1hp0 - Revision history

OCA at 06:13, 9 August 2023

2023-08-09T06:13:58Z

←Older revision		Revision as of 06:13, 9 August 2023
Line 3:		Line 3:
	<StructureSection load='1hp0' size='340' side='right'caption='[[1hp0]], [[Resolution\|resolution]] 2.10Å' scene=''>		<StructureSection load='1hp0' size='340' side='right'caption='[[1hp0]], [[Resolution\|resolution]] 2.10Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1hp0]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1HP0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1HP0 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1hp0]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Trypanosoma_vivax Trypanosoma vivax]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1HP0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1HP0 FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=AD3:3~~-~~DEAZA-ADENOSINE'>AD3</scene>~~, ~~<scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.1Å</td></tr>
-	<tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"><~~div style~~='~~overflow~~: ~~auto; max~~-~~height: 3em;~~'>~~[[1hoz\|1hoz]], [[1mas\|1mas]], [[2mas\|2mas]], [[1ezr\|1ezr]]~~</~~div~~><~~/td></tr>~~	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=AD3:3-DEAZA-ADENOSINE'>AD3</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
-	~~<tr id~~='~~activity'><td class~~=~~"sblockLbl"><b>Activity~~:~~</b></td><td class="sblockDat"><span class='plainlinks~~'>~~[https://en.wikipedia.org/wiki/Purine_nucleosidase Purine nucleosidase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.2.1 3.2.2.1]~~ </~~span~~></td></tr>	+
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1hp0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1hp0 OCA], [https://pdbe.org/1hp0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1hp0 RCSB], [https://www.ebi.ac.uk/pdbsum/1hp0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1hp0 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1hp0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1hp0 OCA], [https://pdbe.org/1hp0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1hp0 RCSB], [https://www.ebi.ac.uk/pdbsum/1hp0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1hp0 ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/Q9GPQ4_TRYVI Q9GPQ4_TRYVI]
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 33:		Line 34:
	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Purine nucleosidase~~]]	+	[[Category: Trypanosoma vivax]]
-	[[Category: Decanniere, K]]	+	[[Category: Decanniere K]]
-	[[Category: Depoorter, J]]	+	[[Category: Depoorter J]]
-	[[Category: Parkin~~, D W~~]]	+	[[Category: Parkin DW]]
-	[[Category: Pelle, R]]	+	[[Category: Pelle R]]
-	[[Category: Steyaert, J]]	+	[[Category: Steyaert J]]
-	[[Category: Versees, W]]	+	[[Category: Versees W]]
-	~~[[Category: Hydrolase]]~~	+
-	~~[[Category: Rossmann-fold-like motif~~]]	+

OCA at 07:26, 7 April 2021

2021-04-07T07:26:15Z

←Older revision		Revision as of 07:26, 7 April 2021
Line 3:		Line 3:
	<StructureSection load='1hp0' size='340' side='right'caption='[[1hp0]], [[Resolution\|resolution]] 2.10Å' scene=''>		<StructureSection load='1hp0' size='340' side='right'caption='[[1hp0]], [[Resolution\|resolution]] 2.10Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1hp0]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1HP0 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1HP0 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1hp0]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1HP0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1HP0 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=AD3:3-DEAZA-ADENOSINE'>AD3</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=AD3:3-DEAZA-ADENOSINE'>AD3</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1hoz\|1hoz]], [[1mas\|1mas]], [[2mas\|2mas]], [[1ezr\|1ezr]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1hoz\|1hoz]], [[1mas\|1mas]], [[2mas\|2mas]], [[1ezr\|1ezr]]</div></td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://en.wikipedia.org/wiki/Purine_nucleosidase Purine nucleosidase], with EC number [~~http~~://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.2.1 3.2.2.1] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Purine_nucleosidase Purine nucleosidase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.2.1 3.2.2.1] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1hp0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1hp0 OCA], [~~http~~://pdbe.org/1hp0 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=1hp0 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/1hp0 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=1hp0 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1hp0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1hp0 OCA], [https://pdbe.org/1hp0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1hp0 RCSB], [https://www.ebi.ac.uk/pdbsum/1hp0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1hp0 ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==

OCA at 07:50, 3 July 2019

2019-07-03T07:50:31Z

←Older revision		Revision as of 07:50, 3 July 2019
Line 1:		Line 1:

	==CRYSTAL STRUCTURE OF AN INOSINE-ADENOSINE-GUANOSINE-PREFERRING NUCLEOSIDE HYDROLASE FROM TRYPANOSOMA VIVAX IN COMPLEX WITH THE SUBSTRATE ANALOGUE 3-DEAZA-ADENOSINE==		==CRYSTAL STRUCTURE OF AN INOSINE-ADENOSINE-GUANOSINE-PREFERRING NUCLEOSIDE HYDROLASE FROM TRYPANOSOMA VIVAX IN COMPLEX WITH THE SUBSTRATE ANALOGUE 3-DEAZA-ADENOSINE==
-	<StructureSection load='1hp0' size='340' side='right' caption='[[1hp0]], [[Resolution\|resolution]] 2.10Å' scene=''>	+	<StructureSection load='1hp0' size='340' side='right'caption='[[1hp0]], [[Resolution\|resolution]] 2.10Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1hp0]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1HP0 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1HP0 FirstGlance]. <br>		<table><tr><td colspan='2'>[[1hp0]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1HP0 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1HP0 FirstGlance]. <br>
Line 13:		Line 13:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/hp/1hp0_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/hp/1hp0_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
Line 32:		Line 32:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Purine nucleosidase]]		[[Category: Purine nucleosidase]]
	[[Category: Decanniere, K]]		[[Category: Decanniere, K]]

OCA at 10:50, 27 September 2017

2017-09-27T10:50:50Z

←Older revision		Revision as of 10:50, 27 September 2017
Line 1:		Line 1:
		+
	==CRYSTAL STRUCTURE OF AN INOSINE-ADENOSINE-GUANOSINE-PREFERRING NUCLEOSIDE HYDROLASE FROM TRYPANOSOMA VIVAX IN COMPLEX WITH THE SUBSTRATE ANALOGUE 3-DEAZA-ADENOSINE==		==CRYSTAL STRUCTURE OF AN INOSINE-ADENOSINE-GUANOSINE-PREFERRING NUCLEOSIDE HYDROLASE FROM TRYPANOSOMA VIVAX IN COMPLEX WITH THE SUBSTRATE ANALOGUE 3-DEAZA-ADENOSINE==
	<StructureSection load='1hp0' size='340' side='right' caption='[[1hp0]], [[Resolution\|resolution]] 2.10Å' scene=''>		<StructureSection load='1hp0' size='340' side='right' caption='[[1hp0]], [[Resolution\|resolution]] 2.10Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1hp0]] is a 2 chain structure ~~with sequence from [http://en.wikipedia.org/wiki/Duttonella_vivax Duttonella vivax]~~. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1HP0 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1HP0 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1hp0]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1HP0 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1HP0 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=AD3:3-DEAZA-ADENOSINE'>AD3</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=AD3:3-DEAZA-ADENOSINE'>AD3</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1hoz\|1hoz]], [[1mas\|1mas]], [[2mas\|2mas]], [[1ezr\|1ezr]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1hoz\|1hoz]], [[1mas\|1mas]], [[2mas\|2mas]], [[1ezr\|1ezr]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Purine_nucleosidase Purine nucleosidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.2.1 3.2.2.1] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Purine_nucleosidase Purine nucleosidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.2.1 3.2.2.1] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1hp0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1hp0 OCA], [http://pdbe.org/1hp0 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1hp0 RCSB], [http://www.ebi.ac.uk/pdbsum/1hp0 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1hp0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1hp0 OCA], [http://pdbe.org/1hp0 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1hp0 RCSB], [http://www.ebi.ac.uk/pdbsum/1hp0 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1hp0 ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 16:		Line 17:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1hp0 ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 31:		Line 32:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Duttonella vivax]]
	[[Category: Purine nucleosidase]]		[[Category: Purine nucleosidase]]
	[[Category: Decanniere, K]]		[[Category: Decanniere, K]]

OCA at 00:13, 12 September 2015

2015-09-12T00:13:55Z

←Older revision		Revision as of 00:13, 12 September 2015
Line 2:		Line 2:
	<StructureSection load='1hp0' size='340' side='right' caption='[[1hp0]], [[Resolution\|resolution]] 2.10Å' scene=''>		<StructureSection load='1hp0' size='340' side='right' caption='[[1hp0]], [[Resolution\|resolution]] 2.10Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1hp0]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Trypanosoma_vivax Trypanosoma~~ vivax]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1HP0 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1HP0 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1hp0]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Duttonella_vivax Duttonella vivax]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1HP0 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1HP0 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=AD3:3-DEAZA-ADENOSINE'>AD3</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=AD3:3-DEAZA-ADENOSINE'>AD3</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1hoz\|1hoz]], [[1mas\|1mas]], [[2mas\|2mas]], [[1ezr\|1ezr]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1hoz\|1hoz]], [[1mas\|1mas]], [[2mas\|2mas]], [[1ezr\|1ezr]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Purine_nucleosidase Purine nucleosidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.2.1 3.2.2.1] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Purine_nucleosidase Purine nucleosidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.2.1 3.2.2.1] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1hp0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1hp0 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1hp0 RCSB], [http://www.ebi.ac.uk/pdbsum/1hp0 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1hp0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1hp0 OCA], [http://pdbe.org/1hp0 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1hp0 RCSB], [http://www.ebi.ac.uk/pdbsum/1hp0 PDBsum]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 26:		Line 26:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 1hp0" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Duttonella vivax]]
	[[Category: Purine nucleosidase]]		[[Category: Purine nucleosidase]]
-	[[Category: Trypanosoma vivax]]
	[[Category: Decanniere, K]]		[[Category: Decanniere, K]]
	[[Category: Depoorter, J]]		[[Category: Depoorter, J]]

