1h02 - Revision history

OCA at 12:11, 13 December 2023

2023-12-13T12:11:53Z

←Older revision		Revision as of 12:11, 13 December 2023
Line 3:		Line 3:
	<StructureSection load='1h02' size='340' side='right'caption='[[1h02]], [[Resolution\|resolution]] 2.00Å' scene=''>		<StructureSection load='1h02' size='340' side='right'caption='[[1h02]], [[Resolution\|resolution]] 2.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1h02]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Human Human~~]. The April 2004 RCSB PDB [https://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/index.html Molecule of the Month] feature on ''Growth Hormone'' by Shuchismita Dutta and David S. Goodsell is [https://dx.doi.org/10.2210/rcsb_pdb/mom_2004_4 10.2210/rcsb_pdb/mom_2004_4]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1H02 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1H02 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1h02]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. The April 2004 RCSB PDB [https://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/index.html Molecule of the Month] feature on ''Growth Hormone'' by Shuchismita Dutta and David S. Goodsell is [https://dx.doi.org/10.2210/rcsb_pdb/mom_2004_4 10.2210/rcsb_pdb/mom_2004_4]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1H02 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1H02 FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=C15:N~~-~~DODECYL-N~~,~~N-DIMETHYL-3-AMMONIO-1-PROPANESULFONATE'>C15</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2Å</td></tr>
-	<tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"><~~div style~~='~~overflow~~: ~~auto; max~~-~~height: 3em;~~'>~~[[1gzr\|1gzr]], [[1gzy\|1gzy]], [[1gzz\|1gzz]], [[1h59\|1h59]], [[1imx\|1imx]], [[2gf1\|2gf1]], [[3gf1\|3gf1]]~~</~~div~~></td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=C15:N-DODECYL-N,N-DIMETHYL-3-AMMONIO-1-PROPANESULFONATE'>C15</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1h02 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1h02 OCA], [https://pdbe.org/1h02 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1h02 RCSB], [https://www.ebi.ac.uk/pdbsum/1h02 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1h02 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1h02 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1h02 OCA], [https://pdbe.org/1h02 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1h02 RCSB], [https://www.ebi.ac.uk/pdbsum/1h02 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1h02 ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
-	[[https://www.uniprot.org/uniprot/IGF1_HUMAN IGF1_HUMAN]] Defects in IGF1 are the cause of insulin-like growth factor I deficiency (IGF1 deficiency) [MIM:[https://omim.org/entry/608747 608747]]. IGF1 deficiency is an autosomal recessive disorder characterized by growth retardation, sensorineural deafness and mental retardation.	+	[https://www.uniprot.org/uniprot/IGF1_HUMAN IGF1_HUMAN] Defects in IGF1 are the cause of insulin-like growth factor I deficiency (IGF1 deficiency) [MIM:[https://omim.org/entry/608747 608747]. IGF1 deficiency is an autosomal recessive disorder characterized by growth retardation, sensorineural deafness and mental retardation.
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/IGF1_HUMAN IGF1_HUMAN]] The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity. May be a physiological regulator of [1-14C]-2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblasts. Stimulates glucose transport in rat bone-derived osteoblastic (PyMS) cells and is effective at much lower concentrations than insulin, not only regarding glycogen and DNA synthesis but also with regard to enhancing glucose uptake.<ref>PMID:21076856</ref>	+	[https://www.uniprot.org/uniprot/IGF1_HUMAN IGF1_HUMAN] The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity. May be a physiological regulator of [1-14C]-2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblasts. Stimulates glucose transport in rat bone-derived osteoblastic (PyMS) cells and is effective at much lower concentrations than insulin, not only regarding glycogen and DNA synthesis but also with regard to enhancing glucose uptake.<ref>PMID:21076856</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 39:		Line 39:
	</StructureSection>		</StructureSection>
	[[Category: Growth Hormone]]		[[Category: Growth Hormone]]
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: RCSB PDB Molecule of the Month]]		[[Category: RCSB PDB Molecule of the Month]]
-	[[Category: ~~Bree, F M.De~~]]	+	[[Category: Brzozowski AM]]
-	[[Category: ~~Brzozowski, A M~~]]	+	[[Category: Dauter Z]]
-	[[Category: ~~Dauter, Z~~]]	+	[[Category: De Bree FM]]
-	[[Category: Dodson~~, E J~~]]	+	[[Category: Dodson EJ]]
-	[[Category: Dodson~~, G G~~]]	+	[[Category: Dodson GG]]
-	[[Category: Murshudov, G]]	+	[[Category: Murshudov G]]
-	[[Category: Turkenburg~~, J P~~]]	+	[[Category: Turkenburg JP]]
-	[[Category: Verma, C]]	+	[[Category: Verma C]]
-	~~[[Category: Cell adhesion]]~~	+
-	~~[[Category: Growth factor]]~~	+
-	~~[[Category: Igf-1]]~~	+
-	~~[[Category: Insulin family]]~~	+
-	~~[[Category: Plasma~~]]	+

