1ieo - Revision history

OCA at 18:41, 29 November 2023

2023-11-29T18:41:38Z

←Older revision		Revision as of 18:41, 29 November 2023
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	==SOLUTION STRUCTURE OF MRIB-NH2==		==SOLUTION STRUCTURE OF MRIB-NH2==
-	<StructureSection load='1ieo' size='340' side='right'caption='[[1ieo~~]], [[NMR_Ensembles_of_Models \| 20 NMR models~~]]' scene=''>	+	<StructureSection load='1ieo' size='340' side='right'caption='[[1ieo]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1ieo]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1IEO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1IEO FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1ieo]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Conus_marmoreus Conus marmoreus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1IEO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1IEO FirstGlance]. <br>
-	</td></tr><tr id='~~NonStdRes~~'><td class="sblockLbl"><b>[[~~Non-Standard_Residue~~\|~~NonStd Res~~:]]</b></td><td class="sblockDat"~~><scene name~~=~~'pdbligand=HYP:4-HYDROXYPROLINE'>HYP</scene>, <scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene~~></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
-	<tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"><~~div style~~='~~overflow~~: ~~auto; max~~-~~height~~: ~~3em;~~'>~~[[1ien\|1ien]]~~</~~div~~></td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=HYP:4-HYDROXYPROLINE'>HYP</scene>, <scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1ieo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ieo OCA], [https://pdbe.org/1ieo PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1ieo RCSB], [https://www.ebi.ac.uk/pdbsum/1ieo PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1ieo ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1ieo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ieo OCA], [https://pdbe.org/1ieo PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1ieo RCSB], [https://www.ebi.ac.uk/pdbsum/1ieo PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1ieo ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/CTA1B_CONMR CTA1B_CONMR]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 21:		Line 23:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Conus marmoreus]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Adams~~, D A~~]]	+	[[Category: Adams DA]]
-	[[Category: Adams~~, D J~~]]	+	[[Category: Adams DJ]]
-	[[Category: Alewood~~, P F~~]]	+	[[Category: Alewood PF]]
-	[[Category: Atkins, A]]	+	[[Category: Atkins A]]
-	[[Category: Craik~~, D J~~]]	+	[[Category: Craik DJ]]
-	[[Category: Gehrmann, J]]	+	[[Category: Gehrmann J]]
-	[[Category: Lewis~~, R J~~]]	+	[[Category: Lewis RJ]]
-	[[Category: Loughnan~~, M L~~]]	+	[[Category: Loughnan ML]]
-	[[Category: Palant, E]]	+	[[Category: Palant E]]
-	[[Category: Sharpe~~, I A~~]]	+	[[Category: Sharpe IA]]
-	[[Category: Thomas, L]]	+	[[Category: Thomas L]]
-	~~[[Category: Conotoxin]]~~	+
-	~~[[Category: Neuronal noradrenaline transporter]]~~	+
-	~~[[Category: Toxin~~]]	+

OCA at 07:41, 7 April 2021

2021-04-07T07:41:19Z

←Older revision		Revision as of 07:41, 7 April 2021
Line 3:		Line 3:
	<StructureSection load='1ieo' size='340' side='right'caption='[[1ieo]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>		<StructureSection load='1ieo' size='340' side='right'caption='[[1ieo]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1ieo]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1IEO OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1IEO FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1ieo]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1IEO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1IEO FirstGlance]. <br>
	</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=HYP:4-HYDROXYPROLINE'>HYP</scene>, <scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene></td></tr>		</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=HYP:4-HYDROXYPROLINE'>HYP</scene>, <scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1ien\|1ien]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1ien\|1ien]]</div></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1ieo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ieo OCA], [~~http~~://pdbe.org/1ieo PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=1ieo RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/1ieo PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=1ieo ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1ieo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ieo OCA], [https://pdbe.org/1ieo PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1ieo RCSB], [https://www.ebi.ac.uk/pdbsum/1ieo PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1ieo ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 07:45, 3 July 2019

