1h7y - Revision history

OCA at 05:30, 15 May 2024

2024-05-15T05:30:53Z

←Older revision		Revision as of 05:30, 15 May 2024
Line 19:		Line 19:
	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1h7y ConSurf].		</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1h7y ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The translationally controlled tumor-associated proteins (TCTPs) are a highly conserved and abundantly expressed family of eukaryotic proteins that are implicated in both cell growth and the human acute allergic response but whose intracellular biochemical function has remained elusive. We report here the solution structure of the TCTP from Schizosaccharomyces pombe, which, on the basis of sequence homology, defines the fold of the entire family. We show that TCTPs form a structural superfamily with the Mss4/Dss4 family of proteins, which bind to the GDP/GTP free form of Rab proteins (members of the Ras superfamily) and have been termed guanine nucleotide-free chaperones (GFCs). Mss4 also acts as a relatively inefficient guanine nucleotide exchange factor (GEF). We further show that the Rab protein binding site on Mss4 coincides with the region of highest sequence conservation in the TCTP family. This is the first link to any other family of proteins that has been established for the TCTP family and suggests the presence of a GFC/GEF at extremely high abundance in eukaryotic cells.
		+
		+	Structure of TCTP reveals unexpected relationship with guanine nucleotide-free chaperones.,Thaw P, Baxter NJ, Hounslow AM, Price C, Waltho JP, Craven CJ Nat Struct Biol. 2001 Aug;8(8):701-4. PMID:11473261<ref>PMID:11473261</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 1h7y" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>

OCA at 11:29, 27 March 2024

2024-03-27T11:29:12Z

←Older revision		Revision as of 11:29, 27 March 2024
Line 1:		Line 1:

	==Translationally Controlled Tumor-associated Protein p23fyp from Schizosaccharomyces pombe==		==Translationally Controlled Tumor-associated Protein p23fyp from Schizosaccharomyces pombe==
-	<StructureSection load='1h7y' size='340' side='right'caption='[[1h7y~~]], [[NMR_Ensembles_of_Models \| 15 NMR models~~]]' scene=''>	+	<StructureSection load='1h7y' size='340' side='right'caption='[[1h7y]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1h7y]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Cbs_356 Cbs 356~~]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1H7Y OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1H7Y FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1h7y]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Schizosaccharomyces_pombe Schizosaccharomyces pombe]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1H7Y OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1H7Y FirstGlance]. <br>
-	</td></tr><tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"~~><div style~~=~~'overflow: auto; max-height: 3em;'>[[1h6q\|1h6q]]</div~~></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1h7y FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1h7y OCA], [https://pdbe.org/1h7y PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1h7y RCSB], [https://www.ebi.ac.uk/pdbsum/1h7y PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1h7y ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1h7y FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1h7y OCA], [https://pdbe.org/1h7y PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1h7y RCSB], [https://www.ebi.ac.uk/pdbsum/1h7y PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1h7y ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/TCTP_SCHPO TCTP_SCHPO]] Involved in calcium binding and microtubule stabilization (By similarity). May be a guanine nucleotide-free chaperone (GFC).	+	[https://www.uniprot.org/uniprot/TCTP_SCHPO TCTP_SCHPO] Involved in calcium binding and microtubule stabilization (By similarity). May be a guanine nucleotide-free chaperone (GFC).
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 19:		Line 19:
	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1h7y ConSurf].		</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1h7y ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
-	<div style="background-color:#fffaf0;">
-	== Publication Abstract from PubMed ==
-	The translationally controlled tumor-associated proteins (TCTPs) are a highly conserved and abundantly expressed family of eukaryotic proteins that are implicated in both cell growth and the human acute allergic response but whose intracellular biochemical function has remained elusive. We report here the solution structure of the TCTP from Schizosaccharomyces pombe, which, on the basis of sequence homology, defines the fold of the entire family. We show that TCTPs form a structural superfamily with the Mss4/Dss4 family of proteins, which bind to the GDP/GTP free form of Rab proteins (members of the Ras superfamily) and have been termed guanine nucleotide-free chaperones (GFCs). Mss4 also acts as a relatively inefficient guanine nucleotide exchange factor (GEF). We further show that the Rab protein binding site on Mss4 coincides with the region of highest sequence conservation in the TCTP family. This is the first link to any other family of proteins that has been established for the TCTP family and suggests the presence of a GFC/GEF at extremely high abundance in eukaryotic cells.
-
-	Structure of TCTP reveals unexpected relationship with guanine nucleotide-free chaperones.,Thaw P, Baxter NJ, Hounslow AM, Price C, Waltho JP, Craven CJ Nat Struct Biol. 2001 Aug;8(8):701-4. PMID:11473261<ref>PMID:11473261</ref>
-
-	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	</div>
-	<div class="pdbe-citations 1h7y" style="background-color:#fffaf0;"></div>
-	== References ==
-	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Cbs 356]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Baxter~~, N J~~]]	+	[[Category: Schizosaccharomyces pombe]]
-	[[Category: Craven~~, C J~~]]	+	[[Category: Baxter NJ]]
-	[[Category: Price, C]]	+	[[Category: Craven CJ]]
-	[[Category: Sedelnikova~~, S E~~]]	+	[[Category: Price C]]
-	[[Category: Thaw, P]]	+	[[Category: Sedelnikova SE]]
-	[[Category: Waltho~~, J P]]~~	+	[[Category: Thaw P]]
-	~~[[Category: Function unknown]]~~	+	[[Category: Waltho JP]]
-	~~[[Category: Tumor-associated protein~~]]	+