OCA at 10:25, 17 February 2021

2021-02-17T10:25:12Z

OCA at 11:35, 10 May 2019

2019-05-10T11:35:49Z

←Older revision		Revision as of 11:35, 10 May 2019
Line 1:		Line 1:

	==Human Insulin-like growth factor; SRS Daresbury data==		==Human Insulin-like growth factor; SRS Daresbury data==
-	<StructureSection load='1h02' size='340' side='right' caption='[[1h02]], [[Resolution\|resolution]] 2.00Å' scene=''>	+	<StructureSection load='1h02' size='340' side='right'caption='[[1h02]], [[Resolution\|resolution]] 2.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1h02]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. The April 2004 RCSB PDB [http://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/index.html Molecule of the Month] feature on ''Growth Hormone'' by Shuchismita Dutta and David S. Goodsell is [http://dx.doi.org/10.2210/rcsb_pdb/mom_2004_4 10.2210/rcsb_pdb/mom_2004_4]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1H02 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1H02 FirstGlance]. <br>		<table><tr><td colspan='2'>[[1h02]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. The April 2004 RCSB PDB [http://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/index.html Molecule of the Month] feature on ''Growth Hormone'' by Shuchismita Dutta and David S. Goodsell is [http://dx.doi.org/10.2210/rcsb_pdb/mom_2004_4 10.2210/rcsb_pdb/mom_2004_4]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1H02 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1H02 FirstGlance]. <br>
Line 31:		Line 31:
	</div>		</div>
	<div class="pdbe-citations 1h02" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 1h02" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Insulin-like growth factor\|Insulin-like growth factor]]
	== References ==		== References ==
	<references/>		<references/>
Line 37:		Line 40:
	[[Category: Growth Hormone]]		[[Category: Growth Hormone]]
	[[Category: Human]]		[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: RCSB PDB Molecule of the Month]]		[[Category: RCSB PDB Molecule of the Month]]
	[[Category: Bree, F M.De]]		[[Category: Bree, F M.De]]

