1ij3 - Revision history

OCA at 11:23, 2 August 2023

2023-08-02T11:23:04Z

←Older revision		Revision as of 11:23, 2 August 2023
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	<StructureSection load='1ij3' size='340' side='right'caption='[[1ij3]], [[Resolution\|resolution]] 1.80Å' scene=''>		<StructureSection load='1ij3' size='340' side='right'caption='[[1ij3]], [[Resolution\|resolution]] 1.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1ij3]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1IJ3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1IJ3 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1ij3]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae_S288C Saccharomyces cerevisiae S288C]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1IJ3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1IJ3 FirstGlance]. <br>
-	</td></tr><tr id='~~NonStdRes~~'><td class="sblockLbl"><b>[[~~Non~~-~~Standard_Residue~~\|~~NonStd Res~~:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.8Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1ij3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ij3 OCA], [https://pdbe.org/1ij3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1ij3 RCSB], [https://www.ebi.ac.uk/pdbsum/1ij3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1ij3 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1ij3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ij3 OCA], [https://pdbe.org/1ij3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1ij3 RCSB], [https://www.ebi.ac.uk/pdbsum/1ij3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1ij3 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/GCN4_YEAST GCN4_YEAST]] Is a transcription factor that is responsible for the activation of more than 30 genes required for amino acid or for purine biosynthesis in response to amino acid or purine starvation. Binds and recognize the DNA sequence: 5'-TGA[CG]TCA-3'.	+	[https://www.uniprot.org/uniprot/GCN4_YEAST GCN4_YEAST] Is a transcription factor that is responsible for the activation of more than 30 genes required for amino acid or for purine biosynthesis in response to amino acid or purine starvation. Binds and recognize the DNA sequence: 5'-TGA[CG]TCA-3'.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 20:		Line 21:

	==See Also==		==See Also==
		+	*[[Gcn4 3D Structures\|Gcn4 3D Structures]]
	*[[Gnc4 3D Structures\|Gnc4 3D Structures]]		*[[Gnc4 3D Structures\|Gnc4 3D Structures]]
	== References ==		== References ==
Line 26:		Line 28:
	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Akey, D L~~]]	+	[[Category: Saccharomyces cerevisiae S288C]]
-	[[Category: ~~Kim, P S~~]]	+	[[Category: Akey DL]]
-	[[Category: ~~Malashkevich, V N~~]]	+	[[Category: Kim PS]]
-	[[Category: ~~Gcn4 coiled coil]]~~	+	[[Category: Malashkevich VN]]
-	~~[[Category: Transcription~~]]	+

OCA at 07:43, 7 April 2021

2021-04-07T07:43:46Z

←Older revision		Revision as of 07:43, 7 April 2021
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	<StructureSection load='1ij3' size='340' side='right'caption='[[1ij3]], [[Resolution\|resolution]] 1.80Å' scene=''>		<StructureSection load='1ij3' size='340' side='right'caption='[[1ij3]], [[Resolution\|resolution]] 1.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1ij3]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1IJ3 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1IJ3 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1ij3]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1IJ3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1IJ3 FirstGlance]. <br>
	</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene></td></tr>		</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1ij3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ij3 OCA], [~~http~~://pdbe.org/1ij3 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=1ij3 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/1ij3 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=1ij3 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1ij3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ij3 OCA], [https://pdbe.org/1ij3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1ij3 RCSB], [https://www.ebi.ac.uk/pdbsum/1ij3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1ij3 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/GCN4_YEAST GCN4_YEAST]] Is a transcription factor that is responsible for the activation of more than 30 genes required for amino acid or for purine biosynthesis in response to amino acid or purine starvation. Binds and recognize the DNA sequence: 5'-TGA[CG]TCA-3'.	+	[[https://www.uniprot.org/uniprot/GCN4_YEAST GCN4_YEAST]] Is a transcription factor that is responsible for the activation of more than 30 genes required for amino acid or for purine biosynthesis in response to amino acid or purine starvation. Binds and recognize the DNA sequence: 5'-TGA[CG]TCA-3'.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 20:		Line 20:

