1kt5 - Revision history

OCA at 09:04, 16 August 2023

2023-08-16T09:04:27Z

←Older revision		Revision as of 09:04, 16 August 2023
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	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1kt5]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1KT5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1KT5 FirstGlance]. <br>		<table><tr><td colspan='2'>[[1kt5]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1KT5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1KT5 FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=RTL:RETINOL'>RTL</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.46Å</td></tr>
-	<tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"><~~div style~~='~~overflow~~: ~~auto; max-height: 3em;~~'>~~[[1hbp\|1hbp]], [[1hbq\|1hbq]], [[1rbp\|1rbp]], [[1kt3\|1kt3]], [[1kt4\|1kt4]], [[1kt6\|1kt6]], [[1kt7\|1kt7]]~~</~~div~~></td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=RTL:RETINOL'>RTL</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1kt5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1kt5 OCA], [https://pdbe.org/1kt5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1kt5 RCSB], [https://www.ebi.ac.uk/pdbsum/1kt5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1kt5 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1kt5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1kt5 OCA], [https://pdbe.org/1kt5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1kt5 RCSB], [https://www.ebi.ac.uk/pdbsum/1kt5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1kt5 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/RET4_BOVIN RET4_BOVIN]] Delivers retinol from the liver stores to the peripheral tissues. In plasma, the RBP-retinol complex interacts with transthyretin, this prevents its loss by filtration through the kidney glomeruli.	+	[https://www.uniprot.org/uniprot/RET4_BOVIN RET4_BOVIN] Delivers retinol from the liver stores to the peripheral tissues. In plasma, the RBP-retinol complex interacts with transthyretin, this prevents its loss by filtration through the kidney glomeruli.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	[[Category: Bos taurus]]		[[Category: Bos taurus]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Berni, R]]	+	[[Category: Berni R]]
-	[[Category: Calderone, V]]	+	[[Category: Calderone V]]
-	[[Category: Zanotti, G]]	+	[[Category: Zanotti G]]
-	~~[[Category: Rbp]]~~	+
-	~~[[Category: Retinol binding]]~~	+
-	~~[[Category: Transport protein~~]]	+

OCA at 06:35, 18 August 2021

2021-08-18T06:35:24Z

←Older revision		Revision as of 06:35, 18 August 2021
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	<StructureSection load='1kt5' size='340' side='right'caption='[[1kt5]], [[Resolution\|resolution]] 1.46Å' scene=''>		<StructureSection load='1kt5' size='340' side='right'caption='[[1kt5]], [[Resolution\|resolution]] 1.46Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1kt5]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1KT5 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1KT5 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1kt5]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1KT5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1KT5 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=RTL:RETINOL'>RTL</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=RTL:RETINOL'>RTL</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1hbp\|1hbp]], [[1hbq\|1hbq]], [[1rbp\|1rbp]], [[1kt3\|1kt3]], [[1kt4\|1kt4]], [[1kt6\|1kt6]], [[1kt7\|1kt7]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1hbp\|1hbp]], [[1hbq\|1hbq]], [[1rbp\|1rbp]], [[1kt3\|1kt3]], [[1kt4\|1kt4]], [[1kt6\|1kt6]], [[1kt7\|1kt7]]</div></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1kt5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1kt5 OCA], [~~http~~://pdbe.org/1kt5 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=1kt5 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/1kt5 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=1kt5 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1kt5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1kt5 OCA], [https://pdbe.org/1kt5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1kt5 RCSB], [https://www.ebi.ac.uk/pdbsum/1kt5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1kt5 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/RET4_BOVIN RET4_BOVIN]] Delivers retinol from the liver stores to the peripheral tissues. In plasma, the RBP-retinol complex interacts with transthyretin, this prevents its loss by filtration through the kidney glomeruli.	+	[[https://www.uniprot.org/uniprot/RET4_BOVIN RET4_BOVIN]] Delivers retinol from the liver stores to the peripheral tissues. In plasma, the RBP-retinol complex interacts with transthyretin, this prevents its loss by filtration through the kidney glomeruli.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	==See Also==		==See Also==
-	*[[Retinol-binding protein\|Retinol-binding protein]]	+	*[[Retinol-binding protein 3D structures\|Retinol-binding protein 3D structures]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 12:22, 13 November 2019

2019-11-13T12:22:23Z

←Older revision		Revision as of 12:22, 13 November 2019
Line 1:		Line 1:

