1jqz - Revision history

OCA at 08:44, 16 August 2023

2023-08-16T08:44:45Z

←Older revision		Revision as of 08:44, 16 August 2023
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	<StructureSection load='1jqz' size='340' side='right'caption='[[1jqz]], [[Resolution\|resolution]] 1.65Å' scene=''>		<StructureSection load='1jqz' size='340' side='right'caption='[[1jqz]], [[Resolution\|resolution]] 1.65Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1jqz]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JQZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1JQZ FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1jqz]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JQZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1JQZ FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=FMT:FORMIC+ACID'>FMT</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.65Å</td></tr>
-	<tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"><~~div style~~='~~overflow~~: ~~auto; max-height: 3em;~~'>~~[[1jt3\|1jt3]], [[1jt4\|1jt4]], [[1jt5\|1jt5]], [[1jt7\|1jt7]], [[1jtc\|1jtc]]~~</~~div~~></td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FMT:FORMIC+ACID'>FMT</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1jqz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1jqz OCA], [https://pdbe.org/1jqz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1jqz RCSB], [https://www.ebi.ac.uk/pdbsum/1jqz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1jqz ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1jqz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1jqz OCA], [https://pdbe.org/1jqz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1jqz RCSB], [https://www.ebi.ac.uk/pdbsum/1jqz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1jqz ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/FGF1_HUMAN FGF1_HUMAN]] Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro.<ref>PMID:8663044</ref> <ref>PMID:16597617</ref> <ref>PMID:20145243</ref>	+	[https://www.uniprot.org/uniprot/FGF1_HUMAN FGF1_HUMAN] Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro.<ref>PMID:8663044</ref> <ref>PMID:16597617</ref> <ref>PMID:20145243</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Blaber, M]]	+	[[Category: Blaber M]]
-	[[Category: Blaber~~, S I~~]]	+	[[Category: Blaber SI]]
-	[[Category: Brych~~, S R~~]]	+	[[Category: Brych SR]]
-	[[Category: Logan~~, T M]]~~	+	[[Category: Logan TM]]
-	~~[[Category: Beta-trefoil]]~~	+
-	~~[[Category: Hormone-growth factor complex~~]]	+

OCA at 07:21, 14 April 2021

2021-04-14T07:21:31Z

←Older revision		Revision as of 07:21, 14 April 2021
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	<StructureSection load='1jqz' size='340' side='right'caption='[[1jqz]], [[Resolution\|resolution]] 1.65Å' scene=''>		<StructureSection load='1jqz' size='340' side='right'caption='[[1jqz]], [[Resolution\|resolution]] 1.65Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1jqz]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JQZ OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1JQZ FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1jqz]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JQZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1JQZ FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FMT:FORMIC+ACID'>FMT</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FMT:FORMIC+ACID'>FMT</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1jt3\|1jt3]], [[1jt4\|1jt4]], [[1jt5\|1jt5]], [[1jt7\|1jt7]], [[1jtc\|1jtc]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1jt3\|1jt3]], [[1jt4\|1jt4]], [[1jt5\|1jt5]], [[1jt7\|1jt7]], [[1jtc\|1jtc]]</div></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1jqz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1jqz OCA], [~~http~~://pdbe.org/1jqz PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=1jqz RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/1jqz PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=1jqz ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1jqz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1jqz OCA], [https://pdbe.org/1jqz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1jqz RCSB], [https://www.ebi.ac.uk/pdbsum/1jqz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1jqz ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/FGF1_HUMAN FGF1_HUMAN]] Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro.<ref>PMID:8663044</ref> <ref>PMID:16597617</ref> <ref>PMID:20145243</ref>	+	[[https://www.uniprot.org/uniprot/FGF1_HUMAN FGF1_HUMAN]] Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro.<ref>PMID:8663044</ref> <ref>PMID:16597617</ref> <ref>PMID:20145243</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]

OCA at 07:06, 10 July 2019

2019-07-10T07:06:07Z

←Older revision		Revision as of 07:06, 10 July 2019
Line 1:		Line 1:

	==Human Acidic Fibroblast Growth Factor. 141 Amino Acid Form with Amino Terminal His Tag.==		==Human Acidic Fibroblast Growth Factor. 141 Amino Acid Form with Amino Terminal His Tag.==
-	<StructureSection load='1jqz' size='340' side='right' caption='[[1jqz]], [[Resolution\|resolution]] 1.65Å' scene=''>	+	<StructureSection load='1jqz' size='340' side='right'caption='[[1jqz]], [[Resolution\|resolution]] 1.65Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1jqz]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JQZ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1JQZ FirstGlance]. <br>		<table><tr><td colspan='2'>[[1jqz]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JQZ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1JQZ FirstGlance]. <br>
Line 14:		Line 14:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/jq/1jqz_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/jq/1jqz_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
Line 31:		Line 31:

	==See Also==		==See Also==
-	*[[Fibroblast growth factor\|Fibroblast growth factor]]	+	*[[Fibroblast growth factor 3D structures\|Fibroblast growth factor 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
Line 37:		Line 37:
	</StructureSection>		</StructureSection>
	[[Category: Human]]		[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Blaber, M]]		[[Category: Blaber, M]]
	[[Category: Blaber, S I]]		[[Category: Blaber, S I]]

OCA at 09:57, 4 October 2017

2017-10-04T09:57:35Z

←Older revision		Revision as of 09:57, 4 October 2017
Line 1:		Line 1:
		+
	==Human Acidic Fibroblast Growth Factor. 141 Amino Acid Form with Amino Terminal His Tag.==		==Human Acidic Fibroblast Growth Factor. 141 Amino Acid Form with Amino Terminal His Tag.==
	<StructureSection load='1jqz' size='340' side='right' caption='[[1jqz]], [[Resolution\|resolution]] 1.65Å' scene=''>		<StructureSection load='1jqz' size='340' side='right' caption='[[1jqz]], [[Resolution\|resolution]] 1.65Å' scene=''>
Line 5:		Line 6:
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FMT:FORMIC+ACID'>FMT</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FMT:FORMIC+ACID'>FMT</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1jt3\|1jt3]], [[1jt4\|1jt4]], [[1jt5\|1jt5]], [[1jt7\|1jt7]], [[1jtc\|1jtc]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1jt3\|1jt3]], [[1jt4\|1jt4]], [[1jt5\|1jt5]], [[1jt7\|1jt7]], [[1jtc\|1jtc]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1jqz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1jqz OCA], [http://pdbe.org/1jqz PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1jqz RCSB], [http://www.ebi.ac.uk/pdbsum/1jqz PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1jqz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1jqz OCA], [http://pdbe.org/1jqz PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1jqz RCSB], [http://www.ebi.ac.uk/pdbsum/1jqz PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1jqz ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 17:		Line 18:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1jqz ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 22:04, 11 September 2015

2015-09-11T22:04:05Z

←Older revision		Revision as of 22:04, 11 September 2015
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	<StructureSection load='1jqz' size='340' side='right' caption='[[1jqz]], [[Resolution\|resolution]] 1.65Å' scene=''>		<StructureSection load='1jqz' size='340' side='right' caption='[[1jqz]], [[Resolution\|resolution]] 1.65Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1jqz]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JQZ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1JQZ FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1jqz]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JQZ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1JQZ FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FMT:FORMIC+ACID'>FMT</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FMT:FORMIC+ACID'>FMT</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1jt3\|1jt3]], [[1jt4\|1jt4]], [[1jt5\|1jt5]], [[1jt7\|1jt7]], [[1jtc\|1jtc]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1jt3\|1jt3]], [[1jt4\|1jt4]], [[1jt5\|1jt5]], [[1jt7\|1jt7]], [[1jtc\|1jtc]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1jqz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1jqz OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1jqz RCSB], [http://www.ebi.ac.uk/pdbsum/1jqz PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1jqz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1jqz OCA], [http://pdbe.org/1jqz PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1jqz RCSB], [http://www.ebi.ac.uk/pdbsum/1jqz PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 27:		Line 27:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 1jqz" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 34:		Line 35:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Homo sapiens~~]]	+	[[Category: Human]]
	[[Category: Blaber, M]]		[[Category: Blaber, M]]
	[[Category: Blaber, S I]]		[[Category: Blaber, S I]]

