1iie - Revision history

OCA at 11:22, 2 August 2023

2023-08-02T11:22:58Z

←Older revision		Revision as of 11:22, 2 August 2023
Line 1:		Line 1:

	==HLA-DR ANTIGENS ASSOCIATED INVARIANT CHAIN==		==HLA-DR ANTIGENS ASSOCIATED INVARIANT CHAIN==
-	<StructureSection load='1iie' size='340' side='right'caption='[[1iie~~]], [[NMR_Ensembles_of_Models \| 20 NMR models~~]]' scene=''>	+	<StructureSection load='1iie' size='340' side='right'caption='[[1iie]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1iie]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Human Human~~]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1IIE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1IIE FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1iie]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1IIE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1IIE FirstGlance]. <br>
-	</td></tr><tr id='~~gene~~'><td class="sblockLbl"><b>[[~~Gene~~\|~~Gene~~:]]</b></td><td class="sblockDat"~~>CD74 OR DHLAG ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&~~id=~~9606 HUMAN])~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1iie FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1iie OCA], [https://pdbe.org/1iie PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1iie RCSB], [https://www.ebi.ac.uk/pdbsum/1iie PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1iie ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1iie FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1iie OCA], [https://pdbe.org/1iie PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1iie RCSB], [https://www.ebi.ac.uk/pdbsum/1iie PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1iie ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
-	[[https://www.uniprot.org/uniprot/HG2A_HUMAN HG2A_HUMAN]] Note=A chromosomal aberration involving CD74 is found in a non-small cell lung tumor. Results in the formation of a CD74-ROS1 chimeric protein.<ref>PMID:12661006</ref>	+	[https://www.uniprot.org/uniprot/HG2A_HUMAN HG2A_HUMAN] Note=A chromosomal aberration involving CD74 is found in a non-small cell lung tumor. Results in the formation of a CD74-ROS1 chimeric protein.<ref>PMID:12661006</ref>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/HG2A_HUMAN HG2A_HUMAN]] Plays a critical role in MHC class II antigen processing by stabilizing peptide-free class II alpha/beta heterodimers in a complex soon after their synthesis and directing transport of the complex from the endoplasmic reticulum to the endosomal/lysosomal system where the antigen processing and binding of antigenic peptides to MHC class II takes place. Serves as cell surface receptor for the cytokine MIF.	+	[https://www.uniprot.org/uniprot/HG2A_HUMAN HG2A_HUMAN] Plays a critical role in MHC class II antigen processing by stabilizing peptide-free class II alpha/beta heterodimers in a complex soon after their synthesis and directing transport of the complex from the endoplasmic reticulum to the endosomal/lysosomal system where the antigen processing and binding of antigenic peptides to MHC class II takes place. Serves as cell surface receptor for the cytokine MIF.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 24:		Line 24:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Jasanoff, A]]	+	[[Category: Jasanoff A]]
-	[[Category: Wagner, G]]	+	[[Category: Wagner G]]
-	[[Category: Wiley~~, D C]]~~	+	[[Category: Wiley DC]]
-	~~[[Category: Antigen processing]]~~	+
-	~~[[Category: Chaperonin]]~~	+
-	~~[[Category: Major histocompatibility complex]]~~	+
-	~~[[Category: Oligomerization~~]]	+

OCA at 06:36, 11 August 2021

2021-08-11T06:36:17Z

←Older revision		Revision as of 06:36, 11 August 2021
Line 3:		Line 3:
	<StructureSection load='1iie' size='340' side='right'caption='[[1iie]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>		<StructureSection load='1iie' size='340' side='right'caption='[[1iie]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1iie]] is a 3 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1IIE OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1IIE FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1iie]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1IIE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1IIE FirstGlance]. <br>
-	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CD74 OR DHLAG ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>	+	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CD74 OR DHLAG ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1iie FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1iie OCA], [~~http~~://pdbe.org/1iie PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=1iie RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/1iie PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=1iie ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1iie FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1iie OCA], [https://pdbe.org/1iie PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1iie RCSB], [https://www.ebi.ac.uk/pdbsum/1iie PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1iie ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
-	[[~~http~~://www.uniprot.org/uniprot/HG2A_HUMAN HG2A_HUMAN]] Note=A chromosomal aberration involving CD74 is found in a non-small cell lung tumor. Results in the formation of a CD74-ROS1 chimeric protein.<ref>PMID:12661006</ref>	+	[[https://www.uniprot.org/uniprot/HG2A_HUMAN HG2A_HUMAN]] Note=A chromosomal aberration involving CD74 is found in a non-small cell lung tumor. Results in the formation of a CD74-ROS1 chimeric protein.<ref>PMID:12661006</ref>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/HG2A_HUMAN HG2A_HUMAN]] Plays a critical role in MHC class II antigen processing by stabilizing peptide-free class II alpha/beta heterodimers in a complex soon after their synthesis and directing transport of the complex from the endoplasmic reticulum to the endosomal/lysosomal system where the antigen processing and binding of antigenic peptides to MHC class II takes place. Serves as cell surface receptor for the cytokine MIF.	+	[[https://www.uniprot.org/uniprot/HG2A_HUMAN HG2A_HUMAN]] Plays a critical role in MHC class II antigen processing by stabilizing peptide-free class II alpha/beta heterodimers in a complex soon after their synthesis and directing transport of the complex from the endoplasmic reticulum to the endosomal/lysosomal system where the antigen processing and binding of antigenic peptides to MHC class II takes place. Serves as cell surface receptor for the cytokine MIF.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==

