1jlw - Revision history

OCA at 07:40, 7 February 2024

2024-02-07T07:40:27Z

←Older revision		Revision as of 07:40, 7 February 2024
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	<StructureSection load='1jlw' size='340' side='right'caption='[[1jlw]], [[Resolution\|resolution]] 2.45Å' scene=''>		<StructureSection load='1jlw' size='340' side='right'caption='[[1jlw]], [[Resolution\|resolution]] 2.45Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1jlw]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Anopheles_(cellia)_cracens~~ Anopheles ~~(cellia)~~ cracens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JLW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1JLW FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1jlw]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Anopheles_cracens Anopheles cracens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JLW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1JLW FirstGlance]. <br>
-	</td></tr><tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat">~~<div style='overflow: auto; max~~-~~height: 3em;'>~~[[~~1jlv~~\|~~1jlv~~]]~~</div></td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.45Å</td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Glutathione_transferase Glutathione transferase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.~~5.1.18 2.5.1.18] </span>~~</td></tr>	+
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1jlw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1jlw OCA], [https://pdbe.org/1jlw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1jlw RCSB], [https://www.ebi.ac.uk/pdbsum/1jlw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1jlw ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1jlw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1jlw OCA], [https://pdbe.org/1jlw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1jlw RCSB], [https://www.ebi.ac.uk/pdbsum/1jlw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1jlw ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/Q7KIF1_9DIPT Q7KIF1_9DIPT]
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1jlw ConSurf].		</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1jlw ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
-	<div style="background-color:#fffaf0;">
-	== Publication Abstract from PubMed ==
-	Glutathione S-transferases (GSTs) are dimeric proteins that play an important role in cellular detoxification. Four GSTs from the mosquito Anopheles dirus species B (Ad), an important malaria vector in South East Asia, are produced by alternate splicing of a single transcription product and were previously shown to have detoxifying activity towards pesticides such as DDT. We have determined the crystal structures for two of these alternatively spliced proteins, AdGST1-3 (complexed with glutathione) and AdGST1-4 (apo form), at 1.75 and 2.45 A resolution, respectively. These GST isozymes show differences from the related GST from the Australian sheep blowfly Lucilia cuprina; in particular, the presence of a C-terminal helix forming part of the active site. This helix causes the active site of the Anopheles GSTs to be enclosed. The glutathione-binding helix alpha2 and flanking residues are disordered in the AdGST1-4 (apo) structure, yet ordered in the AdGST1-3 (GSH-bound) structure, suggesting that insect GSTs operate with an induced fit mechanism similar to that found in the plant phi- and human pi-class GSTs. Despite the high overall sequence identities, the active site residues of AdGST1-4 and AdGST1-3 have different conformations.
-
-	The crystal structures of glutathione S-transferases isozymes 1-3 and 1-4 from Anopheles dirus species B.,Oakley AJ, Harnnoi T, Udomsinprasert R, Jirajaroenrat K, Ketterman AJ, Wilce MC Protein Sci. 2001 Nov;10(11):2176-85. PMID:11604524<ref>PMID:11604524</ref>
-
-	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	</div>
-	<div class="pdbe-citations 1jlw" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
	*[[Glutathione S-transferase 3D structures\|Glutathione S-transferase 3D structures]]		*[[Glutathione S-transferase 3D structures\|Glutathione S-transferase 3D structures]]
-	== References ==
-	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Glutathione transferase~~]]	+	[[Category: Anopheles cracens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Harnnoi, T]]	+	[[Category: Harnnoi T]]
-	[[Category: Jirajaroenrat, K]]	+	[[Category: Jirajaroenrat K]]
-	[[Category: Ketterman~~, A J~~]]	+	[[Category: Ketterman AJ]]
-	[[Category: Oakley~~, A J~~]]	+	[[Category: Oakley AJ]]
-	[[Category: Udomsinprasert, R]]	+	[[Category: Udomsinprasert R]]
-	[[Category: Wilce~~, M C]]~~	+	[[Category: Wilce MC]]
-	~~[[Category: Adgst1-4]]~~	+
-	~~[[Category: Glutathione s-transferase]]~~	+
-	~~[[Category: Gst]]~~	+
-	~~[[Category: Transferase~~]]	+