OCA at 20:09, 25 December 2014

2014-12-25T20:09:50Z

←Older revision		Revision as of 20:09, 25 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1jqz]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JQZ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1JQZ FirstGlance]. <br>		<table><tr><td colspan='2'>[[1jqz]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JQZ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1JQZ FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FMT:FORMIC+ACID'>FMT</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FMT:FORMIC+ACID'>FMT</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1jt3\|1jt3]], [[1jt4\|1jt4]], [[1jt5\|1jt5]], [[1jt7\|1jt7]], [[1jtc\|1jtc]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1jt3\|1jt3]], [[1jt4\|1jt4]], [[1jt5\|1jt5]], [[1jt7\|1jt7]], [[1jtc\|1jtc]]</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1jqz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1jqz OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1jqz RCSB], [http://www.ebi.ac.uk/pdbsum/1jqz PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1jqz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1jqz OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1jqz RCSB], [http://www.ebi.ac.uk/pdbsum/1jqz PDBsum]</span></td></tr>
-	<table>	+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/FGF1_HUMAN FGF1_HUMAN]] Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro.<ref>PMID:8663044</ref> <ref>PMID:16597617</ref> <ref>PMID:20145243</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 33:		Line 35:
	</StructureSection>		</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
-	[[Category: Blaber, M.]]	+	[[Category: Blaber, M]]
-	[[Category: Blaber, S I.]]	+	[[Category: Blaber, S I]]
-	[[Category: Brych, S R.]]	+	[[Category: Brych, S R]]
-	[[Category: Logan, T M.]]	+	[[Category: Logan, T M]]
	[[Category: Beta-trefoil]]		[[Category: Beta-trefoil]]
	[[Category: Hormone-growth factor complex]]		[[Category: Hormone-growth factor complex]]

OCA at 10:16, 28 September 2014

2014-09-28T10:16:03Z

←Older revision		Revision as of 10:16, 28 September 2014
Line 1:		Line 1:
-	[[~~Image:~~1jqz.~~png~~\|~~left~~\|200px]]	+	==Human Acidic Fibroblast Growth Factor. 141 Amino Acid Form with Amino Terminal His Tag.==
		+	<StructureSection load='1jqz' size='340' side='right' caption='[[1jqz]], [[Resolution\|resolution]] 1.65Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[1jqz]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JQZ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1JQZ FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FMT:FORMIC+ACID'>FMT</scene><br>
		+	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1jt3\|1jt3]], [[1jt4\|1jt4]], [[1jt5\|1jt5]], [[1jt7\|1jt7]], [[1jtc\|1jtc]]</td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1jqz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1jqz OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1jqz RCSB], [http://www.ebi.ac.uk/pdbsum/1jqz PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/jq/1jqz_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Human acidic fibroblast growth factor (FGF-1) is a member of the beta-trefoil hyperfamily and exhibits a characteristic threefold symmetry of the tertiary structure. However, evidence of this symmetry is not readily apparent at the level of the primary sequence. This suggests that while selective pressures may exist to retain (or converge upon) a symmetric tertiary structure, other selective pressures have resulted in divergence of the primary sequence during evolution. Using intra-chain and homologue sequence comparisons for 19 members of this family of proteins, we have designed mutants of FGF-1 that constrain a subset of core-packing residues to threefold symmetry at the level of the primary sequence. The consequences of these mutations regarding structure and stability were evaluated using a combination of X-ray crystallography and differential scanning calorimetry. The mutational effects on structure and stability can be rationalized through the characterization of "microcavities" within the core detected using a 1.0A probe radius. The results show that the symmetric constraint within the primary sequence is compatible with a well-packed core and near wild-type stability. However, despite the general maintenance of overall thermal stability, a noticeable increase in non-two-state denaturation follows the increase in primary sequence symmetry. Therefore, properties of folding, rather than stability, may contribute to the selective pressure for asymmetric primary core sequences within symmetric protein architectures.