OCA at 12:19, 2 January 2015

2015-01-02T12:19:44Z

←Older revision		Revision as of 12:19, 2 January 2015
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1hp0]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Trypanosoma_vivax Trypanosoma vivax]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1HP0 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1HP0 FirstGlance]. <br>		<table><tr><td colspan='2'>[[1hp0]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Trypanosoma_vivax Trypanosoma vivax]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1HP0 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1HP0 FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=AD3:3-DEAZA-ADENOSINE'>AD3</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=AD3:3-DEAZA-ADENOSINE'>AD3</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1hoz\|1hoz]], [[1mas\|1mas]], [[2mas\|2mas]], [[1ezr\|1ezr]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1hoz\|1hoz]], [[1mas\|1mas]], [[2mas\|2mas]], [[1ezr\|1ezr]]</td></tr>
-	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Purine_nucleosidase Purine nucleosidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.2.1 3.2.2.1] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Purine_nucleosidase Purine nucleosidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.2.1 3.2.2.1] </span></td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1hp0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1hp0 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1hp0 RCSB], [http://www.ebi.ac.uk/pdbsum/1hp0 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1hp0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1hp0 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1hp0 RCSB], [http://www.ebi.ac.uk/pdbsum/1hp0 PDBsum]</span></td></tr>
-	<table>	+	</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 32:		Line 32:
	[[Category: Purine nucleosidase]]		[[Category: Purine nucleosidase]]
	[[Category: Trypanosoma vivax]]		[[Category: Trypanosoma vivax]]
-	[[Category: Decanniere, K.]]	+	[[Category: Decanniere, K]]
-	[[Category: Depoorter, J.]]	+	[[Category: Depoorter, J]]
-	[[Category: Parkin, D W.]]	+	[[Category: Parkin, D W]]
-	[[Category: Pelle, R.]]	+	[[Category: Pelle, R]]
-	[[Category: Steyaert, J.]]	+	[[Category: Steyaert, J]]
-	[[Category: Versees, W.]]	+	[[Category: Versees, W]]
	[[Category: Hydrolase]]		[[Category: Hydrolase]]
	[[Category: Rossmann-fold-like motif]]		[[Category: Rossmann-fold-like motif]]

