1j2m - Revision history

OCA at 23:41, 27 December 2023

2023-12-27T23:41:12Z

←Older revision		Revision as of 23:41, 27 December 2023
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	==Solution structure of CPI-17(22-120)==		==Solution structure of CPI-17(22-120)==
-	<StructureSection load='1j2m' size='340' side='right'caption='[[1j2m~~]], [[NMR_Ensembles_of_Models \| 1 NMR models~~]]' scene=''>	+	<StructureSection load='1j2m' size='340' side='right'caption='[[1j2m]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1j2m]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Pig Pig~~]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1J2M OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1J2M FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1j2m]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Sus_scrofa Sus scrofa]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1J2M OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1J2M FirstGlance]. <br>
-	</td></tr><tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"~~><div style~~=~~'overflow: auto; max-height: 3em;'>[[1j2n\|1j2n]]</div~~></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1j2m FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1j2m OCA], [https://pdbe.org/1j2m PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1j2m RCSB], [https://www.ebi.ac.uk/pdbsum/1j2m PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1j2m ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1j2m FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1j2m OCA], [https://pdbe.org/1j2m PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1j2m RCSB], [https://www.ebi.ac.uk/pdbsum/1j2m PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1j2m ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/PP14A_PIG PP14A_PIG]] Inhibitor of PPP1CA. Has over 1000-fold higher inhibitory activity when phosphorylated, creating a molecular switch for regulating the phosphorylation status of PPP1CA substrates and smooth muscle contraction.<ref>PMID:9237662</ref> <ref>PMID:8720121</ref> <ref>PMID:10924361</ref> <ref>PMID:10869555</ref>	+	[https://www.uniprot.org/uniprot/PP14A_PIG PP14A_PIG] Inhibitor of PPP1CA. Has over 1000-fold higher inhibitory activity when phosphorylated, creating a molecular switch for regulating the phosphorylation status of PPP1CA substrates and smooth muscle contraction.<ref>PMID:9237662</ref> <ref>PMID:8720121</ref> <ref>PMID:10924361</ref> <ref>PMID:10869555</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 33:		Line 33:
	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Pig~~]]	+	[[Category: Sus scrofa]]
-	[[Category: Brautigan~~, D L~~]]	+	[[Category: Brautigan DL]]
-	[[Category: Eto, M]]	+	[[Category: Eto M]]
-	[[Category: Kainosho, M]]	+	[[Category: Kainosho M]]
-	[[Category: Ohki, S]]	+	[[Category: Ohki S]]
-	[[Category: Shimizu, M]]	+	[[Category: Shimizu M]]
-	[[Category: Takada, R]]	+	[[Category: Takada R]]
-	~~[[Category: Helix bundle]]~~	+
-	~~[[Category: Protein binding~~]]	+

OCA at 07:15, 14 April 2021

2021-04-14T07:15:56Z

←Older revision		Revision as of 07:15, 14 April 2021
Line 3:		Line 3:
	<StructureSection load='1j2m' size='340' side='right'caption='[[1j2m]], [[NMR_Ensembles_of_Models \| 1 NMR models]]' scene=''>		<StructureSection load='1j2m' size='340' side='right'caption='[[1j2m]], [[NMR_Ensembles_of_Models \| 1 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1j2m]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Pig Pig]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1J2M OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1J2M FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1j2m]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Pig Pig]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1J2M OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1J2M FirstGlance]. <br>
-	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1j2n\|1j2n]]</td></tr>	+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1j2n\|1j2n]]</div></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1j2m FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1j2m OCA], [~~http~~://pdbe.org/1j2m PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=1j2m RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/1j2m PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=1j2m ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1j2m FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1j2m OCA], [https://pdbe.org/1j2m PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1j2m RCSB], [https://www.ebi.ac.uk/pdbsum/1j2m PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1j2m ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/PP14A_PIG PP14A_PIG]] Inhibitor of PPP1CA. Has over 1000-fold higher inhibitory activity when phosphorylated, creating a molecular switch for regulating the phosphorylation status of PPP1CA substrates and smooth muscle contraction.<ref>PMID:9237662</ref> <ref>PMID:8720121</ref> <ref>PMID:10924361</ref> <ref>PMID:10869555</ref>	+	[[https://www.uniprot.org/uniprot/PP14A_PIG PP14A_PIG]] Inhibitor of PPP1CA. Has over 1000-fold higher inhibitory activity when phosphorylated, creating a molecular switch for regulating the phosphorylation status of PPP1CA substrates and smooth muscle contraction.<ref>PMID:9237662</ref> <ref>PMID:8720121</ref> <ref>PMID:10924361</ref> <ref>PMID:10869555</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]

