1he5 - Revision history

OCA at 12:24, 13 December 2023

2023-12-13T12:24:18Z

←Older revision		Revision as of 12:24, 13 December 2023
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	<StructureSection load='1he5' size='340' side='right'caption='[[1he5]], [[Resolution\|resolution]] 1.50Å' scene=''>		<StructureSection load='1he5' size='340' side='right'caption='[[1he5]], [[Resolution\|resolution]] 1.50Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1he5]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1HE5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1HE5 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1he5]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1HE5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1HE5 FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=LUM:LUMICHROME'>LUM</scene>~~, ~~<scene name='pdbligand=NAP:NADP+NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NAP</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.5Å</td></tr>
-	<tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"><~~div style~~='~~overflow~~: ~~auto; max-height: 3em;~~'>~~[[1hdo\|1hdo]], [[1he2\|1he2]], [[1he3\|1he3]], [[1he4\|1he4]]~~</~~div~~><~~/td></tr>~~	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=LUM:LUMICHROME'>LUM</scene>, <scene name='pdbligand=NAP:NADP+NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NAP</scene></td></tr>
-	~~<tr id~~='~~activity'><td class~~=~~"sblockLbl"><b>Activity~~:~~</b></td><td class="sblockDat"><span class='plainlinks~~'>~~[https://en.wikipedia.org/wiki/Biliverdin_reductase Biliverdin reductase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.3.1.24 1.3.1.24]~~ </~~span~~></td></tr>	+
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1he5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1he5 OCA], [https://pdbe.org/1he5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1he5 RCSB], [https://www.ebi.ac.uk/pdbsum/1he5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1he5 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1he5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1he5 OCA], [https://pdbe.org/1he5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1he5 RCSB], [https://www.ebi.ac.uk/pdbsum/1he5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1he5 ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/BLVRB_HUMAN BLVRB_HUMAN] Broad specificity oxidoreductase that catalyzes the NADPH-dependent reduction of a variety of flavins, such as riboflavin, FAD or FMN, biliverdins, methemoglobin and PQQ (pyrroloquinoline quinone). Contributes to heme catabolism and metabolizes linear tetrapyrroles. Can also reduce the complexed Fe(3+) iron to Fe(2+) in the presence of FMN and NADPH. In the liver, converts biliverdin to bilirubin.<ref>PMID:10620517</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 35:		Line 36:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Biliverdin reductase]]~~	+	[[Category: Homo sapiens]]
-	~~[[Category: Human~~]]	+
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Coll, M]]	+	[[Category: Coll M]]
-	[[Category: Cunningham, O]]	+	[[Category: Cunningham O]]
-	[[Category: Darcy, K]]	+	[[Category: Darcy K]]
-	[[Category: Macedo-Ribeiro, S]]	+	[[Category: Macedo-Ribeiro S]]
-	[[Category: Mantle~~, T J~~]]	+	[[Category: Mantle TJ]]
-	[[Category: Parraga, A]]	+	[[Category: Parraga A]]
-	[[Category: Pereira~~, P J.B~~]]	+	[[Category: Pereira PJB]]
-	[[Category: Perez-Luque, R]]	+	[[Category: Perez-Luque R]]
-	~~[[Category: Alpha/beta dinucleotide binding fold]]~~	+
-	~~[[Category: Biliverdin-ix beta reductase]]~~	+
-	~~[[Category: Diaphorase]]~~	+
-	~~[[Category: Flavin reductase]]~~	+
-	~~[[Category: Foetal metabolism]]~~	+
-	~~[[Category: Green haem binding protein]]~~	+
-	~~[[Category: Haem degradation]]~~	+
-	~~[[Category: Methaemoglobin reductase~~]]	+

OCA at 07:06, 24 February 2021

2021-02-24T07:06:02Z

←Older revision		Revision as of 07:06, 24 February 2021
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	<StructureSection load='1he5' size='340' side='right'caption='[[1he5]], [[Resolution\|resolution]] 1.50Å' scene=''>		<StructureSection load='1he5' size='340' side='right'caption='[[1he5]], [[Resolution\|resolution]] 1.50Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1he5]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1HE5 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1HE5 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1he5]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1HE5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1HE5 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=LUM:LUMICHROME'>LUM</scene>, <scene name='pdbligand=NAP:NADP+NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NAP</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=LUM:LUMICHROME'>LUM</scene>, <scene name='pdbligand=NAP:NADP+NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NAP</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1hdo\|1hdo]], [[1he2\|1he2]], [[1he3\|1he3]], [[1he4\|1he4]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1hdo\|1hdo]], [[1he2\|1he2]], [[1he3\|1he3]], [[1he4\|1he4]]</div></td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://en.wikipedia.org/wiki/Biliverdin_reductase Biliverdin reductase], with EC number [~~http~~://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.3.1.24 1.3.1.24] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Biliverdin_reductase Biliverdin reductase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.3.1.24 1.3.1.24] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1he5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1he5 OCA], [~~http~~://pdbe.org/1he5 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=1he5 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/1he5 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=1he5 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1he5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1he5 OCA], [https://pdbe.org/1he5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1he5 RCSB], [https://www.ebi.ac.uk/pdbsum/1he5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1he5 ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==