OCA at 07:01, 6 November 2019

2019-11-06T07:01:32Z

←Older revision		Revision as of 07:01, 6 November 2019
Line 3:		Line 3:
	<StructureSection load='1iie' size='340' side='right'caption='[[1iie]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>		<StructureSection load='1iie' size='340' side='right'caption='[[1iie]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1iie]] is a 3 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1IIE OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1IIE FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1iie]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1IIE OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1IIE FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1iie FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1iie OCA], [http://pdbe.org/1iie PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1iie RCSB], [http://www.ebi.ac.uk/pdbsum/1iie PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1iie ProSAT]</span></td></tr>	+	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CD74 OR DHLAG ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1iie FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1iie OCA], [http://pdbe.org/1iie PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1iie RCSB], [http://www.ebi.ac.uk/pdbsum/1iie PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1iie ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
Line 23:		Line 24:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Human]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Jasanoff, A]]		[[Category: Jasanoff, A]]

OCA at 07:08, 3 July 2019

2019-07-03T07:08:38Z

←Older revision		Revision as of 07:08, 3 July 2019
Line 1:		Line 1:

	==HLA-DR ANTIGENS ASSOCIATED INVARIANT CHAIN==		==HLA-DR ANTIGENS ASSOCIATED INVARIANT CHAIN==
-	<StructureSection load='1iie' size='340' side='right' caption='[[1iie]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>	+	<StructureSection load='1iie' size='340' side='right'caption='[[1iie]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1iie]] is a 3 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1IIE OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1IIE FirstGlance]. <br>		<table><tr><td colspan='2'>[[1iie]] is a 3 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1IIE OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1IIE FirstGlance]. <br>
Line 23:		Line 23:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Jasanoff, A]]		[[Category: Jasanoff, A]]
	[[Category: Wagner, G]]		[[Category: Wagner, G]]

OCA at 10:37, 27 September 2017

2017-09-27T10:37:33Z

←Older revision		Revision as of 10:37, 27 September 2017
Line 1:		Line 1:
		+
	==HLA-DR ANTIGENS ASSOCIATED INVARIANT CHAIN==		==HLA-DR ANTIGENS ASSOCIATED INVARIANT CHAIN==
	<StructureSection load='1iie' size='340' side='right' caption='[[1iie]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>		<StructureSection load='1iie' size='340' side='right' caption='[[1iie]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1iie]] is a 3 chain structure ~~with sequence from [http://en.wikipedia.org/wiki/Human Human]~~. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1IIE OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1IIE FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1iie]] is a 3 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1IIE OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1IIE FirstGlance]. <br>
-	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CD74 OR DHLAG ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1iie FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1iie OCA], [http://pdbe.org/1iie PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1iie RCSB], [http://www.ebi.ac.uk/pdbsum/1iie PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1iie ProSAT]</span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1iie FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1iie OCA], [http://pdbe.org/1iie PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1iie RCSB], [http://www.ebi.ac.uk/pdbsum/1iie PDBsum]</span></td></tr>	+
	</table>		</table>
	== Disease ==		== Disease ==
Line 23:		Line 23:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Human]]
	[[Category: Jasanoff, A]]		[[Category: Jasanoff, A]]
	[[Category: Wagner, G]]		[[Category: Wagner, G]]