	==See Also==		==See Also==
-	*[[~~Gcn4~~\|~~Gcn4~~]]	+	*[[Gnc4 3D Structures\|Gnc4 3D Structures]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 07:13, 3 July 2019

2019-07-03T07:13:26Z

←Older revision		Revision as of 07:13, 3 July 2019
Line 1:		Line 1:

	==GCN4-pVSL Coiled-coil trimer with Serine at the a(16) position==		==GCN4-pVSL Coiled-coil trimer with Serine at the a(16) position==
-	<StructureSection load='1ij3' size='340' side='right' caption='[[1ij3]], [[Resolution\|resolution]] 1.80Å' scene=''>	+	<StructureSection load='1ij3' size='340' side='right'caption='[[1ij3]], [[Resolution\|resolution]] 1.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1ij3]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1IJ3 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1IJ3 FirstGlance]. <br>		<table><tr><td colspan='2'>[[1ij3]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1IJ3 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1IJ3 FirstGlance]. <br>
Line 25:		Line 25:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Akey, D L]]		[[Category: Akey, D L]]
	[[Category: Kim, P S]]		[[Category: Kim, P S]]

OCA at 10:40, 27 September 2017

2017-09-27T10:40:58Z

←Older revision		Revision as of 10:40, 27 September 2017
Line 1:		Line 1:
		+
	==GCN4-pVSL Coiled-coil trimer with Serine at the a(16) position==		==GCN4-pVSL Coiled-coil trimer with Serine at the a(16) position==
	<StructureSection load='1ij3' size='340' side='right' caption='[[1ij3]], [[Resolution\|resolution]] 1.80Å' scene=''>		<StructureSection load='1ij3' size='340' side='right' caption='[[1ij3]], [[Resolution\|resolution]] 1.80Å' scene=''>
Line 4:		Line 5:
	<table><tr><td colspan='2'>[[1ij3]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1IJ3 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1IJ3 FirstGlance]. <br>		<table><tr><td colspan='2'>[[1ij3]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1IJ3 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1IJ3 FirstGlance]. <br>
	</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene></td></tr>		</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ij3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ij3 OCA], [http://pdbe.org/1ij3 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1ij3 RCSB], [http://www.ebi.ac.uk/pdbsum/1ij3 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ij3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ij3 OCA], [http://pdbe.org/1ij3 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1ij3 RCSB], [http://www.ebi.ac.uk/pdbsum/1ij3 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1ij3 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==

OCA at 11:37, 10 September 2015

2015-09-10T11:37:55Z

←Older revision		Revision as of 11:37, 10 September 2015
Line 4:		Line 4:
	<table><tr><td colspan='2'>[[1ij3]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1IJ3 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1IJ3 FirstGlance]. <br>		<table><tr><td colspan='2'>[[1ij3]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1IJ3 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1IJ3 FirstGlance]. <br>
	</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene></td></tr>		</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ij3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ij3 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1ij3 RCSB], [http://www.ebi.ac.uk/pdbsum/1ij3 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ij3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ij3 OCA], [http://pdbe.org/1ij3 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1ij3 RCSB], [http://www.ebi.ac.uk/pdbsum/1ij3 PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 16:		Line 16:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 1ij3" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==