OCA at 07:04, 23 May 2019

2019-05-23T07:04:22Z

←Older revision		Revision as of 07:04, 23 May 2019
Line 1:		Line 1:

	==Human biliverdin IX beta reductase: NADP/Lumichrome ternary complex==		==Human biliverdin IX beta reductase: NADP/Lumichrome ternary complex==
-	<StructureSection load='1he5' size='340' side='right' caption='[[1he5]], [[Resolution\|resolution]] 1.50Å' scene=''>	+	<StructureSection load='1he5' size='340' side='right'caption='[[1he5]], [[Resolution\|resolution]] 1.50Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1he5]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1HE5 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1HE5 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1he5]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1HE5 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1HE5 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=LUM:LUMICHROME'>LUM</scene>, <scene name='pdbligand=NAP:NADP+NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NAP</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=LUM:LUMICHROME'>LUM</scene>, <scene name='pdbligand=NAP:NADP+NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NAP</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1hdo\|1hdo]], [[1he2\|1he2]], [[1he3\|1he3]], [[1he4\|1he4]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1hdo\|1hdo]], [[1he2\|1he2]], [[1he3\|1he3]], [[1he4\|1he4]]</td></tr>
Line 13:		Line 13:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/he/1he5_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/he/1he5_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
Line 36:		Line 36:
	</StructureSection>		</StructureSection>
	[[Category: Biliverdin reductase]]		[[Category: Biliverdin reductase]]
		+	[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Coll, M]]		[[Category: Coll, M]]
	[[Category: Cunningham, O]]		[[Category: Cunningham, O]]

OCA at 04:30, 21 September 2017

2017-09-21T04:30:39Z

←Older revision		Revision as of 04:30, 21 September 2017
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-	==~~HUMAN BILIVERDIN~~ IX ~~BETA REDUCTASE~~: NADP/~~LUMICHROME TERNARY COMPLEX~~==	+
		+	==Human biliverdin IX beta reductase: NADP/Lumichrome ternary complex==
	<StructureSection load='1he5' size='340' side='right' caption='[[1he5]], [[Resolution\|resolution]] 1.50Å' scene=''>		<StructureSection load='1he5' size='340' side='right' caption='[[1he5]], [[Resolution\|resolution]] 1.50Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1he5]] is a 1 chain structure ~~with sequence from [http://en.wikipedia.org/wiki/Human Human]~~. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1HE5 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1HE5 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1he5]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1HE5 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1HE5 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=LUM:LUMICHROME'>LUM</scene>, <scene name='pdbligand=NAP:NADP+NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NAP</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=LUM:LUMICHROME'>LUM</scene>, <scene name='pdbligand=NAP:NADP+NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NAP</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1hdo\|1hdo]], [[1he2\|1he2]], [[1he3\|1he3]], [[1he4\|1he4]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1hdo\|1hdo]], [[1he2\|1he2]], [[1he3\|1he3]], [[1he4\|1he4]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Biliverdin_reductase Biliverdin reductase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.3.1.24 1.3.1.24] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Biliverdin_reductase Biliverdin reductase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.3.1.24 1.3.1.24] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1he5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1he5 OCA], [http://pdbe.org/1he5 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1he5 RCSB], [http://www.ebi.ac.uk/pdbsum/1he5 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1he5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1he5 OCA], [http://pdbe.org/1he5 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1he5 RCSB], [http://www.ebi.ac.uk/pdbsum/1he5 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1he5 ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 16:		Line 17:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1he5 ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 35:		Line 36:
	</StructureSection>		</StructureSection>
	[[Category: Biliverdin reductase]]		[[Category: Biliverdin reductase]]
-	[[Category: Human]]
	[[Category: Coll, M]]		[[Category: Coll, M]]
	[[Category: Cunningham, O]]		[[Category: Cunningham, O]]