OCA at 06:35, 3 January 2018

2018-01-03T06:35:58Z

←Older revision		Revision as of 06:35, 3 January 2018
Line 1:		Line 1:
-	==~~HUMAN INSULIN~~-~~LIKE GROWTH FACTOR~~; SRS ~~DARESBURY DATA~~==	+
		+	==Human Insulin-like growth factor; SRS Daresbury data==
	<StructureSection load='1h02' size='340' side='right' caption='[[1h02]], [[Resolution\|resolution]] 2.00Å' scene=''>		<StructureSection load='1h02' size='340' side='right' caption='[[1h02]], [[Resolution\|resolution]] 2.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
Line 5:		Line 6:
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=C15:N-DODECYL-N,N-DIMETHYL-3-AMMONIO-1-PROPANESULFONATE'>C15</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=C15:N-DODECYL-N,N-DIMETHYL-3-AMMONIO-1-PROPANESULFONATE'>C15</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1gzr\|1gzr]], [[1gzy\|1gzy]], [[1gzz\|1gzz]], [[1h59\|1h59]], [[1imx\|1imx]], [[2gf1\|2gf1]], [[3gf1\|3gf1]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1gzr\|1gzr]], [[1gzy\|1gzy]], [[1gzz\|1gzz]], [[1h59\|1h59]], [[1imx\|1imx]], [[2gf1\|2gf1]], [[3gf1\|3gf1]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1h02 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1h02 OCA], [http://pdbe.org/1h02 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1h02 RCSB], [http://www.ebi.ac.uk/pdbsum/1h02 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1h02 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1h02 OCA], [http://pdbe.org/1h02 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1h02 RCSB], [http://www.ebi.ac.uk/pdbsum/1h02 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1h02 ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
Line 15:		Line 16:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/h0/1h02_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/h0/1h02_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
Line 30:		Line 31:
	</div>		</div>
	<div class="pdbe-citations 1h02" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 1h02" style="background-color:#fffaf0;"></div>
-
-	==See Also==
-	*[[Insulin-like growth factor\|Insulin-like growth factor]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 02:53, 7 February 2016

2016-02-07T02:53:56Z

←Older revision		Revision as of 02:53, 7 February 2016
Line 19:		Line 19:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1h02 ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 20:58, 9 September 2015

2015-09-09T20:58:35Z

←Older revision		Revision as of 20:58, 9 September 2015
Line 2:		Line 2:
	<StructureSection load='1h02' size='340' side='right' caption='[[1h02]], [[Resolution\|resolution]] 2.00Å' scene=''>		<StructureSection load='1h02' size='340' side='right' caption='[[1h02]], [[Resolution\|resolution]] 2.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1h02]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. The April 2004 RCSB PDB [http://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/index.html Molecule of the Month] feature on ''Growth Hormone'' by Shuchismita Dutta and David S. Goodsell is [http://dx.doi.org/10.2210/rcsb_pdb/mom_2004_4 10.2210/rcsb_pdb/mom_2004_4]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1H02 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1H02 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1h02]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. The April 2004 RCSB PDB [http://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/index.html Molecule of the Month] feature on ''Growth Hormone'' by Shuchismita Dutta and David S. Goodsell is [http://dx.doi.org/10.2210/rcsb_pdb/mom_2004_4 10.2210/rcsb_pdb/mom_2004_4]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1H02 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1H02 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=C15:N-DODECYL-N,N-DIMETHYL-3-AMMONIO-1-PROPANESULFONATE'>C15</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=C15:N-DODECYL-N,N-DIMETHYL-3-AMMONIO-1-PROPANESULFONATE'>C15</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1gzr\|1gzr]], [[1gzy\|1gzy]], [[1gzz\|1gzz]], [[1h59\|1h59]], [[1imx\|1imx]], [[2gf1\|2gf1]], [[3gf1\|3gf1]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1gzr\|1gzr]], [[1gzy\|1gzy]], [[1gzz\|1gzz]], [[1h59\|1h59]], [[1imx\|1imx]], [[2gf1\|2gf1]], [[3gf1\|3gf1]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1h02 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1h02 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1h02 RCSB], [http://www.ebi.ac.uk/pdbsum/1h02 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1h02 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1h02 OCA], [http://pdbe.org/1h02 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1h02 RCSB], [http://www.ebi.ac.uk/pdbsum/1h02 PDBsum]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
Line 29:		Line 29:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 1h02" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 37:		Line 38:
	</StructureSection>		</StructureSection>
	[[Category: Growth Hormone]]		[[Category: Growth Hormone]]
-	[[Category: ~~Homo sapiens~~]]	+	[[Category: Human]]
	[[Category: RCSB PDB Molecule of the Month]]		[[Category: RCSB PDB Molecule of the Month]]
	[[Category: Bree, F M.De]]		[[Category: Bree, F M.De]]