OCA at 23:21, 24 December 2014

2014-12-24T23:21:34Z

←Older revision		Revision as of 23:21, 24 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1ij3]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1IJ3 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1IJ3 FirstGlance]. <br>		<table><tr><td colspan='2'>[[1ij3]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1IJ3 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1IJ3 FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene></td></tr>	+	</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene></td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ij3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ij3 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1ij3 RCSB], [http://www.ebi.ac.uk/pdbsum/1ij3 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ij3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ij3 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1ij3 RCSB], [http://www.ebi.ac.uk/pdbsum/1ij3 PDBsum]</span></td></tr>
-	<table>	+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/GCN4_YEAST GCN4_YEAST]] Is a transcription factor that is responsible for the activation of more than 30 genes required for amino acid or for purine biosynthesis in response to amino acid or purine starvation. Binds and recognize the DNA sequence: 5'-TGA[CG]TCA-3'.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 21:		Line 23:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Akey, D L.]]	+	[[Category: Akey, D L]]
-	[[Category: Kim, P S.]]	+	[[Category: Kim, P S]]
-	[[Category: Malashkevich, V N.]]	+	[[Category: Malashkevich, V N]]
	[[Category: Gcn4 coiled coil]]		[[Category: Gcn4 coiled coil]]
	[[Category: Transcription]]		[[Category: Transcription]]

OCA at 09:58, 28 September 2014

2014-09-28T09:58:42Z

←Older revision		Revision as of 09:58, 28 September 2014
Line 1:		Line 1:
-	[[~~Image:~~1ij3.~~png~~\|~~left\|200px~~]]	+	==GCN4-pVSL Coiled-coil trimer with Serine at the a(16) position==
		+	<StructureSection load='1ij3' size='340' side='right' caption='[[1ij3]], [[Resolution\|resolution]] 1.80Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[1ij3]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1IJ3 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1IJ3 FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene></td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ij3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ij3 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1ij3 RCSB], [http://www.ebi.ac.uk/pdbsum/1ij3 PDBsum]</span></td></tr>
		+	<table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Coiled coils, estimated to constitute 3-5% of the encoded residues in most genomes, are characterized by a heptad repeat, (abcdefg)(n), where the buried a and d positions form the interface between multiple alpha-helices. Although generally hydrophobic, a substantial fraction ( approximately 20%) of these a- and d-position residues are polar or charged. We constructed variants of the well-characterized coiled coil GCN4-p1 with a single polar residue (Asn, Gln, Ser, or Thr) at either an a or a d position. The stability and oligomeric specificity of each variant were measured, and crystal structures of coiled-coil trimers with threonine or serine at either an a or a d position were determined. The structures show how single polar residues in the interface affect not only local packing, but also overall coiled-coil geometry as seen by changes in the Crick supercoil parameters and core cavity volumes.

-	~~{{STRUCTURE_1ij3\| PDB=1ij3 \| SCENE= }}~~	+	Buried polar residues in coiled-coil interfaces.,Akey DL, Malashkevich VN, Kim PS Biochemistry. 2001 May 29;40(21):6352-60. PMID:11371197<ref>PMID:11371197</ref>

-	~~===GCN4-pVSL Coiled-coil trimer with Serine at the~~ a~~(16) position===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>

-	~~{{ABSTRACT_PUBMED_11371197}}~~	+	==See Also==
-		+	*[[Gcn4\|Gcn4]]
-	==~~About this Structure~~==	+	== References ==
-	[[~~1ij3~~]] ~~is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1IJ3 OCA].~~	+	<references/>
-		+	__TOC__
-	==~~Reference~~==	+	</StructureSection>
-	<~~ref group="xtra">PMID:011371197<~~/~~ref~~><~~references group="xtra"~~/>	+
	[[Category: Akey, D L.]]		[[Category: Akey, D L.]]
	[[Category: Kim, P S.]]		[[Category: Kim, P S.]]

OCA: Protected "1ij3" [edit=sysop:move=sysop]

2012-11-28T14:55:28Z

Protected "1ij3" [edit=sysop:move=sysop]

←Older revision

Revision as of 14:55, 28 November 2012

OCA at 14:55, 28 November 2012

2012-11-28T14:55:25Z

←Older revision		Revision as of 14:55, 28 November 2012
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-	{{Seed}}
	[[Image:1ij3.png\|left\|200px]]		[[Image:1ij3.png\|left\|200px]]