OCA at 06:42, 11 August 2021

2021-08-11T06:42:31Z

←Older revision		Revision as of 06:42, 11 August 2021
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	<StructureSection load='1jlw' size='340' side='right'caption='[[1jlw]], [[Resolution\|resolution]] 2.45Å' scene=''>		<StructureSection load='1jlw' size='340' side='right'caption='[[1jlw]], [[Resolution\|resolution]] 2.45Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1jlw]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Anopheles_(cellia)_cracens Anopheles (cellia) cracens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JLW OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1JLW FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1jlw]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Anopheles_(cellia)_cracens Anopheles (cellia) cracens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JLW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1JLW FirstGlance]. <br>
-	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1jlv\|1jlv]]</td></tr>	+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1jlv\|1jlv]]</div></td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://en.wikipedia.org/wiki/Glutathione_transferase Glutathione transferase], with EC number [~~http~~://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.5.1.18 2.5.1.18] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Glutathione_transferase Glutathione transferase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.5.1.18 2.5.1.18] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1jlw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1jlw OCA], [~~http~~://pdbe.org/1jlw PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=1jlw RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/1jlw PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=1jlw ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1jlw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1jlw OCA], [https://pdbe.org/1jlw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1jlw RCSB], [https://www.ebi.ac.uk/pdbsum/1jlw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1jlw ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==

OCA at 09:45, 6 November 2019

2019-11-06T09:45:22Z

←Older revision		Revision as of 09:45, 6 November 2019
Line 1:		Line 1:

	==Anopheles dirus species B glutathione S-transferases 1-4==		==Anopheles dirus species B glutathione S-transferases 1-4==
-	<StructureSection load='1jlw' size='340' side='right' caption='[[1jlw]], [[Resolution\|resolution]] 2.45Å' scene=''>	+	<StructureSection load='1jlw' size='340' side='right'caption='[[1jlw]], [[Resolution\|resolution]] 2.45Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1jlw]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Anopheles_(cellia)_cracens Anopheles (cellia) cracens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JLW OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1JLW FirstGlance]. <br>		<table><tr><td colspan='2'>[[1jlw]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Anopheles_(cellia)_cracens Anopheles (cellia) cracens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JLW OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1JLW FirstGlance]. <br>
Line 27:		Line 27:
	</div>		</div>
	<div class="pdbe-citations 1jlw" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 1jlw" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Glutathione S-transferase 3D structures\|Glutathione S-transferase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
Line 32:		Line 35:
	</StructureSection>		</StructureSection>
	[[Category: Glutathione transferase]]		[[Category: Glutathione transferase]]
		+	[[Category: Large Structures]]
	[[Category: Harnnoi, T]]		[[Category: Harnnoi, T]]
	[[Category: Jirajaroenrat, K]]		[[Category: Jirajaroenrat, K]]

OCA at 09:21, 17 January 2018

2018-01-17T09:21:38Z

←Older revision		Revision as of 09:21, 17 January 2018
Line 1:		Line 1:
		+
	==Anopheles dirus species B glutathione S-transferases 1-4==		==Anopheles dirus species B glutathione S-transferases 1-4==
	<StructureSection load='1jlw' size='340' side='right' caption='[[1jlw]], [[Resolution\|resolution]] 2.45Å' scene=''>		<StructureSection load='1jlw' size='340' side='right' caption='[[1jlw]], [[Resolution\|resolution]] 2.45Å' scene=''>
Line 5:		Line 6:
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1jlv\|1jlv]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1jlv\|1jlv]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Glutathione_transferase Glutathione transferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.5.1.18 2.5.1.18] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Glutathione_transferase Glutathione transferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.5.1.18 2.5.1.18] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1jlw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1jlw OCA], [http://pdbe.org/1jlw PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1jlw RCSB], [http://www.ebi.ac.uk/pdbsum/1jlw PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1jlw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1jlw OCA], [http://pdbe.org/1jlw PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1jlw RCSB], [http://www.ebi.ac.uk/pdbsum/1jlw PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1jlw ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
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	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/jl/1jlw_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/jl/1jlw_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
Line 26:		Line 27:
	</div>		</div>
	<div class="pdbe-citations 1jlw" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 1jlw" style="background-color:#fffaf0;"></div>
-
-	==See Also==
-	*[[Glutathione S-transferase\|Glutathione S-transferase]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 00:18, 9 February 2016