OCA at 06:56, 10 July 2019

2019-07-10T06:56:30Z

←Older revision		Revision as of 06:56, 10 July 2019
Line 1:		Line 1:

	==Solution structure of CPI-17(22-120)==		==Solution structure of CPI-17(22-120)==
-	<StructureSection load='1j2m' size='340' side='right' caption='[[1j2m]], [[NMR_Ensembles_of_Models \| 1 NMR models]]' scene=''>	+	<StructureSection load='1j2m' size='340' side='right'caption='[[1j2m]], [[NMR_Ensembles_of_Models \| 1 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1j2m]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Pig Pig]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1J2M OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1J2M FirstGlance]. <br>		<table><tr><td colspan='2'>[[1j2m]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Pig Pig]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1J2M OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1J2M FirstGlance]. <br>
Line 13:		Line 13:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/j2/1j2m_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/j2/1j2m_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
Line 32:		Line 32:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Pig]]		[[Category: Pig]]
	[[Category: Brautigan, D L]]		[[Category: Brautigan, D L]]

OCA at 09:47, 4 October 2017

2017-10-04T09:47:32Z

←Older revision		Revision as of 09:47, 4 October 2017
Line 1:		Line 1:
		+
	==Solution structure of CPI-17(22-120)==		==Solution structure of CPI-17(22-120)==
	<StructureSection load='1j2m' size='340' side='right' caption='[[1j2m]], [[NMR_Ensembles_of_Models \| 1 NMR models]]' scene=''>		<StructureSection load='1j2m' size='340' side='right' caption='[[1j2m]], [[NMR_Ensembles_of_Models \| 1 NMR models]]' scene=''>
Line 4:		Line 5:
	<table><tr><td colspan='2'>[[1j2m]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Pig Pig]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1J2M OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1J2M FirstGlance]. <br>		<table><tr><td colspan='2'>[[1j2m]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Pig Pig]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1J2M OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1J2M FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1j2n\|1j2n]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1j2n\|1j2n]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1j2m FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1j2m OCA], [http://pdbe.org/1j2m PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1j2m RCSB], [http://www.ebi.ac.uk/pdbsum/1j2m PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1j2m FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1j2m OCA], [http://pdbe.org/1j2m PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1j2m RCSB], [http://www.ebi.ac.uk/pdbsum/1j2m PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1j2m ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 16:		Line 17:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1j2m ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 16:37, 11 September 2015

2015-09-11T16:37:25Z

←Older revision		Revision as of 16:37, 11 September 2015
Line 2:		Line 2:
	<StructureSection load='1j2m' size='340' side='right' caption='[[1j2m]], [[NMR_Ensembles_of_Models \| 1 NMR models]]' scene=''>		<StructureSection load='1j2m' size='340' side='right' caption='[[1j2m]], [[NMR_Ensembles_of_Models \| 1 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1j2m]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Sus_scrofa Sus scrofa~~]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1J2M OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1J2M FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1j2m]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Pig Pig]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1J2M OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1J2M FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1j2n\|1j2n]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1j2n\|1j2n]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1j2m FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1j2m OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1j2m RCSB], [http://www.ebi.ac.uk/pdbsum/1j2m PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1j2m FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1j2m OCA], [http://pdbe.org/1j2m PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1j2m RCSB], [http://www.ebi.ac.uk/pdbsum/1j2m PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 26:		Line 26:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 1j2m" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Sus scrofa~~]]	+	[[Category: Pig]]
	[[Category: Brautigan, D L]]		[[Category: Brautigan, D L]]
	[[Category: Eto, M]]		[[Category: Eto, M]]