OCA at 23:59, 11 September 2015

2015-09-11T23:59:25Z

←Older revision		Revision as of 23:59, 11 September 2015
Line 2:		Line 2:
	<StructureSection load='1he5' size='340' side='right' caption='[[1he5]], [[Resolution\|resolution]] 1.50Å' scene=''>		<StructureSection load='1he5' size='340' side='right' caption='[[1he5]], [[Resolution\|resolution]] 1.50Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1he5]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1HE5 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1HE5 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1he5]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1HE5 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1HE5 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=LUM:LUMICHROME'>LUM</scene>, <scene name='pdbligand=NAP:NADP+NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NAP</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=LUM:LUMICHROME'>LUM</scene>, <scene name='pdbligand=NAP:NADP+NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NAP</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1hdo\|1hdo]], [[1he2\|1he2]], [[1he3\|1he3]], [[1he4\|1he4]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1hdo\|1hdo]], [[1he2\|1he2]], [[1he3\|1he3]], [[1he4\|1he4]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Biliverdin_reductase Biliverdin reductase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.3.1.24 1.3.1.24] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Biliverdin_reductase Biliverdin reductase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.3.1.24 1.3.1.24] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1he5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1he5 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1he5 RCSB], [http://www.ebi.ac.uk/pdbsum/1he5 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1he5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1he5 OCA], [http://pdbe.org/1he5 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1he5 RCSB], [http://www.ebi.ac.uk/pdbsum/1he5 PDBsum]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 26:		Line 26:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 1he5" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 34:		Line 35:
	</StructureSection>		</StructureSection>
	[[Category: Biliverdin reductase]]		[[Category: Biliverdin reductase]]
-	[[Category: ~~Homo sapiens~~]]	+	[[Category: Human]]
	[[Category: Coll, M]]		[[Category: Coll, M]]
	[[Category: Cunningham, O]]		[[Category: Cunningham, O]]

OCA at 22:09, 22 December 2014

2014-12-22T22:09:24Z

←Older revision		Revision as of 22:09, 22 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1he5]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1HE5 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1HE5 FirstGlance]. <br>		<table><tr><td colspan='2'>[[1he5]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1HE5 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1HE5 FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=LUM:LUMICHROME'>LUM</scene>, <scene name='pdbligand=NAP:NADP+NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NAP</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=LUM:LUMICHROME'>LUM</scene>, <scene name='pdbligand=NAP:NADP+NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NAP</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1hdo\|1hdo]], [[1he2\|1he2]], [[1he3\|1he3]], [[1he4\|1he4]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1hdo\|1hdo]], [[1he2\|1he2]], [[1he3\|1he3]], [[1he4\|1he4]]</td></tr>
-	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Biliverdin_reductase Biliverdin reductase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.3.1.24 1.3.1.24] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Biliverdin_reductase Biliverdin reductase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.3.1.24 1.3.1.24] </span></td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1he5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1he5 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1he5 RCSB], [http://www.ebi.ac.uk/pdbsum/1he5 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1he5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1he5 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1he5 RCSB], [http://www.ebi.ac.uk/pdbsum/1he5 PDBsum]</span></td></tr>
-	<table>	+	</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 35:		Line 35:
	[[Category: Biliverdin reductase]]		[[Category: Biliverdin reductase]]
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
-	[[Category: Coll, M.]]	+	[[Category: Coll, M]]
-	[[Category: Cunningham, O.]]	+	[[Category: Cunningham, O]]
-	[[Category: Darcy, K.]]	+	[[Category: Darcy, K]]
-	[[Category: Macedo-Ribeiro, S.]]	+	[[Category: Macedo-Ribeiro, S]]
-	[[Category: Mantle, T J.]]	+	[[Category: Mantle, T J]]
-	[[Category: Parraga, A.]]	+	[[Category: Parraga, A]]
-	[[Category: Pereira, P J.B.]]	+	[[Category: Pereira, P J.B]]
-	[[Category: Perez-Luque, R.]]	+	[[Category: Perez-Luque, R]]
	[[Category: Alpha/beta dinucleotide binding fold]]		[[Category: Alpha/beta dinucleotide binding fold]]
	[[Category: Biliverdin-ix beta reductase]]		[[Category: Biliverdin-ix beta reductase]]

