1k43 - Revision history

OCA at 18:45, 29 November 2023

2023-11-29T18:45:28Z

←Older revision		Revision as of 18:45, 29 November 2023
Line 1:		Line 1:

	==10 Structure Ensemble of the 14-residue peptide RG-KWTY-NG-ITYE-GR (MBH12)==		==10 Structure Ensemble of the 14-residue peptide RG-KWTY-NG-ITYE-GR (MBH12)==
-	<StructureSection load='1k43' size='340' side='right'caption='[[1k43~~]], [[NMR_Ensembles_of_Models \| 10 NMR models~~]]' scene=''>	+	<StructureSection load='1k43' size='340' side='right'caption='[[1k43]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1k43]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1K43 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1K43 FirstGlance]. <br>		<table><tr><td colspan='2'>[[1k43]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1K43 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1K43 FirstGlance]. <br>
-	</td></tr><tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"~~><div style~~=~~'overflow: auto; max-height: 3em;'>[[1j4m\|1j4m]]</div~~></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1k43 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1k43 OCA], [https://pdbe.org/1k43 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1k43 RCSB], [https://www.ebi.ac.uk/pdbsum/1k43 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1k43 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1k43 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1k43 OCA], [https://pdbe.org/1k43 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1k43 RCSB], [https://www.ebi.ac.uk/pdbsum/1k43 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1k43 ProSAT]</span></td></tr>
	</table>		</table>
Line 21:		Line 21:
	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Lacroix, E]]	+	[[Category: Lacroix E]]
-	[[Category: ~~Pastor,~~ M T]]	+	[[Category: Lopez de la Paz M]]
-	[[Category: ~~Paz, M Lopez de la~~]]	+	[[Category: Pastor MT]]
-	[[Category: Perez-Paya, E]]	+	[[Category: Perez-Paya E]]
-	[[Category: Serrano, L]]	+	[[Category: Serrano L]]
-	~~[[Category: Beta-hairpin]]~~	+
-	~~[[Category: De novo protein~~]]	+

OCA at 08:45, 21 April 2021

2021-04-21T08:45:20Z

←Older revision		Revision as of 08:45, 21 April 2021
Line 3:		Line 3:
	<StructureSection load='1k43' size='340' side='right'caption='[[1k43]], [[NMR_Ensembles_of_Models \| 10 NMR models]]' scene=''>		<StructureSection load='1k43' size='340' side='right'caption='[[1k43]], [[NMR_Ensembles_of_Models \| 10 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1k43]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1K43 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1K43 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1k43]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1K43 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1K43 FirstGlance]. <br>
-	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1j4m\|1j4m]]</td></tr>	+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1j4m\|1j4m]]</div></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1k43 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1k43 OCA], [~~http~~://pdbe.org/1k43 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=1k43 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/1k43 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=1k43 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1k43 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1k43 OCA], [https://pdbe.org/1k43 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1k43 RCSB], [https://www.ebi.ac.uk/pdbsum/1k43 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1k43 ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 13:14, 17 July 2019

2019-07-17T13:14:12Z

←Older revision		Revision as of 13:14, 17 July 2019
Line 1:		Line 1:

	==10 Structure Ensemble of the 14-residue peptide RG-KWTY-NG-ITYE-GR (MBH12)==		==10 Structure Ensemble of the 14-residue peptide RG-KWTY-NG-ITYE-GR (MBH12)==
-	<StructureSection load='1k43' size='340' side='right' caption='[[1k43]], [[NMR_Ensembles_of_Models \| 10 NMR models]]' scene=''>	+	<StructureSection load='1k43' size='340' side='right'caption='[[1k43]], [[NMR_Ensembles_of_Models \| 10 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1k43]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1K43 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1K43 FirstGlance]. <br>		<table><tr><td colspan='2'>[[1k43]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1K43 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1K43 FirstGlance]. <br>
Line 20:		Line 20:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Lacroix, E]]		[[Category: Lacroix, E]]
	[[Category: Pastor, M T]]		[[Category: Pastor, M T]]

OCA at 07:28, 11 October 2017

2017-10-11T07:28:46Z

←Older revision		Revision as of 07:28, 11 October 2017
Line 1:		Line 1:
		+
	==10 Structure Ensemble of the 14-residue peptide RG-KWTY-NG-ITYE-GR (MBH12)==		==10 Structure Ensemble of the 14-residue peptide RG-KWTY-NG-ITYE-GR (MBH12)==
	<StructureSection load='1k43' size='340' side='right' caption='[[1k43]], [[NMR_Ensembles_of_Models \| 10 NMR models]]' scene=''>		<StructureSection load='1k43' size='340' side='right' caption='[[1k43]], [[NMR_Ensembles_of_Models \| 10 NMR models]]' scene=''>
Line 4:		Line 5:
	<table><tr><td colspan='2'>[[1k43]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1K43 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1K43 FirstGlance]. <br>		<table><tr><td colspan='2'>[[1k43]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1K43 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1K43 FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1j4m\|1j4m]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1j4m\|1j4m]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1k43 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1k43 OCA], [http://pdbe.org/1k43 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1k43 RCSB], [http://www.ebi.ac.uk/pdbsum/1k43 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1k43 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1k43 OCA], [http://pdbe.org/1k43 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1k43 RCSB], [http://www.ebi.ac.uk/pdbsum/1k43 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1k43 ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 06:11, 11 September 2015