OCA at 02:58, 11 September 2015

2015-09-11T02:58:17Z

←Older revision		Revision as of 02:58, 11 September 2015
Line 2:		Line 2:
	<StructureSection load='1iie' size='340' side='right' caption='[[1iie]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>		<StructureSection load='1iie' size='340' side='right' caption='[[1iie]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1iie]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1IIE OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1IIE FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1iie]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1IIE OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1IIE FirstGlance]. <br>
-	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CD74 OR DHLAG ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 ~~Homo sapiens~~])</td></tr>	+	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CD74 OR DHLAG ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1iie FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1iie OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1iie RCSB], [http://www.ebi.ac.uk/pdbsum/1iie PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1iie FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1iie OCA], [http://pdbe.org/1iie PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1iie RCSB], [http://www.ebi.ac.uk/pdbsum/1iie PDBsum]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
Line 18:		Line 18:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 1iie" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Homo sapiens~~]]	+	[[Category: Human]]
	[[Category: Jasanoff, A]]		[[Category: Jasanoff, A]]
	[[Category: Wagner, G]]		[[Category: Wagner, G]]

OCA at 11:16, 18 December 2014

2014-12-18T11:16:04Z

←Older revision		Revision as of 11:16, 18 December 2014
Line 1:		Line 1:
-	~~{{STRUCTURE_1iie\| PDB=1iie \| SCENE= }}~~	+	==HLA-DR ANTIGENS ASSOCIATED INVARIANT CHAIN==
-	===HLA-DR ANTIGENS ASSOCIATED INVARIANT CHAIN===	+	<StructureSection load='1iie' size='340' side='right' caption='[[1iie]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
-	~~{{ABSTRACT_PUBMED_9843486}}~~	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[1iie]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1IIE OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1IIE FirstGlance]. <br>
-	==Disease==	+	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CD74 OR DHLAG ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
-	[[http://www.uniprot.org/uniprot/HG2A_HUMAN HG2A_HUMAN]] Note=A chromosomal aberration involving CD74 is found in a non-small cell lung tumor. Results in the formation of a CD74-ROS1 chimeric protein.<ref>PMID:12661006</ref>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1iie FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1iie OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1iie RCSB], [http://www.ebi.ac.uk/pdbsum/1iie PDBsum]</span></td></tr>
-		+	</table>
-	==Function==	+	== Disease ==
		+	[[http://www.uniprot.org/uniprot/HG2A_HUMAN HG2A_HUMAN]] Note=A chromosomal aberration involving CD74 is found in a non-small cell lung tumor. Results in the formation of a CD74-ROS1 chimeric protein.<ref>PMID:12661006</ref>
		+	== Function ==
	[[http://www.uniprot.org/uniprot/HG2A_HUMAN HG2A_HUMAN]] Plays a critical role in MHC class II antigen processing by stabilizing peptide-free class II alpha/beta heterodimers in a complex soon after their synthesis and directing transport of the complex from the endoplasmic reticulum to the endosomal/lysosomal system where the antigen processing and binding of antigenic peptides to MHC class II takes place. Serves as cell surface receptor for the cytokine MIF.		[[http://www.uniprot.org/uniprot/HG2A_HUMAN HG2A_HUMAN]] Plays a critical role in MHC class II antigen processing by stabilizing peptide-free class II alpha/beta heterodimers in a complex soon after their synthesis and directing transport of the complex from the endoplasmic reticulum to the endosomal/lysosomal system where the antigen processing and binding of antigenic peptides to MHC class II takes place. Serves as cell surface receptor for the cytokine MIF.
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The invariant chain (Ii) plays a critical role in MHC class II antigen processing by stabilizing peptide-free class II alphabeta heterodimers in a nonameric (alphabetaIi)3 complex soon after their synthesis and directing transport of the complex from the endoplasmic reticulum to compartments where peptide loading of class II takes place. Loading progresses following Ii proteolysis and via an intermediate complex of MHC class II with an Ii-derived peptide, CLIP. CLIP is substituted by exogenous peptidic fragments in an exchange reaction catalyzed by HLA-DM. The CLIP region of Ii, roughly residues 81-104, is one of two segments shown to interact with class II HLA-DR molecules. The other segment, Ii 118-216, is C-terminal to CLIP, mediates trimerization of the ectodomain of Ii and interferes with DM/class II binding. Here we report the three-dimensional structure of this trimeric domain, determined by nuclear magnetic resonance (NMR) studies of a 27 kDa trimer of human Ii 118-192. The cylindrical shape of the molecule and the mapping of conserved residues delimit surfaces which may be important for interactions between Ii and class II molecules.

