1js8 - Revision history

OCA at 07:54, 3 April 2024

2024-04-03T07:54:36Z

←Older revision		Revision as of 07:54, 3 April 2024
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	<StructureSection load='1js8' size='340' side='right'caption='[[1js8]], [[Resolution\|resolution]] 2.30Å' scene=''>		<StructureSection load='1js8' size='340' side='right'caption='[[1js8]], [[Resolution\|resolution]] 2.30Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1js8]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Octopus_dofleini Octopus~~ dofleini]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JS8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1JS8 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1js8]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Enteroctopus_dofleini Enteroctopus dofleini]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JS8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1JS8 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=CUO:CU2-O2+CLUSTER'>CUO</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=NDG:2-(ACETYLAMINO)-2-DEOXY-A-D-GLUCOPYRANOSE'>NDG</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.3Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=CUO:CU2-O2+CLUSTER'>CUO</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=NDG:2-(ACETYLAMINO)-2-DEOXY-A-D-GLUCOPYRANOSE'>NDG</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1js8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1js8 OCA], [https://pdbe.org/1js8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1js8 RCSB], [https://www.ebi.ac.uk/pdbsum/1js8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1js8 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1js8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1js8 OCA], [https://pdbe.org/1js8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1js8 RCSB], [https://www.ebi.ac.uk/pdbsum/1js8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1js8 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/HCYG_ENTDO HCYG_ENTDO]] Hemocyanins are copper-containing oxygen carriers occurring freely dissolved in the hemolymph of many mollusks and arthropods.	+	[https://www.uniprot.org/uniprot/HCYG_ENTDO HCYG_ENTDO] Hemocyanins are copper-containing oxygen carriers occurring freely dissolved in the hemolymph of many mollusks and arthropods.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 19:		Line 20:
	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1js8 ConSurf].		</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1js8 ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
-	<div style="background-color:#fffaf0;">
-	== Publication Abstract from PubMed ==
-	Hemocyanins are giant oxygen transport proteins found in many arthropods and molluscs. Freely dissolved in the hemolymph, they are multisubunit proteins that contain many copies of the active site, a copper atom pair that reversibly binds oxygen. Octopus hemocyanin is composed of ten subunits, each of which contain seven oxygen-binding "functional units". The carboxyl-terminal 47 kDa functional unit, Odg, is a proteolytic isolate that binds oxygen reversibly while exhibiting slight Bohr and magnesium ion effects. In this work we present the X-ray structure determination and analysis of Odg at 2.3 A resolution. Odg has two structural domains: a largely alpha-helical copper binding domain, and a five-stranded anti-parallel beta-sandwich with the jelly roll topology found in many viruses. Six histidine residues ligate the copper atoms, one of which is involved in a thioether bridge. The results show that the hemocyanin from the mollusc and that from the arthropod have distinct tertiary folds in addition to the long recognized differences in their quaternary structures. Nonetheless, a comparison of Octopus and horseshoe crab hemocyanin reveals a similar active site, in a striking example of perhaps both convergent and divergent evolution.
-
-	Crystal structure of a functional unit from Octopus hemocyanin.,Cuff ME, Miller KI, van Holde KE, Hendrickson WA J Mol Biol. 1998 May 15;278(4):855-70. PMID:9614947<ref>PMID:9614947</ref>
-
-	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	</div>
-	<div class="pdbe-citations 1js8" style="background-color:#fffaf0;"></div>
-	== References ==
-	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Enteroctopus dofleini]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	~~[[Category: Octopus dofleini]]~~	+	[[Category: Cuff ME]]
-	[[Category: Cuff~~, M E~~]]	+	[[Category: Hendrickson WA]]
-	[[Category: Hendrickson~~, W A]]~~	+	[[Category: Miller KI]]
-	~~[[Category: Holde, K E.van~~]]	+	[[Category: Van Holde KE]]
-	[[Category: Miller~~, K I~~]]	+
-	[[Category: ~~Glycoprotein]]~~	+
-	~~[[Category: Mollusc]]~~	+
-	~~[[Category: Oxygen storage-transport complex]]~~	+
-	~~[[Category: Oxygen-transport]]~~	+
-	~~[[Category: Thioether bond~~]]	+