2015-09-11T06:11:22Z

←Older revision		Revision as of 06:11, 11 September 2015
Line 4:		Line 4:
	<table><tr><td colspan='2'>[[1k43]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1K43 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1K43 FirstGlance]. <br>		<table><tr><td colspan='2'>[[1k43]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1K43 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1K43 FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1j4m\|1j4m]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1j4m\|1j4m]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1k43 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1k43 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1k43 RCSB], [http://www.ebi.ac.uk/pdbsum/1k43 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1k43 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1k43 OCA], [http://pdbe.org/1k43 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1k43 RCSB], [http://www.ebi.ac.uk/pdbsum/1k43 PDBsum]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 14:		Line 14:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 1k43" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>

OCA at 15:39, 5 January 2015

2015-01-05T15:39:40Z

←Older revision		Revision as of 15:39, 5 January 2015
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1k43]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1K43 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1K43 FirstGlance]. <br>		<table><tr><td colspan='2'>[[1k43]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1K43 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1K43 FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1j4m\|1j4m]]</td></tr>	+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1j4m\|1j4m]]</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1k43 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1k43 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1k43 RCSB], [http://www.ebi.ac.uk/pdbsum/1k43 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1k43 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1k43 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1k43 RCSB], [http://www.ebi.ac.uk/pdbsum/1k43 PDBsum]</span></td></tr>
-	<table>	+	</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 18:		Line 18:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Lacroix, E.]]	+	[[Category: Lacroix, E]]
-	[[Category: Pastor, M T.]]	+	[[Category: Pastor, M T]]
-	[[Category: Paz, M Lopez de la.]]	+	[[Category: Paz, M Lopez de la]]
-	[[Category: Perez-Paya, E.]]	+	[[Category: Perez-Paya, E]]
-	[[Category: Serrano, L.]]	+	[[Category: Serrano, L]]
	[[Category: Beta-hairpin]]		[[Category: Beta-hairpin]]
	[[Category: De novo protein]]		[[Category: De novo protein]]

OCA at 10:14, 28 September 2014

2014-09-28T10:14:14Z

←Older revision		Revision as of 10:14, 28 September 2014
Line 1:		Line 1:
-	[[~~Image:~~1k43.~~png~~\|~~left~~\|~~200px~~]]	+	==10 Structure Ensemble of the 14-residue peptide RG-KWTY-NG-ITYE-GR (MBH12)==
		+	<StructureSection load='1k43' size='340' side='right' caption='[[1k43]], [[NMR_Ensembles_of_Models \| 10 NMR models]]' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[1k43]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1K43 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1K43 FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1j4m\|1j4m]]</td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1k43 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1k43 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1k43 RCSB], [http://www.ebi.ac.uk/pdbsum/1k43 PDBsum]</span></td></tr>
		+	<table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Here we present a combinatorial approach to evolve a stable beta-hairpin fold in a linear peptide. Starting with a de novo-designed linear peptide that shows a beta-hairpin structure population of around 30%, we selected four positions to build up a combinatorial library of 20(4) sequences. Deconvolution of the library using circular dichroism reduced such a sequence complexity to 36 defined sequences. Circular dichroism and NMR of these peptides resulted in the identification of two linear 14-aa-long peptides that in plain buffered solutions showed a percentage of beta-hairpin structure higher than 70%. Our results show how combinatorial approaches can be used to obtain highly structured peptide sequences that could be used as templates in which functionality can be introduced.

-	~~{{STRUCTURE_1k43\| PDB=1k43 \| SCENE= }}~~	+	Combinatorial approaches: a new tool to search for highly structured beta-hairpin peptides.,Pastor MT, Lopez de la Paz M, Lacroix E, Serrano L, Perez-Paya E Proc Natl Acad Sci U S A. 2002 Jan 22;99(2):614-9. Epub 2002 Jan 8. PMID:11782528<ref>PMID:11782528</ref>

-	~~===10 Structure Ensemble~~ of the ~~14-residue peptide RG-KWTY-NG-ITYE-GR (MBH12)===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_11782528}}~~	+	== References ==
-		+	<references/>
-	~~==About this Structure==~~	+	__TOC__
-	~~[[1k43]] is a 1 chain structure~~. ~~Full experimental information is available from [http://oca~~.~~weizmann~~.~~ac.il~~/~~oca-bin/ocashort?id=1K43 OCA].~~	+	</StructureSection>
-		+
-	==~~Reference~~==	+
-	<~~ref group="xtra">PMID:011782528<~~/~~ref~~><~~references group="xtra"~~/>	+
	[[Category: Lacroix, E.]]		[[Category: Lacroix, E.]]
	[[Category: Pastor, M T.]]		[[Category: Pastor, M T.]]