OCA at 18:43, 22 December 2014

2014-12-22T18:43:51Z

←Older revision		Revision as of 18:43, 22 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1h02]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. The April 2004 RCSB PDB [http://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/index.html Molecule of the Month] feature on ''Growth Hormone'' by Shuchismita Dutta and David S. Goodsell is [http://dx.doi.org/10.2210/rcsb_pdb/mom_2004_4 10.2210/rcsb_pdb/mom_2004_4]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1H02 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1H02 FirstGlance]. <br>		<table><tr><td colspan='2'>[[1h02]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. The April 2004 RCSB PDB [http://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/index.html Molecule of the Month] feature on ''Growth Hormone'' by Shuchismita Dutta and David S. Goodsell is [http://dx.doi.org/10.2210/rcsb_pdb/mom_2004_4 10.2210/rcsb_pdb/mom_2004_4]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1H02 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1H02 FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=C15:N-DODECYL-N,N-DIMETHYL-3-AMMONIO-1-PROPANESULFONATE'>C15</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=C15:N-DODECYL-N,N-DIMETHYL-3-AMMONIO-1-PROPANESULFONATE'>C15</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1gzr\|1gzr]], [[1gzy\|1gzy]], [[1gzz\|1gzz]], [[1h59\|1h59]], [[1imx\|1imx]], [[2gf1\|2gf1]], [[3gf1\|3gf1]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1gzr\|1gzr]], [[1gzy\|1gzy]], [[1gzz\|1gzz]], [[1h59\|1h59]], [[1imx\|1imx]], [[2gf1\|2gf1]], [[3gf1\|3gf1]]</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1h02 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1h02 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1h02 RCSB], [http://www.ebi.ac.uk/pdbsum/1h02 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1h02 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1h02 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1h02 RCSB], [http://www.ebi.ac.uk/pdbsum/1h02 PDBsum]</span></td></tr>
-	<table>	+	</table>
	== Disease ==		== Disease ==
	[[http://www.uniprot.org/uniprot/IGF1_HUMAN IGF1_HUMAN]] Defects in IGF1 are the cause of insulin-like growth factor I deficiency (IGF1 deficiency) [MIM:[http://omim.org/entry/608747 608747]]. IGF1 deficiency is an autosomal recessive disorder characterized by growth retardation, sensorineural deafness and mental retardation.		[[http://www.uniprot.org/uniprot/IGF1_HUMAN IGF1_HUMAN]] Defects in IGF1 are the cause of insulin-like growth factor I deficiency (IGF1 deficiency) [MIM:[http://omim.org/entry/608747 608747]]. IGF1 deficiency is an autosomal recessive disorder characterized by growth retardation, sensorineural deafness and mental retardation.
Line 39:		Line 39:
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: RCSB PDB Molecule of the Month]]		[[Category: RCSB PDB Molecule of the Month]]
-	[[Category: Bree, F M.De.]]	+	[[Category: Bree, F M.De]]
-	[[Category: Brzozowski, A M.]]	+	[[Category: Brzozowski, A M]]
-	[[Category: Dauter, Z.]]	+	[[Category: Dauter, Z]]
-	[[Category: Dodson, E J.]]	+	[[Category: Dodson, E J]]
-	[[Category: Dodson, G G.]]	+	[[Category: Dodson, G G]]
-	[[Category: Murshudov, G.]]	+	[[Category: Murshudov, G]]
-	[[Category: Turkenburg, J P.]]	+	[[Category: Turkenburg, J P]]
-	[[Category: Verma, C.]]	+	[[Category: Verma, C]]
	[[Category: Cell adhesion]]		[[Category: Cell adhesion]]
	[[Category: Growth factor]]		[[Category: Growth factor]]

