1h9w - Revision history

OCA at 12:22, 13 December 2023

2023-12-13T12:22:09Z

←Older revision		Revision as of 12:22, 13 December 2023
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	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1h9w]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Dioclea_guianensis Dioclea guianensis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1H9W OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1H9W FirstGlance]. <br>		<table><tr><td colspan='2'>[[1h9w]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Dioclea_guianensis Dioclea guianensis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1H9W OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1H9W FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>~~, ~~<scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2Å</td></tr>
-	<tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"><~~div style~~='~~overflow~~: ~~auto; max-height~~: ~~3em;~~'>~~[[1h9p\|1h9p]]~~</~~div~~></td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1h9w FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1h9w OCA], [https://pdbe.org/1h9w PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1h9w RCSB], [https://www.ebi.ac.uk/pdbsum/1h9w PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1h9w ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1h9w FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1h9w OCA], [https://pdbe.org/1h9w PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1h9w RCSB], [https://www.ebi.ac.uk/pdbsum/1h9w PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1h9w ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/LECA_DIOGU LECA_DIOGU]] D-mannose/D-glucose-binding lectin. Has anti-inflammatory activity in rats. Induces histamine release in mast cells from rat. Induces lymphocyte proliferation and IFNG production.<ref>PMID:1398779</ref> <ref>PMID:7524287</ref> <ref>PMID:18472821</ref> <ref>PMID:9575151</ref> <ref>PMID:10747944</ref>	+	[https://www.uniprot.org/uniprot/LECA_DIOGU LECA_DIOGU] D-mannose/D-glucose-binding lectin. Has anti-inflammatory activity in rats. Induces histamine release in mast cells from rat. Induces lymphocyte proliferation and IFNG production.<ref>PMID:1398779</ref> <ref>PMID:7524287</ref> <ref>PMID:18472821</ref> <ref>PMID:9575151</ref> <ref>PMID:10747944</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 35:		Line 35:
	[[Category: Dioclea guianensis]]		[[Category: Dioclea guianensis]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Calvete~~, J J~~]]	+	[[Category: Calvete JJ]]
-	[[Category: Cavada~~, B S~~]]	+	[[Category: Cavada BS]]
-	[[Category: Grangeiro~~, T B~~]]	+	[[Category: Grangeiro TB]]
-	[[Category: Ramos~~, M V~~]]	+	[[Category: Ramos MV]]
-	[[Category: Romero, A]]	+	[[Category: Romero A]]
-	[[Category: Sampaio~~, A H~~]]	+	[[Category: Sampaio AH]]
-	[[Category: Sol~~, F G.D~~]]	+	[[Category: Sol FGD]]
-	[[Category: Wah~~, D A]]~~	+	[[Category: Wah DA]]
-	~~[[Category: Lectin]]~~	+
-	~~[[Category: Legume lectin oligomerisation~~]]	+

OCA at 10:25, 17 February 2021

2021-02-17T10:25:45Z

←Older revision		Revision as of 10:25, 17 February 2021
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	<StructureSection load='1h9w' size='340' side='right'caption='[[1h9w]], [[Resolution\|resolution]] 2.00Å' scene=''>		<StructureSection load='1h9w' size='340' side='right'caption='[[1h9w]], [[Resolution\|resolution]] 2.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1h9w]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Dioclea_guianensis Dioclea guianensis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1H9W OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1H9W FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1h9w]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Dioclea_guianensis Dioclea guianensis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1H9W OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1H9W FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1h9p\|1h9p]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1h9p\|1h9p]]</div></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1h9w FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1h9w OCA], [~~http~~://pdbe.org/1h9w PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=1h9w RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/1h9w PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=1h9w ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1h9w FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1h9w OCA], [https://pdbe.org/1h9w PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1h9w RCSB], [https://www.ebi.ac.uk/pdbsum/1h9w PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1h9w ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/LECA_DIOGU LECA_DIOGU]] D-mannose/D-glucose-binding lectin. Has anti-inflammatory activity in rats. Induces histamine release in mast cells from rat. Induces lymphocyte proliferation and IFNG production.<ref>PMID:1398779</ref> <ref>PMID:7524287</ref> <ref>PMID:18472821</ref> <ref>PMID:9575151</ref> <ref>PMID:10747944</ref>	+	[[https://www.uniprot.org/uniprot/LECA_DIOGU LECA_DIOGU]] D-mannose/D-glucose-binding lectin. Has anti-inflammatory activity in rats. Induces histamine release in mast cells from rat. Induces lymphocyte proliferation and IFNG production.<ref>PMID:1398779</ref> <ref>PMID:7524287</ref> <ref>PMID:18472821</ref> <ref>PMID:9575151</ref> <ref>PMID:10747944</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]

OCA at 11:37, 10 May 2019

2019-05-10T11:37:30Z

←Older revision		Revision as of 11:37, 10 May 2019
Line 1:		Line 1:

	==Native Dioclea Guianensis seed lectin==		==Native Dioclea Guianensis seed lectin==
-	<StructureSection load='1h9w' size='340' side='right' caption='[[1h9w]], [[Resolution\|resolution]] 2.00Å' scene=''>	+	<StructureSection load='1h9w' size='340' side='right'caption='[[1h9w]], [[Resolution\|resolution]] 2.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1h9w]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Dioclea_guianensis Dioclea guianensis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1H9W OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1H9W FirstGlance]. <br>		<table><tr><td colspan='2'>[[1h9w]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Dioclea_guianensis Dioclea guianensis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1H9W OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1H9W FirstGlance]. <br>
Line 34:		Line 34:
	</StructureSection>		</StructureSection>
	[[Category: Dioclea guianensis]]		[[Category: Dioclea guianensis]]
		+	[[Category: Large Structures]]
	[[Category: Calvete, J J]]		[[Category: Calvete, J J]]
	[[Category: Cavada, B S]]		[[Category: Cavada, B S]]

OCA at 08:51, 10 January 2018

2018-01-10T08:51:49Z

←Older revision		Revision as of 08:51, 10 January 2018
Line 1:		Line 1:
-	==~~NATIVE DIOCLEA GUIANENSIS SEED LECTIN~~==	+
		+	==Native Dioclea Guianensis seed lectin==
	<StructureSection load='1h9w' size='340' side='right' caption='[[1h9w]], [[Resolution\|resolution]] 2.00Å' scene=''>		<StructureSection load='1h9w' size='340' side='right' caption='[[1h9w]], [[Resolution\|resolution]] 2.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
Line 5:		Line 6:
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1h9p\|1h9p]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1h9p\|1h9p]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1h9w FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1h9w OCA], [http://pdbe.org/1h9w PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1h9w RCSB], [http://www.ebi.ac.uk/pdbsum/1h9w PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1h9w FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1h9w OCA], [http://pdbe.org/1h9w PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1h9w RCSB], [http://www.ebi.ac.uk/pdbsum/1h9w PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1h9w ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 13:		Line 14:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/h9/1h9w_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/h9/1h9w_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>

OCA at 07:09, 9 February 2016

2016-02-09T07:09:22Z

←Older revision		Revision as of 07:09, 9 February 2016
Line 17:		Line 17:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1h9w ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 19:49, 10 September 2015

2015-09-10T19:49:35Z

←Older revision		Revision as of 19:49, 10 September 2015
Line 5:		Line 5:
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1h9p\|1h9p]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1h9p\|1h9p]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1h9w FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1h9w OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1h9w RCSB], [http://www.ebi.ac.uk/pdbsum/1h9w PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1h9w FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1h9w OCA], [http://pdbe.org/1h9w PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1h9w RCSB], [http://www.ebi.ac.uk/pdbsum/1h9w PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 27:		Line 27:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 1h9w" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>

OCA at 05:15, 25 December 2014

2014-12-25T05:15:11Z

←Older revision		Revision as of 05:15, 25 December 2014
Line 7:		Line 7:
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1h9w FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1h9w OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1h9w RCSB], [http://www.ebi.ac.uk/pdbsum/1h9w PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1h9w FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1h9w OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1h9w RCSB], [http://www.ebi.ac.uk/pdbsum/1h9w PDBsum]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/LECA_DIOGU LECA_DIOGU]] D-mannose/D-glucose-binding lectin. Has anti-inflammatory activity in rats. Induces histamine release in mast cells from rat. Induces lymphocyte proliferation and IFNG production.<ref>PMID:1398779</ref> <ref>PMID:7524287</ref> <ref>PMID:18472821</ref> <ref>PMID:9575151</ref> <ref>PMID:10747944</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]

OCA at 22:33, 22 December 2014

2014-12-22T22:33:51Z

←Older revision		Revision as of 22:33, 22 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1h9w]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Dioclea_guianensis Dioclea guianensis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1H9W OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1H9W FirstGlance]. <br>		<table><tr><td colspan='2'>[[1h9w]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Dioclea_guianensis Dioclea guianensis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1H9W OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1H9W FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1h9p\|1h9p]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1h9p\|1h9p]]</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1h9w FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1h9w OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1h9w RCSB], [http://www.ebi.ac.uk/pdbsum/1h9w PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1h9w FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1h9w OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1h9w RCSB], [http://www.ebi.ac.uk/pdbsum/1h9w PDBsum]</span></td></tr>
-	<table>	+	</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 30:		Line 30:
	</StructureSection>		</StructureSection>
	[[Category: Dioclea guianensis]]		[[Category: Dioclea guianensis]]
-	[[Category: Calvete, J J.]]	+	[[Category: Calvete, J J]]
-	[[Category: Cavada, B S.]]	+	[[Category: Cavada, B S]]
-	[[Category: Grangeiro, T B.]]	+	[[Category: Grangeiro, T B]]
-	[[Category: Ramos, M V.]]	+	[[Category: Ramos, M V]]
-	[[Category: Romero, A.]]	+	[[Category: Romero, A]]
-	[[Category: Sampaio, A H.]]	+	[[Category: Sampaio, A H]]
-	[[Category: Sol, F G.D.]]	+	[[Category: Sol, F G.D]]
-	[[Category: Wah, D A.]]	+	[[Category: Wah, D A]]
	[[Category: Lectin]]		[[Category: Lectin]]
	[[Category: Legume lectin oligomerisation]]		[[Category: Legume lectin oligomerisation]]