-	<!--
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	{{STRUCTURE_1ij3\| PDB=1ij3 \| SCENE= }}		{{STRUCTURE_1ij3\| PDB=1ij3 \| SCENE= }}

	===GCN4-pVSL Coiled-coil trimer with Serine at the a(16) position===		===GCN4-pVSL Coiled-coil trimer with Serine at the a(16) position===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_11371197}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 11371197 is the PubMed ID number.
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	{{ABSTRACT_PUBMED_11371197}}		{{ABSTRACT_PUBMED_11371197}}

	==About this Structure==		==About this Structure==
-	~~1IJ3 is a~~ [[~~Single protein~~]] structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1IJ3 OCA].	+	[[1ij3]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1IJ3 OCA].

	==Reference==		==Reference==
-	~~Buried polar residues in coiled-coil interfaces., Akey DL, Malashkevich VN, Kim PS, Biochemistry. 2001 May 29;40(21):6352-60.~~ PMID:~~[http:~~//~~www.ncbi.nlm.nih.gov/pubmed/11371197 11371197]~~	+	<ref group="xtra">PMID:011371197</ref><references group="xtra"/>
-	~~[[Category: Single protein]]~~	+
	[[Category: Akey, D L.]]		[[Category: Akey, D L.]]
	[[Category: Kim, P S.]]		[[Category: Kim, P S.]]
	[[Category: Malashkevich, V N.]]		[[Category: Malashkevich, V N.]]
	[[Category: Gcn4 coiled coil]]		[[Category: Gcn4 coiled coil]]
-		+	[[Category: Transcription]]
-	~~''Page seeded by~~ [~~http~~:~~//oca.weizmann.ac.il/oca OCA~~ ] ~~on Tue Jul 1 12:18:29 2008''~~	+

OCA at 09:18, 1 July 2008

2008-07-01T09:18:30Z

←Older revision		Revision as of 09:18, 1 July 2008
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-	[[Image:1ij3.~~jpg~~\|left\|200px]]	+	{{Seed}}
		+	[[Image:1ij3.png\|left\|200px]]

	<!--		<!--
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	{{STRUCTURE_1ij3\| PDB=1ij3 \| SCENE= }}		{{STRUCTURE_1ij3\| PDB=1ij3 \| SCENE= }}

-	~~'''~~GCN4-pVSL Coiled-coil trimer with Serine at the a(16) position~~'''~~	+	===GCN4-pVSL Coiled-coil trimer with Serine at the a(16) position===


-	~~==Overview==~~	+	<!--
-	~~Coiled coils~~, ~~estimated~~ to ~~constitute 3-5% of~~ the ~~encoded residues in most genomes, are characterized by a heptad repeat,~~ (~~abcdefg)(n~~), where the ~~buried a and d positions form the interface between multiple alpha-helices~~. ~~Although generally hydrophobic, a substantial fraction ( approximately 20%) of these a~~- ~~and d~~-position residues are polar or charged. We constructed variants of the well-characterized coiled coil GCN4-p1 with a single polar residue (Asn, Gln, Ser, or Thr) at either an a or a d position. The stability and oligomeric specificity of each variant were measured, and crystal structures of coiled-coil trimers with threonine or serine at either an a or a d position were determined. The structures show how single polar residues in the interface affect not only local packing, but also overall coiled-coil geometry as seen by changes in the Crick supercoil parameters and core cavity volumes.	+	The line below this paragraph, {{ABSTRACT_PUBMED_11371197}}, adds the Publication Abstract to the page
		+	(as it appears on PubMed at http://www.pubmed.gov), where 11371197 is the PubMed ID number.
		+	-->
		+	{{ABSTRACT_PUBMED_11371197}}

	==About this Structure==		==About this Structure==
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	[[Category: Malashkevich, V N.]]		[[Category: Malashkevich, V N.]]
	[[Category: Gcn4 coiled coil]]		[[Category: Gcn4 coiled coil]]
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Fri May~~ ~~2 20~~:03:32 2008''	+
		+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 12:18:29 2008''