OCA at 14:08, 29 September 2014

2014-09-29T14:08:25Z

←Older revision		Revision as of 14:08, 29 September 2014
Line 1:		Line 1:
-	~~{{STRUCTURE_1h02\| PDB=1h02 \| SCENE= }}~~	+	==HUMAN INSULIN-LIKE GROWTH FACTOR; SRS DARESBURY DATA==
-	===HUMAN INSULIN-LIKE GROWTH FACTOR; SRS DARESBURY DATA===	+	<StructureSection load='1h02' size='340' side='right' caption='[[1h02]], [[Resolution\|resolution]] 2.00Å' scene=''>
-	~~{{ABSTRACT_PUBMED_12135360}}~~	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[1h02]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. The April 2004 RCSB PDB [http://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/index.html Molecule of the Month] feature on ''Growth Hormone'' by Shuchismita Dutta and David S. Goodsell is [http://dx.doi.org/10.2210/rcsb_pdb/mom_2004_4 10.2210/rcsb_pdb/mom_2004_4]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1H02 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1H02 FirstGlance]. <br>
-	==Disease==	+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=C15:N-DODECYL-N,N-DIMETHYL-3-AMMONIO-1-PROPANESULFONATE'>C15</scene><br>
		+	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1gzr\|1gzr]], [[1gzy\|1gzy]], [[1gzz\|1gzz]], [[1h59\|1h59]], [[1imx\|1imx]], [[2gf1\|2gf1]], [[3gf1\|3gf1]]</td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1h02 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1h02 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1h02 RCSB], [http://www.ebi.ac.uk/pdbsum/1h02 PDBsum]</span></td></tr>
		+	<table>
		+	== Disease ==
	[[http://www.uniprot.org/uniprot/IGF1_HUMAN IGF1_HUMAN]] Defects in IGF1 are the cause of insulin-like growth factor I deficiency (IGF1 deficiency) [MIM:[http://omim.org/entry/608747 608747]]. IGF1 deficiency is an autosomal recessive disorder characterized by growth retardation, sensorineural deafness and mental retardation.		[[http://www.uniprot.org/uniprot/IGF1_HUMAN IGF1_HUMAN]] Defects in IGF1 are the cause of insulin-like growth factor I deficiency (IGF1 deficiency) [MIM:[http://omim.org/entry/608747 608747]]. IGF1 deficiency is an autosomal recessive disorder characterized by growth retardation, sensorineural deafness and mental retardation.
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/IGF1_HUMAN IGF1_HUMAN]] The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity. May be a physiological regulator of [1-14C]-2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblasts. Stimulates glucose transport in rat bone-derived osteoblastic (PyMS) cells and is effective at much lower concentrations than insulin, not only regarding glycogen and DNA synthesis but also with regard to enhancing glucose uptake.<ref>PMID:21076856</ref>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/h0/1h02_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Human insulin-like growth factors I and II (hIGF-I, hIGF-II) are potent stimulators of cell and growth processes. They display high sequence similarity to both the A and B chains of insulin but contain an additional connecting C-domain, which reflects their secretion without specific packaging or precursor conversion. IGFs also have an extension at the C-terminus known as the D-domain. This paper describes four homologous hIGF-1 structures, obtained from crystals grown in the presence of the detergent SB12, which reveal additional detail in the C- and D-domains. Two different detergent binding modes observed in the crystals may reflect different hIGF-I biological properties such as the interaction with IGF binding proteins and self-aggregation. While the helical core of hIGF-I is very similar to that in insulin, there are distinct differences in the region of hIGF-I corresponding to the insulin B chain C-terminus, residues B25-B30. In hIGF-I, these residues (24-29) and the following C-domain form an extensive loop protruding 20 A from the core, which results in a substantially different conformation for the receptor binding epitope in hIGF-I compared to insulin. One notable feature of the structures presented here is demonstration of peptide-bond cleavage between Ser35 and Arg36 resulting in an apparent gap between residues 35 and 39. The equivalent region of proinsulin is involved in hormone processing demanding a reassessment of the structural integrity of hIGF-I in relation to its biological function.