OCA at 06:44, 11 August 2021

2021-08-11T06:44:54Z

←Older revision		Revision as of 06:44, 11 August 2021
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	<StructureSection load='1js8' size='340' side='right'caption='[[1js8]], [[Resolution\|resolution]] 2.30Å' scene=''>		<StructureSection load='1js8' size='340' side='right'caption='[[1js8]], [[Resolution\|resolution]] 2.30Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1js8]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Octopus_dofleini Octopus dofleini]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JS8 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1JS8 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1js8]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Octopus_dofleini Octopus dofleini]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JS8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1JS8 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=CUO:CU2-O2+CLUSTER'>CUO</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=NDG:2-(ACETYLAMINO)-2-DEOXY-A-D-GLUCOPYRANOSE'>NDG</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=CUO:CU2-O2+CLUSTER'>CUO</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=NDG:2-(ACETYLAMINO)-2-DEOXY-A-D-GLUCOPYRANOSE'>NDG</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1js8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1js8 OCA], [~~http~~://pdbe.org/1js8 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=1js8 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/1js8 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=1js8 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1js8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1js8 OCA], [https://pdbe.org/1js8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1js8 RCSB], [https://www.ebi.ac.uk/pdbsum/1js8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1js8 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/HCYG_ENTDO HCYG_ENTDO]] Hemocyanins are copper-containing oxygen carriers occurring freely dissolved in the hemolymph of many mollusks and arthropods.	+	[[https://www.uniprot.org/uniprot/HCYG_ENTDO HCYG_ENTDO]] Hemocyanins are copper-containing oxygen carriers occurring freely dissolved in the hemolymph of many mollusks and arthropods.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]

OCA at 09:36, 6 November 2019

2019-11-06T09:36:10Z

←Older revision		Revision as of 09:36, 6 November 2019
Line 1:		Line 1:

	==Structure of a Functional Unit from Octopus Hemocyanin==		==Structure of a Functional Unit from Octopus Hemocyanin==
-	<StructureSection load='1js8' size='340' side='right' caption='[[1js8]], [[Resolution\|resolution]] 2.30Å' scene=''>	+	<StructureSection load='1js8' size='340' side='right'caption='[[1js8]], [[Resolution\|resolution]] 2.30Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1js8]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Octopus_dofleini Octopus dofleini]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JS8 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1JS8 FirstGlance]. <br>		<table><tr><td colspan='2'>[[1js8]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Octopus_dofleini Octopus dofleini]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JS8 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1JS8 FirstGlance]. <br>
Line 32:		Line 32:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Octopus dofleini]]		[[Category: Octopus dofleini]]
	[[Category: Cuff, M E]]		[[Category: Cuff, M E]]

OCA at 09:11, 17 January 2018

2018-01-17T09:11:19Z

←Older revision		Revision as of 09:11, 17 January 2018
Line 1:		Line 1:
		+
	==Structure of a Functional Unit from Octopus Hemocyanin==		==Structure of a Functional Unit from Octopus Hemocyanin==
	<StructureSection load='1js8' size='340' side='right' caption='[[1js8]], [[Resolution\|resolution]] 2.30Å' scene=''>		<StructureSection load='1js8' size='340' side='right' caption='[[1js8]], [[Resolution\|resolution]] 2.30Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1js8]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Enteroctopus_dofleini Enteroctopus~~ dofleini]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JS8 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1JS8 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1js8]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Octopus_dofleini Octopus dofleini]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JS8 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1JS8 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=CUO:CU2-O2+CLUSTER'>CUO</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=NDG:2-(ACETYLAMINO)-2-DEOXY-A-D-GLUCOPYRANOSE'>NDG</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=CUO:CU2-O2+CLUSTER'>CUO</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=NDG:2-(ACETYLAMINO)-2-DEOXY-A-D-GLUCOPYRANOSE'>NDG</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1js8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1js8 OCA], [http://pdbe.org/1js8 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1js8 RCSB], [http://www.ebi.ac.uk/pdbsum/1js8 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1js8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1js8 OCA], [http://pdbe.org/1js8 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1js8 RCSB], [http://www.ebi.ac.uk/pdbsum/1js8 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1js8 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 12:		Line 13:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/js/1js8_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/js/1js8_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
Line 31:		Line 32:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Enteroctopus~~ dofleini]]	+	[[Category: Octopus dofleini]]
	[[Category: Cuff, M E]]		[[Category: Cuff, M E]]
	[[Category: Hendrickson, W A]]		[[Category: Hendrickson, W A]]

OCA at 13:42, 7 February 2016

2016-02-07T13:42:30Z

←Older revision		Revision as of 13:42, 7 February 2016
Line 16:		Line 16:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1js8 ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 02:01, 10 September 2015