	==Crystal structure of bovine holo-RBP at pH 4.0==		==Crystal structure of bovine holo-RBP at pH 4.0==
-	<StructureSection load='1kt5' size='340' side='right' caption='[[1kt5]], [[Resolution\|resolution]] 1.46Å' scene=''>	+	<StructureSection load='1kt5' size='340' side='right'caption='[[1kt5]], [[Resolution\|resolution]] 1.46Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1kt5]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1KT5 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1KT5 FirstGlance]. <br>		<table><tr><td colspan='2'>[[1kt5]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1KT5 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1KT5 FirstGlance]. <br>
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	</div>		</div>
	<div class="pdbe-citations 1kt5" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 1kt5" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Retinol-binding protein\|Retinol-binding protein]]
	== References ==		== References ==
	<references/>		<references/>
Line 34:		Line 37:
	</StructureSection>		</StructureSection>
	[[Category: Bos taurus]]		[[Category: Bos taurus]]
		+	[[Category: Large Structures]]
	[[Category: Berni, R]]		[[Category: Berni, R]]
	[[Category: Calderone, V]]		[[Category: Calderone, V]]

OCA at 21:32, 24 January 2018

2018-01-24T21:32:36Z

←Older revision		Revision as of 21:32, 24 January 2018
Line 1:		Line 1:
		+
	==Crystal structure of bovine holo-RBP at pH 4.0==		==Crystal structure of bovine holo-RBP at pH 4.0==
	<StructureSection load='1kt5' size='340' side='right' caption='[[1kt5]], [[Resolution\|resolution]] 1.46Å' scene=''>		<StructureSection load='1kt5' size='340' side='right' caption='[[1kt5]], [[Resolution\|resolution]] 1.46Å' scene=''>
Line 5:		Line 6:
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=RTL:RETINOL'>RTL</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=RTL:RETINOL'>RTL</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1hbp\|1hbp]], [[1hbq\|1hbq]], [[1rbp\|1rbp]], [[1kt3\|1kt3]], [[1kt4\|1kt4]], [[1kt6\|1kt6]], [[1kt7\|1kt7]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1hbp\|1hbp]], [[1hbq\|1hbq]], [[1rbp\|1rbp]], [[1kt3\|1kt3]], [[1kt4\|1kt4]], [[1kt6\|1kt6]], [[1kt7\|1kt7]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1kt5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1kt5 OCA], [http://pdbe.org/1kt5 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1kt5 RCSB], [http://www.ebi.ac.uk/pdbsum/1kt5 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1kt5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1kt5 OCA], [http://pdbe.org/1kt5 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1kt5 RCSB], [http://www.ebi.ac.uk/pdbsum/1kt5 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1kt5 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 13:		Line 14:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/kt/1kt5_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/kt/1kt5_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
Line 28:		Line 29:
	</div>		</div>
	<div class="pdbe-citations 1kt5" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 1kt5" style="background-color:#fffaf0;"></div>
-
-	==See Also==
-	*[[Retinol-binding protein\|Retinol-binding protein]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 21:00, 7 February 2016

2016-02-07T21:00:39Z

←Older revision		Revision as of 21:00, 7 February 2016
Line 17:		Line 17:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1kt5 ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 04:56, 10 September 2015

2015-09-10T04:56:53Z

←Older revision		Revision as of 04:56, 10 September 2015
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	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=RTL:RETINOL'>RTL</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=RTL:RETINOL'>RTL</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1hbp\|1hbp]], [[1hbq\|1hbq]], [[1rbp\|1rbp]], [[1kt3\|1kt3]], [[1kt4\|1kt4]], [[1kt6\|1kt6]], [[1kt7\|1kt7]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1hbp\|1hbp]], [[1hbq\|1hbq]], [[1rbp\|1rbp]], [[1kt3\|1kt3]], [[1kt4\|1kt4]], [[1kt6\|1kt6]], [[1kt7\|1kt7]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1kt5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1kt5 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1kt5 RCSB], [http://www.ebi.ac.uk/pdbsum/1kt5 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1kt5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1kt5 OCA], [http://pdbe.org/1kt5 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1kt5 RCSB], [http://www.ebi.ac.uk/pdbsum/1kt5 PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 27:		Line 27:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 1kt5" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==

OCA at 18:13, 24 December 2014

2014-12-24T18:13:13Z

←Older revision		Revision as of 18:13, 24 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1kt5]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1KT5 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1KT5 FirstGlance]. <br>		<table><tr><td colspan='2'>[[1kt5]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1KT5 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1KT5 FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=RTL:RETINOL'>RTL</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=RTL:RETINOL'>RTL</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1hbp\|1hbp]], [[1hbq\|1hbq]], [[1rbp\|1rbp]], [[1kt3\|1kt3]], [[1kt4\|1kt4]], [[1kt6\|1kt6]], [[1kt7\|1kt7]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1hbp\|1hbp]], [[1hbq\|1hbq]], [[1rbp\|1rbp]], [[1kt3\|1kt3]], [[1kt4\|1kt4]], [[1kt6\|1kt6]], [[1kt7\|1kt7]]</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1kt5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1kt5 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1kt5 RCSB], [http://www.ebi.ac.uk/pdbsum/1kt5 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1kt5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1kt5 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1kt5 RCSB], [http://www.ebi.ac.uk/pdbsum/1kt5 PDBsum]</span></td></tr>
-	<table>	+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/RET4_BOVIN RET4_BOVIN]] Delivers retinol from the liver stores to the peripheral tissues. In plasma, the RBP-retinol complex interacts with transthyretin, this prevents its loss by filtration through the kidney glomeruli.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	</StructureSection>		</StructureSection>
	[[Category: Bos taurus]]		[[Category: Bos taurus]]
-	[[Category: Berni, R.]]	+	[[Category: Berni, R]]
-	[[Category: Calderone, V.]]	+	[[Category: Calderone, V]]
-	[[Category: Zanotti, G.]]	+	[[Category: Zanotti, G]]
	[[Category: Rbp]]		[[Category: Rbp]]
	[[Category: Retinol binding]]		[[Category: Retinol binding]]
	[[Category: Transport protein]]		[[Category: Transport protein]]