2019-07-03T07:45:29Z

←Older revision		Revision as of 07:45, 3 July 2019
Line 1:		Line 1:

	==SOLUTION STRUCTURE OF MRIB-NH2==		==SOLUTION STRUCTURE OF MRIB-NH2==
-	<StructureSection load='1ieo' size='340' side='right' caption='[[1ieo]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>	+	<StructureSection load='1ieo' size='340' side='right'caption='[[1ieo]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1ieo]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1IEO OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1IEO FirstGlance]. <br>		<table><tr><td colspan='2'>[[1ieo]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1IEO OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1IEO FirstGlance]. <br>
Line 21:		Line 21:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Adams, D A]]		[[Category: Adams, D A]]
	[[Category: Adams, D J]]		[[Category: Adams, D J]]

OCA at 10:46, 27 September 2017

2017-09-27T10:46:40Z

←Older revision		Revision as of 10:46, 27 September 2017
Line 1:		Line 1:
		+
	==SOLUTION STRUCTURE OF MRIB-NH2==		==SOLUTION STRUCTURE OF MRIB-NH2==
	<StructureSection load='1ieo' size='340' side='right' caption='[[1ieo]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>		<StructureSection load='1ieo' size='340' side='right' caption='[[1ieo]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
Line 5:		Line 6:
	</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=HYP:4-HYDROXYPROLINE'>HYP</scene>, <scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene></td></tr>		</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=HYP:4-HYDROXYPROLINE'>HYP</scene>, <scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1ien\|1ien]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1ien\|1ien]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ieo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ieo OCA], [http://pdbe.org/1ieo PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1ieo RCSB], [http://www.ebi.ac.uk/pdbsum/1ieo PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ieo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ieo OCA], [http://pdbe.org/1ieo PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1ieo RCSB], [http://www.ebi.ac.uk/pdbsum/1ieo PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1ieo ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 22:16, 9 September 2015

2015-09-09T22:16:58Z

←Older revision		Revision as of 22:16, 9 September 2015
Line 5:		Line 5:
	</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=HYP:4-HYDROXYPROLINE'>HYP</scene>, <scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene></td></tr>		</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=HYP:4-HYDROXYPROLINE'>HYP</scene>, <scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1ien\|1ien]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1ien\|1ien]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ieo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ieo OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1ieo RCSB], [http://www.ebi.ac.uk/pdbsum/1ieo PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ieo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ieo OCA], [http://pdbe.org/1ieo PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1ieo RCSB], [http://www.ebi.ac.uk/pdbsum/1ieo PDBsum]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 15:		Line 15:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 1ieo" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>

OCA at 08:11, 24 December 2014

2014-12-24T08:11:45Z

←Older revision		Revision as of 08:11, 24 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1ieo]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1IEO OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1IEO FirstGlance]. <br>		<table><tr><td colspan='2'>[[1ieo]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1IEO OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1IEO FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=HYP:4-HYDROXYPROLINE'>HYP</scene>, <scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene></td></tr>	+	</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=HYP:4-HYDROXYPROLINE'>HYP</scene>, <scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1ien\|1ien]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1ien\|1ien]]</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ieo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ieo OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1ieo RCSB], [http://www.ebi.ac.uk/pdbsum/1ieo PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ieo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ieo OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1ieo RCSB], [http://www.ebi.ac.uk/pdbsum/1ieo PDBsum]</span></td></tr>
-	<table>	+	</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 19:		Line 19:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Adams, D A.]]	+	[[Category: Adams, D A]]
-	[[Category: Adams, D J.]]	+	[[Category: Adams, D J]]
-	[[Category: Alewood, P F.]]	+	[[Category: Alewood, P F]]
-	[[Category: Atkins, A.]]	+	[[Category: Atkins, A]]
-	[[Category: Craik, D J.]]	+	[[Category: Craik, D J]]
-	[[Category: Gehrmann, J.]]	+	[[Category: Gehrmann, J]]
-	[[Category: Lewis, R J.]]	+	[[Category: Lewis, R J]]
-	[[Category: Loughnan, M L.]]	+	[[Category: Loughnan, M L]]
-	[[Category: Palant, E.]]	+	[[Category: Palant, E]]
-	[[Category: Sharpe, I A.]]	+	[[Category: Sharpe, I A]]
-	[[Category: Thomas, L.]]	+	[[Category: Thomas, L]]
	[[Category: Conotoxin]]		[[Category: Conotoxin]]
	[[Category: Neuronal noradrenaline transporter]]		[[Category: Neuronal noradrenaline transporter]]
	[[Category: Toxin]]		[[Category: Toxin]]

