1jfp - Revision history

OCA at 07:51, 3 April 2024

2024-04-03T07:51:50Z

←Older revision		Revision as of 07:51, 3 April 2024
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	==Structure of bovine rhodopsin (dark adapted)==		==Structure of bovine rhodopsin (dark adapted)==
-	<StructureSection load='1jfp' size='340' side='right'caption='[[1jfp~~]], [[NMR_Ensembles_of_Models \| 1 NMR models~~]]' scene=''>	+	<StructureSection load='1jfp' size='340' side='right'caption='[[1jfp]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1jfp]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JFP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1JFP FirstGlance]. <br>		<table><tr><td colspan='2'>[[1jfp]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JFP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1JFP FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=RET:RETINAL'>RET</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
-	<tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"><~~div style~~='~~overflow~~: ~~auto; max-height: 3em;~~'>~~[[1eds\|1eds]], [[1edv\|1edv]], [[1edw\|1edw]], [[1edx\|1edx]], [[1fdf\|1fdf]]~~</~~div~~></td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=RET:RETINAL'>RET</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1jfp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1jfp OCA], [https://pdbe.org/1jfp PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1jfp RCSB], [https://www.ebi.ac.uk/pdbsum/1jfp PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1jfp ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1jfp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1jfp OCA], [https://pdbe.org/1jfp PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1jfp RCSB], [https://www.ebi.ac.uk/pdbsum/1jfp PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1jfp ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/OPSD_BOVIN OPSD_BOVIN]] Photoreceptor required for image-forming vision at low light intensity. Required for photoreceptor cell viability after birth. Light-induced isomerization of 11-cis to all-trans retinal triggers a conformational change leading to G-protein activation and release of all-trans retinal (By similarity).<ref>PMID:16908857</ref> <ref>PMID:17060607</ref>	+	[https://www.uniprot.org/uniprot/OPSD_BOVIN OPSD_BOVIN] Photoreceptor required for image-forming vision at low light intensity. Required for photoreceptor cell viability after birth. Light-induced isomerization of 11-cis to all-trans retinal triggers a conformational change leading to G-protein activation and release of all-trans retinal (By similarity).<ref>PMID:16908857</ref> <ref>PMID:17060607</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 20:		Line 20:
	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1jfp ConSurf].		</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1jfp ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
-	<div style="background-color:#fffaf0;">
-	== Publication Abstract from PubMed ==
-	Activation of G-protein coupled receptors (GPCR) is not yet understood. A recent structure showed most of rhodopsin in the ground (not activated) state of the GPCR, but the cytoplasmic face, which couples to the G protein in signal transduction, was not well-defined. We have determined an experimental three-dimensional structure for rhodopsin in the unactivated state, which shows good agreement with the crystal structure in the transmembrane domain. This new structure defines the cytoplasmic face of rhodopsin. The G-protein binding site can be mapped. The same experimental approach yields a preliminary structure of the cytoplasmic face in the activated (metarhodopsin II) receptor. Differences between the two structures suggest how the receptor is activated to couple with transducin.
-
-	Studies on the structure of the G-protein-coupled receptor rhodopsin including the putative G-protein binding site in unactivated and activated forms.,Yeagle PL, Choi G, Albert AD Biochemistry. 2001 Oct 2;40(39):11932-7. PMID:11570894<ref>PMID:11570894</ref>
-
-	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	</div>
-	<div class="pdbe-citations 1jfp" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 39:		Line 30:
	[[Category: Bos taurus]]		[[Category: Bos taurus]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Albert~~, A D~~]]	+	[[Category: Albert AD]]
-	[[Category: Choi, G]]	+	[[Category: Choi G]]
-	[[Category: Yeagle~~, P L]]~~	+	[[Category: Yeagle PL]]
-	~~[[Category: G-protein coupled receptor]]~~	+
-	~~[[Category: Membrane protein]]~~	+
-	~~[[Category: Signaling protein~~]]	+