OCA at 10:46, 4 August 2021

2021-08-04T10:46:56Z

←Older revision		Revision as of 10:46, 4 August 2021
Line 3:		Line 3:
	<StructureSection load='1h7y' size='340' side='right'caption='[[1h7y]], [[NMR_Ensembles_of_Models \| 15 NMR models]]' scene=''>		<StructureSection load='1h7y' size='340' side='right'caption='[[1h7y]], [[NMR_Ensembles_of_Models \| 15 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1h7y]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Cbs_356 Cbs 356]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1H7Y OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1H7Y FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1h7y]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Cbs_356 Cbs 356]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1H7Y OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1H7Y FirstGlance]. <br>
-	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1h6q\|1h6q]]</td></tr>	+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1h6q\|1h6q]]</div></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1h7y FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1h7y OCA], [~~http~~://pdbe.org/1h7y PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=1h7y RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/1h7y PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=1h7y ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1h7y FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1h7y OCA], [https://pdbe.org/1h7y PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1h7y RCSB], [https://www.ebi.ac.uk/pdbsum/1h7y PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1h7y ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/TCTP_SCHPO TCTP_SCHPO]] Involved in calcium binding and microtubule stabilization (By similarity). May be a guanine nucleotide-free chaperone (GFC).	+	[[https://www.uniprot.org/uniprot/TCTP_SCHPO TCTP_SCHPO]] Involved in calcium binding and microtubule stabilization (By similarity). May be a guanine nucleotide-free chaperone (GFC).
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]

OCA at 10:19, 30 October 2019

2019-10-30T10:19:42Z

←Older revision		Revision as of 10:19, 30 October 2019
Line 1:		Line 1:

	==Translationally Controlled Tumor-associated Protein p23fyp from Schizosaccharomyces pombe==		==Translationally Controlled Tumor-associated Protein p23fyp from Schizosaccharomyces pombe==
-	<StructureSection load='1h7y' size='340' side='right' caption='[[1h7y]], [[NMR_Ensembles_of_Models \| 15 NMR models]]' scene=''>	+	<StructureSection load='1h7y' size='340' side='right'caption='[[1h7y]], [[NMR_Ensembles_of_Models \| 15 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1h7y]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Cbs_356 Cbs 356]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1H7Y OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1H7Y FirstGlance]. <br>		<table><tr><td colspan='2'>[[1h7y]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Cbs_356 Cbs 356]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1H7Y OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1H7Y FirstGlance]. <br>
Line 33:		Line 33:
	</StructureSection>		</StructureSection>
	[[Category: Cbs 356]]		[[Category: Cbs 356]]
		+	[[Category: Large Structures]]
	[[Category: Baxter, N J]]		[[Category: Baxter, N J]]
	[[Category: Craven, C J]]		[[Category: Craven, C J]]