OCA at 09:39, 28 September 2014

2014-09-28T09:39:49Z

←Older revision		Revision as of 09:39, 28 September 2014
Line 1:		Line 1:
-	[[~~Image:~~1ieo.~~png~~\|~~left~~\|~~200px~~]]	+	==SOLUTION STRUCTURE OF MRIB-NH2==
		+	<StructureSection load='1ieo' size='340' side='right' caption='[[1ieo]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[1ieo]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1IEO OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1IEO FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=HYP:4-HYDROXYPROLINE'>HYP</scene>, <scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene></td></tr>
		+	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1ien\|1ien]]</td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ieo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ieo OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1ieo RCSB], [http://www.ebi.ac.uk/pdbsum/1ieo PDBsum]</span></td></tr>
		+	<table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Cone snails use venom containing a cocktail of peptides ('conopeptides') to capture their prey. Many of these peptides also target mammalian receptors, often with exquisite selectivity. Here we report the discovery of two new classes of conopeptides. One class targets alpha1-adrenoceptors (rho-TIA from the fish-hunting Conus tulipa), and the second class targets the neuronal noradrenaline transporter (chi-MrIA and chi-MrIB from the mollusk-hunting C. marmoreus). rho-TIA and chi-MrIA selectively modulate these important membrane-bound proteins. Both peptides act as reversible non-competitive inhibitors and provide alternative avenues for the identification of inhibitor drugs.

-	~~{{STRUCTURE_1ieo\| PDB=1ieo \| SCENE= }}~~	+	Two new classes of conopeptides inhibit the alpha1-adrenoceptor and noradrenaline transporter.,Sharpe IA, Gehrmann J, Loughnan ML, Thomas L, Adams DA, Atkins A, Palant E, Craik DJ, Adams DJ, Alewood PF, Lewis RJ Nat Neurosci. 2001 Sep;4(9):902-7. PMID:11528421<ref>PMID:11528421</ref>

-	~~===SOLUTION STRUCTURE OF MRIB-NH2===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_11528421}}~~	+	== References ==
-		+	<references/>
-	==~~About this Structure~~==	+	__TOC__
-	~~[[1ieo]] is a 1 chain structure. Full experimental information is available from [http:~~//~~oca.weizmann.ac.il/oca-bin/ocashort?id=1IEO OCA].~~	+	</StructureSection>
	[[Category: Adams, D A.]]		[[Category: Adams, D A.]]
	[[Category: Adams, D J.]]		[[Category: Adams, D J.]]

OCA: Protected "1ieo" [edit=sysop:move=sysop]

2012-11-28T15:03:28Z

Protected "1ieo" [edit=sysop:move=sysop]

←Older revision

Revision as of 15:03, 28 November 2012

OCA at 15:03, 28 November 2012

2012-11-28T15:03:25Z

←Older revision		Revision as of 15:03, 28 November 2012
Line 1:		Line 1:
-	{{Seed}}
	[[Image:1ieo.png\|left\|200px]]		[[Image:1ieo.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_1ieo", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_1ieo\| PDB=1ieo \| SCENE= }}		{{STRUCTURE_1ieo\| PDB=1ieo \| SCENE= }}

