1jl6 - Revision history

OCA at 07:40, 7 February 2024

2024-02-07T07:40:22Z

←Older revision		Revision as of 07:40, 7 February 2024
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	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1jl6]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Glycera_dibranchiata Glycera dibranchiata]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JL6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1JL6 FirstGlance]. <br>		<table><tr><td colspan='2'>[[1jl6]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Glycera_dibranchiata Glycera dibranchiata]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JL6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1JL6 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CYN:CYANIDE+ION'>CYN</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.4Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CYN:CYANIDE+ION'>CYN</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1jl6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1jl6 OCA], [https://pdbe.org/1jl6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1jl6 RCSB], [https://www.ebi.ac.uk/pdbsum/1jl6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1jl6 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1jl6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1jl6 OCA], [https://pdbe.org/1jl6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1jl6 RCSB], [https://www.ebi.ac.uk/pdbsum/1jl6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1jl6 ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/GLB4_GLYDI GLB4_GLYDI]
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 17:		Line 20:
	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1jl6 ConSurf].		</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1jl6 ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
-	<div style="background-color:#fffaf0;">
-	== Publication Abstract from PubMed ==
-	Erythrocytes of the marine annelid, Glycera dibranchiata, contain a mixture of monomeric and polymeric hemoglobins. There are three major monomer hemoglobin components, II, III, IV (also called GMH2, 3, and 4), that have been highly purified and well characterized. We have now crystallized GMH3 and GMH4 and determined their structures to 1.4-1.8 A resolution. The structures were determined for these two monomer hemoglobins in the oxidized (Fe3+, ferric, or met-) forms in both the unligated and cyanide-ligated states. This work differs from two published, refined structures of a Glycera dibranchiata monomer hemoglobin, which has a sequence that is substantially different from any bona fide major monomer hemoglobins (GMH2, 3, or 4). The high-resolution crystal structures (presented here) and the previous NMR structure of CO-ligated GMH4, provide a basis for interpreting structure/function details of the monomer hemoglobins. These details include: (1) the strong correlation between temperature factor and NMR dynamics for respective protein forms; (2) the unique nature of the HisE7Leu primary sequence substitutions in GMH3 and GMH4 and their impact on cyanide ion binding kinetics; (3) the LeuB10Phe difference between GMH3 and GMH4 and its impact on ligand binding; and (4) elucidation of changes in the structural details of the distal and proximal heme pockets upon cyanide binding.
-
-	Crystal structures of unligated and CN-ligated Glycera dibranchiata monomer ferric hemoglobin components III and IV.,Park HJ, Yang C, Treff N, Satterlee JD, Kang C Proteins. 2002 Oct 1;49(1):49-60. PMID:12211015<ref>PMID:12211015</ref>
-
-	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	</div>
-	<div class="pdbe-citations 1jl6" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
	*[[Hemoglobin 3D structures\|Hemoglobin 3D structures]]		*[[Hemoglobin 3D structures\|Hemoglobin 3D structures]]
-	== References ==
-	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: Glycera dibranchiata]]		[[Category: Glycera dibranchiata]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Kang, C]]	+	[[Category: Kang C]]
-	[[Category: Park~~, H J~~]]	+	[[Category: Park HJ]]
-	[[Category: Satterlee~~, J D~~]]	+	[[Category: Satterlee JD]]
-	[[Category: Treff, N]]	+	[[Category: Treff N]]
-	[[Category: Yang, C]]	+	[[Category: Yang C]]
-	~~[[Category: Glycera]]~~	+
-	~~[[Category: Monomer hemoglobin]]~~	+
-	~~[[Category: Oxygen storage-transport complex~~]]	+

OCA at 06:42, 11 August 2021

2021-08-11T06:42:11Z

←Older revision		Revision as of 06:42, 11 August 2021
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	<StructureSection load='1jl6' size='340' side='right'caption='[[1jl6]], [[Resolution\|resolution]] 1.40Å' scene=''>		<StructureSection load='1jl6' size='340' side='right'caption='[[1jl6]], [[Resolution\|resolution]] 1.40Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1jl6]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Glycera_dibranchiata Glycera dibranchiata]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JL6 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1JL6 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1jl6]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Glycera_dibranchiata Glycera dibranchiata]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JL6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1JL6 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CYN:CYANIDE+ION'>CYN</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CYN:CYANIDE+ION'>CYN</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1jl6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1jl6 OCA], [~~http~~://pdbe.org/1jl6 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=1jl6 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/1jl6 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=1jl6 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1jl6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1jl6 OCA], [https://pdbe.org/1jl6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1jl6 RCSB], [https://www.ebi.ac.uk/pdbsum/1jl6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1jl6 ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==

OCA at 09:08, 6 November 2019

2019-11-06T09:08:47Z

←Older revision		Revision as of 09:08, 6 November 2019
Line 1:		Line 1:

	==Crystal Structure of CN-Ligated Component IV Glycera Dibranchiata Monomeric Hemoglobin==		==Crystal Structure of CN-Ligated Component IV Glycera Dibranchiata Monomeric Hemoglobin==
-	<StructureSection load='1jl6' size='340' side='right' caption='[[1jl6]], [[Resolution\|resolution]] 1.40Å' scene=''>	+	<StructureSection load='1jl6' size='340' side='right'caption='[[1jl6]], [[Resolution\|resolution]] 1.40Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1jl6]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Glycera_dibranchiata Glycera dibranchiata]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JL6 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1JL6 FirstGlance]. <br>		<table><tr><td colspan='2'>[[1jl6]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Glycera_dibranchiata Glycera dibranchiata]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JL6 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1JL6 FirstGlance]. <br>
Line 34:		Line 34:
	</StructureSection>		</StructureSection>
	[[Category: Glycera dibranchiata]]		[[Category: Glycera dibranchiata]]
		+	[[Category: Large Structures]]
	[[Category: Kang, C]]		[[Category: Kang, C]]
	[[Category: Park, H J]]		[[Category: Park, H J]]

OCA at 08:45, 17 January 2018

2018-01-17T08:45:58Z

←Older revision		Revision as of 08:45, 17 January 2018
Line 1:		Line 1:
		+
	==Crystal Structure of CN-Ligated Component IV Glycera Dibranchiata Monomeric Hemoglobin==		==Crystal Structure of CN-Ligated Component IV Glycera Dibranchiata Monomeric Hemoglobin==
	<StructureSection load='1jl6' size='340' side='right' caption='[[1jl6]], [[Resolution\|resolution]] 1.40Å' scene=''>		<StructureSection load='1jl6' size='340' side='right' caption='[[1jl6]], [[Resolution\|resolution]] 1.40Å' scene=''>
Line 4:		Line 5:
	<table><tr><td colspan='2'>[[1jl6]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Glycera_dibranchiata Glycera dibranchiata]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JL6 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1JL6 FirstGlance]. <br>		<table><tr><td colspan='2'>[[1jl6]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Glycera_dibranchiata Glycera dibranchiata]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JL6 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1JL6 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CYN:CYANIDE+ION'>CYN</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CYN:CYANIDE+ION'>CYN</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1jl6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1jl6 OCA], [http://pdbe.org/1jl6 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1jl6 RCSB], [http://www.ebi.ac.uk/pdbsum/1jl6 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1jl6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1jl6 OCA], [http://pdbe.org/1jl6 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1jl6 RCSB], [http://www.ebi.ac.uk/pdbsum/1jl6 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1jl6 ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 10:		Line 11:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/jl/1jl6_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/jl/1jl6_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>

OCA at 05:38, 8 February 2016

2016-02-08T05:38:21Z

←Older revision		Revision as of 05:38, 8 February 2016
Line 14:		Line 14:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1jl6 ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 08:25, 10 September 2015

2015-09-10T08:25:52Z

←Older revision		Revision as of 08:25, 10 September 2015
Line 4:		Line 4:
	<table><tr><td colspan='2'>[[1jl6]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Glycera_dibranchiata Glycera dibranchiata]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JL6 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1JL6 FirstGlance]. <br>		<table><tr><td colspan='2'>[[1jl6]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Glycera_dibranchiata Glycera dibranchiata]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JL6 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1JL6 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CYN:CYANIDE+ION'>CYN</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CYN:CYANIDE+ION'>CYN</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1jl6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1jl6 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1jl6 RCSB], [http://www.ebi.ac.uk/pdbsum/1jl6 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1jl6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1jl6 OCA], [http://pdbe.org/1jl6 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1jl6 RCSB], [http://www.ebi.ac.uk/pdbsum/1jl6 PDBsum]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 24:		Line 24:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 1jl6" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==

OCA at 12:10, 2 January 2015

2015-01-02T12:10:56Z

←Older revision		Revision as of 12:10, 2 January 2015
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1jl6]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Glycera_dibranchiata Glycera dibranchiata]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JL6 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1JL6 FirstGlance]. <br>		<table><tr><td colspan='2'>[[1jl6]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Glycera_dibranchiata Glycera dibranchiata]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JL6 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1JL6 FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CYN:CYANIDE+ION'>CYN</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CYN:CYANIDE+ION'>CYN</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene></td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1jl6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1jl6 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1jl6 RCSB], [http://www.ebi.ac.uk/pdbsum/1jl6 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1jl6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1jl6 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1jl6 RCSB], [http://www.ebi.ac.uk/pdbsum/1jl6 PDBsum]</span></td></tr>
-	<table>	+	</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 32:		Line 32:
	</StructureSection>		</StructureSection>
	[[Category: Glycera dibranchiata]]		[[Category: Glycera dibranchiata]]
-	[[Category: Kang, C.]]	+	[[Category: Kang, C]]
-	[[Category: Park, H J.]]	+	[[Category: Park, H J]]
-	[[Category: Satterlee, J D.]]	+	[[Category: Satterlee, J D]]
-	[[Category: Treff, N.]]	+	[[Category: Treff, N]]
-	[[Category: Yang, C.]]	+	[[Category: Yang, C]]
	[[Category: Glycera]]		[[Category: Glycera]]
	[[Category: Monomer hemoglobin]]		[[Category: Monomer hemoglobin]]
	[[Category: Oxygen storage-transport complex]]		[[Category: Oxygen storage-transport complex]]