OCA at 09:21, 10 January 2018

2018-01-10T09:21:14Z

←Older revision		Revision as of 09:21, 10 January 2018
Line 1:		Line 1:
-	==~~TRANSLATIONALLY CONTROLLED TUMOR~~-~~ASSOCIATED PROTEIN P23FYP FROM SCHIZOSACCHAROMYCES POMBE~~==	+
		+	==Translationally Controlled Tumor-associated Protein p23fyp from Schizosaccharomyces pombe==
	<StructureSection load='1h7y' size='340' side='right' caption='[[1h7y]], [[NMR_Ensembles_of_Models \| 15 NMR models]]' scene=''>		<StructureSection load='1h7y' size='340' side='right' caption='[[1h7y]], [[NMR_Ensembles_of_Models \| 15 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1h7y]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Cbs_356 Cbs 356]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1H7Y OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1H7Y FirstGlance]. <br>		<table><tr><td colspan='2'>[[1h7y]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Cbs_356 Cbs 356]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1H7Y OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1H7Y FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1h6q\|1h6q]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1h6q\|1h6q]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1h7y FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1h7y OCA], [http://pdbe.org/1h7y PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1h7y RCSB], [http://www.ebi.ac.uk/pdbsum/1h7y PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1h7y FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1h7y OCA], [http://pdbe.org/1h7y PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1h7y RCSB], [http://www.ebi.ac.uk/pdbsum/1h7y PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1h7y ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 12:		Line 13:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/h7/1h7y_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/h7/1h7y_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>

OCA at 22:09, 8 February 2016

2016-02-08T22:09:11Z

←Older revision		Revision as of 22:09, 8 February 2016
Line 16:		Line 16:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1h7y ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 15:49, 10 September 2015

2015-09-10T15:49:41Z

←Older revision		Revision as of 15:49, 10 September 2015
Line 2:		Line 2:
	<StructureSection load='1h7y' size='340' side='right' caption='[[1h7y]], [[NMR_Ensembles_of_Models \| 15 NMR models]]' scene=''>		<StructureSection load='1h7y' size='340' side='right' caption='[[1h7y]], [[NMR_Ensembles_of_Models \| 15 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1h7y]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Schizosaccharomyces_pombe Schizosaccharomyces pombe~~]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1H7Y OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1H7Y FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1h7y]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Cbs_356 Cbs 356]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1H7Y OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1H7Y FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1h6q\|1h6q]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1h6q\|1h6q]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1h7y FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1h7y OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1h7y RCSB], [http://www.ebi.ac.uk/pdbsum/1h7y PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1h7y FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1h7y OCA], [http://pdbe.org/1h7y PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1h7y RCSB], [http://www.ebi.ac.uk/pdbsum/1h7y PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 26:		Line 26:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 1h7y" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Schizosaccharomyces pombe~~]]	+	[[Category: Cbs 356]]
	[[Category: Baxter, N J]]		[[Category: Baxter, N J]]
	[[Category: Craven, C J]]		[[Category: Craven, C J]]

OCA at 02:27, 25 December 2014

2014-12-25T02:27:54Z

←Older revision		Revision as of 02:27, 25 December 2014
Line 6:		Line 6:
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1h7y FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1h7y OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1h7y RCSB], [http://www.ebi.ac.uk/pdbsum/1h7y PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1h7y FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1h7y OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1h7y RCSB], [http://www.ebi.ac.uk/pdbsum/1h7y PDBsum]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/TCTP_SCHPO TCTP_SCHPO]] Involved in calcium binding and microtubule stabilization (By similarity). May be a guanine nucleotide-free chaperone (GFC).
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]