-	~~{{STRUCTURE_1jqz\| PDB=1jqz \| SCENE= }}~~	+	Structure and stability effects of mutations designed to increase the primary sequence symmetry within the core region of a beta-trefoil.,Brych SR, Blaber SI, Logan TM, Blaber M Protein Sci. 2001 Dec;10(12):2587-99. PMID:11714927<ref>PMID:11714927</ref>

-	~~===Human Acidic Fibroblast Growth Factor~~. ~~141 Amino Acid Form with Amino Terminal His Tag~~.~~===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>

-	~~{{ABSTRACT_PUBMED_11714927}}~~	+	==See Also==
-		+	*[[Fibroblast growth factor\|Fibroblast growth factor]]
-	==~~About this Structure~~==	+	== References ==
-	[[~~1jqz~~]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JQZ OCA].	+	<references/>
-		+	__TOC__
-	==~~Reference~~==	+	</StructureSection>
-	<~~ref group="xtra">PMID:011714927<~~/~~ref~~><~~ref group="xtra">PMID:018308335</ref><references group="xtra"~~/>	+
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Blaber, M.]]		[[Category: Blaber, M.]]

OCA: Protected "1jqz" [edit=sysop:move=sysop]

2012-12-05T11:34:35Z

Protected "1jqz" [edit=sysop:move=sysop]

←Older revision

Revision as of 11:34, 5 December 2012

OCA at 11:34, 5 December 2012

2012-12-05T11:34:30Z

←Older revision		Revision as of 11:34, 5 December 2012
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-	{{Seed}}
	[[Image:1jqz.png\|left\|200px]]		[[Image:1jqz.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_1jqz", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_1jqz\| PDB=1jqz \| SCENE= }}		{{STRUCTURE_1jqz\| PDB=1jqz \| SCENE= }}

	===Human Acidic Fibroblast Growth Factor. 141 Amino Acid Form with Amino Terminal His Tag.===		===Human Acidic Fibroblast Growth Factor. 141 Amino Acid Form with Amino Terminal His Tag.===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_11714927}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 11714927 is the PubMed ID number.
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	{{ABSTRACT_PUBMED_11714927}}		{{ABSTRACT_PUBMED_11714927}}

	==About this Structure==		==About this Structure==
-	~~1JQZ~~ is a 2 ~~chains~~ structure ~~of sequences~~ from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JQZ OCA].	+	[[1jqz]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JQZ OCA].

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~11714927~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:011714927</ref><ref group="xtra">PMID:018308335</ref><references group="xtra"/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Blaber, M.]]		[[Category: Blaber, M.]]
Line 30:		Line 18:
	[[Category: Logan, T M.]]		[[Category: Logan, T M.]]
	[[Category: Beta-trefoil]]		[[Category: Beta-trefoil]]
-		+	[[Category: Hormone-growth factor complex]]
-	~~''Page seeded by~~ [~~http~~:~~//oca.weizmann.ac.il/oca OCA~~ ] ~~on Wed Feb 18 05:42:22 2009''~~	+

OCA at 03:42, 18 February 2009

2009-02-18T03:42:24Z

←Older revision		Revision as of 03:42, 18 February 2009
Line 20:		Line 20:

	==About this Structure==		==About this Structure==
-	1JQZ is a ~~[[Single protein]]~~ structure of ~~sequence~~ from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JQZ OCA].	+	1JQZ is a 2 chains structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JQZ OCA].

	==Reference==		==Reference==
-	Structure and stability effects of mutations designed to increase the primary sequence symmetry within the core region of a beta-trefoil., Brych SR, Blaber SI, Logan TM, Blaber M, Protein Sci. 2001 Dec;10(12):2587-99. PMID:~~[http:~~//~~www.ncbi.nlm.nih.gov/pubmed/11714927 11714927]~~	+	<ref group="xtra">PMID:11714927</ref><references group="xtra"/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
-	[[Category: Single protein]]
	[[Category: Blaber, M.]]		[[Category: Blaber, M.]]
	[[Category: Blaber, S I.]]		[[Category: Blaber, S I.]]
Line 32:		Line 31:
	[[Category: Beta-trefoil]]		[[Category: Beta-trefoil]]

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Tue Jul 1 20~~:40:~~10 2008~~''	+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Feb 18 05:42:22 2009''