OCA at 13:12, 28 September 2014

2014-09-28T13:12:40Z

←Older revision		Revision as of 13:12, 28 September 2014
Line 1:		Line 1:
-	[[~~Image~~:1jl6.~~png\|left~~\|200px]]	+	==Crystal Structure of CN-Ligated Component IV Glycera Dibranchiata Monomeric Hemoglobin==
		+	<StructureSection load='1jl6' size='340' side='right' caption='[[1jl6]], [[Resolution\|resolution]] 1.40Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[1jl6]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Glycera_dibranchiata Glycera dibranchiata]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JL6 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1JL6 FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CYN:CYANIDE+ION'>CYN</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene><br>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1jl6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1jl6 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1jl6 RCSB], [http://www.ebi.ac.uk/pdbsum/1jl6 PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/jl/1jl6_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Erythrocytes of the marine annelid, Glycera dibranchiata, contain a mixture of monomeric and polymeric hemoglobins. There are three major monomer hemoglobin components, II, III, IV (also called GMH2, 3, and 4), that have been highly purified and well characterized. We have now crystallized GMH3 and GMH4 and determined their structures to 1.4-1.8 A resolution. The structures were determined for these two monomer hemoglobins in the oxidized (Fe3+, ferric, or met-) forms in both the unligated and cyanide-ligated states. This work differs from two published, refined structures of a Glycera dibranchiata monomer hemoglobin, which has a sequence that is substantially different from any bona fide major monomer hemoglobins (GMH2, 3, or 4). The high-resolution crystal structures (presented here) and the previous NMR structure of CO-ligated GMH4, provide a basis for interpreting structure/function details of the monomer hemoglobins. These details include: (1) the strong correlation between temperature factor and NMR dynamics for respective protein forms; (2) the unique nature of the HisE7Leu primary sequence substitutions in GMH3 and GMH4 and their impact on cyanide ion binding kinetics; (3) the LeuB10Phe difference between GMH3 and GMH4 and its impact on ligand binding; and (4) elucidation of changes in the structural details of the distal and proximal heme pockets upon cyanide binding.

-	~~{{STRUCTURE_1jl6\| PDB=1jl6 \| SCENE= }}~~	+	Crystal structures of unligated and CN-ligated Glycera dibranchiata monomer ferric hemoglobin components III and IV.,Park HJ, Yang C, Treff N, Satterlee JD, Kang C Proteins. 2002 Oct 1;49(1):49-60. PMID:12211015<ref>PMID:12211015</ref>

-	~~===Crystal Structure~~ of ~~CN-Ligated Component IV Glycera Dibranchiata Monomeric Hemoglobin===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_12211015}}~~	+
-		+
-	~~==About this Structure==~~	+
-	~~[[1jl6]] is a 1 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Glycera_dibranchiata Glycera dibranchiata]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=1JL6 OCA].~~	+

	==See Also==		==See Also==
-	*[[Hemoglobin\|Hemoglobin]]	+	*[[Hemoglobin 3D structures\|Hemoglobin 3D structures]]
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	<~~ref group="xtra">PMID:012211015<~~/~~ref~~><~~references group="xtra"~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Glycera dibranchiata]]		[[Category: Glycera dibranchiata]]
	[[Category: Kang, C.]]		[[Category: Kang, C.]]

OCA at 09:05, 20 October 2012

2012-10-20T09:05:44Z

←Older revision		Revision as of 09:05, 20 October 2012
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	==About this Structure==		==About this Structure==
-	[[1jl6]] is a 1 chain structure ~~of [[Hemoglobin]]~~ with sequence from [http://en.wikipedia.org/wiki/Glycera_dibranchiata Glycera dibranchiata]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JL6 OCA].	+	[[1jl6]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Glycera_dibranchiata Glycera dibranchiata]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JL6 OCA].

	==See Also==		==See Also==

OCA: Protected "1jl6" [edit=sysop:move=sysop]

2012-07-25T21:45:28Z

Protected "1jl6" [edit=sysop:move=sysop]

←Older revision

Revision as of 21:45, 25 July 2012