OCA at 19:06, 25 December 2014

2014-12-25T19:06:16Z

←Older revision		Revision as of 19:06, 25 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1j2m]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Sus_scrofa Sus scrofa]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1J2M OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1J2M FirstGlance]. <br>		<table><tr><td colspan='2'>[[1j2m]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Sus_scrofa Sus scrofa]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1J2M OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1J2M FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1j2n\|1j2n]]</td></tr>	+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1j2n\|1j2n]]</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1j2m FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1j2m OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1j2m RCSB], [http://www.ebi.ac.uk/pdbsum/1j2m PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1j2m FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1j2m OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1j2m RCSB], [http://www.ebi.ac.uk/pdbsum/1j2m PDBsum]</span></td></tr>
-	<table>	+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/PP14A_PIG PP14A_PIG]] Inhibitor of PPP1CA. Has over 1000-fold higher inhibitory activity when phosphorylated, creating a molecular switch for regulating the phosphorylation status of PPP1CA substrates and smooth muscle contraction.<ref>PMID:9237662</ref> <ref>PMID:8720121</ref> <ref>PMID:10924361</ref> <ref>PMID:10869555</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 29:		Line 31:
	</StructureSection>		</StructureSection>
	[[Category: Sus scrofa]]		[[Category: Sus scrofa]]
-	[[Category: Brautigan, D L.]]	+	[[Category: Brautigan, D L]]
-	[[Category: Eto, M.]]	+	[[Category: Eto, M]]
-	[[Category: Kainosho, M.]]	+	[[Category: Kainosho, M]]
-	[[Category: Ohki, S.]]	+	[[Category: Ohki, S]]
-	[[Category: Shimizu, M.]]	+	[[Category: Shimizu, M]]
-	[[Category: Takada, R.]]	+	[[Category: Takada, R]]
	[[Category: Helix bundle]]		[[Category: Helix bundle]]
	[[Category: Protein binding]]		[[Category: Protein binding]]

OCA at 08:25, 28 September 2014

2014-09-28T08:25:35Z

←Older revision		Revision as of 08:25, 28 September 2014
Line 1:		Line 1:
-	[[~~Image:~~1j2m.~~png~~\|~~left~~\|200px]]	+	==Solution structure of CPI-17(22-120)==
		+	<StructureSection load='1j2m' size='340' side='right' caption='[[1j2m]], [[NMR_Ensembles_of_Models \| 1 NMR models]]' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[1j2m]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Sus_scrofa Sus scrofa]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1J2M OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1J2M FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1j2n\|1j2n]]</td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1j2m FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1j2m OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1j2m RCSB], [http://www.ebi.ac.uk/pdbsum/1j2m PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/j2/1j2m_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	We present solution NMR structures for wild-type and mutated forms of CPI-17, a phosphoinhibitor for protein phosphatase 1. Phosphorylation of Thr38 of CPI-17 produces a >1000-fold increase in inhibitory potency for myosin phosphatase. We compared the 1H-15N heteronuclear single quantum coherence spectroscopy (HSQC) chemical shifts of wild-type CPI-17, partially phosphorylated CPI-17 and CPI-17 with Thr38 replaced with Asp to introduce a negative charge. There was a switch in the protein conformation due to either Asp substitution or phosphorylation, so we determined the solution NMR structure of the CPI-17 T38D mutant as a model for the active (phospho-) conformation. The structures reveal a molecular switch in conformation that involves the rotation of two of the four helices in the four helix bundle. Despite this conformational switch, there was little increase in the inhibitory potency with T38D. We propose that for this inhibitor, a negative charge at residue 38 is sufficient to trigger an active conformation, but a phosphoryl group is required for full inhibitory potency against protein phosphatase-1.