OCA at 13:54, 28 September 2014

2014-09-28T13:54:28Z

←Older revision		Revision as of 13:54, 28 September 2014
Line 1:		Line 1:
-	[[~~Image:~~1kt5.~~png~~\|~~left~~\|200px]]	+	==Crystal structure of bovine holo-RBP at pH 4.0==
		+	<StructureSection load='1kt5' size='340' side='right' caption='[[1kt5]], [[Resolution\|resolution]] 1.46Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[1kt5]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1KT5 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1KT5 FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=RTL:RETINOL'>RTL</scene><br>
		+	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1hbp\|1hbp]], [[1hbq\|1hbq]], [[1rbp\|1rbp]], [[1kt3\|1kt3]], [[1kt4\|1kt4]], [[1kt6\|1kt6]], [[1kt7\|1kt7]]</td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1kt5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1kt5 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1kt5 RCSB], [http://www.ebi.ac.uk/pdbsum/1kt5 PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/kt/1kt5_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The targeted delivery of non-polar ligands by binding proteins to membranes or membrane receptors involves the release of these ligands on or near the plasma membrane of target cells. Because these hydrophobic ligands are often bound inside a deep cavity of binding proteins, as shown previously for plasma retinol-binding protein (RBP), their release from these proteins might require the destabilization of the protein structure by partially denaturing conditions, such as those possibly present near plasma membranes. RBP is a plasma transport protein which delivers specifically retinol from its store sites to target cells. Here, we report the high-resolution (1.1-1.4A) crystal structures of bovine holo-RBP at five different pH values, ranging from 9 to 2. While unraveling details of the native protein structure and of the interactions with retinol at nearly atomic resolution at neutral pH, this study provides evidence for definite pH-induced modifications of several structural features of RBP. The structure most representative of the changes that holo-RBP undergoes at different pH values is that of its flexible state at pH 2. At this pH, most significant are the alteration of the arrangement of salt bridges and of the network of water molecules/H-bonds that participates in the retinol-RBP interaction, an appreciable increase of the volume of the beta-barrel cavity, a considerably higher degree of mobility of the RBP-bound ligand and of several protein regions and the disorder of a large number of solvent molecules that are ordered at neutral pH. These changes are likely to be accompanied by a modification of the pattern of charge distribution on the protein surface. All these changes, which reveal a substantially lowered conformational stability of RBP, presumably occur at the initial stages of the acidic denaturation of RBP and are possibly associated with a facilitated release of the retinol molecule from its carrier protein.

-	~~{{STRUCTURE_1kt5\| PDB=1kt5 \| SCENE= }}~~	+	High-resolution structures of retinol-binding protein in complex with retinol: pH-induced protein structural changes in the crystal state.,Calderone V, Berni R, Zanotti G J Mol Biol. 2003 Jun 13;329(4):841-50. PMID:12787682<ref>PMID:12787682</ref>

-	~~===Crystal structure~~ of ~~bovine holo-RBP at pH 4~~.~~0===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_12787682}}~~	+
-		+
-	~~==About this Structure==~~	+
-	~~[[1kt5]] is a 1 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org~~/~~wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1KT5 OCA].~~	+

	==See Also==		==See Also==
	*[[Retinol-binding protein\|Retinol-binding protein]]		*[[Retinol-binding protein\|Retinol-binding protein]]
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	<~~ref group="xtra">PMID:012787682<~~/~~ref~~><~~references group="xtra"~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Bos taurus]]		[[Category: Bos taurus]]
	[[Category: Berni, R.]]		[[Category: Berni, R.]]

OCA at 07:51, 20 October 2012

2012-10-20T07:51:14Z

←Older revision		Revision as of 07:51, 20 October 2012
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	==About this Structure==		==About this Structure==
-	[[1kt5]] is a 1 chain structure ~~of [[Retinol-binding protein]]~~ with sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1KT5 OCA].	+	[[1kt5]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1KT5 OCA].

	==See Also==		==See Also==

OCA: Protected "1kt5" [edit=sysop:move=sysop]

2012-07-25T17:40:17Z

Protected "1kt5" [edit=sysop:move=sysop]

←Older revision

Revision as of 17:40, 25 July 2012