1k6z - Revision history

OCA at 06:05, 3 April 2024

2024-04-03T06:05:09Z

←Older revision		Revision as of 06:05, 3 April 2024
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	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1k6z]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Yersinia_pestis Yersinia pestis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1K6Z OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1K6Z FirstGlance]. <br>		<table><tr><td colspan='2'>[[1k6z]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Yersinia_pestis Yersinia pestis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1K6Z OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1K6Z FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=IMD:IMIDAZOLE'>IMD</scene>, <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=IMD:IMIDAZOLE'>IMD</scene>, <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1k6z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1k6z OCA], [https://pdbe.org/1k6z PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1k6z RCSB], [https://www.ebi.ac.uk/pdbsum/1k6z PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1k6z ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1k6z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1k6z OCA], [https://pdbe.org/1k6z PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1k6z RCSB], [https://www.ebi.ac.uk/pdbsum/1k6z PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1k6z ProSAT]</span></td></tr>
	</table>		</table>
Line 19:		Line 20:
	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1k6z ConSurf].		</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1k6z ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
-	<div style="background-color:#fffaf0;">
-	== Publication Abstract from PubMed ==
-	Many bacterial pathogens utilize a type III (contact-dependent) secretion system to inject cytotoxic effector proteins directly into host cells. This ingenious mechanism, designed for both bacterial offense and defense, has been studied most extensively in Yersinia spp. To be exported efficiently, at least three of the effectors (YopE, YopH and YopT) and several other proteins that transit the type III secretion pathway in Yersinia (YopN, YopD and YopB) must first form transient complexes with cognate-specific Yop chaperone (Syc) proteins. The cytotoxic effector YopE, a selective activator of mammalian Rho-family GTPases, associates with SycE. Here, the structure of Y. pestis SycE at 1.95A resolution is reported. SycE possesses a novel fold with an unusual dimerization motif and an intriguing basic cavity located on the dyad axis of the dimer that may participate in its interaction with YopE.
-
-	Three-dimensional structure of the type III secretion chaperone SycE from Yersinia pestis.,Evdokimov AG, Tropea JE, Routzahn KM, Waugh DS Acta Crystallogr D Biol Crystallogr. 2002 Mar;58(Pt 3):398-406. Epub 2002, Feb 21. PMID:11856824<ref>PMID:11856824</ref>
-
-	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	</div>
-	<div class="pdbe-citations 1k6z" style="background-color:#fffaf0;"></div>
-	== References ==
-	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>

OCA at 09:42, 21 December 2022

2022-12-21T09:42:37Z

←Older revision		Revision as of 09:42, 21 December 2022
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	<StructureSection load='1k6z' size='340' side='right'caption='[[1k6z]], [[Resolution\|resolution]] 2.00Å' scene=''>		<StructureSection load='1k6z' size='340' side='right'caption='[[1k6z]], [[Resolution\|resolution]] 2.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1k6z]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~"bacillus_pestis"_(lehmann_and_neumann_1896)_migula_1900 "bacillus~~ pestis~~" (lehmann and neumann 1896) migula 1900~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1K6Z OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=1K6Z FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1k6z]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Yersinia_pestis Yersinia pestis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1K6Z OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1K6Z FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=IMD:IMIDAZOLE'>IMD</scene>~~</td></tr>~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=IMD:IMIDAZOLE'>IMD</scene>, <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
-	~~<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat">~~<scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene>~~</td></tr>~~	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1k6z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1k6z OCA], [https://pdbe.org/1k6z PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1k6z RCSB], [https://www.ebi.ac.uk/pdbsum/1k6z PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1k6z ProSAT]</span></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1huf\|1huf]], [[1g9u\|1g9u]], [[1jl5\|1jl5]], [[1jyo\|1jyo]], [[1k3e\|1k3e]], [[1k3s\|1k3s]]</div></td></tr>	+
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">SycE ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=632 "Bacillus pestis" (Lehmann and Neumann 1896) Migula 1900])</td></tr>	+
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=1k6z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1k6z OCA], [~~http~~://pdbe.org/1k6z PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=1k6z RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/1k6z PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=1k6z ProSAT]</span></td></tr>	+
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/YERA_YERPE YERA_YERPE]] Positive regulator of YopE.	+	[https://www.uniprot.org/uniprot/YERA_YERPE YERA_YERPE] Positive regulator of YopE.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Evdokimov, A G~~]]	+	[[Category: Yersinia pestis]]
-	[[Category: ~~Routzahn, K M~~]]	+	[[Category: Evdokimov AG]]
-	[[Category: ~~Tropea, J E~~]]	+	[[Category: Routzahn KM]]
-	[[Category: ~~Waugh, D S~~]]	+	[[Category: Tropea JE]]
-	[[Category: ~~Chaperone]]~~	+	[[Category: Waugh DS]]
-	~~[[Category: Secretion]]~~	+
-	~~[[Category: Toxin]]~~	+
-	~~[[Category: Yersinia pesti~~]]	+