OCA at 00:33, 23 December 2014

2014-12-23T00:33:13Z

←Older revision		Revision as of 00:33, 23 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1h7y]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Schizosaccharomyces_pombe Schizosaccharomyces pombe]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1H7Y OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1H7Y FirstGlance]. <br>		<table><tr><td colspan='2'>[[1h7y]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Schizosaccharomyces_pombe Schizosaccharomyces pombe]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1H7Y OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1H7Y FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1h6q\|1h6q]]</td></tr>	+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1h6q\|1h6q]]</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1h7y FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1h7y OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1h7y RCSB], [http://www.ebi.ac.uk/pdbsum/1h7y PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1h7y FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1h7y OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1h7y RCSB], [http://www.ebi.ac.uk/pdbsum/1h7y PDBsum]</span></td></tr>
-	<table>	+	</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 29:		Line 29:
	</StructureSection>		</StructureSection>
	[[Category: Schizosaccharomyces pombe]]		[[Category: Schizosaccharomyces pombe]]
-	[[Category: Baxter, N J.]]	+	[[Category: Baxter, N J]]
-	[[Category: Craven, C J.]]	+	[[Category: Craven, C J]]
-	[[Category: Price, C.]]	+	[[Category: Price, C]]
-	[[Category: Sedelnikova, S E.]]	+	[[Category: Sedelnikova, S E]]
-	[[Category: Thaw, P.]]	+	[[Category: Thaw, P]]
-	[[Category: Waltho, J P.]]	+	[[Category: Waltho, J P]]
	[[Category: Function unknown]]		[[Category: Function unknown]]
	[[Category: Tumor-associated protein]]		[[Category: Tumor-associated protein]]

OCA at 14:23, 28 September 2014

2014-09-28T14:23:00Z

←Older revision		Revision as of 14:23, 28 September 2014
Line 1:		Line 1:
-	[[~~Image:~~1h7y.~~png~~\|~~left~~\|200px]]	+	==TRANSLATIONALLY CONTROLLED TUMOR-ASSOCIATED PROTEIN P23FYP FROM SCHIZOSACCHAROMYCES POMBE==
		+	<StructureSection load='1h7y' size='340' side='right' caption='[[1h7y]], [[NMR_Ensembles_of_Models \| 15 NMR models]]' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[1h7y]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Schizosaccharomyces_pombe Schizosaccharomyces pombe]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1H7Y OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1H7Y FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1h6q\|1h6q]]</td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1h7y FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1h7y OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1h7y RCSB], [http://www.ebi.ac.uk/pdbsum/1h7y PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/h7/1h7y_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The translationally controlled tumor-associated proteins (TCTPs) are a highly conserved and abundantly expressed family of eukaryotic proteins that are implicated in both cell growth and the human acute allergic response but whose intracellular biochemical function has remained elusive. We report here the solution structure of the TCTP from Schizosaccharomyces pombe, which, on the basis of sequence homology, defines the fold of the entire family. We show that TCTPs form a structural superfamily with the Mss4/Dss4 family of proteins, which bind to the GDP/GTP free form of Rab proteins (members of the Ras superfamily) and have been termed guanine nucleotide-free chaperones (GFCs). Mss4 also acts as a relatively inefficient guanine nucleotide exchange factor (GEF). We further show that the Rab protein binding site on Mss4 coincides with the region of highest sequence conservation in the TCTP family. This is the first link to any other family of proteins that has been established for the TCTP family and suggests the presence of a GFC/GEF at extremely high abundance in eukaryotic cells.

-	~~{{STRUCTURE_1h7y\| PDB=1h7y \| SCENE= }}~~	+	Structure of TCTP reveals unexpected relationship with guanine nucleotide-free chaperones.,Thaw P, Baxter NJ, Hounslow AM, Price C, Waltho JP, Craven CJ Nat Struct Biol. 2001 Aug;8(8):701-4. PMID:11473261<ref>PMID:11473261</ref>

-	~~===TRANSLATIONALLY CONTROLLED TUMOR-ASSOCIATED PROTEIN P23FYP FROM SCHIZOSACCHAROMYCES POMBE===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_11473261}}~~	+	== References ==
-		+	<references/>
-	~~==About this Structure==~~	+	__TOC__
-	~~[[1h7y]] is~~ a ~~1 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Schizosaccharomyces_pombe Schizosaccharomyces pombe]~~. ~~Full experimental information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=1H7Y OCA].~~	+	</StructureSection>
-		+
-	==~~Reference~~==	+
-	<~~ref group="xtra">PMID:011473261<~~/~~ref~~><~~references group="xtra"~~/>	+
	[[Category: Schizosaccharomyces pombe]]		[[Category: Schizosaccharomyces pombe]]
	[[Category: Baxter, N J.]]		[[Category: Baxter, N J.]]