-inducing factor AIF.,Mate MJ, Ortiz-Lombardia M, Boitel B, Haouz A, Tello D, Susin SA, Penninger J, Kroemer G, Alzari PM Nat Struct Biol. 2002 Jun;9(6):442-6. PMID:11967568<ref>PMID:11967568</ref>

-	~~===MURINE APOPTOSIS-INDUCING FACTOR (AIF)===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>

-	~~{{ABSTRACT_PUBMED_11967568}}~~	+	==See Also==
-		+	*[[Cell death protein\|Cell death protein]]
-	==~~About this Structure~~==	+	== References ==
-	[[~~1gv4~~]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1GV4 OCA].	+	<references/>
-		+	__TOC__
-	==~~Reference~~==	+	</StructureSection>
-	<~~ref group="xtra">PMID:011967568<~~/~~ref~~><~~references group="xtra"~~/>	+
	[[Category: Mus musculus]]		[[Category: Mus musculus]]
	[[Category: Alzari, P M.]]		[[Category: Alzari, P M.]]

OCA: Protected "1gv4" [edit=sysop:move=sysop]

2012-11-21T15:33:58Z

Protected "1gv4" [edit=sysop:move=sysop]

←Older revision

Revision as of 15:33, 21 November 2012

OCA at 15:33, 21 November 2012

2012-11-21T15:33:55Z

←Older revision		Revision as of 15:33, 21 November 2012
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-	{{Seed}}
	[[Image:1gv4.png\|left\|200px]]		[[Image:1gv4.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_1gv4", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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	{{STRUCTURE_1gv4\| PDB=1gv4 \| SCENE= }}		{{STRUCTURE_1gv4\| PDB=1gv4 \| SCENE= }}

	===MURINE APOPTOSIS-INDUCING FACTOR (AIF)===		===MURINE APOPTOSIS-INDUCING FACTOR (AIF)===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_11967568}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 11967568 is the PubMed ID number.
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	{{ABSTRACT_PUBMED_11967568}}		{{ABSTRACT_PUBMED_11967568}}

	==About this Structure==		==About this Structure==
-	~~1GV4~~ is a 2 ~~chains~~ structure ~~of sequences~~ from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1GV4 OCA].	+	[[1gv4]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1GV4 OCA].

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~11967568~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:011967568</ref><references group="xtra"/>
	[[Category: Mus musculus]]		[[Category: Mus musculus]]
	[[Category: Alzari, P M.]]		[[Category: Alzari, P M.]]
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	[[Category: Nuclear protein]]		[[Category: Nuclear protein]]
	[[Category: Oxidoreductase]]		[[Category: Oxidoreductase]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 10:28:36 2009''