OCA at 07:41, 25 November 2020

2020-11-25T07:41:21Z

←Older revision		Revision as of 07:41, 25 November 2020
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	==Crystal Structure of the Yersinia Secretion Chaperone SycE==		==Crystal Structure of the Yersinia Secretion Chaperone SycE==
-	<StructureSection load='1k6z' size='340' side='right' caption='[[1k6z]], [[Resolution\|resolution]] 2.00Å' scene=''>	+	<StructureSection load='1k6z' size='340' side='right'caption='[[1k6z]], [[Resolution\|resolution]] 2.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1k6z]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_pestis"_(lehmann_and_neumann_1896)_migula_1900 "bacillus pestis" (lehmann and neumann 1896) migula 1900]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1K6Z OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1K6Z FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1k6z]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_pestis"_(lehmann_and_neumann_1896)_migula_1900 "bacillus pestis" (lehmann and neumann 1896) migula 1900]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1K6Z OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=1K6Z FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=IMD:IMIDAZOLE'>IMD</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=IMD:IMIDAZOLE'>IMD</scene></td></tr>
	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>		<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1huf\|1huf]], [[1g9u\|1g9u]], [[1jl5\|1jl5]], [[1jyo\|1jyo]], [[1k3e\|1k3e]], [[1k3s\|1k3s]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1huf\|1huf]], [[1g9u\|1g9u]], [[1jl5\|1jl5]], [[1jyo\|1jyo]], [[1k3e\|1k3e]], [[1k3s\|1k3s]]</div></td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">SycE ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=632 "Bacillus pestis" (Lehmann and Neumann 1896) Migula 1900])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">SycE ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=632 "Bacillus pestis" (Lehmann and Neumann 1896) Migula 1900])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1k6z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1k6z OCA], [http://pdbe.org/1k6z PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1k6z RCSB], [http://www.ebi.ac.uk/pdbsum/1k6z PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1k6z ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=1k6z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1k6z OCA], [http://pdbe.org/1k6z PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1k6z RCSB], [http://www.ebi.ac.uk/pdbsum/1k6z PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1k6z ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Evdokimov, A G]]		[[Category: Evdokimov, A G]]
	[[Category: Routzahn, K M]]		[[Category: Routzahn, K M]]

OCA at 21:27, 24 January 2018

2018-01-24T21:27:26Z

←Older revision		Revision as of 21:27, 24 January 2018
Line 1:		Line 1:
		+
	==Crystal Structure of the Yersinia Secretion Chaperone SycE==		==Crystal Structure of the Yersinia Secretion Chaperone SycE==
	<StructureSection load='1k6z' size='340' side='right' caption='[[1k6z]], [[Resolution\|resolution]] 2.00Å' scene=''>		<StructureSection load='1k6z' size='340' side='right' caption='[[1k6z]], [[Resolution\|resolution]] 2.00Å' scene=''>
Line 7:		Line 8:
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1huf\|1huf]], [[1g9u\|1g9u]], [[1jl5\|1jl5]], [[1jyo\|1jyo]], [[1k3e\|1k3e]], [[1k3s\|1k3s]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1huf\|1huf]], [[1g9u\|1g9u]], [[1jl5\|1jl5]], [[1jyo\|1jyo]], [[1k3e\|1k3e]], [[1k3s\|1k3s]]</td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">SycE ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=632 "Bacillus pestis" (Lehmann and Neumann 1896) Migula 1900])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">SycE ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=632 "Bacillus pestis" (Lehmann and Neumann 1896) Migula 1900])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1k6z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1k6z OCA], [http://pdbe.org/1k6z PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1k6z RCSB], [http://www.ebi.ac.uk/pdbsum/1k6z PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1k6z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1k6z OCA], [http://pdbe.org/1k6z PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1k6z RCSB], [http://www.ebi.ac.uk/pdbsum/1k6z PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1k6z ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 15:		Line 16:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/k6/1k6z_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/k6/1k6z_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>