OCA at 10:31, 3 October 2014

2014-10-03T10:31:45Z

←Older revision		Revision as of 10:31, 3 October 2014
Line 1:		Line 1:
-	~~{{STRUCTURE_1hp0\| PDB=1hp0 \| SCENE= }}~~	+	==CRYSTAL STRUCTURE OF AN INOSINE-ADENOSINE-GUANOSINE-PREFERRING NUCLEOSIDE HYDROLASE FROM TRYPANOSOMA VIVAX IN COMPLEX WITH THE SUBSTRATE ANALOGUE 3-DEAZA-ADENOSINE==
-	===CRYSTAL STRUCTURE OF AN INOSINE-ADENOSINE-GUANOSINE-PREFERRING NUCLEOSIDE HYDROLASE FROM TRYPANOSOMA VIVAX IN COMPLEX WITH THE SUBSTRATE ANALOGUE 3-DEAZA-ADENOSINE===	+	<StructureSection load='1hp0' size='340' side='right' caption='[[1hp0]], [[Resolution\|resolution]] 2.10Å' scene=''>
-	~~{{ABSTRACT_PUBMED_11292348}}~~	+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[1hp0]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Trypanosoma_vivax Trypanosoma vivax]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1HP0 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1HP0 FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=AD3:3-DEAZA-ADENOSINE'>AD3</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene><br>
		+	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1hoz\|1hoz]], [[1mas\|1mas]], [[2mas\|2mas]], [[1ezr\|1ezr]]</td></tr>
		+	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Purine_nucleosidase Purine nucleosidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.2.1 3.2.2.1] </span></td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1hp0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1hp0 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1hp0 RCSB], [http://www.ebi.ac.uk/pdbsum/1hp0 PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/hp/1hp0_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The purine salvage pathway of parasitic protozoa is currently considered as a target for drug development because these organisms cannot synthesize purines de novo. Insight into the structure and mechanism of the involved enzymes can aid in the development of potent inhibitors, leading to new curative drugs. Nucleoside hydrolases are key enzymes in the purine salvage pathway of Trypanosomatidae, and they are especially attractive because they have no equivalent in mammalian cells. We cloned, expressed and purified a nucleoside hydrolase from Trypanosoma vivax. The substrate activity profile establishes the enzyme to be a member of the inosine-adenosine-guanosine-preferring nucleoside hydrolases (IAG-NH). We solved the crystal structure of the enzyme at 1.6 A resolution using MAD techniques. The complex of the enzyme with the substrate analogue 3-deaza-adenosine is presented. These are the first structures of an IAG-NH reported in the literature. The T. vivax IAG-NH is a homodimer, with each subunit consisting of ten beta-strands, 12 alpha-helices and three small 3(10)-helices. Six of the eight strands of the central beta-sheet form a motif resembling the Rossmann fold. Superposition of the active sites of this IAG-NH and the inosine-uridine-preferring nucleoside hydrolase (IU-NH) of Crithidia fasciculata shows the molecular basis of the different substrate specificity distinguishing these two classes of nucleoside hydrolases. An "aromatic stacking network" in the active site of the IAG-NH, absent from the IU-NH, imposes the purine specificity. Asp10 is the proposed general base in the reaction mechanism, abstracting a proton from a nucleophilic water molecule. Asp40 (replaced by Asn39 in the IU-NH) is positioned appropriately to act as a general acid and to protonate the purine leaving group. The second general acid, needed for full enzymatic activity, is probably part of a flexible loop located in the vicinity of the active site.

-	~~==About this~~ Structure==	+	Structure and function of a novel purine specific nucleoside hydrolase from Trypanosoma vivax.,Versees W, Decanniere K, Pelle R, Depoorter J, Brosens E, Parkin DW, Steyaert J J Mol Biol. 2001 Apr 13;307(5):1363-79. PMID:11292348<ref>PMID:11292348</ref>
-	~~[[1hp0]] is~~ a ~~2 chain structure with sequence~~ from ~~[http://en.wikipedia.org/wiki/Trypanosoma_vivax~~ Trypanosoma vivax]. ~~Full crystallographic information is available from [http~~:~~//oca~~.~~weizmann.ac.il~~/~~oca-bin/ocashort?id=1HP0 OCA].~~	+

-	==~~Reference~~==	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~<ref group="xtra">PMID:011292348</ref>~~<references ~~group="xtra"~~/><~~references~~/>	+	</div>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
	[[Category: Purine nucleosidase]]		[[Category: Purine nucleosidase]]
	[[Category: Trypanosoma vivax]]		[[Category: Trypanosoma vivax]]

OCA at 10:55, 16 April 2014

2014-04-16T10:55:25Z

←Older revision		Revision as of 10:55, 16 April 2014
Line 1:		Line 1:
-	[[Image:1hp0.png\|left\|200px]]
-
-	<!--
-	The line below this paragraph, containing "STRUCTURE_1hp0", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_1hp0\| PDB=1hp0 \| SCENE= }}		{{STRUCTURE_1hp0\| PDB=1hp0 \| SCENE= }}
-
	===CRYSTAL STRUCTURE OF AN INOSINE-ADENOSINE-GUANOSINE-PREFERRING NUCLEOSIDE HYDROLASE FROM TRYPANOSOMA VIVAX IN COMPLEX WITH THE SUBSTRATE ANALOGUE 3-DEAZA-ADENOSINE===		===CRYSTAL STRUCTURE OF AN INOSINE-ADENOSINE-GUANOSINE-PREFERRING NUCLEOSIDE HYDROLASE FROM TRYPANOSOMA VIVAX IN COMPLEX WITH THE SUBSTRATE ANALOGUE 3-DEAZA-ADENOSINE===
-
-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_11292348}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 11292348 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_11292348}}		{{ABSTRACT_PUBMED_11292348}}

Line 22:		Line 7:

	==Reference==		==Reference==
-	<ref group="xtra">PMID:011292348</ref><references group="xtra"/>	+	<ref group="xtra">PMID:011292348</ref><references group="xtra"/><references/>
	[[Category: Purine nucleosidase]]		[[Category: Purine nucleosidase]]
	[[Category: Trypanosoma vivax]]		[[Category: Trypanosoma vivax]]

OCA: Protected "1hp0" [edit=sysop:move=sysop]

2012-06-02T09:44:15Z

Protected "1hp0" [edit=sysop:move=sysop]

←Older revision

Revision as of 09:44, 2 June 2012