2016-02-09T00:18:23Z

←Older revision		Revision as of 00:18, 9 February 2016
Line 15:		Line 15:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1jlw ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 16:45, 10 September 2015

2015-09-10T16:45:46Z

←Older revision		Revision as of 16:45, 10 September 2015
Line 2:		Line 2:
	<StructureSection load='1jlw' size='340' side='right' caption='[[1jlw]], [[Resolution\|resolution]] 2.45Å' scene=''>		<StructureSection load='1jlw' size='340' side='right' caption='[[1jlw]], [[Resolution\|resolution]] 2.45Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1jlw]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Anopheles_cracens~~ Anopheles cracens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JLW OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1JLW FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1jlw]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Anopheles_(cellia)_cracens Anopheles (cellia) cracens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JLW OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1JLW FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1jlv\|1jlv]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1jlv\|1jlv]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Glutathione_transferase Glutathione transferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.5.1.18 2.5.1.18] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Glutathione_transferase Glutathione transferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.5.1.18 2.5.1.18] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1jlw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1jlw OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1jlw RCSB], [http://www.ebi.ac.uk/pdbsum/1jlw PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1jlw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1jlw OCA], [http://pdbe.org/1jlw PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1jlw RCSB], [http://www.ebi.ac.uk/pdbsum/1jlw PDBsum]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 25:		Line 25:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 1jlw" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 32:		Line 33:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Anopheles cracens]]
	[[Category: Glutathione transferase]]		[[Category: Glutathione transferase]]
	[[Category: Harnnoi, T]]		[[Category: Harnnoi, T]]

OCA at 12:26, 2 January 2015

2015-01-02T12:26:11Z

←Older revision		Revision as of 12:26, 2 January 2015
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1jlw]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Anopheles_cracens Anopheles cracens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JLW OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1JLW FirstGlance]. <br>		<table><tr><td colspan='2'>[[1jlw]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Anopheles_cracens Anopheles cracens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JLW OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1JLW FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1jlv\|1jlv]]</td></tr>	+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1jlv\|1jlv]]</td></tr>
-	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Glutathione_transferase Glutathione transferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.5.1.18 2.5.1.18] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Glutathione_transferase Glutathione transferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.5.1.18 2.5.1.18] </span></td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1jlw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1jlw OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1jlw RCSB], [http://www.ebi.ac.uk/pdbsum/1jlw PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1jlw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1jlw OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1jlw RCSB], [http://www.ebi.ac.uk/pdbsum/1jlw PDBsum]</span></td></tr>
-	<table>	+	</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 34:		Line 34:
	[[Category: Anopheles cracens]]		[[Category: Anopheles cracens]]
	[[Category: Glutathione transferase]]		[[Category: Glutathione transferase]]
-	[[Category: Harnnoi, T.]]	+	[[Category: Harnnoi, T]]
-	[[Category: Jirajaroenrat, K.]]	+	[[Category: Jirajaroenrat, K]]
-	[[Category: Ketterman, A J.]]	+	[[Category: Ketterman, A J]]
-	[[Category: Oakley, A J.]]	+	[[Category: Oakley, A J]]
-	[[Category: Udomsinprasert, R.]]	+	[[Category: Udomsinprasert, R]]
-	[[Category: Wilce, M C.]]	+	[[Category: Wilce, M C]]
	[[Category: Adgst1-4]]		[[Category: Adgst1-4]]
	[[Category: Glutathione s-transferase]]		[[Category: Glutathione s-transferase]]
	[[Category: Gst]]		[[Category: Gst]]
	[[Category: Transferase]]		[[Category: Transferase]]