OCA: Protected "1k43" [edit=sysop:move=sysop]

2012-12-05T19:55:08Z

Protected "1k43" [edit=sysop:move=sysop]

←Older revision

Revision as of 19:55, 5 December 2012

OCA at 19:55, 5 December 2012

2012-12-05T19:55:05Z

←Older revision		Revision as of 19:55, 5 December 2012
Line 1:		Line 1:
-	{{Seed}}
	[[Image:1k43.png\|left\|200px]]		[[Image:1k43.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_1k43", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_1k43\| PDB=1k43 \| SCENE= }}		{{STRUCTURE_1k43\| PDB=1k43 \| SCENE= }}

	===10 Structure Ensemble of the 14-residue peptide RG-KWTY-NG-ITYE-GR (MBH12)===		===10 Structure Ensemble of the 14-residue peptide RG-KWTY-NG-ITYE-GR (MBH12)===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_11782528}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 11782528 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_11782528}}		{{ABSTRACT_PUBMED_11782528}}

	==About this Structure==		==About this Structure==
-	Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1K43 OCA].	+	[[1k43]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1K43 OCA].

	==Reference==		==Reference==
-	Combinatorial approaches: a new tool to search for highly structured beta-hairpin peptides., Pastor MT, Lopez de la Paz M, Lacroix E, Serrano L, Perez-Paya E, Proc Natl Acad Sci U S A. 2002 Jan 22;99(2):614-9. Epub 2002 Jan 8. PMID:~~[http://www.ncbi.nlm.nih.gov~~/~~pubmed~~/~~11782528 11782528]~~	+	<ref group="xtra">PMID:011782528</ref><references group="xtra"/>
	[[Category: Lacroix, E.]]		[[Category: Lacroix, E.]]
	[[Category: Pastor, M T.]]		[[Category: Pastor, M T.]]
Line 30:		Line 18:
	[[Category: Serrano, L.]]		[[Category: Serrano, L.]]
	[[Category: Beta-hairpin]]		[[Category: Beta-hairpin]]
-		+	[[Category: De novo protein]]
-	~~''Page seeded by~~ [~~http~~:~~//oca.weizmann.ac.il/oca OCA~~ ] ~~on Wed Jul 2 05:43:22 2008''~~	+

OCA at 04:12, 2 July 2008

2008-07-02T04:12:42Z

←Older revision		Revision as of 04:12, 2 July 2008
Line 1:		Line 1:
-	[[Image:1k43.~~gif~~\|left\|200px]]	+	{{Seed}}
		+	[[Image:1k43.png\|left\|200px]]

	<!--		<!--
Line 9:		Line 10:
	{{STRUCTURE_1k43\| PDB=1k43 \| SCENE= }}		{{STRUCTURE_1k43\| PDB=1k43 \| SCENE= }}

-	~~'''~~10 Structure Ensemble of the 14-residue peptide RG-KWTY-NG-ITYE-GR (MBH12)~~'''~~	+	===10 Structure Ensemble of the 14-residue peptide RG-KWTY-NG-ITYE-GR (MBH12)===


-	~~==Overview==~~	+	<!--
-	~~Here we present a combinatorial approach to evolve a stable beta~~-~~hairpin fold in a linear peptide. Starting with a de novo~~-~~designed linear peptide that shows a beta-hairpin structure population of around 30%~~, ~~we selected four positions~~ to ~~build up a combinatorial library of 20~~(4) ~~sequences. Deconvolution of~~ the ~~library using circular dichroism reduced such a sequence complexity to 36 defined sequences~~. ~~Circular dichroism and NMR of these peptides resulted in the identification of two linear 14~~-aa-long peptides that in plain buffered solutions showed a percentage of beta-hairpin structure higher than 70%. Our results show how combinatorial approaches can be used to obtain highly structured peptide sequences that could be used as templates in which functionality can be introduced.	+	The line below this paragraph, {{ABSTRACT_PUBMED_11782528}}, adds the Publication Abstract to the page
		+	(as it appears on PubMed at http://www.pubmed.gov), where 11782528 is the PubMed ID number.
		+	-->
		+	{{ABSTRACT_PUBMED_11782528}}

	==About this Structure==		==About this Structure==
-	Full ~~crystallographic~~ information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1K43 OCA].	+	Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1K43 OCA].

	==Reference==		==Reference==
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	[[Category: Serrano, L.]]		[[Category: Serrano, L.]]
	[[Category: Beta-hairpin]]		[[Category: Beta-hairpin]]
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Fri May~~ 2 22:16:52 2008''	+
		+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul 2 05:43:22 2008''