2015-09-10T02:01:16Z

←Older revision		Revision as of 02:01, 10 September 2015
Line 4:		Line 4:
	<table><tr><td colspan='2'>[[1js8]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Enteroctopus_dofleini Enteroctopus dofleini]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JS8 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1JS8 FirstGlance]. <br>		<table><tr><td colspan='2'>[[1js8]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Enteroctopus_dofleini Enteroctopus dofleini]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JS8 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1JS8 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=CUO:CU2-O2+CLUSTER'>CUO</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=NDG:2-(ACETYLAMINO)-2-DEOXY-A-D-GLUCOPYRANOSE'>NDG</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=CUO:CU2-O2+CLUSTER'>CUO</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=NDG:2-(ACETYLAMINO)-2-DEOXY-A-D-GLUCOPYRANOSE'>NDG</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1js8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1js8 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1js8 RCSB], [http://www.ebi.ac.uk/pdbsum/1js8 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1js8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1js8 OCA], [http://pdbe.org/1js8 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1js8 RCSB], [http://www.ebi.ac.uk/pdbsum/1js8 PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[http://www.uniprot.org/uniprot/~~HCYG_OCTDO HCYG_OCTDO~~]] Hemocyanins are copper-containing oxygen carriers occurring freely dissolved in the hemolymph of many mollusks and arthropods.	+	[[http://www.uniprot.org/uniprot/HCYG_ENTDO HCYG_ENTDO]] Hemocyanins are copper-containing oxygen carriers occurring freely dissolved in the hemolymph of many mollusks and arthropods.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 26:		Line 26:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 1js8" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>

OCA at 15:30, 24 December 2014

2014-12-24T15:30:13Z

←Older revision		Revision as of 15:30, 24 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1js8]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Enteroctopus_dofleini Enteroctopus dofleini]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JS8 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1JS8 FirstGlance]. <br>		<table><tr><td colspan='2'>[[1js8]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Enteroctopus_dofleini Enteroctopus dofleini]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JS8 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1JS8 FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=CUO:CU2-O2+CLUSTER'>CUO</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=NDG:2-(ACETYLAMINO)-2-DEOXY-A-D-GLUCOPYRANOSE'>NDG</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=CUO:CU2-O2+CLUSTER'>CUO</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=NDG:2-(ACETYLAMINO)-2-DEOXY-A-D-GLUCOPYRANOSE'>NDG</scene></td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1js8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1js8 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1js8 RCSB], [http://www.ebi.ac.uk/pdbsum/1js8 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1js8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1js8 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1js8 RCSB], [http://www.ebi.ac.uk/pdbsum/1js8 PDBsum]</span></td></tr>
-	<table>	+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/HCYG_OCTDO HCYG_OCTDO]] Hemocyanins are copper-containing oxygen carriers occurring freely dissolved in the hemolymph of many mollusks and arthropods.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 29:		Line 31:
	</StructureSection>		</StructureSection>
	[[Category: Enteroctopus dofleini]]		[[Category: Enteroctopus dofleini]]
-	[[Category: Cuff, M E.]]	+	[[Category: Cuff, M E]]
-	[[Category: Hendrickson, W A.]]	+	[[Category: Hendrickson, W A]]
-	[[Category: Holde, K E.van.]]	+	[[Category: Holde, K E.van]]
-	[[Category: Miller, K I.]]	+	[[Category: Miller, K I]]
	[[Category: Glycoprotein]]		[[Category: Glycoprotein]]
	[[Category: Mollusc]]		[[Category: Mollusc]]