OCA at 06:40, 11 August 2021

2021-08-11T06:40:08Z

←Older revision		Revision as of 06:40, 11 August 2021
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	<StructureSection load='1jfp' size='340' side='right'caption='[[1jfp]], [[NMR_Ensembles_of_Models \| 1 NMR models]]' scene=''>		<StructureSection load='1jfp' size='340' side='right'caption='[[1jfp]], [[NMR_Ensembles_of_Models \| 1 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1jfp]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JFP OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1JFP FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1jfp]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JFP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1JFP FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=RET:RETINAL'>RET</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=RET:RETINAL'>RET</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1eds\|1eds]], [[1edv\|1edv]], [[1edw\|1edw]], [[1edx\|1edx]], [[1fdf\|1fdf]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1eds\|1eds]], [[1edv\|1edv]], [[1edw\|1edw]], [[1edx\|1edx]], [[1fdf\|1fdf]]</div></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1jfp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1jfp OCA], [~~http~~://pdbe.org/1jfp PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=1jfp RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/1jfp PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=1jfp ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1jfp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1jfp OCA], [https://pdbe.org/1jfp PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1jfp RCSB], [https://www.ebi.ac.uk/pdbsum/1jfp PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1jfp ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/OPSD_BOVIN OPSD_BOVIN]] Photoreceptor required for image-forming vision at low light intensity. Required for photoreceptor cell viability after birth. Light-induced isomerization of 11-cis to all-trans retinal triggers a conformational change leading to G-protein activation and release of all-trans retinal (By similarity).<ref>PMID:16908857</ref> <ref>PMID:17060607</ref>	+	[[https://www.uniprot.org/uniprot/OPSD_BOVIN OPSD_BOVIN]] Photoreceptor required for image-forming vision at low light intensity. Required for photoreceptor cell viability after birth. Light-induced isomerization of 11-cis to all-trans retinal triggers a conformational change leading to G-protein activation and release of all-trans retinal (By similarity).<ref>PMID:16908857</ref> <ref>PMID:17060607</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 32:		Line 32:
	==See Also==		==See Also==
	*[[Rhodopsin\|Rhodopsin]]		*[[Rhodopsin\|Rhodopsin]]
-	*[[Rhodopsin ~~Structure and Function~~\|Rhodopsin ~~Structure and Function~~]]	+	*[[Rhodopsin 3D structures\|Rhodopsin 3D structures]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 09:45, 6 November 2019

2019-11-06T09:45:39Z

←Older revision		Revision as of 09:45, 6 November 2019
Line 1:		Line 1:

	==Structure of bovine rhodopsin (dark adapted)==		==Structure of bovine rhodopsin (dark adapted)==
-	<StructureSection load='1jfp' size='340' side='right' caption='[[1jfp]], [[NMR_Ensembles_of_Models \| 1 NMR models]]' scene=''>	+	<StructureSection load='1jfp' size='340' side='right'caption='[[1jfp]], [[NMR_Ensembles_of_Models \| 1 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1jfp]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JFP OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1JFP FirstGlance]. <br>		<table><tr><td colspan='2'>[[1jfp]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JFP OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1JFP FirstGlance]. <br>
Line 29:		Line 29:
	</div>		</div>
	<div class="pdbe-citations 1jfp" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 1jfp" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Rhodopsin\|Rhodopsin]]
		+	*[[Rhodopsin Structure and Function\|Rhodopsin Structure and Function]]
	== References ==		== References ==
	<references/>		<references/>
Line 34:		Line 38:
	</StructureSection>		</StructureSection>
	[[Category: Bos taurus]]		[[Category: Bos taurus]]
		+	[[Category: Large Structures]]
	[[Category: Albert, A D]]		[[Category: Albert, A D]]
	[[Category: Choi, G]]		[[Category: Choi, G]]