OCA at 04:41, 10 February 2016

2016-02-10T04:41:04Z

←Older revision		Revision as of 04:41, 10 February 2016
Line 19:		Line 19:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1k6z ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 05:28, 11 September 2015

2015-09-11T05:28:35Z

←Older revision		Revision as of 05:28, 11 September 2015
Line 2:		Line 2:
	<StructureSection load='1k6z' size='340' side='right' caption='[[1k6z]], [[Resolution\|resolution]] 2.00Å' scene=''>		<StructureSection load='1k6z' size='340' side='right' caption='[[1k6z]], [[Resolution\|resolution]] 2.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1k6z]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Yersinia_pestis Yersinia~~ pestis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1K6Z OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1K6Z FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1k6z]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_pestis"_(lehmann_and_neumann_1896)_migula_1900 "bacillus pestis" (lehmann and neumann 1896) migula 1900]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1K6Z OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1K6Z FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=IMD:IMIDAZOLE'>IMD</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=IMD:IMIDAZOLE'>IMD</scene></td></tr>
	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>		<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1huf\|1huf]], [[1g9u\|1g9u]], [[1jl5\|1jl5]], [[1jyo\|1jyo]], [[1k3e\|1k3e]], [[1k3s\|1k3s]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1huf\|1huf]], [[1g9u\|1g9u]], [[1jl5\|1jl5]], [[1jyo\|1jyo]], [[1k3e\|1k3e]], [[1k3s\|1k3s]]</td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">SycE ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=632 ~~Yersinia~~ pestis])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">SycE ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=632 "Bacillus pestis" (Lehmann and Neumann 1896) Migula 1900])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1k6z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1k6z OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1k6z RCSB], [http://www.ebi.ac.uk/pdbsum/1k6z PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1k6z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1k6z OCA], [http://pdbe.org/1k6z PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1k6z RCSB], [http://www.ebi.ac.uk/pdbsum/1k6z PDBsum]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/YERA_YERPE YERA_YERPE]] Positive regulator of YopE.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 27:		Line 29:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 1k6z" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Yersinia pestis]]
	[[Category: Evdokimov, A G]]		[[Category: Evdokimov, A G]]
	[[Category: Routzahn, K M]]		[[Category: Routzahn, K M]]

OCA at 16:39, 5 January 2015

2015-01-05T16:39:05Z

←Older revision		Revision as of 16:39, 5 January 2015
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1k6z]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Yersinia_pestis Yersinia pestis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1K6Z OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1K6Z FirstGlance]. <br>		<table><tr><td colspan='2'>[[1k6z]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Yersinia_pestis Yersinia pestis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1K6Z OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1K6Z FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=IMD:IMIDAZOLE'>IMD</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=IMD:IMIDAZOLE'>IMD</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>	+	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1huf\|1huf]], [[1g9u\|1g9u]], [[1jl5\|1jl5]], [[1jyo\|1jyo]], [[1k3e\|1k3e]], [[1k3s\|1k3s]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1huf\|1huf]], [[1g9u\|1g9u]], [[1jl5\|1jl5]], [[1jyo\|1jyo]], [[1k3e\|1k3e]], [[1k3s\|1k3s]]</td></tr>
-	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">SycE ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=632 Yersinia pestis])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">SycE ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=632 Yersinia pestis])</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1k6z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1k6z OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1k6z RCSB], [http://www.ebi.ac.uk/pdbsum/1k6z PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1k6z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1k6z OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1k6z RCSB], [http://www.ebi.ac.uk/pdbsum/1k6z PDBsum]</span></td></tr>
-	<table>	+	</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 32:		Line 32:
	</StructureSection>		</StructureSection>
	[[Category: Yersinia pestis]]		[[Category: Yersinia pestis]]
-	[[Category: Evdokimov, A G.]]	+	[[Category: Evdokimov, A G]]
-	[[Category: Routzahn, K M.]]	+	[[Category: Routzahn, K M]]
-	[[Category: Tropea, J E.]]	+	[[Category: Tropea, J E]]
-	[[Category: Waugh, D S.]]	+	[[Category: Waugh, D S]]
	[[Category: Chaperone]]		[[Category: Chaperone]]
	[[Category: Secretion]]		[[Category: Secretion]]
	[[Category: Toxin]]		[[Category: Toxin]]
	[[Category: Yersinia pesti]]		[[Category: Yersinia pesti]]