	===SOLUTION STRUCTURE OF MRIB-NH2===		===SOLUTION STRUCTURE OF MRIB-NH2===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_11528421}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 11528421 is the PubMed ID number.
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	{{ABSTRACT_PUBMED_11528421}}		{{ABSTRACT_PUBMED_11528421}}

	==About this Structure==		==About this Structure==
-	~~1IEO is a~~ [[~~Single protein~~]] structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1IEO OCA].	+	[[1ieo]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1IEO OCA].
-		+
-	~~==Reference==~~	+
-	Two new classes of conopeptides inhibit the alpha1-adrenoceptor and noradrenaline transporter., Sharpe IA, Gehrmann J, Loughnan ML, Thomas L, Adams DA, Atkins A, Palant E, Craik DJ, Adams DJ, Alewood PF, Lewis RJ, Nat Neurosci. 2001 Sep;4(9):902-7. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/11528421 11528421]	+
-	~~[[Category: Single protein]]~~	+
	[[Category: Adams, D A.]]		[[Category: Adams, D A.]]
	[[Category: Adams, D J.]]		[[Category: Adams, D J.]]
Line 38:		Line 22:
	[[Category: Conotoxin]]		[[Category: Conotoxin]]
	[[Category: Neuronal noradrenaline transporter]]		[[Category: Neuronal noradrenaline transporter]]
-		+	[[Category: Toxin]]
-	~~''Page seeded by~~ [~~http~~:~~//oca.weizmann.ac.il/oca OCA~~ ] ~~on Tue Jul 1 10:51:21 2008''~~	+

OCA at 07:51, 1 July 2008

2008-07-01T07:51:22Z

←Older revision		Revision as of 07:51, 1 July 2008
Line 1:		Line 1:
-	[[Image:1ieo.~~gif~~\|left\|200px]]	+	{{Seed}}
		+	[[Image:1ieo.png\|left\|200px]]

	<!--		<!--
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	{{STRUCTURE_1ieo\| PDB=1ieo \| SCENE= }}		{{STRUCTURE_1ieo\| PDB=1ieo \| SCENE= }}

-	~~'''~~SOLUTION STRUCTURE OF MRIB-NH2~~'''~~	+	===SOLUTION STRUCTURE OF MRIB-NH2===


-	~~==Overview==~~	+	<!--
-	Cone snails use venom containing a cocktail of peptides ('conopeptides') to capture their prey. Many of these peptides also target mammalian receptors, often with exquisite selectivity. Here we report the discovery of two new classes of conopeptides. One class targets alpha1-~~adrenoceptors (rho~~-~~TIA from the fish-hunting Conus tulipa)~~, ~~and~~ the ~~second class targets~~ the ~~neuronal noradrenaline transporter~~ (~~chi-MrIA and chi-MrIB from the mollusk-hunting C~~. ~~marmoreus~~). ~~rho~~-~~TIA and chi~~-~~MrIA selectively modulate these important membrane-bound proteins. Both peptides act as reversible non-competitive inhibitors and provide alternative avenues for the identification of inhibitor drugs.~~	+	The line below this paragraph, {{ABSTRACT_PUBMED_11528421}}, adds the Publication Abstract to the page
		+	(as it appears on PubMed at http://www.pubmed.gov), where 11528421 is the PubMed ID number.
		+	-->
		+	{{ABSTRACT_PUBMED_11528421}}

	==About this Structure==		==About this Structure==
-	1IEO is a [[Single protein]] structure. Full ~~crystallographic~~ information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1IEO OCA].	+	1IEO is a [[Single protein]] structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1IEO OCA].

	==Reference==		==Reference==
Line 34:		Line 38:
	[[Category: Conotoxin]]		[[Category: Conotoxin]]
	[[Category: Neuronal noradrenaline transporter]]		[[Category: Neuronal noradrenaline transporter]]
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Fri May~~ ~~2 19~~:55:10 2008''	+
		+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 10:51:21 2008''