OCA at 12:53, 28 September 2014

2014-09-28T12:53:13Z

←Older revision		Revision as of 12:53, 28 September 2014
Line 1:		Line 1:
-	[[~~Image~~:1js8.~~png\|left~~\|200px]]	+	==Structure of a Functional Unit from Octopus Hemocyanin==
		+	<StructureSection load='1js8' size='340' side='right' caption='[[1js8]], [[Resolution\|resolution]] 2.30Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[1js8]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Enteroctopus_dofleini Enteroctopus dofleini]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JS8 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1JS8 FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=CUO:CU2-O2+CLUSTER'>CUO</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=NDG:2-(ACETYLAMINO)-2-DEOXY-A-D-GLUCOPYRANOSE'>NDG</scene><br>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1js8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1js8 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1js8 RCSB], [http://www.ebi.ac.uk/pdbsum/1js8 PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/js/1js8_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Hemocyanins are giant oxygen transport proteins found in many arthropods and molluscs. Freely dissolved in the hemolymph, they are multisubunit proteins that contain many copies of the active site, a copper atom pair that reversibly binds oxygen. Octopus hemocyanin is composed of ten subunits, each of which contain seven oxygen-binding "functional units". The carboxyl-terminal 47 kDa functional unit, Odg, is a proteolytic isolate that binds oxygen reversibly while exhibiting slight Bohr and magnesium ion effects. In this work we present the X-ray structure determination and analysis of Odg at 2.3 A resolution. Odg has two structural domains: a largely alpha-helical copper binding domain, and a five-stranded anti-parallel beta-sandwich with the jelly roll topology found in many viruses. Six histidine residues ligate the copper atoms, one of which is involved in a thioether bridge. The results show that the hemocyanin from the mollusc and that from the arthropod have distinct tertiary folds in addition to the long recognized differences in their quaternary structures. Nonetheless, a comparison of Octopus and horseshoe crab hemocyanin reveals a similar active site, in a striking example of perhaps both convergent and divergent evolution.

-	~~{{STRUCTURE_1js8\| PDB=1js8 \| SCENE= }}~~	+	Crystal structure of a functional unit from Octopus hemocyanin.,Cuff ME, Miller KI, van Holde KE, Hendrickson WA J Mol Biol. 1998 May 15;278(4):855-70. PMID:9614947<ref>PMID:9614947</ref>

-	~~===Structure~~ of ~~a Functional Unit from Octopus Hemocyanin===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_9614947}}~~	+	== References ==
-		+	<references/>
-	~~==About this Structure==~~	+	__TOC__
-	~~[[1js8]] is a 2 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Enteroctopus_dofleini Enteroctopus dofleini]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=1JS8 OCA].~~	+	</StructureSection>
-		+
-	==~~Reference~~==	+
-	<~~ref group="xtra">PMID:009614947<~~/~~ref~~><~~references group="xtra"~~/>	+
	[[Category: Enteroctopus dofleini]]		[[Category: Enteroctopus dofleini]]
	[[Category: Cuff, M E.]]		[[Category: Cuff, M E.]]

OCA: Protected "1js8" [edit=sysop:move=sysop]

2012-12-05T11:24:49Z

Protected "1js8" [edit=sysop:move=sysop]

←Older revision

Revision as of 11:24, 5 December 2012

OCA at 11:24, 5 December 2012

2012-12-05T11:24:44Z

←Older revision		Revision as of 11:24, 5 December 2012
Line 1:		Line 1:
-	{{Seed}}
	[[Image:1js8.png\|left\|200px]]		[[Image:1js8.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_1js8", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_1js8\| PDB=1js8 \| SCENE= }}		{{STRUCTURE_1js8\| PDB=1js8 \| SCENE= }}

	===Structure of a Functional Unit from Octopus Hemocyanin===		===Structure of a Functional Unit from Octopus Hemocyanin===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_9614947}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 9614947 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_9614947}}		{{ABSTRACT_PUBMED_9614947}}

	==About this Structure==		==About this Structure==
-	~~1JS8~~ is a 2 ~~chains~~ structure ~~of sequences~~ from [http://en.wikipedia.org/wiki/~~Octopus_dofleini Octopus~~ dofleini]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JS8 OCA].	+	[[1js8]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Enteroctopus_dofleini Enteroctopus dofleini]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JS8 OCA].

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~9614947~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:009614947</ref><references group="xtra"/>
-	[[Category: ~~Octopus~~ dofleini]]	+	[[Category: Enteroctopus dofleini]]
	[[Category: Cuff, M E.]]		[[Category: Cuff, M E.]]
	[[Category: Hendrickson, W A.]]		[[Category: Hendrickson, W A.]]
	[[Category: Holde, K E.van.]]		[[Category: Holde, K E.van.]]
	[[Category: Miller, K I.]]		[[Category: Miller, K I.]]
-	[[Category: Copper]]
	[[Category: Glycoprotein]]		[[Category: Glycoprotein]]
	[[Category: Mollusc]]		[[Category: Mollusc]]
		+	[[Category: Oxygen storage-transport complex]]
	[[Category: Oxygen-transport]]		[[Category: Oxygen-transport]]
	[[Category: Thioether bond]]		[[Category: Thioether bond]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Feb 16 14:11:17 2009''