OCA at 12:01, 28 September 2014

2014-09-28T12:01:41Z

←Older revision		Revision as of 12:01, 28 September 2014
Line 1:		Line 1:
-	[[~~Image:~~1he5.~~png~~\|~~left~~\|200px]]	+	==HUMAN BILIVERDIN IX BETA REDUCTASE: NADP/LUMICHROME TERNARY COMPLEX==
		+	<StructureSection load='1he5' size='340' side='right' caption='[[1he5]], [[Resolution\|resolution]] 1.50Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[1he5]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1HE5 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1HE5 FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=LUM:LUMICHROME'>LUM</scene>, <scene name='pdbligand=NAP:NADP+NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NAP</scene><br>
		+	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1hdo\|1hdo]], [[1he2\|1he2]], [[1he3\|1he3]], [[1he4\|1he4]]</td></tr>
		+	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Biliverdin_reductase Biliverdin reductase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.3.1.24 1.3.1.24] </span></td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1he5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1he5 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1he5 RCSB], [http://www.ebi.ac.uk/pdbsum/1he5 PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/he/1he5_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Biliverdin IXbeta reductase (BVR-B) catalyzes the pyridine nucleotide-dependent production of bilirubin-IXbeta, the major heme catabolite during early fetal development. BVR-B displays a preference for biliverdin isomers without propionates straddling the C10 position, in contrast to biliverdin IXalpha reductase (BVR-A), the major form of BVR in adult human liver. In addition to its tetrapyrrole clearance role in the fetus, BVR-B has flavin and ferric reductase activities in the adult. We have solved the structure of human BVR-B in complex with NADP+ at 1.15 A resolution. Human BVR-B is a monomer displaying an alpha/beta dinucleotide binding fold. The structures of ternary complexes with mesobiliverdin IValpha, biliverdin IXalpha, FMN and lumichrome show that human BVR-B has a single substrate binding site, to which substrates and inhibitors bind primarily through hydrophobic interactions, explaining its broad specificity. The reducible atom of both biliverdin and flavin substrates lies above the reactive C4 of the cofactor, an appropriate position for direct hydride transfer. BVR-B discriminates against the biliverdin IXalpha isomer through steric hindrance at the bilatriene side chain binding pockets. The structure also explains the enzyme's preference for NADP(H) and its B-face stereospecificity.

-	~~{{STRUCTURE_1he5\| PDB=1he5 \| SCENE= }}~~	+	Structure of human biliverdin IXbeta reductase, an early fetal bilirubin IXbeta producing enzyme.,Pereira PJ, Macedo-Ribeiro S, Parraga A, Perez-Luque R, Cunningham O, Darcy K, Mantle TJ, Coll M Nat Struct Biol. 2001 Mar;8(3):215-20. PMID:11224564<ref>PMID:11224564</ref>

-	~~===HUMAN BILIVERDIN IX BETA REDUCTASE: NADP~~/~~LUMICHROME TERNARY COMPLEX===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_11224564}}~~	+
-		+
-	~~==About this Structure==~~	+
-	~~[[1he5]] is~~ a ~~1 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Homo_sapiens Homo sapiens]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=1HE5 OCA].~~	+

	==See Also==		==See Also==
	*[[Flavin reductase\|Flavin reductase]]		*[[Flavin reductase\|Flavin reductase]]
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	<~~ref group="xtra">PMID:011224564<~~/~~ref~~><~~references group="xtra"~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Biliverdin reductase]]		[[Category: Biliverdin reductase]]
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]

OCA at 21:40, 20 October 2012

2012-10-20T21:40:12Z

←Older revision		Revision as of 21:40, 20 October 2012
Line 8:		Line 8:

	==About this Structure==		==About this Structure==
-	[[1he5]] is a 1 chain structure ~~of [[Flavin reductase]]~~ with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1HE5 OCA].	+	[[1he5]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1HE5 OCA].

	==See Also==		==See Also==

OCA: Protected "1he5" [edit=sysop:move=sysop]

2012-07-27T13:55:38Z

Protected "1he5" [edit=sysop:move=sysop]

←Older revision

Revision as of 13:55, 27 July 2012

OCA at 13:55, 27 July 2012

2012-07-27T13:55:37Z

←Older revision		Revision as of 13:55, 27 July 2012
Line 1:		Line 1:
-	{{Seed}}
	[[Image:1he5.png\|left\|200px]]		[[Image:1he5.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_1he5", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_1he5\| PDB=1he5 \| SCENE= }}		{{STRUCTURE_1he5\| PDB=1he5 \| SCENE= }}

	===HUMAN BILIVERDIN IX BETA REDUCTASE: NADP/LUMICHROME TERNARY COMPLEX===		===HUMAN BILIVERDIN IX BETA REDUCTASE: NADP/LUMICHROME TERNARY COMPLEX===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_11224564}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 11224564 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_11224564}}		{{ABSTRACT_PUBMED_11224564}}

	==About this Structure==		==About this Structure==
-	~~1HE5~~ is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1HE5 OCA].	+	[[1he5]] is a 1 chain structure of [[Flavin reductase]] with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1HE5 OCA].
		+
		+	==See Also==
		+	*[[Flavin reductase\|Flavin reductase]]

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~11224564~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:011224564</ref><references group="xtra"/>
	[[Category: Biliverdin reductase]]		[[Category: Biliverdin reductase]]
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
Line 42:		Line 33:
	[[Category: Haem degradation]]		[[Category: Haem degradation]]
	[[Category: Methaemoglobin reductase]]		[[Category: Methaemoglobin reductase]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Feb 18 07:38:58 2009''