OCA at 09:21, 17 January 2018

2018-01-17T09:21:52Z

←Older revision		Revision as of 09:21, 17 January 2018
Line 1:		Line 1:
		+
	==Structure of bovine rhodopsin (dark adapted)==		==Structure of bovine rhodopsin (dark adapted)==
	<StructureSection load='1jfp' size='340' side='right' caption='[[1jfp]], [[NMR_Ensembles_of_Models \| 1 NMR models]]' scene=''>		<StructureSection load='1jfp' size='340' side='right' caption='[[1jfp]], [[NMR_Ensembles_of_Models \| 1 NMR models]]' scene=''>
Line 5:		Line 6:
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=RET:RETINAL'>RET</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=RET:RETINAL'>RET</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1eds\|1eds]], [[1edv\|1edv]], [[1edw\|1edw]], [[1edx\|1edx]], [[1fdf\|1fdf]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1eds\|1eds]], [[1edv\|1edv]], [[1edw\|1edw]], [[1edx\|1edx]], [[1fdf\|1fdf]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1jfp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1jfp OCA], [http://pdbe.org/1jfp PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1jfp RCSB], [http://www.ebi.ac.uk/pdbsum/1jfp PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1jfp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1jfp OCA], [http://pdbe.org/1jfp PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1jfp RCSB], [http://www.ebi.ac.uk/pdbsum/1jfp PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1jfp ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
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	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/jf/1jfp_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/jf/1jfp_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
Line 28:		Line 29:
	</div>		</div>
	<div class="pdbe-citations 1jfp" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 1jfp" style="background-color:#fffaf0;"></div>
-
-	==See Also==
-	*[[Rhodopsin\|Rhodopsin]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 19:39, 9 February 2016

2016-02-09T19:39:25Z

←Older revision		Revision as of 19:39, 9 February 2016
Line 17:		Line 17:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1jfp ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 01:26, 11 September 2015

2015-09-11T01:26:01Z

←Older revision		Revision as of 01:26, 11 September 2015
Line 5:		Line 5:
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=RET:RETINAL'>RET</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=RET:RETINAL'>RET</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1eds\|1eds]], [[1edv\|1edv]], [[1edw\|1edw]], [[1edx\|1edx]], [[1fdf\|1fdf]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1eds\|1eds]], [[1edv\|1edv]], [[1edw\|1edw]], [[1edx\|1edx]], [[1fdf\|1fdf]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1jfp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1jfp OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1jfp RCSB], [http://www.ebi.ac.uk/pdbsum/1jfp PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1jfp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1jfp OCA], [http://pdbe.org/1jfp PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1jfp RCSB], [http://www.ebi.ac.uk/pdbsum/1jfp PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 27:		Line 27:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 1jfp" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==

OCA at 09:05, 25 December 2014

2014-12-25T09:05:51Z

←Older revision		Revision as of 09:05, 25 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1jfp]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JFP OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1JFP FirstGlance]. <br>		<table><tr><td colspan='2'>[[1jfp]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JFP OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1JFP FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=RET:RETINAL'>RET</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=RET:RETINAL'>RET</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1eds\|1eds]], [[1edv\|1edv]], [[1edw\|1edw]], [[1edx\|1edx]], [[1fdf\|1fdf]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1eds\|1eds]], [[1edv\|1edv]], [[1edw\|1edw]], [[1edx\|1edx]], [[1fdf\|1fdf]]</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1jfp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1jfp OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1jfp RCSB], [http://www.ebi.ac.uk/pdbsum/1jfp PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1jfp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1jfp OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1jfp RCSB], [http://www.ebi.ac.uk/pdbsum/1jfp PDBsum]</span></td></tr>
-	<table>	+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/OPSD_BOVIN OPSD_BOVIN]] Photoreceptor required for image-forming vision at low light intensity. Required for photoreceptor cell viability after birth. Light-induced isomerization of 11-cis to all-trans retinal triggers a conformational change leading to G-protein activation and release of all-trans retinal (By similarity).<ref>PMID:16908857</ref> <ref>PMID:17060607</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	</StructureSection>		</StructureSection>
	[[Category: Bos taurus]]		[[Category: Bos taurus]]
-	[[Category: Albert, A D.]]	+	[[Category: Albert, A D]]
-	[[Category: Choi, G.]]	+	[[Category: Choi, G]]
-	[[Category: Yeagle, P L.]]	+	[[Category: Yeagle, P L]]
	[[Category: G-protein coupled receptor]]		[[Category: G-protein coupled receptor]]
	[[Category: Membrane protein]]		[[Category: Membrane protein]]
	[[Category: Signaling protein]]		[[Category: Signaling protein]]