-	~~==Function==~~	+	Structural origins of the functional divergence of human insulin-like growth factor-I and insulin.,Brzozowski AM, Dodson EJ, Dodson GG, Murshudov GN, Verma C, Turkenburg JP, de Bree FM, Dauter Z Biochemistry. 2002 Jul 30;41(30):9389-97. PMID:12135360<ref>PMID:12135360</ref>
-	~~[[http://www.uniprot.org/uniprot/IGF1_HUMAN IGF1_HUMAN]] The~~ insulin-like growth ~~factors, isolated from plasma, are structurally~~ and ~~functionally related to~~ insulin ~~but have a much higher growth-promoting activity~~. ~~May be a physiological regulator of [1-14C]-2-deoxy-D-glucose~~ (~~2DG~~) ~~transport and glycogen synthesis in osteoblasts. Stimulates glucose transport in rat bone~~-~~derived osteoblastic (PyMS) cells and is effective at much lower concentrations than insulin, not only regarding glycogen and DNA synthesis but also with regard to enhancing glucose uptake~~.<ref>PMID:~~21076856~~</ref>	+

-	~~==About this Structure==~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~[[1h02]] is~~ a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. The April 2004 RCSB PDB [http://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/index.html Molecule of the ~~Month] feature on ''Growth Hormone'' by Shuchismita Dutta and David~~ S. ~~Goodsell is [http://dx~~.~~doi.org~~/~~10.2210/rcsb_pdb/mom_2004_4 10.2210/rcsb_pdb/mom_2004_4]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1H02 OCA].~~	+	</div>

	==See Also==		==See Also==
	*[[Insulin-like growth factor\|Insulin-like growth factor]]		*[[Insulin-like growth factor\|Insulin-like growth factor]]
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	~~<ref group="xtra">PMID:012135360</ref>~~<references ~~group="xtra"~~/><~~references~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Growth Hormone]]		[[Category: Growth Hormone]]
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]

OCA at 09:50, 24 March 2013

2013-03-24T09:50:01Z

←Older revision		Revision as of 09:50, 24 March 2013
Line 1:		Line 1:
-	[[Image:1h02.png\|left\|200px]]
-
	{{STRUCTURE_1h02\| PDB=1h02 \| SCENE= }}		{{STRUCTURE_1h02\| PDB=1h02 \| SCENE= }}
-
	===HUMAN INSULIN-LIKE GROWTH FACTOR; SRS DARESBURY DATA===		===HUMAN INSULIN-LIKE GROWTH FACTOR; SRS DARESBURY DATA===
		+	{{ABSTRACT_PUBMED_12135360}}

-	~~{{ABSTRACT_PUBMED_12135360}}~~	+	==Disease==
		+	[[http://www.uniprot.org/uniprot/IGF1_HUMAN IGF1_HUMAN]] Defects in IGF1 are the cause of insulin-like growth factor I deficiency (IGF1 deficiency) [MIM:[http://omim.org/entry/608747 608747]]. IGF1 deficiency is an autosomal recessive disorder characterized by growth retardation, sensorineural deafness and mental retardation.
		+
		+	==Function==
		+	[[http://www.uniprot.org/uniprot/IGF1_HUMAN IGF1_HUMAN]] The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity. May be a physiological regulator of [1-14C]-2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblasts. Stimulates glucose transport in rat bone-derived osteoblastic (PyMS) cells and is effective at much lower concentrations than insulin, not only regarding glycogen and DNA synthesis but also with regard to enhancing glucose uptake.<ref>PMID:21076856</ref>

	==About this Structure==		==About this Structure==
Line 14:		Line 16:

	==Reference==		==Reference==
-	<ref group="xtra">PMID:012135360</ref><references group="xtra"/>	+	<ref group="xtra">PMID:012135360</ref><references group="xtra"/><references/>
	[[Category: Growth Hormone]]		[[Category: Growth Hormone]]
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]