OCA at 16:16, 29 September 2014

2014-09-29T16:16:41Z

←Older revision		Revision as of 16:16, 29 September 2014
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-	[[~~Image:~~1h9w.~~png~~\|~~left~~\|200px]]	+	==NATIVE DIOCLEA GUIANENSIS SEED LECTIN==
		+	<StructureSection load='1h9w' size='340' side='right' caption='[[1h9w]], [[Resolution\|resolution]] 2.00Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[1h9w]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Dioclea_guianensis Dioclea guianensis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1H9W OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1H9W FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene><br>
		+	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1h9p\|1h9p]]</td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1h9w FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1h9w OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1h9w RCSB], [http://www.ebi.ac.uk/pdbsum/1h9w PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/h9/1h9w_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Diocleinae legume lectins are a group of oligomeric proteins whose subunits display a high degree of primary structure and tertiary fold conservation but exhibit considerable diversity in their oligomerisation modes. To elucidate the structural determinants underlaying Diocleinae lectin oligomerisation, we have determined the crystal structures of native and cadmium-substituted Dioclea guianensis (Dguia) seed lectin. These structures have been solved by molecular replacement using concanavalin (ConA) coordinates as the starting model, and refined against data to 2.0 A resolution. In the native (Mn/Ca-Dguia) crystal form (P4(3)2(1)2), the asymmetric unit contains two monomers arranged into a canonical legume lectin dimer, and the tetramer is formed with a symmetry-related dimer. In the Cd/Cd-substituted form (I4(1)22), the asymmetric unit is occupied by a monomer. In both crystal forms, the tetrameric association is achieved by the corresponding symmetry operators. Like other legume lectins, native D. guianensis lectin contains manganese and calcium ions bound in the vicinity of the saccharide-combining site. The architecture of these metal-binding sites (S1 and S2) changed only slightly in the cadmium/cadmium-substituted form. A highly ordered calcium (native lectin) or cadmium (Cd/Cd-substituted lectin) ion is coordinated at the interface between dimers that are not tetrameric partners in a similar manner as the previously identified Cd(2+) in site S3 of a Cd/Ca-ConA. An additional Mn(2+) coordination site (called S5), whose presence has not been reported in crystal structures of any other homologous lectin, is present in both, the Mn/Ca and the Cd/Cd-substituted D. guianensis lectin forms. On the other hand, comparison of the primary and quaternary crystal structures of seed lectins from D. guianensis and Dioclea grandiflora (1DGL) indicates that the loop comprising residues 117-123 is ordered to make interdimer contacts in the D. grandiflora lectin structure, while this loop is disordered in the D. guianensis lectin structure. A single amino acid difference at position 131 (histidine in D. grandiflora and asparagine in D. guianensis) drastically reduces interdimer contacts, accounting for the disordered loop. Further, this amino acid change yields a conformation that may explain why a pH-dependent dimer-tetramer equilibrium exists for the D. guianensis lectin but not for the D. grandiflora lectin.

-	~~{{STRUCTURE_1h9w\| PDB=1h9w \| SCENE= }}~~	+	Crystal structure of native and Cd/Cd-substituted Dioclea guianensis seed lectin. A novel manganese-binding site and structural basis of dimer-tetramer association.,Wah DA, Romero A, Gallego del Sol F, Cavada BS, Ramos MV, Grangeiro TB, Sampaio AH, Calvete JJ J Mol Biol. 2001 Jul 20;310(4):885-94. PMID:11453695<ref>PMID:11453695</ref>

-	~~===NATIVE DIOCLEA GUIANENSIS SEED LECTIN===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_11453695}}~~	+	== References ==
-		+	<references/>
-	~~==About this Structure==~~	+	__TOC__
-	~~[[1h9w]] is~~ a ~~2 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Dioclea_guianensis Dioclea guianensis]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=1H9W OCA].~~	+	</StructureSection>
-		+
-	==~~Reference~~==	+
-	<~~ref group="xtra">PMID:011453695<~~/~~ref~~><~~ref group="xtra">PMID:010082964</ref><references group="xtra"~~/>	+
	[[Category: Dioclea guianensis]]		[[Category: Dioclea guianensis]]
	[[Category: Calvete, J J.]]		[[Category: Calvete, J J.]]

OCA at 09:25, 16 January 2013

2013-01-16T09:25:30Z

←Older revision		Revision as of 09:25, 16 January 2013
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	[[Image:1h9w.png\|left\|200px]]		[[Image:1h9w.png\|left\|200px]]

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	===NATIVE DIOCLEA GUIANENSIS SEED LECTIN===		===NATIVE DIOCLEA GUIANENSIS SEED LECTIN===

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	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~11453695~~</ref><ref group="xtra">PMID:~~10082964~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:011453695</ref><ref group="xtra">PMID:010082964</ref><references group="xtra"/>
	[[Category: Dioclea guianensis]]		[[Category: Dioclea guianensis]]
	[[Category: Calvete, J J.]]		[[Category: Calvete, J J.]]