OCA at 11:33, 28 September 2014

2014-09-28T11:33:16Z

←Older revision		Revision as of 11:33, 28 September 2014
Line 1:		Line 1:
-	[[~~Image:~~1jfp.~~png~~\|~~left~~\|200px]]	+	==Structure of bovine rhodopsin (dark adapted)==
		+	<StructureSection load='1jfp' size='340' side='right' caption='[[1jfp]], [[NMR_Ensembles_of_Models \| 1 NMR models]]' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[1jfp]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JFP OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1JFP FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=RET:RETINAL'>RET</scene><br>
		+	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1eds\|1eds]], [[1edv\|1edv]], [[1edw\|1edw]], [[1edx\|1edx]], [[1fdf\|1fdf]]</td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1jfp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1jfp OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1jfp RCSB], [http://www.ebi.ac.uk/pdbsum/1jfp PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/jf/1jfp_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Activation of G-protein coupled receptors (GPCR) is not yet understood. A recent structure showed most of rhodopsin in the ground (not activated) state of the GPCR, but the cytoplasmic face, which couples to the G protein in signal transduction, was not well-defined. We have determined an experimental three-dimensional structure for rhodopsin in the unactivated state, which shows good agreement with the crystal structure in the transmembrane domain. This new structure defines the cytoplasmic face of rhodopsin. The G-protein binding site can be mapped. The same experimental approach yields a preliminary structure of the cytoplasmic face in the activated (metarhodopsin II) receptor. Differences between the two structures suggest how the receptor is activated to couple with transducin.

-	~~{{STRUCTURE_1jfp\| PDB=1jfp \| SCENE= }}~~	+	Studies on the structure of the G-protein-coupled receptor rhodopsin including the putative G-protein binding site in unactivated and activated forms.,Yeagle PL, Choi G, Albert AD Biochemistry. 2001 Oct 2;40(39):11932-7. PMID:11570894<ref>PMID:11570894</ref>

-	~~===Structure~~ of ~~bovine rhodopsin (dark adapted)===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_11570894}}~~	+
-		+
-	~~==About this Structure==~~	+
-	~~[[1jfp]] is a 1 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Bos_taurus Bos taurus]~~. ~~Full experimental information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=1JFP OCA].~~	+

	==See Also==		==See Also==
	*[[Rhodopsin\|Rhodopsin]]		*[[Rhodopsin\|Rhodopsin]]
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	<~~ref group="xtra">PMID:011570894<~~/~~ref~~><~~references group="xtra"~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Bos taurus]]		[[Category: Bos taurus]]
	[[Category: Albert, A D.]]		[[Category: Albert, A D.]]

OCA at 14:55, 20 October 2012

2012-10-20T14:55:05Z

←Older revision		Revision as of 14:55, 20 October 2012
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	==About this Structure==		==About this Structure==
-	[[1jfp]] is a 1 chain structure ~~of [[Rhodopsin]]~~ with sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JFP OCA].	+	[[1jfp]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JFP OCA].

	==See Also==		==See Also==

OCA: Protected "1jfp" [edit=sysop:move=sysop]

2012-07-26T16:41:07Z

Protected "1jfp" [edit=sysop:move=sysop]

←Older revision

Revision as of 16:41, 26 July 2012