-	~~{{STRUCTURE_1j2m\| PDB=1j2m \| SCENE= }}~~	+	Distinctive solution conformation of phosphatase inhibitor CPI-17 substituted with aspartate at the phosphorylation-site threonine residue.,Ohki S, Eto M, Shimizu M, Takada R, Brautigan DL, Kainosho M J Mol Biol. 2003 Mar 7;326(5):1539-47. PMID:12595264<ref>PMID:12595264</ref>

-	~~===Solution structure~~ of ~~CPI-17(22-120)===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_12595264}}~~	+	== References ==
-		+	<references/>
-	~~==About this Structure==~~	+	__TOC__
-	~~[[1j2m]] is a 1 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Sus_scrofa Sus scrofa]~~. ~~Full experimental information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=1J2M OCA].~~	+	</StructureSection>
-		+
-	==~~Reference~~==	+
-	<~~ref group="xtra">PMID:012595264<~~/~~ref~~><~~references group="xtra"~~/>	+
	[[Category: Sus scrofa]]		[[Category: Sus scrofa]]
	[[Category: Brautigan, D L.]]		[[Category: Brautigan, D L.]]

OCA: Protected "1j2m" [edit=sysop:move=sysop]

2012-11-28T15:00:25Z

Protected "1j2m" [edit=sysop:move=sysop]

←Older revision

Revision as of 15:00, 28 November 2012

OCA at 15:00, 28 November 2012

2012-11-28T15:00:23Z

←Older revision		Revision as of 15:00, 28 November 2012
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-	{{Seed}}
	[[Image:1j2m.png\|left\|200px]]		[[Image:1j2m.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_1j2m", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_1j2m\| PDB=1j2m \| SCENE= }}		{{STRUCTURE_1j2m\| PDB=1j2m \| SCENE= }}

	===Solution structure of CPI-17(22-120)===		===Solution structure of CPI-17(22-120)===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_12595264}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 12595264 is the PubMed ID number.
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	{{ABSTRACT_PUBMED_12595264}}		{{ABSTRACT_PUBMED_12595264}}

	==About this Structure==		==About this Structure==
-	~~1J2M~~ is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Sus_scrofa Sus scrofa]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1J2M OCA].	+	[[1j2m]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Sus_scrofa Sus scrofa]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1J2M OCA].

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~12595264~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:012595264</ref><references group="xtra"/>
	[[Category: Sus scrofa]]		[[Category: Sus scrofa]]
	[[Category: Brautigan, D L.]]		[[Category: Brautigan, D L.]]
Line 32:		Line 20:
	[[Category: Takada, R.]]		[[Category: Takada, R.]]
	[[Category: Helix bundle]]		[[Category: Helix bundle]]
-		+	[[Category: Protein binding]]
-	~~''Page seeded by~~ [~~http~~:~~//oca.weizmann.ac.il/oca OCA~~ ] ~~on Wed Feb 18 03:57:34 2009''~~	+

OCA at 01:57, 18 February 2009

2009-02-18T01:57:35Z

←Older revision		Revision as of 01:57, 18 February 2009
Line 20:		Line 20:

	==About this Structure==		==About this Structure==
-	1J2M is a ~~[[Single protein]]~~ structure of sequence from [http://en.wikipedia.org/wiki/Sus_scrofa Sus scrofa]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1J2M OCA].	+	1J2M is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Sus_scrofa Sus scrofa]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1J2M OCA].

	==Reference==		==Reference==
-	Distinctive solution conformation of phosphatase inhibitor CPI-17 substituted with aspartate at the phosphorylation-site threonine residue., Ohki S, Eto M, Shimizu M, Takada R, Brautigan DL, Kainosho M, J Mol Biol. 2003 Mar 7;326(5):1539-47. PMID:~~[http:~~//~~www.ncbi.nlm.nih.gov/pubmed/12595264 12595264]~~	+	<ref group="xtra">PMID:12595264</ref><references group="xtra"/>
-	~~[[Category: Single protein]]~~	+
	[[Category: Sus scrofa]]		[[Category: Sus scrofa]]
	[[Category: Brautigan, D L.]]		[[Category: Brautigan, D L.]]
Line 34:		Line 33:
	[[Category: Helix bundle]]		[[Category: Helix bundle]]

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Tue Jul 1 14~~:24:~~22 2008~~''	+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Feb 18 03:57:34 2009''