OCA at 09:04, 28 September 2014

2014-09-28T09:04:45Z

←Older revision		Revision as of 09:04, 28 September 2014
Line 1:		Line 1:
-	[[~~Image:~~1jlw.~~png~~\|~~left~~\|200px]]	+	==Anopheles dirus species B glutathione S-transferases 1-4==
		+	<StructureSection load='1jlw' size='340' side='right' caption='[[1jlw]], [[Resolution\|resolution]] 2.45Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[1jlw]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Anopheles_cracens Anopheles cracens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JLW OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1JLW FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1jlv\|1jlv]]</td></tr>
		+	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Glutathione_transferase Glutathione transferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.5.1.18 2.5.1.18] </span></td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1jlw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1jlw OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1jlw RCSB], [http://www.ebi.ac.uk/pdbsum/1jlw PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/jl/1jlw_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Glutathione S-transferases (GSTs) are dimeric proteins that play an important role in cellular detoxification. Four GSTs from the mosquito Anopheles dirus species B (Ad), an important malaria vector in South East Asia, are produced by alternate splicing of a single transcription product and were previously shown to have detoxifying activity towards pesticides such as DDT. We have determined the crystal structures for two of these alternatively spliced proteins, AdGST1-3 (complexed with glutathione) and AdGST1-4 (apo form), at 1.75 and 2.45 A resolution, respectively. These GST isozymes show differences from the related GST from the Australian sheep blowfly Lucilia cuprina; in particular, the presence of a C-terminal helix forming part of the active site. This helix causes the active site of the Anopheles GSTs to be enclosed. The glutathione-binding helix alpha2 and flanking residues are disordered in the AdGST1-4 (apo) structure, yet ordered in the AdGST1-3 (GSH-bound) structure, suggesting that insect GSTs operate with an induced fit mechanism similar to that found in the plant phi- and human pi-class GSTs. Despite the high overall sequence identities, the active site residues of AdGST1-4 and AdGST1-3 have different conformations.

-	~~{{STRUCTURE_1jlw\| PDB=1jlw \| SCENE= }}~~	+	The crystal structures of glutathione S-transferases isozymes 1-3 and 1-4 from Anopheles dirus species B.,Oakley AJ, Harnnoi T, Udomsinprasert R, Jirajaroenrat K, Ketterman AJ, Wilce MC Protein Sci. 2001 Nov;10(11):2176-85. PMID:11604524<ref>PMID:11604524</ref>

-	~~===Anopheles dirus species B glutathione~~ S~~-transferases 1-4===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>

-	~~{{ABSTRACT_PUBMED_11604524}}~~	+	==See Also==
-		+	*[[Glutathione S-transferase\|Glutathione S-transferase]]
-	==~~About this Structure~~==	+	== References ==
-	[[~~1jlw~~]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Anopheles_cracens Anopheles cracens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JLW OCA].	+	<references/>
-		+	__TOC__
-	==~~Reference~~==	+	</StructureSection>
-	<~~ref group="xtra">PMID:011604524<~~/~~ref~~><~~references group="xtra"~~/>	+
	[[Category: Anopheles cracens]]		[[Category: Anopheles cracens]]
	[[Category: Glutathione transferase]]		[[Category: Glutathione transferase]]

OCA: Protected "1jlw" [edit=sysop:move=sysop]

2012-12-05T11:35:39Z

Protected "1jlw" [edit=sysop:move=sysop]

←Older revision

Revision as of 11:35, 5 December 2012

OCA at 11:35, 5 December 2012

2012-12-05T11:35:36Z

←Older revision		Revision as of 11:35, 5 December 2012
Line 1:		Line 1:
-	{{Seed}}
	[[Image:1jlw.png\|left\|200px]]		[[Image:1jlw.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_1jlw", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_1jlw\| PDB=1jlw \| SCENE= }}		{{STRUCTURE_1jlw\| PDB=1jlw \| SCENE= }}

	===Anopheles dirus species B glutathione S-transferases 1-4===		===Anopheles dirus species B glutathione S-transferases 1-4===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_11604524}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 11604524 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_11604524}}		{{ABSTRACT_PUBMED_11604524}}

	==About this Structure==		==About this Structure==
-	~~1JLW~~ is a 2 ~~chains~~ structure ~~of sequences~~ from [http://en.wikipedia.org/wiki/Anopheles_cracens Anopheles cracens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JLW OCA].	+	[[1jlw]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Anopheles_cracens Anopheles cracens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JLW OCA].

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~11604524~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:011604524</ref><references group="xtra"/>
	[[Category: Anopheles cracens]]		[[Category: Anopheles cracens]]
	[[Category: Glutathione transferase]]		[[Category: Glutathione transferase]]
Line 35:		Line 23:
	[[Category: Glutathione s-transferase]]		[[Category: Glutathione s-transferase]]
	[[Category: Gst]]		[[Category: Gst]]
-		+	[[Category: Transferase]]
-	~~''Page seeded by~~ [~~http~~:~~//oca.weizmann.ac.il/oca OCA~~ ] ~~on Tue Feb 17 04:49:16 2009''~~	+