OCA: Protected "1h02" [edit=sysop:move=sysop]

2012-10-20T05:23:49Z

Protected "1h02" [edit=sysop:move=sysop]

←Older revision

Revision as of 05:23, 20 October 2012

←Older revision		Revision as of 10:25, 17 February 2021
Line 3:		Line 3:
	<StructureSection load='1h02' size='340' side='right'caption='[[1h02]], [[Resolution\|resolution]] 2.00Å' scene=''>		<StructureSection load='1h02' size='340' side='right'caption='[[1h02]], [[Resolution\|resolution]] 2.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1h02]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Human Human]. The April 2004 RCSB PDB [~~http~~://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/index.html Molecule of the Month] feature on ''Growth Hormone'' by Shuchismita Dutta and David S. Goodsell is [~~http~~://dx.doi.org/10.2210/rcsb_pdb/mom_2004_4 10.2210/rcsb_pdb/mom_2004_4]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1H02 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1H02 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1h02]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. The April 2004 RCSB PDB [https://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/index.html Molecule of the Month] feature on ''Growth Hormone'' by Shuchismita Dutta and David S. Goodsell is [https://dx.doi.org/10.2210/rcsb_pdb/mom_2004_4 10.2210/rcsb_pdb/mom_2004_4]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1H02 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1H02 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=C15:N-DODECYL-N,N-DIMETHYL-3-AMMONIO-1-PROPANESULFONATE'>C15</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=C15:N-DODECYL-N,N-DIMETHYL-3-AMMONIO-1-PROPANESULFONATE'>C15</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1gzr\|1gzr]], [[1gzy\|1gzy]], [[1gzz\|1gzz]], [[1h59\|1h59]], [[1imx\|1imx]], [[2gf1\|2gf1]], [[3gf1\|3gf1]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1gzr\|1gzr]], [[1gzy\|1gzy]], [[1gzz\|1gzz]], [[1h59\|1h59]], [[1imx\|1imx]], [[2gf1\|2gf1]], [[3gf1\|3gf1]]</div></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1h02 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1h02 OCA], [~~http~~://pdbe.org/1h02 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=1h02 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/1h02 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=1h02 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1h02 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1h02 OCA], [https://pdbe.org/1h02 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1h02 RCSB], [https://www.ebi.ac.uk/pdbsum/1h02 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1h02 ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
-	[[~~http~~://www.uniprot.org/uniprot/IGF1_HUMAN IGF1_HUMAN]] Defects in IGF1 are the cause of insulin-like growth factor I deficiency (IGF1 deficiency) [MIM:[~~http~~://omim.org/entry/608747 608747]]. IGF1 deficiency is an autosomal recessive disorder characterized by growth retardation, sensorineural deafness and mental retardation.	+	[[https://www.uniprot.org/uniprot/IGF1_HUMAN IGF1_HUMAN]] Defects in IGF1 are the cause of insulin-like growth factor I deficiency (IGF1 deficiency) [MIM:[https://omim.org/entry/608747 608747]]. IGF1 deficiency is an autosomal recessive disorder characterized by growth retardation, sensorineural deafness and mental retardation.
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/IGF1_HUMAN IGF1_HUMAN]] The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity. May be a physiological regulator of [1-14C]-2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblasts. Stimulates glucose transport in rat bone-derived osteoblastic (PyMS) cells and is effective at much lower concentrations than insulin, not only regarding glycogen and DNA synthesis but also with regard to enhancing glucose uptake.<ref>PMID:21076856</ref>	+	[[https://www.uniprot.org/uniprot/IGF1_HUMAN IGF1_HUMAN]] The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity. May be a physiological regulator of [1-14C]-2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblasts. Stimulates glucose transport in rat bone-derived osteoblastic (PyMS) cells and is effective at much lower concentrations than insulin, not only regarding glycogen and DNA synthesis but also with regard to enhancing glucose uptake.<ref>PMID:21076856</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]