-	~~==About this~~ Structure==	+	Structure of a trimeric domain of the MHC class II-associated chaperonin and targeting protein Ii.,Jasanoff A, Wagner G, Wiley DC EMBO J. 1998 Dec 1;17(23):6812-8. PMID:9843486<ref>PMID:9843486</ref>
-	~~[[1iie]] is~~ a ~~3 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Homo_sapiens Homo sapiens]~~. ~~Full experimental information is available from [http~~:/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=1IIE OCA].~~	+

-	==~~Reference~~==	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	<references ~~group="xtra"~~/><~~references~~/>	+	</div>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
-	[[Category: Jasanoff, A.]]	+	[[Category: Jasanoff, A]]
-	[[Category: Wagner, G.]]	+	[[Category: Wagner, G]]
-	[[Category: Wiley, D C.]]	+	[[Category: Wiley, D C]]
	[[Category: Antigen processing]]		[[Category: Antigen processing]]
	[[Category: Chaperonin]]		[[Category: Chaperonin]]
	[[Category: Major histocompatibility complex]]		[[Category: Major histocompatibility complex]]
	[[Category: Oligomerization]]		[[Category: Oligomerization]]

OCA at 20:26, 24 March 2013

2013-03-24T20:26:03Z

←Older revision		Revision as of 20:26, 24 March 2013
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-	[[Image:1iie.png\|left\|200px]]
-
	{{STRUCTURE_1iie\| PDB=1iie \| SCENE= }}		{{STRUCTURE_1iie\| PDB=1iie \| SCENE= }}
-
	===HLA-DR ANTIGENS ASSOCIATED INVARIANT CHAIN===		===HLA-DR ANTIGENS ASSOCIATED INVARIANT CHAIN===
-
	{{ABSTRACT_PUBMED_9843486}}		{{ABSTRACT_PUBMED_9843486}}
		+
		+	==Disease==
		+	[[http://www.uniprot.org/uniprot/HG2A_HUMAN HG2A_HUMAN]] Note=A chromosomal aberration involving CD74 is found in a non-small cell lung tumor. Results in the formation of a CD74-ROS1 chimeric protein.<ref>PMID:12661006</ref>
		+
		+	==Function==
		+	[[http://www.uniprot.org/uniprot/HG2A_HUMAN HG2A_HUMAN]] Plays a critical role in MHC class II antigen processing by stabilizing peptide-free class II alpha/beta heterodimers in a complex soon after their synthesis and directing transport of the complex from the endoplasmic reticulum to the endosomal/lysosomal system where the antigen processing and binding of antigenic peptides to MHC class II takes place. Serves as cell surface receptor for the cytokine MIF.

	==About this Structure==		==About this Structure==
	[[1iie]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1IIE OCA].		[[1iie]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1IIE OCA].
		+
		+	==Reference==
		+	<references group="xtra"/><references/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Jasanoff, A.]]		[[Category: Jasanoff, A.]]

OCA: Protected "1iie" [edit=sysop:move=sysop]

2012-11-28T14:49:18Z

Protected "1iie" [edit=sysop:move=sysop]

←Older revision

Revision as of 14:49, 28 November 2012

OCA at 14:49, 28 November 2012

2012-11-28T14:49:14Z

←Older revision		Revision as of 14:49, 28 November 2012
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-	{{Seed}}
	[[Image:1iie.png\|left\|200px]]		[[Image:1iie.png\|left\|200px]]

-	<!--
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	{{STRUCTURE_1iie\| PDB=1iie \| SCENE= }}		{{STRUCTURE_1iie\| PDB=1iie \| SCENE= }}

	===HLA-DR ANTIGENS ASSOCIATED INVARIANT CHAIN===		===HLA-DR ANTIGENS ASSOCIATED INVARIANT CHAIN===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_9843486}}, adds the Publication Abstract to the page
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	{{ABSTRACT_PUBMED_9843486}}		{{ABSTRACT_PUBMED_9843486}}

	==About this Structure==		==About this Structure==
-	~~1IIE is a~~ [[~~Single protein~~]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1IIE OCA].	+	[[1iie]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1IIE OCA].
-		+
-	~~==Reference==~~	+
-	Structure of a trimeric domain of the MHC class II-associated chaperonin and targeting protein Ii., Jasanoff A, Wagner G, Wiley DC, EMBO J. 1998 Dec 1;17(23):6812-8. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/9843486 9843486]	+
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
-	[[Category: Single protein]]
	[[Category: Jasanoff, A.]]		[[Category: Jasanoff, A.]]
	[[Category: Wagner, G.]]		[[Category: Wagner, G.]]
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	[[Category: Major histocompatibility complex]]		[[Category: Major histocompatibility complex]]
	[[Category: Oligomerization]]		[[Category: Oligomerization]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 12:15:59 2008''