OCA at 09:22, 28 September 2014

2014-09-28T09:22:19Z

←Older revision		Revision as of 09:22, 28 September 2014
Line 1:		Line 1:
-	[[~~Image:~~1k6z.~~png~~\|~~left~~\|200px]]	+	==Crystal Structure of the Yersinia Secretion Chaperone SycE==
		+	<StructureSection load='1k6z' size='340' side='right' caption='[[1k6z]], [[Resolution\|resolution]] 2.00Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[1k6z]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Yersinia_pestis Yersinia pestis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1K6Z OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1K6Z FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=IMD:IMIDAZOLE'>IMD</scene><br>
		+	<tr><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
		+	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1huf\|1huf]], [[1g9u\|1g9u]], [[1jl5\|1jl5]], [[1jyo\|1jyo]], [[1k3e\|1k3e]], [[1k3s\|1k3s]]</td></tr>
		+	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">SycE ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=632 Yersinia pestis])</td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1k6z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1k6z OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1k6z RCSB], [http://www.ebi.ac.uk/pdbsum/1k6z PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/k6/1k6z_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Many bacterial pathogens utilize a type III (contact-dependent) secretion system to inject cytotoxic effector proteins directly into host cells. This ingenious mechanism, designed for both bacterial offense and defense, has been studied most extensively in Yersinia spp. To be exported efficiently, at least three of the effectors (YopE, YopH and YopT) and several other proteins that transit the type III secretion pathway in Yersinia (YopN, YopD and YopB) must first form transient complexes with cognate-specific Yop chaperone (Syc) proteins. The cytotoxic effector YopE, a selective activator of mammalian Rho-family GTPases, associates with SycE. Here, the structure of Y. pestis SycE at 1.95A resolution is reported. SycE possesses a novel fold with an unusual dimerization motif and an intriguing basic cavity located on the dyad axis of the dimer that may participate in its interaction with YopE.

-	~~{{STRUCTURE_1k6z\| PDB=1k6z \| SCENE= }}~~	+	Three-dimensional structure of the type III secretion chaperone SycE from Yersinia pestis.,Evdokimov AG, Tropea JE, Routzahn KM, Waugh DS Acta Crystallogr D Biol Crystallogr. 2002 Mar;58(Pt 3):398-406. Epub 2002, Feb 21. PMID:11856824<ref>PMID:11856824</ref>

-	~~===Crystal Structure~~ of the ~~Yersinia Secretion Chaperone SycE===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_11856824}}~~	+	== References ==
-		+	<references/>
-	~~==About this Structure==~~	+	__TOC__
-	~~[[1k6z]] is a 2 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Yersinia_pestis Yersinia pestis]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=1K6Z OCA].~~	+	</StructureSection>
-		+
-	==~~Reference~~==	+
-	<~~ref group="xtra">PMID:011856824<~~/~~ref~~><~~references group="xtra"~~/>	+
	[[Category: Yersinia pestis]]		[[Category: Yersinia pestis]]
	[[Category: Evdokimov, A G.]]		[[Category: Evdokimov, A G.]]

OCA: Protected "1k6z" [edit=sysop:move=sysop]

2012-12-05T20:55:42Z

Protected "1k6z" [edit=sysop:move=sysop]

←Older revision

Revision as of 20:55, 5 December 2012

OCA at 20:55, 5 December 2012

2012-12-05T20:55:40Z

←Older revision		Revision as of 20:55, 5 December 2012
Line 1:		Line 1:
-	{{Seed}}
	[[Image:1k6z.png\|left\|200px]]		[[Image:1k6z.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_1k6z", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_1k6z\| PDB=1k6z \| SCENE= }}		{{STRUCTURE_1k6z\| PDB=1k6z \| SCENE= }}

	===Crystal Structure of the Yersinia Secretion Chaperone SycE===		===Crystal Structure of the Yersinia Secretion Chaperone SycE===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_11856824}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 11856824 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_11856824}}		{{ABSTRACT_PUBMED_11856824}}

	==About this Structure==		==About this Structure==
-	~~1K6Z~~ is a 2 ~~chains~~ structure ~~of sequences~~ from [http://en.wikipedia.org/wiki/Yersinia_pestis Yersinia pestis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1K6Z OCA].	+	[[1k6z]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Yersinia_pestis Yersinia pestis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1K6Z OCA].

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~11856824~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:011856824</ref><references group="xtra"/>
	[[Category: Yersinia pestis]]		[[Category: Yersinia pestis]]
	[[Category: Evdokimov, A G.]]		[[Category: Evdokimov, A G.]]
Line 33:		Line 21:
	[[Category: Toxin]]		[[Category: Toxin]]
	[[Category: Yersinia pesti]]		[[Category: Yersinia pesti]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 15:30:32 2009''